The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Meeae Y Kwon - One of the best experts on this subject based on the ideXlab platform.
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true malignant Mixed Tumor carcinosarcoma of parotid gland with unusual mesenchymal component a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2001Co-Authors: Meeae Y KwonAbstract:True malignant Mixed Tumor (carcinosarcoma) of the salivary gland is an extremely rare Tumor. By definition, it is composed of both malignant epithelial and malignant mesenchymal elements. The most common type of the former is squamous cell carcinoma or adenocarcinoma and the most common type of the latter is chondrosarcoma, followed in frequency by fibrosarcoma, leiomyosarcoma, osteosarcoma, and in rare instances liposarcoma. We report a case of true malignant Mixed Tumor of the parotid gland in association with a pleomorphic adenoma in a 47-year-old man that contained a very unusual type of malignant mesenchymal component, rhabdomyosarcoma. Cytologic and histologic features and immunohistochemical results are presented. In addition, the literature is reviewed, and the possible histogenesis and pathogenesis of malignant Mixed Tumor of the salivary gland are briefly discussed.
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true malignant Mixed Tumor carcinosarcoma of parotid gland with unusual mesenchymal component a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2001Co-Authors: Meeae Y Kwon, Mai GuAbstract:c True malignant Mixed Tumor (carcinosarcoma) of the salivary gland is an extremely rare Tumor. By definition, it is composed of both malignant epithelial and malignant mesenchymal elements. The most common type of the former is squamous cell carcinoma or adenocarcinoma and the most common type of the latter is chondrosarcoma, followed in frequency by fibrosarcoma, leiomyosarcoma, osteosarcoma, and in rare instances liposarcoma. We report a case of true malignant Mixed Tumor of the parotid gland in association with a pleomorphic adenoma in a 47-yearold man that contained a very unusual type of malignant mesenchymal component, rhabdomyosarcoma. Cytologic and histologic features and immunohistochemical results are presented. In addition, the literature is reviewed, and the possible histogenesis and pathogenesis of malignant Mixed Tumor of the salivary gland are briefly discussed. (Arch Pathol Lab Med. 2001;125:812‐815)
Mai Gu - One of the best experts on this subject based on the ideXlab platform.
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true malignant Mixed Tumor carcinosarcoma of parotid gland with unusual mesenchymal component a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2001Co-Authors: Meeae Y Kwon, Mai GuAbstract:c True malignant Mixed Tumor (carcinosarcoma) of the salivary gland is an extremely rare Tumor. By definition, it is composed of both malignant epithelial and malignant mesenchymal elements. The most common type of the former is squamous cell carcinoma or adenocarcinoma and the most common type of the latter is chondrosarcoma, followed in frequency by fibrosarcoma, leiomyosarcoma, osteosarcoma, and in rare instances liposarcoma. We report a case of true malignant Mixed Tumor of the parotid gland in association with a pleomorphic adenoma in a 47-yearold man that contained a very unusual type of malignant mesenchymal component, rhabdomyosarcoma. Cytologic and histologic features and immunohistochemical results are presented. In addition, the literature is reviewed, and the possible histogenesis and pathogenesis of malignant Mixed Tumor of the salivary gland are briefly discussed. (Arch Pathol Lab Med. 2001;125:812‐815)
Domenico Andrea Campanacci - One of the best experts on this subject based on the ideXlab platform.
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primary juxtacortical myoepithelioma Mixed Tumor of the bone a report of 3 cases with clinicopathologic immunohistochemical ultrastructural and molecular characterization
Human Pathology, 2013Co-Authors: Alessandro Franchi, Annarita Palomba, Giuliana Roselli, Claudio Gambini, Giovanni Beltrami, Rodolfo Capanna, Domenico Andrea CampanacciAbstract:Summary We describe the clinicopathological, immunohistochemical, and molecular features of 3 primary juxtacortical myoepithelioma/Mixed Tumor of bone. The patients were 2 males (13 and 23 years of age) and a 15-year-old female. The juxtacortical lesions were all located in the femur, and were surgically removed, 2 with wide margins and one with marginal margins. This latter Tumor recurred locally 18 months later. The 3 patients were free of disease at 6 to 17 months follow-up. Histologically, all lesions showed a prominent multinodular architecture, and were formed by epithelioid and stellate elements, organized in solid sheets, or embedded in myxoid or chondroid matrix. Areas of osteoid formation were also observed. One Tumor had the appearance of classical Mixed Tumor, showing aspects of duct formation and focal squamous differentiation. Immunohistochemically, all cases were positive for cytokeratins, epithelial membrane antigen, and S100 protein. The expression of other myoepithelial markers, including p63, glial fibrillary acid protein and calponin was more limited. No rearrangement of Ewing sarcoma region 1 ( EWSR1 ) and fused in sarcoma ( FUS ) genes was observed by fluorescent in situ hybridization. To our knowledge, this is the first report of primary myoepitheliomas of bone arising at juxtacortical sites. These lesions must be distinguished from other benign and malignant bone and cartilage–forming surface Tumors, including periosteal chondroma and chondrosarcoma, juxtacortical chondromyxoid fibroma, and periosteal and paraosteal osteosarcoma. The clinicoradiologic presentation and their histological and immunohistochemical features are distinctive enough to allow the separation from these entities.
Kyungwhan Min - One of the best experts on this subject based on the ideXlab platform.
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carcinosarcoma malignant Mixed Tumor of the parotid report of a case with a pure rhabdomyosarcoma component
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 1994Co-Authors: Regina F Gandouredwards, Paul J Donald, Philip J Vogt, Robert J Munn, Kyungwhan MinAbstract:Background. Carcinosarcoma or true malignant Mixed Tumor of the parotid gland is extremely rare, accounting for <1% of all salivary gland malignancies. Methods. A 63-year-old woman presented with a 5-cm right parotid mass which was resected with a radical parotidectomy and infratemporal fossa dissection. Results. The Tumor contained two distinctive histologic patterns, that of a poorly differentiated ductal carcinoma and a pleomorphic rhabdomyosarcoma. Additionally, a residual focus of pleomorphic adenoma was present peripherally, Immunohistochemical and electron microscopic studies confirmed the skeletal muscle differentiation. Conclusions. The pattern of combined rhabdomyosarcoma and ductal carcinoma has not been previously reported and adds further evidence to the myoepithelial derivation of these Tumors. © 1994 John Wiley & Sons, Inc.
Gyungyub Gong - One of the best experts on this subject based on the ideXlab platform.
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fine needle aspiration diagnosis of malignant Mixed Tumor carcinosarcoma arising in pleomorphic adenoma of the salivary gland
Acta Cytologica, 1998Co-Authors: Taeyub Kim, Ghil Suk Yoon, Onja Kim, Gyungyub GongAbstract:BACKGROUND: True malignant Mixed Tumor (carcinosarcoma), composed of carcinoma and sarcoma components, is rare in salivary gland neoplasms. Even rarer is a true malignant Mixed Tumor arising in the pleomorphic adenoma of the salivary gland. CASE: A 64-year-old male was admitted with left pharyngeal pain. Head and neck magnetic resonance imaging revealed a left parapharungeal mass; fine needle aspiration (FNA) cytology through the oral cavity was performed. CONCLUSION: The aspirate presented a mixture of large, pleomorphic, vacuolated, single or multinucleated cells in a mucoid matrix and clusters of adenocarcinoma cells. Additionally, occasional benign glandular cells were noted. A cytologic diagnosis of malignant Mixed Tumor arising in the pleomorphic adenoma of the deep lobe of the parotid gland was made and confirmed by the surgically resected specimen.