The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Tao Zhang - One of the best experts on this subject based on the ideXlab platform.
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Carboxybetaine methacrylate oligomer Modified Nylon for circulating tumor cells capture.
Journal of colloid and interface science, 2014Co-Authors: Chaoqun Dong, Huiyu Wang, Zhuo Zhang, Tao ZhangAbstract:Circulating tumor cells (CTC) capture is one of the most effective approaches in diagnosis and treatment of cancers in the field of personalized cancer medicine. In our study, zwitterionic carboxybetaine methacrylate (CBMA) oligomers were grafted onto Nylon via atomic transfer random polymerization (ATRP) which would serve as a novel material for the development of convenient CTC capture interventional medical devices. The chemical, physical and biological properties of pristine and Modified Nylon surfaces were assessed by Fourier transform infrared spectra, atomic force microscope, water contact angle measurements, X-ray photoelectron spectroscopy, protein adsorption, platelet adhesion, and plasma recalcification time (PRT) determinations, etc. The results, including the significant decrease of proteins adsorption and platelets adhesion, as well as prolonged PRTs demonstrated the extraordinary biocompatibility and blood compatibility of the Modified surface. Furthermore, we showed that upon immobilization of anti-epithelial cell adhesion molecular (anti-EpCAM) antibody onto the CBMA moiety, the Modified Nylon surface can selectively capture EpCAM positive tumor cells from blood with high efficiency, indicating the potential of the Modified Nylon in the manufacture of convenient interventional CTC capture medical devices.
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carboxybetaine methacrylate Modified Nylon surface for circulating tumor cell capture
ACS Applied Materials & Interfaces, 2014Co-Authors: Huiyu Wang, Chaoqun Dong, Fenglei Wu, Yang Yang, Lifeng Wang, Xiaoping Qian, Tao ZhangAbstract:Conventional in vitro circulating tumor cell (CTC) detection methods are always limited by blood sample volume because of the requirement of a large amount of blood. The aim of this study was to overcome the limitation by designing and making an in vivo CTC capture device. In this study, we designed and prepared a kind of proper material to serve the purpose of intervention. A method employing 3-aminopropyltriethoxysilane (γ-APS) as the coupling reagent to graft carboxybetaine methacrylate (CBMA) and to immobilize an anti-epithelial cell adhesion molecular (EpCAM) antibody on Nylon was developed. The results of X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy proved the successful graft of γ-APS and CBMA to Nylon. Furthermore, the predicted improvement in the biocompatibilities of our Modified Nylon was confirmed by water contact angle measurement, bovine serum albumin adhesion, platelet adhesion, plasma recalcification time determination, and cytotoxicity tests. The tumor cell...
Huiyu Wang - One of the best experts on this subject based on the ideXlab platform.
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Carboxybetaine methacrylate oligomer Modified Nylon for circulating tumor cells capture.
Journal of colloid and interface science, 2014Co-Authors: Chaoqun Dong, Huiyu Wang, Zhuo Zhang, Tao ZhangAbstract:Circulating tumor cells (CTC) capture is one of the most effective approaches in diagnosis and treatment of cancers in the field of personalized cancer medicine. In our study, zwitterionic carboxybetaine methacrylate (CBMA) oligomers were grafted onto Nylon via atomic transfer random polymerization (ATRP) which would serve as a novel material for the development of convenient CTC capture interventional medical devices. The chemical, physical and biological properties of pristine and Modified Nylon surfaces were assessed by Fourier transform infrared spectra, atomic force microscope, water contact angle measurements, X-ray photoelectron spectroscopy, protein adsorption, platelet adhesion, and plasma recalcification time (PRT) determinations, etc. The results, including the significant decrease of proteins adsorption and platelets adhesion, as well as prolonged PRTs demonstrated the extraordinary biocompatibility and blood compatibility of the Modified surface. Furthermore, we showed that upon immobilization of anti-epithelial cell adhesion molecular (anti-EpCAM) antibody onto the CBMA moiety, the Modified Nylon surface can selectively capture EpCAM positive tumor cells from blood with high efficiency, indicating the potential of the Modified Nylon in the manufacture of convenient interventional CTC capture medical devices.
