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Olaf Rötzschke - One of the best experts on this subject based on the ideXlab platform.
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Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study
International journal of nephrology, 2017Co-Authors: Francisco Salcido-ochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Doreen Haase, John Carson Allen, Jabed Iqbal, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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analysis of t cell subsets in adult primary idiopathic Minimal Change Disease a pilot study
International Journal of Nephrology, 2017Co-Authors: Francisco Salcidoochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Doreen Haase, John Carson Allen, Jabed Iqbal, Alwin Loh, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
Eduardo H. Garin - One of the best experts on this subject based on the ideXlab platform.
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Angiopoietin-like-4 and Minimal Change Disease.
PloS one, 2017Co-Authors: Gabriel Cara-fuentes, Richard J. Johnson, Heiman Wang, Alfons Segarra, Cecilia Silva-sanchez, Miguel A. Lanaspa, Eduardo H. GarinAbstract:Background Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4 as a biomarker in MCD. Methods Patients with biopsy-proven primary MCD, focal segmental glomerulosclerosis, membranous nephropathy (60, 52 and 52 respectively) and 18 control subjects had urinary and serum Angptl4 measured by Elisa. Frozen kidney tissue sections were stained for Angptl4. Results Angptl4 was not identified in glomeruli of MCD patients in relapse. Urinary Angptl4 levels were elevated in MCD in relapse as well as in patients with massive proteinuria due to other glomerular Diseases. Conclusion Neither serum nor urine Angptl4 appear to be good biomarkers in MCD. Elevated urinary Angptl4 n glomerular Disease appears to reflect the degree of proteinuria rather than any specific Disease.
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Pathogenesis of proteinuria in idiopathic Minimal Change Disease: molecular mechanisms
Pediatric Nephrology, 2016Co-Authors: Gabriel Cara-fuentes, Richard J. Johnson, William L. Clapp, Eduardo H. GarinAbstract:Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children and adolescents. The pathogenesis of proteinuria in this condition is currently being reassessed. Following the Shalhoub hypothesis, most efforts have been placed on identifying the putative circulating factor, but recent advancement in podocyte biology has focused attention on the molecular Changes at the glomerular capillary wall, which could explain the mechanism of proteinuria in MCD. This report critically reviews current knowledge on the different postulated mechanisms at the glomerular capillary wall level for increased permeability to plasma proteins in MCD. The report helps describe the rationale behind novel therapies and suggests future targeted therapies for MCD.
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Minimal Change Disease
Proteinuria: Basic Mechanisms Pathophysiology and Clinical Relevance, 2016Co-Authors: Gabriel Cara-fuentes, Richard J. Johnson, Eduardo H. GarinAbstract:Minimal Change Disease (MDC) is the most common type of nephrotic syndrome in childhood. Currently, advancements in podocyte biology suggest that podocyte may play a pathogenic role in the development of proteinuria in this Disease. In the majority of children, MCD presents a relapsing pattern that may persist to adulthood. Steroids are considered the drug of choice to control proteinuria. Recently, new therapeutic modalities including ACTH and rituximab have been tried with variable results. There is a need for multicenter, randomized, controlled studies to define the efficacy of these drugs in MCD.
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case series ctla4 igg1 therapy in Minimal Change Disease and focal segmental glomerulosclerosis
Pediatric Nephrology, 2015Co-Authors: Eduardo H. Garin, Jochen Reiser, Gabriel Carafuentes, Changli Wei, Dany Matar, Heiman Wang, Nada Alachkar, Richard J. JohnsonAbstract:Background Minimal Change Disease (MCD) in relapse is associated with increased podocyte CD80 expression and elevated urinary CD80 excretion, whereas focal segmental glomerulosclerosis (FSGS) has mild or absent CD80 podocyte expression and normal urinary CD80 excretion.
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Minimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Axis?
Pediatric nephrology (Berlin Germany), 2014Co-Authors: Gabriel Cara-fuentes, Richard J. Johnson, Heiman Wang, Clive Wasserfall, Eduardo H. GarinAbstract:Background Minimal Change Disease (MCD) is associated with CD80 expression in podocytes and elevated urinary CD80 excretion during active renal Disease. We have evaluated the urinary excretion of CTLA-4 and CD80 during different stages of the nephrotic syndrome in patients with MCD to test the hypothesis that persistent increased urinary CD80 excretion in patients with MCD in relapse is due to an ineffectual CTLA-4 response of the host to curtail the activation of CD80.
