The Experts below are selected from a list of 5670 Experts worldwide ranked by ideXlab platform
Borbala Turcsan - One of the best experts on this subject based on the ideXlab platform.
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owner perceived differences between Mixed breed and purebred dogs
PLOS ONE, 2017Co-Authors: Borbala Turcsan, Adam Miklosi, Enikő KubinyiAbstract:Studies about the behaviours of Mixed-breed dogs are rare, although Mixed-Breeds represent the majority of the world's dog population. We have conducted two surveys to investigate the behavioural, demographic, and dog keeping differences between purebred and Mixed-breed companion dogs. Questionnaire data were collected on a large sample of dogs living in Germany (N = 7,700 purebred dogs representing more than 200 Breeds, and N = 7,691 Mixed-Breeds). We found that according to their owners, Mixed-Breeds were (1) less calm, (2) less sociable toward other dogs, and (3) showed more problematic behaviour than purebreds (p 10%) differences: neutering was more frequent among Mixed-Breeds, and they were acquired at older ages than purebreds (p < 0.001 for both), which could result in the observed behaviour differences. After controlling for the distribution of the demographic and dog keeping factors, we found that Mixed-Breeds were (1) more trainable than purebreds, (2) less calm, and (3) showed more problematic behaviour than purebreds (p < 0.001 for all). We discuss that these differences at least partly might be due to selective forces. Our results suggest that instead of being the "average" dogs, Mixed-Breeds represent a special group with characteristic behavioural traits.
Elaine Ostrander - One of the best experts on this subject based on the ideXlab platform.
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"Lassie," "Toto," and fellow pet dogs: poised to lead the way for advances in cancer prevention.
American Society of Clinical Oncology educational book ASCO. American Society of Clinical Oncology. Meeting, 2015Co-Authors: Deborah W. Knapp, Deepika Dhawan, Elaine OstranderAbstract:Cancer causes substantial morbidity and takes the lives of over 8 million people worldwide each year. Advances in cancer prevention research are crucial, and animal models are key to this. There are many valuable experimentally induced cancer models, but these do not fully meet the needs for cancer prevention studies. Pet dogs with risks for naturally occurring cancer can fill important gaps in cancer prevention research. Using invasive urothelial carcinoma (iUC) as an example, the advantages of utilizing pet dogs include: (1) close similarities between dogs and humans in carcinogenesis, molecular and cellular features, invasive and metastatic behavior, and response to treatment, thus providing high relevance for comparative studies, (2) shared environment between dogs and humans to help identify not-yet-known environmental iUC risks, (3) strong breed-associated risk (5- to 21-fold increased risk compared with Mixed Breeds) that facilitates investigation of gene-environment interactions, screening, and early intervention, (4) large size of dogs (versus rodents) that allows collection of fluids and tissues via cystoscopy, and detailed imaging at multiple time points, and (5) acceptance for studies in which each participating dog can benefit while enjoying life in their family environment, and in which findings will help other dogs and humans. An ongoing 3-year study in Scottish Terriers (comparable to a 15- to 20-year study in humans) is aimed at defining genetic and environmental risk factors for iUC, effective methods for screening/early detection, and a successful secondary cancer prevention approach with very promising results to date. Pet dogs can indeed propel cancer prevention research.
Enikő Kubinyi - One of the best experts on this subject based on the ideXlab platform.
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owner perceived differences between Mixed breed and purebred dogs
PLOS ONE, 2017Co-Authors: Borbala Turcsan, Adam Miklosi, Enikő KubinyiAbstract:Studies about the behaviours of Mixed-breed dogs are rare, although Mixed-Breeds represent the majority of the world's dog population. We have conducted two surveys to investigate the behavioural, demographic, and dog keeping differences between purebred and Mixed-breed companion dogs. Questionnaire data were collected on a large sample of dogs living in Germany (N = 7,700 purebred dogs representing more than 200 Breeds, and N = 7,691 Mixed-Breeds). We found that according to their owners, Mixed-Breeds were (1) less calm, (2) less sociable toward other dogs, and (3) showed more problematic behaviour than purebreds (p 10%) differences: neutering was more frequent among Mixed-Breeds, and they were acquired at older ages than purebreds (p < 0.001 for both), which could result in the observed behaviour differences. After controlling for the distribution of the demographic and dog keeping factors, we found that Mixed-Breeds were (1) more trainable than purebreds, (2) less calm, and (3) showed more problematic behaviour than purebreds (p < 0.001 for all). We discuss that these differences at least partly might be due to selective forces. Our results suggest that instead of being the "average" dogs, Mixed-Breeds represent a special group with characteristic behavioural traits.
