The Experts below are selected from a list of 609 Experts worldwide ranked by ideXlab platform
Toshihiro Nohara - One of the best experts on this subject based on the ideXlab platform.
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pharmacological study on the novel antinociceptive agent a novel Monoterpene Alkaloid from incarvillea sinensis
Biological & Pharmaceutical Bulletin, 2005Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Shinobu SakuradaAbstract:To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.
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A Monoterpene Alkaloid from incarvillea sinensis.
Chemical & pharmaceutical bulletin, 2005Co-Authors: Yu Ming Chi, Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Wen Mei Yan, Toshihiro NoharaAbstract:A novel Monoterpene Alkaloid, named incarvillateine E, possessing three moles of incarvilline moieties, has been obtained from the aerial parts of Incarvillea sinensis LAM. (Bignoniaceae). On the basis of spectroscopic evidence, the structure of incarvillateine E has been characterized.
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Structure-antinociceptive activity studies of incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis.
Planta medica, 2001Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Akihiko Yonezawa, Yumiko Nakasugi, Shinobu SakuradaAbstract:Incarvillateine (1), a new Monoterpene Alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice. To investigate the correlation between its structure and antinociceptive activity, and especially to study whether a cyclobutane ring is necessary or not for expression of activity, we evaluated the antinociceptive activity of two constructive units of incarvillateine, such as a Monoterpene unit (incarvilline, 3) and a phenylpropanoid unit (ferulic acid, 2) in the formalin test, and compared activity of the units with that of incarvillateine. Furthermore, in order to obtain more information about the structure-activity relationships, Monoterpene Alkaloid derivatives, such as incarvine C (5, a precursor of incarvillateine), incarvine A (4, an ester compound comprised of two Monoterpene Alkaloids and a Monoterpene) and 3,3'-demethoxy-4,4'-dehydroxyincarvillateine (6, a synthetic new compound), were examined. The antinociceptive effect of 3,3'-demethoxy-4,4'-dehydroxyincarvillateine was equal to that of incarvillateine. Meanwhile, the other compounds exhibited no or weak activity. These results suggested that the cyclobutane moiety of incarvillateine plays an important role in expression of antinociceptive action.
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Antinociceptive substances from Incarvillea delavayi
Phytochemistry, 2000Co-Authors: Motoyuki Nakamura, Junei Kinjo, Katsumi Kido, Toshihiro NoharaAbstract:Antinociceptive activities of an Incarvillea delavayi extract, as well as its constituents, 8-epideoxyloganic acid and delavayine A, were evaluated in the acetic acid induced writhing test in mice. An oral administration of the delavayi extract weakly decreased the number of writhings and stretchings in this test, in a dose-dependent manner. Furthermore, orally administered 8-epideoxyloganic acid showed weak antinociceptive activity, whereas administration by subcutaneous injection did not. However, subcutaneous injection of delavayine A, a novel Monoterpene Alkaloid, showed a more significant level of antinociceptive activity.
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Strong antinociceptive effect of incarvillateine, a novel Monoterpene Alkaloid from Incarvillea sinensis.
Journal of natural products, 1999Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Yumiko Nakasugi, Nobuto Irino, Shinobu SakuradaAbstract:Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel Monoterpene Alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.
Yu Ming Chi - One of the best experts on this subject based on the ideXlab platform.
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A Monoterpene Alkaloid from incarvillea sinensis.
Chemical & pharmaceutical bulletin, 2005Co-Authors: Yu Ming Chi, Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Wen Mei Yan, Toshihiro NoharaAbstract:A novel Monoterpene Alkaloid, named incarvillateine E, possessing three moles of incarvilline moieties, has been obtained from the aerial parts of Incarvillea sinensis LAM. (Bignoniaceae). On the basis of spectroscopic evidence, the structure of incarvillateine E has been characterized.
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Structure-antinociceptive activity studies of incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis.
