The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Kay S Kane - One of the best experts on this subject based on the ideXlab platform.
-
milia en plaque of the nose report of a case and successful treatment with topical tretinoin
Pediatrics, 2014Co-Authors: Vinod E Nambudiri, Nancy Habib, Kenneth A Arndt, Kay S KaneAbstract:Milia are benign, superficial keratinaceous cysts that present as fine, small white papules. Milia en plaque is a rare, challenging-to-treat variant most often seen in the posterior auricular region. A total of 9 cases of milia en plaque have been reported in the pediatric literature to date. We report a case of milia en plaque of the nose in a 7-year-old boy, a novel site of involvement in the pediatric population, and successful treatment with the use of topical tretinoin. Topical retinoids offer an effective treatment option for the management of milia en plaque in the pediatric population.
Dick Mol - One of the best experts on this subject based on the ideXlab platform.
-
the paradise lost of milia grevena greece late pliocene early villafranchian mn15 mn16a faunal composition and diversity
Quaternary, 2018Co-Authors: Evangelos Vlachos, Evangelia Tsoukala, Evelyne Cregutbonnoure, Claude Guerin, Dick MolAbstract:(1) Background: Over the last decades, important fossil records of Late Pliocene mammals and reptiles have been unearthed in Milia, Grevena (N Greece). This assemblage shows a remarkable composition and diversity, including the partial skeletons of mastodons that reached record-breaking sizes, abundant rhinos—the first occurrence of this species in Greece—and some new species; (2) Methods: We perform a thorough quantitative analysis of the recovered assemblage, presenting the information of the various collection spots in Milia, and calculate various biodiversity indices for each spot; (3) Results: Our research has revealed the vast majority of expected taxa in the assemblage. We argue that the various sub-localities in Milia could be grouped into a larger, composite assemblage representing a short period. We analyze the diversity changes through the various localities in Milia and highlight potential barriers that could affect the distribution of taxa; (4) Conclusions: We re-affirm the Early Villafranchian affinities of the fauna. In particular, Milia should date at MN16a, with a surprising presence of some more archaic, Ruscinian taxa. The fossils of Milia depict a Late Pliocene paradise in the Southern Balkans; a paradise, unfortunately, lost with the onset of the dramatic climate changes of the Quaternary.
-
The Proboscidea of the Early Villafranchian site of Milia (Grevena, Macedonia, Greece)
Quaternary International, 2016Co-Authors: Evangelia Tsoukala, Dick MolAbstract:Abstract Two different species of Early Villafranchian proboscideans were contemporaneous in Milia (Grevena, Western Macedonia, Greece): the large zygodont, Borson's mastodon, Mammut borsoni (Hays, 1834), and the smaller gomphothere, the mastodon of Auvergne, Anancus arvernensis (Croizet et Jobert, 1828), the former being predominant. Since 1996 partial skeletons and a large number of isolated skeletal elements of the zygodonts have been excavated from Aliakmon River sand deposits in Milia. The skeletons include substantial portions of the cranium with left and right molars (M2, M3); two complete pairs of the longest upper tusks ever recorded in the world (4.39 m and 5.02 m) and the most complete mandible in Europe, with the two entire lower tusks in anatomical position, as well as two almost-complete mandibles with dentition (m2 + m3); and post-cranials. These partial skeletons represent very robust male individuals in the prime of their life at time of death. In this paper, we describe a new partial skeleton and we discuss the evolutionary position of the specimens among mammutids, the stratigraphy and the paleoenvironment. The enriched Milia zygodont material is compared with other European specimens in order to get a better understanding of its extinction.
Vinod E Nambudiri - One of the best experts on this subject based on the ideXlab platform.
-
milia en plaque of the nose report of a case and successful treatment with topical tretinoin
Pediatrics, 2014Co-Authors: Vinod E Nambudiri, Nancy Habib, Kenneth A Arndt, Kay S KaneAbstract:Milia are benign, superficial keratinaceous cysts that present as fine, small white papules. Milia en plaque is a rare, challenging-to-treat variant most often seen in the posterior auricular region. A total of 9 cases of milia en plaque have been reported in the pediatric literature to date. We report a case of milia en plaque of the nose in a 7-year-old boy, a novel site of involvement in the pediatric population, and successful treatment with the use of topical tretinoin. Topical retinoids offer an effective treatment option for the management of milia en plaque in the pediatric population.
Clauspeter Stelzer - One of the best experts on this subject based on the ideXlab platform.
