The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform

Nanette B Silverberg - One of the best experts on this subject based on the ideXlab platform.

  • Efficacy and Safety of Topical Cantharidin Treatment for Molluscum contagiosum and Warts: A Systematic Review
    American Journal of Clinical Dermatology, 2018
    Co-Authors: Paras P. Vakharia, Nanette B Silverberg, Rishi Chopra, Jonathan I. Silverberg
    Abstract:

    Background and Objective Topical cantharidin is routinely used for the treatment of Molluscum contagiosum and warts. The objective of this systematic review is to assess the efficacy and safety of topical cantharidin treatment for Molluscum contagiosum and warts. Methods We performed a systematic review of studies assessing topical cantharidin treatment of Molluscum contagiosum or warts. We searched the databases of Cochrane, EMBASE, GREAT, LILACS, MEDLINE, and Scopus. Two authors performed the study selection and data extraction. Results Twenty studies (1958–2018) met inclusion/exclusion criteria. Twelve studies assessed warts, and eight studies assessed Molluscum contagiosum. Overall, 1752 patients were included (range 0.3–62 years; specified in 15 studies). Clearance rates with topical cantharidin for Molluscum contagiosum were variable (range 15.4–100%). Significant clearance of warts with maintenance of clearance was demonstrated with topical cantharidin alone. Topical cantharidin in combination with podophyllotoxin and salicylic acid demonstrated efficacy for plantar warts (pediatric and adult; clearance rate range 81–100%; four studies had 100% clearance), with the majority clearing after a single treatment. Satisfaction with cantharidin therapy was high, especially in Molluscum contagiosum. Pain (7–85.7%), blistering (10–100%), and hyper-/hypopigmentation (1.8–53.3%) were the most commonly occurring adverse effects with cantharidin treatment. Conclusion Topical cantharidin demonstrated clearance of warts, particularly in combination with podophyllotixin and salicylic acid, and modest benefit for pediatric Molluscum contagiosum with good tolerability and safety.

  • vertically transmitted Molluscum contagiosum infection
    Pediatrics, 2010
    Co-Authors: Janiene D Luke, Nanette B Silverberg
    Abstract:

    We report a case of vertically transmitted Molluscum contagiosum viral infection in which the maternal infection was clinically documented before vaginal delivery. The aim of this report is to make practitioners aware that Molluscum infections in neonates are likely vertically transmitted.

Jonathan I. Silverberg - One of the best experts on this subject based on the ideXlab platform.

  • Efficacy and Safety of Topical Cantharidin Treatment for Molluscum contagiosum and Warts: A Systematic Review
    American Journal of Clinical Dermatology, 2018
    Co-Authors: Paras P. Vakharia, Nanette B Silverberg, Rishi Chopra, Jonathan I. Silverberg
    Abstract:

    Background and Objective Topical cantharidin is routinely used for the treatment of Molluscum contagiosum and warts. The objective of this systematic review is to assess the efficacy and safety of topical cantharidin treatment for Molluscum contagiosum and warts. Methods We performed a systematic review of studies assessing topical cantharidin treatment of Molluscum contagiosum or warts. We searched the databases of Cochrane, EMBASE, GREAT, LILACS, MEDLINE, and Scopus. Two authors performed the study selection and data extraction. Results Twenty studies (1958–2018) met inclusion/exclusion criteria. Twelve studies assessed warts, and eight studies assessed Molluscum contagiosum. Overall, 1752 patients were included (range 0.3–62 years; specified in 15 studies). Clearance rates with topical cantharidin for Molluscum contagiosum were variable (range 15.4–100%). Significant clearance of warts with maintenance of clearance was demonstrated with topical cantharidin alone. Topical cantharidin in combination with podophyllotoxin and salicylic acid demonstrated efficacy for plantar warts (pediatric and adult; clearance rate range 81–100%; four studies had 100% clearance), with the majority clearing after a single treatment. Satisfaction with cantharidin therapy was high, especially in Molluscum contagiosum. Pain (7–85.7%), blistering (10–100%), and hyper-/hypopigmentation (1.8–53.3%) were the most commonly occurring adverse effects with cantharidin treatment. Conclusion Topical cantharidin demonstrated clearance of warts, particularly in combination with podophyllotixin and salicylic acid, and modest benefit for pediatric Molluscum contagiosum with good tolerability and safety.

Philip R Cohen - One of the best experts on this subject based on the ideXlab platform.

  • Molluscum contagiosum of the nipple areola complex
    2018
    Co-Authors: Brian S Hoyt, Jaime Tschen, Philip R Cohen
    Abstract:

    Molluscum contagiosum is a skin lesion caused by a poxvirus that commonly affects young children or immunocompromised adults. Although cutaneous infection with Molluscum contagiosum has been well described, occurrence in the nipple-areola complex is rare, and there is little data on the clinical presentation, disease course, and treatment methods of Molluscum contagiosum lesions in these areas. This chapter reviews the characteristics of Molluscum contagiosum and describes six cases of this viral infection occurring in the nipple-areola complex.

