The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jorg Oehlmann - One of the best experts on this subject based on the ideXlab platform.
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endocrine disruptors in bottled Mineral Water total estrogenic burden and migration from plastic bottles
Environmental Science and Pollution Research, 2009Co-Authors: Martin Wagner, Jorg OehlmannAbstract:Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g., phthalates) and human body fluids (e.g., urine and blood). Since the research in this field is focused on few chemicals (and thus missing mixture effects), the overall contamination of edibles with xenohormones is largely unknown. The aim of this study was to assess the integrated estrogenic burden of bottled Mineral Water as model foodstuff and to characterize the potential sources of the estrogenic contamination. In the present study, we analyzed commercially available Mineral Water in an in vitro system with the human estrogen receptor alpha and detected estrogenic contamination in 60% of all samples with a maximum activity equivalent to 75.2 ng/l of the natural sex hormone 17β-estradiol. Furthermore, breeding of the molluskan model Potamopyrgus antipodarum in Water bottles made of glass and plastic [polyethylene terephthalate (PET)] resulted in an increased reproductive output of snails cultured in PET bottles. This provides first evidence that substances leaching from plastic food packaging materials act as functional estrogens in vivo. Our results demonstrate a widespread contamination of Mineral Water with xenoestrogens that partly originates from compounds leaching from the plastic packaging material. These substances possess potent estrogenic activity in vivo in a molluskan sentinel. Overall, the results indicate that a broader range of foodstuff may be contaminated with endocrine disruptors when packed in plastics.
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endocrine disruptors in bottled Mineral Water total estrogenic burden and migration from plastic bottles
Environmental Science and Pollution Research, 2009Co-Authors: Martin Wagner, Jorg OehlmannAbstract:Background, aim, and scope Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g., phthalates) and human body fluids (e.g., urine and blood). Since the research in this field is focused on few chemicals (and thus missing mixture effects), the overall contamination of edibles with xenohormones is largely unknown. The aim of this study was to assess the integrated estrogenic burden of bottled Mineral Water as model foodstuff and to characterize the potential sources of the estrogenic contamination.
Albrecht Hesse - One of the best experts on this subject based on the ideXlab platform.
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influence of a Mineral Water rich in calcium magnesium and bicarbonate on urine composition and the risk of calcium oxalate crystallization
European Journal of Clinical Nutrition, 2004Co-Authors: Roswitha Siener, A Jahnen, Albrecht HesseAbstract:Objective: To evaluate the effect of a Mineral Water rich in magnesium (337 mg/l), calcium (232 mg/l) and bicarbonate (3388 mg/l) on urine composition and the risk of calcium oxalate crystallization. Design: A total of 12 healthy male volunteers participated in the study. During the baseline phase, subjects collected two 24-h urine samples while on their usual diet. Throughout the control and test phases, lasting 5 days each, the subjects received a standardized diet calculated according to the recommendations. During the control phase, subjects consumed 1.4 l/day of a neutral fruit tea, which was replaced by an equal volume of a Mineral Water during the test phase. On the follow-up phase, subjects continued to drink 1.4 l/day of the Mineral Water on their usual diet and collected 24-h urine samples weekly. Results: During the intake of Mineral Water, urinary pH, magnesium and citrate excretion increased significantly on both standardized and normal dietary conditions. The Mineral Water led to a significant increase in urinary calcium excretion only on the standardized diet, and to a significantly higher urinary volume and decreased supersaturation with calcium oxalate only on the usual diet. Conclusions: The magnesium and bicarbonate content of the Mineral Water resulted in favorable changes in urinary pH, magnesium and citrate excretion, inhibitors of calcium oxalate stone formation, counterbalancing increased calcium excretion. Since urinary oxalate excretion did not diminish, further studies are necessary to evaluate whether the ingestion of calcium-rich Mineral Water with, rather than between, meals may complex oxalate in the gut thus limiting intestinal absorption and urinary excretion of calcium and oxalate.