-
a protein signal triggers sexual reproduction in brachionus plicatilis rotifera
Marine Biology, 2006Co-Authors: Terry W Snell, Julia Kubanek, William M Carter, Audra B Payne, Jerry Kim, Melissa K Hicks, Clauspeter StelzerAbstract:The defining feature of the life cycle in monogonont rotifers such as Brachionus plicatilis (Muller) is alternation of asexual and sexual reproduction (mixis). Why sex is maintained in such life cycles is an important unsolved evolutionary question and one especially amenable to experimental analysis. Mixis is induced by a chemical signal produced by the rotifers which accumulates to threshold levels at high population densities. The chemical features of this signal were characterized using size exclusion, enzymatic degradation, protease protection assays, selective binding to anion ion exchange and C3 reversed phase HPLC columns, and the sequence of 17 N-terminal amino acids. These studies were carried out over two years beginning in 2003 using B. plicatilis Russian strain. When rotifer-conditioned medium was treated with proteinase K, its mixis-inducing ability was reduced by 70%. Proteinase K was added to medium auto-conditioned by 1 female ml−1 where typically 17% of daughters became mictic and mixis was reduced to 1%. A cocktail of protease inhibitors added to conditioned medium significantly reduced degradation of the mixis signal by natural proteases. Conditioned medium subjected to ultrafiltration retained mixis-inducing activity in the >10 kDa fraction, but the <10 kDa fraction had no significant activity. The putative mixis signal bound to an anion exchange column, eluting off at 0.72 M NaCl. These fractions were further separated on a C3 reversed phase HPLC column and mixis-inducing activity was associated with a 39 kDa protein. Seventeen amino acids from the N-terminus have strong similarity to a steroidogenesis-inducing protein isolated from human ovarian follicular fluid. The 39 kDa protein is an excellent candidate for the rotifer mixis induction signal.
-
induction of sexual reproduction in brachionus plicatilis monogononta rotifera by a density dependent chemical cue
Limnology and Oceanography, 2003Co-Authors: Clauspeter Stelzer, Terry W SnellAbstract:Induction of mixis (sexual reproduction) in rotifers of the genus Brachionus is believed to be triggered by a chemical that is released into the water and accumulates at high population densities. However, direct and conclusive evidence for this hypothesis is thus far lacking. In this study, two mass cultures of the rotifer Brachionus plicatilis were monitored as they grew from low to high population densities. Conditioned water was prepared daily from these cultures, and females were exposed in a bioassay, which consisted of juvenile Brachionus, cultured individually in large volumes that would normally suppress mixis. Conditioned water induced mixis in the bioassay at rates comparable to those found in the mass cultures. Both in bioassay and mass cultures, mixis was essentially absent in the beginning of the experiment, when population densities were very low. The first mictic females appeared at densities of 0.1 females ml-1, and their proportion increased rapidly as the populations grew to ≫1 female ml-1. The maximum rates of mixis in the bioassay were highly significant and reached 51% of those observed in the mass cultures. These results strongly support the hypothesis that mixis in Brachionus plicatilis is induced by a density-dependent chemical cue.
Terry W Snell - One of the best experts on this subject based on the ideXlab platform.
-
a protein signal triggers sexual reproduction in brachionus plicatilis rotifera
Marine Biology, 2006Co-Authors: Terry W Snell, Julia Kubanek, William M Carter, Audra B Payne, Jerry Kim, Melissa K Hicks, Clauspeter StelzerAbstract:The defining feature of the life cycle in monogonont rotifers such as Brachionus plicatilis (Muller) is alternation of asexual and sexual reproduction (mixis). Why sex is maintained in such life cycles is an important unsolved evolutionary question and one especially amenable to experimental analysis. Mixis is induced by a chemical signal produced by the rotifers which accumulates to threshold levels at high population densities. The chemical features of this signal were characterized using size exclusion, enzymatic degradation, protease protection assays, selective binding to anion ion exchange and C3 reversed phase HPLC columns, and the sequence of 17 N-terminal amino acids. These studies were carried out over two years beginning in 2003 using B. plicatilis Russian strain. When rotifer-conditioned medium was treated with proteinase K, its mixis-inducing ability was reduced by 70%. Proteinase K was added to medium auto-conditioned by 1 female ml−1 where typically 17% of daughters became mictic and mixis was reduced to 1%. A cocktail of protease inhibitors added to conditioned medium significantly reduced degradation of the mixis signal by natural proteases. Conditioned medium subjected to ultrafiltration retained mixis-inducing activity in the >10 kDa fraction, but the <10 kDa fraction had no significant activity. The putative mixis signal bound to an anion exchange column, eluting off at 0.72 M NaCl. These fractions were further separated on a C3 reversed phase HPLC column and mixis-inducing activity was associated with a 39 kDa protein. Seventeen amino acids from the N-terminus have strong similarity to a steroidogenesis-inducing protein isolated from human ovarian follicular fluid. The 39 kDa protein is an excellent candidate for the rotifer mixis induction signal.
-
induction of sexual reproduction in brachionus plicatilis monogononta rotifera by a density dependent chemical cue
Limnology and Oceanography, 2003Co-Authors: Clauspeter Stelzer, Terry W SnellAbstract:Induction of mixis (sexual reproduction) in rotifers of the genus Brachionus is believed to be triggered by a chemical that is released into the water and accumulates at high population densities. However, direct and conclusive evidence for this hypothesis is thus far lacking. In this study, two mass cultures of the rotifer Brachionus plicatilis were monitored as they grew from low to high population densities. Conditioned water was prepared daily from these cultures, and females were exposed in a bioassay, which consisted of juvenile Brachionus, cultured individually in large volumes that would normally suppress mixis. Conditioned water induced mixis in the bioassay at rates comparable to those found in the mass cultures. Both in bioassay and mass cultures, mixis was essentially absent in the beginning of the experiment, when population densities were very low. The first mictic females appeared at densities of 0.1 females ml-1, and their proportion increased rapidly as the populations grew to ≫1 female ml-1. The maximum rates of mixis in the bioassay were highly significant and reached 51% of those observed in the mass cultures. These results strongly support the hypothesis that mixis in Brachionus plicatilis is induced by a density-dependent chemical cue.