The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform
Gonzalo De Quesada - One of the best experts on this subject based on the ideXlab platform.
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Heterophile antibody positive, acute cytomegaloviral infection in an immunocompetent pre-teen: An atypical presentation of an atypical infection
Elsevier, 2015Co-Authors: Md ,junaid Raja, Gonzalo De QuesadaAbstract:Summary: Mononucleosis and Mononucleosis-like illnesses comprise a significant proportion of pediatric and adolescent infectious illnesses. By far, the most common cause of these illnesses is Epstein–Barr virus, which causes Mononucleosis, and a distant second is cytomegalovirus, which is the most common cause of Mononucleosis-like illnesses. This case provides an interesting juxtaposition of laboratory findings of an adolescent who was heterophile antibody positive but acute Epstein–Barr virus antigen–antibody negative. A subsequent immunologic assay resulted in a final diagnosis of an acute cytomegaloviral infection. This is, to our knowledge, the first such report in the literature. Keywords: Acute CMV, Mononucleosis-like infection, Monospot test, Transaminitis of unknown etiology, Leukopenia of unknown etiology, Atypical viral infection in an immunocompetent individua
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Heterophile antibody positive, acute cytomegaloviral infection in an immunocompetent pre-teen: an atypical presentation of an atypical infection.
Journal of infection and public health, 2014Co-Authors: Junaid Raja, Gonzalo De QuesadaAbstract:Summary Mononucleosis and Mononucleosis-like illnesses comprise a significant proportion of pediatric and adolescent infectious illnesses. By far, the most common cause of these illnesses is Epstein–Barr virus, which causes Mononucleosis, and a distant second is cytomegalovirus, which is the most common cause of Mononucleosis-like illnesses. This case provides an interesting juxtaposition of laboratory findings of an adolescent who was heterophile antibody positive but acute Epstein–Barr virus antigen–antibody negative. A subsequent immunologic assay resulted in a final diagnosis of an acute cytomegaloviral infection. This is, to our knowledge, the first such report in the literature.
George M Abraham - One of the best experts on this subject based on the ideXlab platform.
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splenic infarction an under recognized complication of infectious Mononucleosis
Open Forum Infectious Diseases, 2018Co-Authors: Yan Li, Ann George, Sami Arnaout, Jennifer P Wang, George M AbrahamAbstract:: Splenic infarction is a rare complication of infectious Mononucleosis. We describe 3 cases of splenic infarction attributed to infectious Mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious Mononucleosis and discuss the differential diagnosis of splenic infarction, including infectious etiologies. While symptomatic management is usually sufficient for infectious Mononucleosis-associated splenic infarction, close monitoring for other complications, including splenic rupture, is mandated.
Junaid Raja - One of the best experts on this subject based on the ideXlab platform.
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Heterophile antibody positive, acute cytomegaloviral infection in an immunocompetent pre-teen: an atypical presentation of an atypical infection.
Journal of infection and public health, 2014Co-Authors: Junaid Raja, Gonzalo De QuesadaAbstract:Summary Mononucleosis and Mononucleosis-like illnesses comprise a significant proportion of pediatric and adolescent infectious illnesses. By far, the most common cause of these illnesses is Epstein–Barr virus, which causes Mononucleosis, and a distant second is cytomegalovirus, which is the most common cause of Mononucleosis-like illnesses. This case provides an interesting juxtaposition of laboratory findings of an adolescent who was heterophile antibody positive but acute Epstein–Barr virus antigen–antibody negative. A subsequent immunologic assay resulted in a final diagnosis of an acute cytomegaloviral infection. This is, to our knowledge, the first such report in the literature.
Henrik Hjalgrim - One of the best experts on this subject based on the ideXlab platform.
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Multiple sclerosis after infectious Mononucleosis.