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cross over study of the influence of bicarbonate rich Mineral Water on urinary composition in comparison with sodium potassium citrate in healthy male subjects
British Journal of Nutrition, 2000Co-Authors: Torsten Kessler, Albrecht HesseAbstract:Urine volume is the greatest risk factor for nephrolithiasis. High fluid intake is the first general advice given to stone-forming patients for the prevention of their recurrence. The aim of the present study was to evaluate the influence of bicarbonate-rich Mineral Water (1715 mg bicarbonate/l) on urinary-stone risk factors in comparison with sodium potassium citrate, a well-established treatment for urinary stones. The Mineral Water and sodium potassium citrate were administered in equimolar concentrations, with respect to the alkali load. All investigations were carried out in healthy male subjects aged 23-38 years. The study followed a cross-over design. All subjects received a standardized diet during the cross-over phase, which was formulated according to the dietary recommendations of the German Society of Nutrition (Deutsche Gesellschaft fur Ernahrung, 1996). On the loading day of the cross-over phase, fruit tea was substituted for either Mineral Water or sodium potassium citrate dissolved in fruit tea. The treatment offered during the second part of the cross-over phase was continued for a 4-week follow-up under normal dietary conditions. During the cross-over phase, there was a significant increase in urinary pH (p < 0.001). There was also a significant increase in the excretion of citric acid (P < 0.01), a decrease in the excretion of oxalic acid, and therefore a decrease in the relative supersaturations for calcium oxalate and uric acid. In the follow-up phase also, the relative supersaturations decreased and there were beneficial effects on the other urinary variables. The effect of the bicarbonate-rich Mineral Water was similar to that of the sodium potassium citrate, which suggests that it could be useful in the prevention of the recurrence of calcium oxalate and uric acid stones.
Denis Barclay - One of the best experts on this subject based on the ideXlab platform.
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calcium bioavailability from a calcium and sulfate rich Mineral Water compared with milk in young adult women
The American Journal of Clinical Nutrition, 1995Co-Authors: François Couzy, Peter Kastenmayer, Markel Vigo, R Munozbox, Jennifer Clough, Denis BarclayAbstract:Some Mineral Waters have a high calcium content and may contribute a significant part of the human daily requirements. Calcium bioavailability from a calcium- and sulfate-rich Mineral Water (CS-W) containing 11.2 mmol Ca/L (467 mg/L) was compared with that from milk in nine healthy young women. Calcium absorption was measured in the fasting state with a dual-label stable-isotope technique. Fractional absorption rates from milk and CS-W were 25.0 ± 6.7% and 23.8 ± 4.8% (x ± SD), respectively, and did not differ significantly (P = 0.05). Urine was collected for 36 h after the administration of the oral stable isotope while the subjects consumed a controlled diet and a quantity of milk or CS-W providing 25 mmol (1000 mg) Ca. No significant difference was found in the excretion of calcium, nor in the excretion of the two stable isotopes. Mean urinary sulfate excretion was significantly increased by 35% when the CS-W was consumed. No significant correlation was found between 36-h urinary excretion of the intravenous calcium tracer and sulfate, sodium, or urine volume. Therefore, calcium from the CS-W was as well absorbed and retained as that from milk, and no calciuric effect of sulfate was found, showing that such Mineral Waters can be valuable dietary sources of calcium.
Martin Wagner - One of the best experts on this subject based on the ideXlab platform.
