The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Edward F Domino - One of the best experts on this subject based on the ideXlab platform.
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in vivo imaging of Monoaminergic Nerve terminals in normal and mptp lesioned primate brain using positron emission tomography pet and 11c tetrabenazine
1993Co-Authors: Jean N Dasilva, Michael R Kilbourn, Edward F DominoAbstract:The first successful in vivo imaging of monoamine vesicular transporters in the living primate brain is described, using [11C]tetrabenazine ([11C]TBZ) and Positron Emission Tomography (PET). Radioligand uptake into brain is rapid, and at short time periods (10-30 minutes) the higher uptake and retention of the radiotracer in the more densely dopaminergic innervated striatum is clearly visualized. Specific binding in striatum can be entirely blocked with co-administration of a pharmacological dose (1 mg/kg i. v.) of tetrabenazine. In a unilaterally MPTP-lesioned monkey, specific binding of radioligand was absent in the striatum on the lesioned side, with no effect on radiotracer distribution in the cortex, cerebellum or contralateral striatum. PET imaging with [11C]TBZ provides a new approach to the in vivo study of Monoaminergic neurons and their loss in neurodegenerative diseases. © 1993 Wiley-Liss, Inc.
Jean N Dasilva - One of the best experts on this subject based on the ideXlab platform.
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SYNAPSE 14:128-131 (1993) In Vivo Imaging of Monoaminergic Nerve Terminals in Normal and MPTP-Lesioned Primate Brain Using Positron Emission Tomography (PET) and ["CITetrabenazine
2016Co-Authors: Jean N Dasilva, Michael R Kilbourn, F. DominoAbstract:ABSTRACT The first successful in vivo imaging of monoamine vesicular transport-ers in the living primate brain is described, using [llcltetrabenazine (["ClTBZ) and Positron Emission Tomography (PET). Radioligand uptake into brain is rapid, and at short time periods (10-30 minutes) the higher uptake and retention of the radiotracer in the more densely dopaminergic innervated striaturn is clearly visualized. Specific bind-ing in striatum can be entirely blocked with co-administration of a pharmacological dose (1 m a g i.v.1 of tetrabenazine. In a unilaterally MPTP-lesioned monkey, specific binding of radioligand was absent in the striatum on the lesioned side, with no effect on ra-diotracer distribution in the cortex, cerebellum or contralateral striatum. PET imaging with [llC]TBZ provides a new approach to the in vivo study of Monoaminergic neurons and their loss in neurodegenerative diseases
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in vivo imaging of Monoaminergic Nerve terminals in normal and mptp lesioned primate brain using positron emission tomography pet and 11c tetrabenazine
1993Co-Authors: Jean N Dasilva, Michael R Kilbourn, Edward F DominoAbstract:The first successful in vivo imaging of monoamine vesicular transporters in the living primate brain is described, using [11C]tetrabenazine ([11C]TBZ) and Positron Emission Tomography (PET). Radioligand uptake into brain is rapid, and at short time periods (10-30 minutes) the higher uptake and retention of the radiotracer in the more densely dopaminergic innervated striatum is clearly visualized. Specific binding in striatum can be entirely blocked with co-administration of a pharmacological dose (1 mg/kg i. v.) of tetrabenazine. In a unilaterally MPTP-lesioned monkey, specific binding of radioligand was absent in the striatum on the lesioned side, with no effect on radiotracer distribution in the cortex, cerebellum or contralateral striatum. PET imaging with [11C]TBZ provides a new approach to the in vivo study of Monoaminergic neurons and their loss in neurodegenerative diseases. © 1993 Wiley-Liss, Inc.
David J Brooks - One of the best experts on this subject based on the ideXlab platform.
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18f fdopa uptake in the raphe nuclei complex reflects serotonin transporter availability a combined 18f fdopa and 11c dasb pet study in parkinson s disease
2012Co-Authors: Nicola Pavese, B S Simpson, Vinod Metta, Anil Ramlackhansingh, Ray K Chaudhuri, David J BrooksAbstract:Abstract Brain uptake of [18F]FDOPA, measured with PET, reflects the activity of aromatic amino acid decarboxylase, an enzyme largely expressed in Monoaminergic Nerve terminals. This enzyme catalyzes a number of decarboxylation reactions including conversion of l -dopa into dopamine and 5-hydroxytryptophan into serotonin. For more than 20 years [18F]FDOPA PET has been used to assess dopaminergic nigrostriatal dysfunction in patients with Parkinson's disease (PD). More recently, however, [18F]FDOPA PET has also been employed as a marker of serotoninergic and noradrenergic function in PD patients. In this study, we provide further evidence in support of the view that [18F]FDOPA PET can be used to evaluate the distribution and the function of serotoninergic systems in the brain. Eighteen patients with PD were investigated with both [18F]FDOPA and [11C]DASB PET, the latter being a marker of serotonin transport (SERT) availability. We then assessed the relationship between measurements of the two tracers within brain serotoninergic structures. [18F]FDOPA uptake in the median raphe nuclei complex of PD patients was significantly correlated with SERT availability in the same structure. Trends towards significant correlations between [18F]FDOPA Ki values and [11C]DASB binding values were also observed in the hypothalamus and the anterior cingulate cortex, suggesting a serotoninergic contribution to [18F]FDOPA uptake in these regions. Conversely, no correlations were found in brain structures with mixed dopaminergic, serotoninergic and noradrenergic innervations, or with predominant dopaminergic innervation. These findings provide evidence that [18F]FDOPA PET represents a valid marker of raphe serotoninergic function in PD and supports previous studies where [18F]FDOPA PET has been used to assess serotoninergic function in PD.