Archives of neurology, 2007Co-Authors: Trine Rasmussen Nielsen, Klaus Rostgaard, Nete Munk Nielsen, Nils Koch-henriksen, Sven Haahr, Per Soelberg Sørensen, Henrik HjalgrimAbstract:Background Infectious Mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about the characteristics of this association. Objective To assess the significance of sex, age at and time since infectious Mononucleosis, and attained age to the risk of developing multiple sclerosis after infectious Mononucleosis. Design Cohort study using persons tested serologically for infectious Mononucleosis at Statens Serum Institut, the Danish Civil Registration System, the Danish National Hospital Discharge Register, and the Danish Multiple Sclerosis Registry. Setting Statens Serum Institut. Patients A cohort of 25 234 Danish patients with Mononucleosis was followed up for the occurrence of multiple sclerosis beginning on April 1, 1968, or January 1 of the year after the diagnosis of Mononucleosis or after a negative Paul-Bunnell test result, respectively, whichever came later and ending on the date of multiple sclerosis diagnosis, death, emigration, or December 31, 1996, whichever came first. Main Outcome Measure The ratio of observed to expected multiple sclerosis cases in the cohort (standardized incidence ratio). Results A total of 104 cases of multiple sclerosis were observed during 556 703 person-years of follow-up, corresponding to a standardized incidence ratio of 2.27 (95% confidence interval, 1.87-2.75). The risk of multiple sclerosis was persistently increased for more than 30 years after infectious Mononucleosis and uniformly distributed across all investigated strata of sex and age. The relative risk of multiple sclerosis did not vary by presumed severity of infectious Mononucleosis. Conclusions The risk of multiple sclerosis is increased in persons with prior infectious Mononucleosis, regardless of sex, age, and time since infectious Mononucleosis or severity of infection. The risk of multiple sclerosis may be increased soon after infectious Mononucleosis and persists for at least 30 years after the infection.
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characteristics of hodgkin s lymphoma after infectious Mononucleosis
The New England Journal of Medicine, 2003Co-Authors: Henrik Hjalgrim, Klaus Rostgaard, Johan Askling, Mette Madsen, Nils Rosdahl, Stephen Hamiltondutoit, Morten Frisch, Jinsong Zhang, Helle Bossen Konradsen, Hans H StormAbstract:Background Infectious Mononucleosis–related Epstein–Barr virus (EBV) infection has been associated with an increased risk of Hodgkin's lymphoma in young adults. Whether the association is causal remains unclear. Methods We compared the incidence rates of Hodgkin's lymphoma in two population-based Danish cohorts of patients who were tested for infectious Mononucleosis: 17,045 with serologic evidence of having had acute EBV infection, and 24,614 with no such evidence. We combined the cohort of patients who had serologically verified infectious Mononucleosis with a cohort of 21,510 Swedish patients with infectious Mononucleosis (combined total, 38,555). Biopsy specimens of Hodgkin's lymphomas occurring during follow-up in this combined cohort were tested serologically for the presence of EBV. Using this information, we modeled the relative risk of EBV-negative and EBV-positive Hodgkin's lymphoma in different periods after the diagnosis of infectious Mononucleosis and estimated the median incubation time for ...