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carboxybetaine methacrylate Modified Nylon surface for circulating tumor cell capture
ACS Applied Materials & Interfaces, 2014Co-Authors: Huiyu Wang, Chaoqun Dong, Fenglei Wu, Yang Yang, Lifeng Wang, Xiaoping Qian, Tao ZhangAbstract:Conventional in vitro circulating tumor cell (CTC) detection methods are always limited by blood sample volume because of the requirement of a large amount of blood. The aim of this study was to overcome the limitation by designing and making an in vivo CTC capture device. In this study, we designed and prepared a kind of proper material to serve the purpose of intervention. A method employing 3-aminopropyltriethoxysilane (γ-APS) as the coupling reagent to graft carboxybetaine methacrylate (CBMA) and to immobilize an anti-epithelial cell adhesion molecular (EpCAM) antibody on Nylon was developed. The results of X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy proved the successful graft of γ-APS and CBMA to Nylon. Furthermore, the predicted improvement in the biocompatibilities of our Modified Nylon was confirmed by water contact angle measurement, bovine serum albumin adhesion, platelet adhesion, plasma recalcification time determination, and cytotoxicity tests. The tumor cell...
Chaoqun Dong - One of the best experts on this subject based on the ideXlab platform.
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Carboxybetaine methacrylate oligomer Modified Nylon for circulating tumor cells capture.
Journal of colloid and interface science, 2014Co-Authors: Chaoqun Dong, Huiyu Wang, Zhuo Zhang, Tao ZhangAbstract:Circulating tumor cells (CTC) capture is one of the most effective approaches in diagnosis and treatment of cancers in the field of personalized cancer medicine. In our study, zwitterionic carboxybetaine methacrylate (CBMA) oligomers were grafted onto Nylon via atomic transfer random polymerization (ATRP) which would serve as a novel material for the development of convenient CTC capture interventional medical devices. The chemical, physical and biological properties of pristine and Modified Nylon surfaces were assessed by Fourier transform infrared spectra, atomic force microscope, water contact angle measurements, X-ray photoelectron spectroscopy, protein adsorption, platelet adhesion, and plasma recalcification time (PRT) determinations, etc. The results, including the significant decrease of proteins adsorption and platelets adhesion, as well as prolonged PRTs demonstrated the extraordinary biocompatibility and blood compatibility of the Modified surface. Furthermore, we showed that upon immobilization of anti-epithelial cell adhesion molecular (anti-EpCAM) antibody onto the CBMA moiety, the Modified Nylon surface can selectively capture EpCAM positive tumor cells from blood with high efficiency, indicating the potential of the Modified Nylon in the manufacture of convenient interventional CTC capture medical devices.
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carboxybetaine methacrylate Modified Nylon surface for circulating tumor cell capture
ACS Applied Materials & Interfaces, 2014Co-Authors: Huiyu Wang, Chaoqun Dong, Fenglei Wu, Yang Yang, Lifeng Wang, Xiaoping Qian, Tao ZhangAbstract:Conventional in vitro circulating tumor cell (CTC) detection methods are always limited by blood sample volume because of the requirement of a large amount of blood. The aim of this study was to overcome the limitation by designing and making an in vivo CTC capture device. In this study, we designed and prepared a kind of proper material to serve the purpose of intervention. A method employing 3-aminopropyltriethoxysilane (γ-APS) as the coupling reagent to graft carboxybetaine methacrylate (CBMA) and to immobilize an anti-epithelial cell adhesion molecular (EpCAM) antibody on Nylon was developed. The results of X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy proved the successful graft of γ-APS and CBMA to Nylon. Furthermore, the predicted improvement in the biocompatibilities of our Modified Nylon was confirmed by water contact angle measurement, bovine serum albumin adhesion, platelet adhesion, plasma recalcification time determination, and cytotoxicity tests. The tumor cell...
T Grant Glover - One of the best experts on this subject based on the ideXlab platform.
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Modification of fibers with nanostructures using reactive dye chemistry
Industrial and Engineering Chemistry Research, 2015Co-Authors: Meagan A. Bunge, K. Neil Ruckart, Silas Leavesley, Nien Nguyen, Kevin N. West, Gregory W Peterson, T Grant GloverAbstract:Reactive dyes conventionally used to chemically bind chromophores to fabrics have been used to develop a platform technology that can modify commercially available fibers with nanoscale structures. To illustrate this concept, commercial Nylon and cellulose fibers have been Modified with gold nanoparticles of three sizes, metal organic framework (MOF) crystals, and quantum dots in five sizes. The gold Modified cellulose and Nylon samples have colors that vary based on the size of the gold particles, and the particles remained attached to the fibers, even after being washed with solvents, water, and soap. The MOF was grown on the fibers after applying reactive dyes to anchor the metal building unit to the fibers, and the process produced cellulose fibers with surface areas of ∼980 m2/g. Both the Nylon and cellulose MOF Modified fabrics show preferential adsorption of ethylene over ethane and the ability to adsorb ammonia from air. Quantum dot Modified Nylon and cellulose fibers have fluorescent properties c...