Deborah W. Knapp - One of the best experts on this subject based on the ideXlab platform.
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"Lassie," "Toto," and fellow pet dogs: poised to lead the way for advances in cancer prevention.
American Society of Clinical Oncology educational book ASCO. American Society of Clinical Oncology. Meeting, 2015Co-Authors: Deborah W. Knapp, Deepika Dhawan, Elaine OstranderAbstract:Cancer causes substantial morbidity and takes the lives of over 8 million people worldwide each year. Advances in cancer prevention research are crucial, and animal models are key to this. There are many valuable experimentally induced cancer models, but these do not fully meet the needs for cancer prevention studies. Pet dogs with risks for naturally occurring cancer can fill important gaps in cancer prevention research. Using invasive urothelial carcinoma (iUC) as an example, the advantages of utilizing pet dogs include: (1) close similarities between dogs and humans in carcinogenesis, molecular and cellular features, invasive and metastatic behavior, and response to treatment, thus providing high relevance for comparative studies, (2) shared environment between dogs and humans to help identify not-yet-known environmental iUC risks, (3) strong breed-associated risk (5- to 21-fold increased risk compared with Mixed Breeds) that facilitates investigation of gene-environment interactions, screening, and early intervention, (4) large size of dogs (versus rodents) that allows collection of fluids and tissues via cystoscopy, and detailed imaging at multiple time points, and (5) acceptance for studies in which each participating dog can benefit while enjoying life in their family environment, and in which findings will help other dogs and humans. An ongoing 3-year study in Scottish Terriers (comparable to a 15- to 20-year study in humans) is aimed at defining genetic and environmental risk factors for iUC, effective methods for screening/early detection, and a successful secondary cancer prevention approach with very promising results to date. Pet dogs can indeed propel cancer prevention research.
Ruotanen Päivi - One of the best experts on this subject based on the ideXlab platform.
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Frequency and distribution of 152 genetic disease variants in over 100,000 Mixed breed and purebred dogs
'Public Library of Science (PLoS)', 2018Co-Authors: Donner Jonas, Anderson Heidi, Davison Stephen, Hughes, Angela M., Bouirmane Julia, Lindqvist Johan, Lytle, Katherine M., Ganesan Balasubramanian, Ottka Claudia, Ruotanen PäiviAbstract:Knowledge on the genetic epidemiology of disorders in the dog population has implications for both veterinary medicine and sustainable breeding. Limited data on frequencies of genetic disease variants across Breeds exists, and the disease heritage of Mixed breed dogs remains poorly explored to date. Advances in genetic screening technologies now enable comprehensive investigations of the canine disease heritage, and generate health-related big data that can be turned into action. We pursued population screening of genetic variants implicated in Mendelian disorders in the largest canine study sample examined to date by examining over 83,000 Mixed breed and 18,000 purebred dogs representing 330 Breeds for 152 known variants using a custom-designed beadchip microarray. We further announce the creation of MyBreedData (www.mybreeddata.com), an online updated inherited disorder prevalence resource with its foundation in the generated data. We identified the most prevalent, and rare, disease susceptibility variants across the general dog population while providing the first extensive snapshot of the Mixed breed disease heritage. Approximately two in five dogs carried at least one copy of a tested disease variant. Most disease variants are shared by both Mixed Breeds and purebreds, while breed-or line-specificity of others is strongly suggested. Mixed breed dogs were more likely to carry a common recessive disease, whereas purebreds were more likely to be genetically affected with one, providing DNA-based evidence for hybrid vigor. We discovered genetic presence of 22 disease variants in at least one additional breed in which they were previously undescribed. Some mutations likely manifest similarly independently of breed background; however, we emphasize the need for follow up investigations in each case and provide a suggested validation protocol for broader consideration. In conclusion, our study provides unique insight into genetic epidemiology of canine disease risk variants, and their relevance for veterinary medicine, breeding programs and animal welfare
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Data from: Frequency and distribution of 152 genetic disease variants in over 100,000 Mixed breed and purebred dogs