Michael R Kilbourn - One of the best experts on this subject based on the ideXlab platform.
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SYNAPSE 14:128-131 (1993) In Vivo Imaging of Monoaminergic Nerve Terminals in Normal and MPTP-Lesioned Primate Brain Using Positron Emission Tomography (PET) and ["CITetrabenazine
2016Co-Authors: Jean N Dasilva, Michael R Kilbourn, F. DominoAbstract:ABSTRACT The first successful in vivo imaging of monoamine vesicular transport-ers in the living primate brain is described, using [llcltetrabenazine (["ClTBZ) and Positron Emission Tomography (PET). Radioligand uptake into brain is rapid, and at short time periods (10-30 minutes) the higher uptake and retention of the radiotracer in the more densely dopaminergic innervated striaturn is clearly visualized. Specific bind-ing in striatum can be entirely blocked with co-administration of a pharmacological dose (1 m a g i.v.1 of tetrabenazine. In a unilaterally MPTP-lesioned monkey, specific binding of radioligand was absent in the striatum on the lesioned side, with no effect on ra-diotracer distribution in the cortex, cerebellum or contralateral striatum. PET imaging with [llC]TBZ provides a new approach to the in vivo study of Monoaminergic neurons and their loss in neurodegenerative diseases
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in vivo imaging of Monoaminergic Nerve terminals in normal and mptp lesioned primate brain using positron emission tomography pet and 11c tetrabenazine
1993Co-Authors: Jean N Dasilva, Michael R Kilbourn, Edward F DominoAbstract:The first successful in vivo imaging of monoamine vesicular transporters in the living primate brain is described, using [11C]tetrabenazine ([11C]TBZ) and Positron Emission Tomography (PET). Radioligand uptake into brain is rapid, and at short time periods (10-30 minutes) the higher uptake and retention of the radiotracer in the more densely dopaminergic innervated striatum is clearly visualized. Specific binding in striatum can be entirely blocked with co-administration of a pharmacological dose (1 mg/kg i. v.) of tetrabenazine. In a unilaterally MPTP-lesioned monkey, specific binding of radioligand was absent in the striatum on the lesioned side, with no effect on radiotracer distribution in the cortex, cerebellum or contralateral striatum. PET imaging with [11C]TBZ provides a new approach to the in vivo study of Monoaminergic neurons and their loss in neurodegenerative diseases. © 1993 Wiley-Liss, Inc.
J Oki - One of the best experts on this subject based on the ideXlab platform.
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developmental regulation of spinal motoneurons by Monoaminergic Nerve fibers
1997Co-Authors: H Tanaka, S Takahashi, J OkiAbstract:1. In rats, both diameter and area of the cell bodies of spinal MNs increase rapidly during the first few postnatal weeks and slowly thereafter. The total dendritic length, radial extent and arbor area of spinal MNs also increase significantly throughout the first few postnatal weeks. This development is coincident with motor development in rat, which progresses rapidly during the first two to four weeks of life. The dendritic length and radial extent of spinal MNs increase more significantly in the cervical cord than in the lumbar cord throughout the first three postnatal days, and are possibly related to the motor development, with a rostro-caudal gradient. 2. All Monoaminergic neurons projecting their axons to the spinal cord are located in the brainstem. namely in the locus coeruleus, the subcoeruleus and the medulla raphe nuclei in rats. The NA neurons of the locus coeruleus begin to be detected at ED 10-13, slightly earlier than the 5HT neurons in the raphe nuclei, which are first detected at ED 13. At ED 16, the NA fibers are seen in the ventral funiculus only at the cervical level, and many NA fibers are seen in the ventral horns at all levels at ED 18. The 5HT fibers reach the caudalmost levels of spinal cord by ED 16-17, which is earlier than NA fibers; this occurs in spite of the earlier ontogeny of NA neurons in the locus coeruleus than that of 5HT neurons in the raphe nuclei. 3. The monoamine system is thought to exert a variety of modulatory effects on target neurons during both pre- and postnatal periods, and many reports support the idea that monoamine systems have a "neurotrophic effect." On the other hand, important roles of NA and 5HT in MN activity and/or motor behavior have also been reported. It is suggested, therefore, that Monoaminergic systems play important roles in motor development through a two-step mechanism: during early developmental stage. Monoaminergic systems mainly act as neurotrophic agents on spinal MNs, which are the final motor output neurons; thereafter, they mainly play neuromodulatory roles on MN activities.