Susan Swee-shan Hue - One of the best experts on this subject based on the ideXlab platform.
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analysis of t cell subsets in adult primary idiopathic Minimal Change Disease a pilot study
International Journal of Nephrology, 2017Co-Authors: Francisco Salcidoochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Doreen Haase, John Carson Allen, Jabed Iqbal, Alwin Loh, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study
International journal of nephrology, 2017Co-Authors: Francisco Salcido-ochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Doreen Haase, John Carson Allen, Jabed Iqbal, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?
ISRN Pathology, 2014Co-Authors: Susan Swee-shan Hue, Sufi Muhammad Suhail, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Francisco Salcido-ochoaAbstract:Minimal Change Disease constitutes a major cause of nephrotic syndrome. It is regarded as a non-immune-complex mediated primary glomerulopathy and pathogenetically is characterised by podocyte injury and effacement of foot processes; therefore, it is also classified as a type of podocytopathy. T cell dysfunction with increased levels of a soluble glomerular permeability factor has been proposed to play a major role in the pathogenesis of Minimal Change Disease. It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary Minimal Change Disease is still largely unclear. We here propose a theoretical model based on the available evidence.
Jason Chon Jun Choo - One of the best experts on this subject based on the ideXlab platform.
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analysis of t cell subsets in adult primary idiopathic Minimal Change Disease a pilot study
International Journal of Nephrology, 2017Co-Authors: Francisco Salcidoochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Doreen Haase, John Carson Allen, Jabed Iqbal, Alwin Loh, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study
International journal of nephrology, 2017Co-Authors: Francisco Salcido-ochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Doreen Haase, John Carson Allen, Jabed Iqbal, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?
ISRN Pathology, 2014Co-Authors: Susan Swee-shan Hue, Sufi Muhammad Suhail, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Francisco Salcido-ochoaAbstract:Minimal Change Disease constitutes a major cause of nephrotic syndrome. It is regarded as a non-immune-complex mediated primary glomerulopathy and pathogenetically is characterised by podocyte injury and effacement of foot processes; therefore, it is also classified as a type of podocytopathy. T cell dysfunction with increased levels of a soluble glomerular permeability factor has been proposed to play a major role in the pathogenesis of Minimal Change Disease. It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary Minimal Change Disease is still largely unclear. We here propose a theoretical model based on the available evidence.
Nurhashikin Yusof - One of the best experts on this subject based on the ideXlab platform.
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analysis of t cell subsets in adult primary idiopathic Minimal Change Disease a pilot study
International Journal of Nephrology, 2017Co-Authors: Francisco Salcidoochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Doreen Haase, John Carson Allen, Jabed Iqbal, Alwin Loh, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study
International journal of nephrology, 2017Co-Authors: Francisco Salcido-ochoa, Susan Swee-shan Hue, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Doreen Haase, John Carson Allen, Jabed Iqbal, Olaf RötzschkeAbstract:Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic Minimal Change Disease. Methods. In a cohort of 9 adult patients with primary/idiopathic Minimal Change recruited consecutively at Disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic Minimal Change Disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3
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Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?
ISRN Pathology, 2014Co-Authors: Susan Swee-shan Hue, Sufi Muhammad Suhail, Jason Chon Jun Choo, Nurhashikin Yusof, Alwin Hwai Liang Loh, Francisco Salcido-ochoaAbstract:Minimal Change Disease constitutes a major cause of nephrotic syndrome. It is regarded as a non-immune-complex mediated primary glomerulopathy and pathogenetically is characterised by podocyte injury and effacement of foot processes; therefore, it is also classified as a type of podocytopathy. T cell dysfunction with increased levels of a soluble glomerular permeability factor has been proposed to play a major role in the pathogenesis of Minimal Change Disease. It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary Minimal Change Disease is still largely unclear. We here propose a theoretical model based on the available evidence.