2018Co-Authors: Donner Jonas, Anderson Heidi, Davison Stephen, Hughes, Angela M., Bouirmane Julia, Lindqvist Johan, Lytle, Katherine M., Ganesan Balasubramanian, Ottka Claudia, Ruotanen PäiviAbstract:Knowledge on the genetic epidemiology of disorders in the dog population has implications for both veterinary medicine and sustainable breeding. Limited data on frequencies of genetic disease variants across Breeds exists, and the disease heritage of Mixed breed dogs remains poorly explored to date. Advances in genetic screening technologies now enable comprehensive investigations of the canine disease heritage, and generate health-related big data that can be turned into action. We pursued population screening of genetic variants implicated in Mendelian disorders in the largest canine study sample examined to date by examining around 83,000 Mixed breed and 18,000 purebred dogs representing 330 Breeds for 152 known variants using a custom-designed beadchip microarray. We further announce the creation of MyBreedData (www.mybreeddata.com), an online updated inherited disorder prevalence resource with its foundation in the generated data. We identified the most prevalent, and rare, disease susceptibility variants across the general dog population while providing the first extensive snapshot of the Mixed breed disease heritage. Around 2 in 5 dogs carried at least one copy of a tested disease variant. Most disease variants are shared by both Mixed Breeds and purebreds, while breed- or line-specificity of others is strongly suggested. Mixed breed dogs were more likely to carry a common recessive disease, whereas purebreds were more likely to be genetically affected with one, providing DNA-based evidence for hybrid vigor. We discovered genetic presence of 22 disease variants in at least one additional breed in which they were previously undescribed. Some mutations likely manifest similarly independently of breed background; however, we emphasize the need for follow up investigations in each case and provide a suggested validation protocol for broader consideration. In conclusion, our study provides unique insight into genetic epidemiology of canine disease risk variants, and their relevance for veterinary medicine, breeding programs and animal welfare
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Frequency and distribution of 152 genetic disease variants in over 100,000 Mixed breed and purebred dogs
'Public Library of Science (PLoS)', 2018Co-Authors: Donner Jonas, Anderson Heidi, Davison Stephen, Hughes, Angela M., Bouirmane Julia, Lindqvist Johan, Lytle, Katherine M., Ganesan Balasubramanian, Ottka Claudia, Ruotanen PäiviAbstract:Knowledge on the genetic epidemiology of disorders in the dog population has implications for both veterinary medicine and sustainable breeding. Limited data on frequencies of genetic disease variants across Breeds exists, and the disease heritage of Mixed breed dogs remains poorly explored to date. Advances in genetic screening technologies now enable comprehensive investigations of the canine disease heritage, and generate health-related big data that can be turned into action. We pursued population screening of genetic variants implicated in Mendelian disorders in the largest canine study sample examined to date by examining over 83,000 Mixed breed and 18,000 purebred dogs representing 330 Breeds for 152 known variants using a custom-designed beadchip microarray. We further announce the creation of MyBreedData (www.mybreeddata.com), an online updated inherited disorder prevalence resource with its foundation in the generated data. We identified the most prevalent, and rare, disease susceptibility variants across the general dog population while providing the first extensive snapshot of the Mixed breed disease heritage. Approximately two in five dogs carried at least one copy of a tested disease variant. Most disease variants are shared by both Mixed Breeds and purebreds, while breed-or line-specificity of others is strongly suggested. Mixed breed dogs were more likely to carry a common recessive disease, whereas purebreds were more likely to be genetically affected with one, providing DNA-based evidence for hybrid vigor. We discovered genetic presence of 22 disease variants in at least one additional breed in which they were previously undescribed. Some mutations likely manifest similarly independently of breed background; however, we emphasize the need for follow up investigations in each case and provide a suggested validation protocol for broader consideration. In conclusion, our study provides unique insight into genetic epidemiology of canine disease risk variants, and their relevance for veterinary medicine, breeding programs and animal welfare.Peer reviewe