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risk of hodgkin s disease and other cancers after infectious Mononucleosis
Journal of the National Cancer Institute, 2000Co-Authors: Henrik Hjalgrim, Per Soelberg Sørensen, Johan Askling, Mette Madsen, Nils Rosdahl, Hans H Storm, Stephen Hamiltondutoit, Lise Stener Eriksen, Morten Frisch, Anders EkbomAbstract:Background: Infectious Mononucleosis, which is caused by the Epstein-Barr virus, has been associated with an increased risk for Hodgkin’s disease. Little is known, however, about how infectious Mononucleosis affects longterm risk of Hodgkin’s disease, how this risk varies with age at infectious Mononucleosis diagnosis, or how the risk for Hodgkin’s disease varies in different age groups. In addition, the general cancer profile among patients who have had infectious Mononucleosis has been sparsely studied. Methods: Population-based cohorts of infectious Mononucleosis patients in Denmark and Sweden were followed for cancer occurrence. The ratio of observed-toexpected numbers of cancers (standardized incidence ratio [SIR]) served as a measure of the relative risk for cancer. SIRs of Hodgkin’s disease in different subsets of patients were compared with the use of Poisson regression analysis. All statistical tests including the trend tests were two-sided. Results: A total of 1381 cancers were observed during 689 619 person-years of follow-up among 38 562 infectious Mononucleosis patients (SIR = 1.03; 95% confidence interval [CI] = 0.98– 1.09). Apart from Hodgkin’s disease (SIR = 2.55; 95% CI = 1.87–3.40; n = 46), only skin cancers (SIR = 1.27; 95% CI = 1.13–1.43; n = 291) occurred in statistically significant excess. In contrast, the SIR for lung cancer was reduced (SIR = 0.71; 95% CI = 0.58–0.86; n = 102). The SIR for Hodgkin’s disease remained elevated for up to two decades after the occurrence of infectious Mononucleosis but decreased with time since diagnosis of infectious Mononucleosis (P for trend <.001). The SIR for Hodgkin’s disease tended to increase with age at diagnosis of infectious Mononucleosis (P for trend = .05).
Marcel Binnebosel - One of the best experts on this subject based on the ideXlab platform.
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fulminant epstein barr virus infectious Mononucleosis in an adult with liver failure splenic rupture and spontaneous esophageal bleeding with ensuing esophageal necrosis a case report
Journal of Medical Case Reports, 2014Co-Authors: Daniel Busch, Sarah Hilswicht, Dominik S Schob, Klaus T Von Trotha, K Junge, Nikolaus Gassler, S Truong, Ulf P Neumann, Marcel BinneboselAbstract:Infectious Mononucleosis is a clinical syndrome most commonly associated with primary Epstein-Barr virus infection. The majority of patients with infectious Mononucleosis recovers without apparent sequelae. However, infectious Mononucleosis may be associated with several acute complications. In this report we present a rare case of esophageal rupture that has never been described in the literature before. We present the case of an 18-year-old Caucasian man affected by severe infectious Mononucleosis complicated by fulminant hepatic failure, splenic rupture and esophageal necrosis. Although primary Epstein-Barr virus infection is rarely fatal, fulminant infection may occur - in this case leading to hepatic failure, splenic rupture and esophageal necrosis, subsequently making several surgical interventions necessary. We show here that infectious Mononucleosis is not only a strictly medical condition, but can also lead to severe surgical complications.
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Fulminant Epstein-Barr virus - infectious Mononucleosis in an adult with liver failure, splenic rupture, and spontaneous esophageal bleeding with ensuing esophageal necrosis: a case report
Journal of Medical Case Reports, 2014Co-Authors: Daniel Busch, Sarah Hilswicht, Dominik S Schob, Klaus T Von Trotha, K Junge, Nikolaus Gassler, S Truong, Ulf P Neumann, Marcel BinneboselAbstract:Introduction Infectious Mononucleosis is a clinical syndrome most commonly associated with primary Epstein-Barr virus infection. The majority of patients with infectious Mononucleosis recovers without apparent sequelae. However, infectious Mononucleosis may be associated with several acute complications. In this report we present a rare case of esophageal rupture that has never been described in the literature before. Case presentation We present the case of an 18-year-old Caucasian man affected by severe infectious Mononucleosis complicated by fulminant hepatic failure, splenic rupture and esophageal necrosis. Conclusions Although primary Epstein-Barr virus infection is rarely fatal, fulminant infection may occur - in this case leading to hepatic failure, splenic rupture and esophageal necrosis, subsequently making several surgical interventions necessary. We show here that infectious Mononucleosis is not only a strictly medical condition, but can also lead to severe surgical complications.