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endocrine disruptors in bottled Mineral Water total estrogenic burden and migration from plastic bottles
Environmental Science and Pollution Research, 2009Co-Authors: Martin Wagner, Jorg OehlmannAbstract:Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g., phthalates) and human body fluids (e.g., urine and blood). Since the research in this field is focused on few chemicals (and thus missing mixture effects), the overall contamination of edibles with xenohormones is largely unknown. The aim of this study was to assess the integrated estrogenic burden of bottled Mineral Water as model foodstuff and to characterize the potential sources of the estrogenic contamination. In the present study, we analyzed commercially available Mineral Water in an in vitro system with the human estrogen receptor alpha and detected estrogenic contamination in 60% of all samples with a maximum activity equivalent to 75.2 ng/l of the natural sex hormone 17β-estradiol. Furthermore, breeding of the molluskan model Potamopyrgus antipodarum in Water bottles made of glass and plastic [polyethylene terephthalate (PET)] resulted in an increased reproductive output of snails cultured in PET bottles. This provides first evidence that substances leaching from plastic food packaging materials act as functional estrogens in vivo. Our results demonstrate a widespread contamination of Mineral Water with xenoestrogens that partly originates from compounds leaching from the plastic packaging material. These substances possess potent estrogenic activity in vivo in a molluskan sentinel. Overall, the results indicate that a broader range of foodstuff may be contaminated with endocrine disruptors when packed in plastics.
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endocrine disruptors in bottled Mineral Water total estrogenic burden and migration from plastic bottles
Environmental Science and Pollution Research, 2009Co-Authors: Martin Wagner, Jorg OehlmannAbstract:Background, aim, and scope Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g., phthalates) and human body fluids (e.g., urine and blood). Since the research in this field is focused on few chemicals (and thus missing mixture effects), the overall contamination of edibles with xenohormones is largely unknown. The aim of this study was to assess the integrated estrogenic burden of bottled Mineral Water as model foodstuff and to characterize the potential sources of the estrogenic contamination.
Pilar M Vaquero - One of the best experts on this subject based on the ideXlab platform.
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An Intervention with Mineral Water Decreases Cardiometabolic Risk Biomarkers. A Crossover, Randomised, Controlled Trial with Two Mineral Waters in Moderately Hypercholesterolaemic Adults
MDPI AG, 2016Co-Authors: Laura Toxqui, Pilar M VaqueroAbstract:Water intake is essential for health maintenance and disease prevention. The effects of an intervention with two Mineral Waters, sodium-bicarbonated Mineral Water (BW) or control Mineral Water low in Mineral content (CW), on cardiometabolic risk biomarkers were studied. In a randomised-controlled crossover-trial, sixty-four moderately hypercholesterolaemic adults were randomly assigned to consume 1 L/day of either BW (sodium, 1 g/L; bicarbonate, 2 g/L) or CW with the main meals for eight weeks, separated by an eight-week washout period. Blood lipids, lipid oxidation, glucose, insulin, aldosterone, urine pH, urinary electrolytes, blood pressure, body weight, fluid intake, energy, and nutrients from total diet and beverages were determined. Total cholesterol, LDL cholesterol, and glucose decreased (p < 0.01), oxidised LDL tended to decrease (p = 0.073), and apolipoprotein B increased during the intervention, without Water type effect. Energy and carbohydrates from beverages decreased since soft drinks and fruit juice consumptions decreased throughout the trial. BW increased urinary pH (p = 0.006) and reduced calcium/creatinine excretion (p = 0.011). Urinary potassium/creatinine decreased with both Waters. Consumption of 1 L/day of Mineral Water with the main meals reduces cardiometabolic risk biomarkers, likely to be attributed to a replacement of soft drinks by Water. In addition, BW does not affect blood pressure and exerts a moderate alkalizing effect in the body
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a sodium bicarbonated Mineral Water reduces gallbladder emptying and postprandial lipaemia a randomised four way crossover study
European Journal of Nutrition, 2012Co-Authors: Laura Toxqui, Ana M Perezgranados, Ruth Blancorojo, Pilar M VaqueroAbstract:Background Sodium-bicarbonated Mineral Waters are reported to have beneficial digestive and hypocholesterolaemic properties. The aim of the study was to investigate the effects of consumption of a sodium-bicarbonated Mineral Water (BW) with or without a meal, compared to a low Mineral content Water as the control Water (CW), on postprandial serum triacylglycerols (TAG), cholecystokinin (CCK) and gallbladder volume.