Donald R Paul - One of the best experts on this subject based on the ideXlab platform.
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Impact-Modified Nylon 6/polypropylene blends: 3. Deformation mechanisms
Polymer, 1995Co-Authors: A. González-montiel, H Keskkula, Donald R PaulAbstract:The processes that occur during the deformation of Nylon 6/polypropylene blends Modified with maleated rubbers were identified by dilatometric measurements and electron microscopy. These toughening mechanisms were found to depend on the type of rubber used as modifier (ethylene-propylene random copolymer, EPR-g-maleic anhydride (MA), or styrene-ethylene/butylene-styrene triblock copolymer, SEBS-g-MA), and on the relative ratio of Nylon 6 to polypropylene (PP) in the blend. Blends based on EPR-g-MA showed significant volume dilation during deformation in a low strain rate tensile test. Electron microscopy techniques revealed that the main dilational mechanism in these blends is cavitation of the rubber dispersed as particles in the Nylon 6 phase and at the Nylon 6/PP interface. Similar results were obtained for specimens deformed in a high speed impact test. Except for one composition, Nylon 6/PP blends Modified with SEBS-g-MA showed negligible changes in volume during slow tensile deformation, and no indication of dilational processes (as determined by electron microscopy) was found in broken specimens deformed under notched Izod impact conditions. However, cavitation of the rubber particles was observed in 80/20 Nylon 6/SEBS-g-MA blends deformed in the high speed impact test. This indicates that under appropriate stress and strain conditions, cavitation of SEBS-g-MA particles can occur. The structure and properties of the rubber and its particle size are factors that contribute to the differences in the extent of cavitation of Nylon 6/PP blends Modified with SEBS-g-MA or EPR-g-MA.
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impact Modified Nylon 6 polypropylene blends 2 effect of reactive functionality on morphology and mechanical properties
Polymer, 1995Co-Authors: A Gonzalezmontiel, H Keskkula, Donald R PaulAbstract:Abstract The morphology of Nylon 6/polypropylene blends Modified with maleated rubbers, such as styrene-ethylene/butylene—styrene triblock copolymers (SEBS- g -maleic anhydride (MA)) and ethylene-propylene random copolymers (EPR- g -MA), is affected by changes in the level of functionality of the rubber. By adjusting this level of functionality it is possible to induce drastic changes in the morphology of blends with fixed composition. Unfunctionalized versions of these elastomers are difficult to disperse in the Nylon 6 phase, even in the presence of maleic anhydride-polypropylene, and lead to blends with low toughness. The use of polypropylene (PP) grafted with maleic anhydride (PP- g -MA) in addition to the maleated rubbers improves the degree of dispersion of the polypropylene phase and the low temperature toughness of the blends. Blends with up to 16% PP- g -MA showed ductile—brittle transition temperatures as low as the transition temperature of toughened Nylon 6 (−30°C). The degree of heterogeneity of mixtures of PP and PP- g -MA has a profound effect on the low temperature toughness and morphology of the rubber-Modified Nylon 6/PP blends, particularly in blends with compositions in the transition region of phase continuity. A fine degree of dispersion of the PP- g -MA in PP is desired in these mixtures, since it leads to the best low temperature toughness in blends of fixed composition.
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impact Modified Nylon 6 polypropylene blends 1 morphology property relationships
Polymer, 1995Co-Authors: A Gonzalezmontiel, H Keskkula, Donald R PaulAbstract:Abstract Two types of elastomers grafted with maleic anhydride (MA), an ethylene—propylene random copolymer (EPR) and a styrene—ethylene/butylene—styrene triblock copolymer (SEBS) were found to function both as impact modifiers and compatibilizers for Nylon 6/polypropylene blends. The maleic anhydride grafted to the rubber reacts with the amine end-groups of the polyamide, forming a rubber-Nylon 6 graft copolymer that locates at the interface between Nylon 6 and polypropylene (PP) and thus acts as a compatibilizer. The SEBS-g-MA material appears to be the most effective compatibilizer. The two rubbers were equally effective for increasing room temperature toughness by dispersing in the Nylon 6 phase of the blends. Lower ductile-brittle transition temperatures are obtained when EPR-g-MA rubber is used, owing to its lower Tg and lower modulus at low temperatures compared to SEBS-g-MA rubber. Blend parameters such as rubber content, Nylon 6/PP ratio and molecular weight of the components strongly influence the morphology and toughness of the blends. Low ductile—brittle transition temperatures were obtained for blends in which any combination of the above parameters yielded a morphology where Nylon 6 was the matrix phase with polypropylene and rubber finely dispersed in it, provided the component molecular weights were high enough to provide adequate intrinsic ductility.