  • Molluscum contagiosum of the eyelid case report in a man receiving methotrexate and literature review of Molluscum contagiosum in patients who are immunosuppressed secondary to methotrexate or hiv infection
    Dermatology Online Journal, 2016
    Co-Authors: Bryce D Beutler, Philip R Cohen
    Abstract:

    Background: Molluscum contagiosum is a benign viral infection of the skin. Lesions typically present as dome-shaped, flesh-colored, umbilicated papules that range in size from 1 to 5 millimeters in diameter. They are usually asymptomatic, but can become tender or pruritic. Children and immunocompromised adults, including individuals being treated with immunosuppressive drugs, are most susceptible to infection. Single or multiple lesions most commonly appear on the extremities, face, genitals, and trunk. However, albeit rarely, Molluscum contagiosum may also develop at other sites, including the eyelids.Purpose: We describe the clinical and pathologic findings of a man who developed Molluscum contagiosum of the eyelid while receiving methotrexate. We also review the characteristics of other patients with Molluscum contagiosum acquired either during treatment with methotrexate or associated with human immunodeficiency virus (HIV) infection and summarize the unusual sites of presentation for the viral lesions in these individuals.Materials and methods: The features of a man receiving methotrexate who developed Molluscum contagiosum of the eyelid are presented. Using PubMed, the following terms were searched and relevant citations assessed: adalimumab, contagiosum, Enbrel, etanercept, Humira, infliximab, methotrexate, Molluscum, Remicade, TNF alpha, and tumor necrosis factor alpha. In addition, the literature on methotrexate treatment and Molluscum contagiosum is reviewed.Results: Several small papules were observed on the eyelid of a 24-year-old man who had been receiving methotrexate and adalimumab (Humira) for the treatment of Crohn disease. The lesions were removed by shave biopsy. Microscopic examination revealed epidermal hyperplasia composed of keratinocytes filled with large eosinophilic intracytoplasmic inclusions. Based on correlation of the clinical presentation and histopathologic findings, a diagnosis of Molluscum contagiosum was established. The patient applied mupirocin 2% ointment to the biopsy sites, which subsequently healed without complication or recurrence.Conclusion: Molluscum contagiosum is a benign viral papular eruption that frequently affects children and immunocompromised adults. Patients treated with immunosuppressive agents, such as methotrexate, have a heightened risk of developing Molluscum contagiosum lesions. It remains to be determined whether adjunct therapy with a tumor necrosis factor alpha inhibitor increasesthe risk of this viral infection. Diagnosis can usually be established by clinical presentation, although a biopsy is sometimesrequired to exclude other conditions. Molluscum contagiosum is generally self-limiting and often resolves spontaneously within18 months. However, topical (cantharidin) or locally destructive (curettage, cryotherapy, and/or laser) therapy may be indic tedfor patients who are concerned about persistent lesions and for children who are particularly susceptible to autoinoculation.

  • Molluscum contagiosum of the areola and nipple: case report and literature review.
    Dermatology Online Journal, 2013
    Co-Authors: Brian S Hoyt, Jaime Tschen, Philip R Cohen
    Abstract:

    Molluscum contagiosum is a common cutaneous infection caused by a double-stranded DNA poxvirus. Skin lesions classically present as small, flesh-colored papules with central umbilication. Lesions are frequently seen on the face, trunk, and extremities of children, or on the genitals of young adults as a sexually transmitted infection. Molluscum contagiosum on the nipple or areola has only been previously described in 4 women. We describe a woman with Molluscum contagiosum on the left areola and review the clinical characteristics and histological findings of patients who developed Molluscum contagiosum of the nipple or areola.

Robert B Skinner - One of the best experts on this subject based on the ideXlab platform.

Stephen K Tyring - One of the best experts on this subject based on the ideXlab platform.

  • An update on the clinical management of cutaneous Molluscum contagiosum.
    Skin therapy letter, 2014
    Co-Authors: Harrison P. Nguyen, Stephen K Tyring
    Abstract:

    : Molluscum contagiosum is a poxvirus infection of the skin that is commonly observed in children. The Molluscum contagiosum virus (MCV) expresses several gene-products that are involved in its pathogenesis and evasion of the host immune system. MCV can be transmitted both to other sites of the body and to other individuals through direct physical contact as well as fomites. While diagnosis is generally straightforward clinically, management of Molluscum contagiosum is controversial. Several treatment options are available for the destruction of individual lesions, but there is insufficient evidence for therapeutic intervention being any more effective than natural, spontaneous resolution. Complex cases, such as infection occurring in immunocompromised patients and in mucocutaneous sites, require an alternative approach to management. Molluscum contagiosum continues to represent a burden on children and parents worldwide.

  • Molluscum contagiosum the importance of early diagnosis and treatment
    American Journal of Obstetrics and Gynecology, 2003
    Co-Authors: Stephen K Tyring
    Abstract:

    Molluscum contagiosum is a viral infection that is becoming an increasing problem in sexually active individuals and in patients with human immunodeficiency virus. Although Molluscum contagiosum lesions are generally self-limiting, it may take 6 months to 5 years for lesions to disappear. Furthermore, patients with weakened immune systems have increased difficulty in clearing lesions; therefore lesions typically persist for prolonged periods. Although there has been continued debate about whether Molluscum contagiosum lesions should be treated or allowed to resolve spontaneously, many clinicians recommend treatment of genital Molluscum contagiosum lesions to reduce the risk of sexual transmission, prevent autoinoculation, and increase patient quality of life. Treatment options for Molluscum contagiosum include physician-administered and patient-administered therapies. Novel patient-administered treatment options allow administration in the privacy of a patient's home, providing added convenience and reducing patient embarrassment or stress. With the novel treatment opportunities currently available or in development, physicians are able to improve patient quality of life while providing patients with a convenient, well-tolerated, easily administered treatment regimen. This review summarizes the clinical diagnosis of Molluscum contagiosum and provides a critical assessment of several current and emerging treatment options.