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bone remodelling is not affected by consumption of a sodium rich carbonated Mineral Water in healthy postmenopausal women
British Journal of Nutrition, 2005Co-Authors: Stefanie Schoppen, Concepción De La ,piedra, Ana M Perezgranados, A Carbajal, Pilar M VaqueroAbstract:This study was designed to investigate the possible effects of consuming Na-rich carbonated Mineral Water on bone remodelling and urinary Mineral excretion in postmenopausal women. Women (n 18) included were amenorrhoeic (>1 year), healthy and not obese (BMI <30 kg/m2). No woman was taking oestrogen replacement therapy, Mineral and vitamin supplements, phyto-oestrogens or medications known to affect bone and lipid metabolism. In two consecutive interventions that lasted 8 weeks each, women drank 1 litre of control Mineral Water daily and 1 litre of carbonated Mineral Water, rich in Na, HCO3- and Cl-, daily. Body weight and height were measured, BMI was calculated and blood pressure was measured. Blood samples were taken from fasting subjects and serum obtained to analyse the biochemical bone markers, procollagen I amino-terminal propeptide (PINP) and beta-carboxy-terminal telopeptide of collagen (beta-CTX). At the end of each period, 24 h urine samples were collected to determine Ca, Mg, P, Na+, K+, Cl-, urine excretion and urinary pH. No changes in body weight, BMI or blood pressure were observed during the experimental period. Ca excretion was lower after the intake of carbonated Water than after intake of the control Water (P=0.037) while P excretion was higher (P=0.015). Total urine, Na and Cl- excretion did not differ between the two periods but urinary pH was increased after the intake of carbonated Mineral Water. PINP and beta-CTX did not differ between the two periods. Daily consumption of 1 litre of Na-rich carbonated Mineral Water for 8 weeks does not affect bone remodelling in healthy postmenopausal women.
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a sodium rich carbonated Mineral Water reduces cardiovascular risk in postmenopausal women
Journal of Nutrition, 2004Co-Authors: Stefanie Schoppen, Ana M Perezgranados, A Carbajal, Pilar Oubina, Francisco J Sanchezmuniz, Juan A Gomezgerique, Pilar M VaqueroAbstract:This study was designed to investigate the possible beneficial effects of consuming a sodium-rich carbonated Mineral Water on lipoprotein metabolism and to determine whether consumption of this Water influences endothelial dysfunction (ED) in postmenopausal women. Women included in the study were amenorrheic (>1 y), healthy, and not obese (BMI < 30 kg/m(2)). The subjects did not take estrogen replacement therapy; supplements of vitamins, Minerals, and phytoestrogens; or other medications known to affect bone and lipid metabolism. The study consisted of 2 intervention periods of 2 mo each, during which women drank 1 L/d of a control Mineral Water (low Mineral content) for 2 mo followed by the carbonated Mineral Water, rich in sodium, bicarbonate, and chloride, for 2 mo. Body weight, height, and blood pressure were measured, and BMI was calculated. Blood samples were taken from fasting subjects and serum was analyzed for total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols, apolipoprotein AI, apolipoprotein B, soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and glucose. Blood pressure levels did not change throughout the study. Carbonated Water intake decreased total cholesterol and LDL-cholesterol levels by 6.8% (P = 0.001) and 14.8% (P < 0.0001), respectively, whereas HDL-cholesterol concentration increased by 8.7% (P = 0.018), compared to the control period. Therefore, cardiovascular disease (CVD) risk indexes (total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol) were markedly reduced (both P < 0.0001). Soluble ICAM-1 and sVCAM-1 levels decreased by 8.4% (P = 0.007) and 14.8% (P = 0.015), respectively. Fasting serum glucose concentration decreased by 6.7% (P < 0.0001). Triacylglycerol levels did not change. Consumption of this sodium rich carbonated Water can play a beneficial role in the prevention of CVD and the metabolic syndrome.