Planta medica, 2001Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Akihiko Yonezawa, Yumiko Nakasugi, Shinobu SakuradaAbstract:Incarvillateine (1), a new Monoterpene Alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice. To investigate the correlation between its structure and antinociceptive activity, and especially to study whether a cyclobutane ring is necessary or not for expression of activity, we evaluated the antinociceptive activity of two constructive units of incarvillateine, such as a Monoterpene unit (incarvilline, 3) and a phenylpropanoid unit (ferulic acid, 2) in the formalin test, and compared activity of the units with that of incarvillateine. Furthermore, in order to obtain more information about the structure-activity relationships, Monoterpene Alkaloid derivatives, such as incarvine C (5, a precursor of incarvillateine), incarvine A (4, an ester compound comprised of two Monoterpene Alkaloids and a Monoterpene) and 3,3'-demethoxy-4,4'-dehydroxyincarvillateine (6, a synthetic new compound), were examined. The antinociceptive effect of 3,3'-demethoxy-4,4'-dehydroxyincarvillateine was equal to that of incarvillateine. Meanwhile, the other compounds exhibited no or weak activity. These results suggested that the cyclobutane moiety of incarvillateine plays an important role in expression of antinociceptive action.
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Strong antinociceptive effect of incarvillateine, a novel Monoterpene Alkaloid from Incarvillea sinensis.
Journal of natural products, 1999Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Yumiko Nakasugi, Nobuto Irino, Shinobu SakuradaAbstract:Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel Monoterpene Alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.
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Four Monoterpene Alkaloid derivatives from Incarvillea sinensis
Phytochemistry, 1997Co-Authors: Motoyuki Nakamura, Junei Kinjo, Yu Ming Chi, Wen Mei Yan, Toshihiro NoharaAbstract:Two new derivatives of Monoterpene Alkaloids, named incarvillateine C and incarvillateine D which are related to an antinociceptive Alkaloid, incarvillateine, were isolated from the aerial parts of Incarvillea sinensis LAM. On the basis of both chemical and spectroscopic evidence, the structures of the first two were characterized as a bis-demethoxy and demethoxy derivatives of incarvillateine, respectively.
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Incarvine A, a Monoterpene Alkaloid from Incarvillea sinensis
Phytochemistry, 1995Co-Authors: Yu Ming Chi, Fumio Hashimoto, Wen Mei Yan, Toshihiro NoharaAbstract:A novel ester compound comprised of a Monoterpene Alkaloid and a Monoterpene, named incarvine A, has been isolated from Incarvillea sinensis. Its chemical structure was characterized by chemical and spectroscopic means.
Motoyuki Nakamura - One of the best experts on this subject based on the ideXlab platform.
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pharmacological study on the novel antinociceptive agent a novel Monoterpene Alkaloid from incarvillea sinensis
Biological & Pharmaceutical Bulletin, 2005Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Shinobu SakuradaAbstract:To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.
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A Monoterpene Alkaloid from incarvillea sinensis.
Chemical & pharmaceutical bulletin, 2005Co-Authors: Yu Ming Chi, Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Wen Mei Yan, Toshihiro NoharaAbstract:A novel Monoterpene Alkaloid, named incarvillateine E, possessing three moles of incarvilline moieties, has been obtained from the aerial parts of Incarvillea sinensis LAM. (Bignoniaceae). On the basis of spectroscopic evidence, the structure of incarvillateine E has been characterized.
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Structure-antinociceptive activity studies of incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis.
Planta medica, 2001Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Akihiko Yonezawa, Yumiko Nakasugi, Shinobu SakuradaAbstract:Incarvillateine (1), a new Monoterpene Alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice. To investigate the correlation between its structure and antinociceptive activity, and especially to study whether a cyclobutane ring is necessary or not for expression of activity, we evaluated the antinociceptive activity of two constructive units of incarvillateine, such as a Monoterpene unit (incarvilline, 3) and a phenylpropanoid unit (ferulic acid, 2) in the formalin test, and compared activity of the units with that of incarvillateine. Furthermore, in order to obtain more information about the structure-activity relationships, Monoterpene Alkaloid derivatives, such as incarvine C (5, a precursor of incarvillateine), incarvine A (4, an ester compound comprised of two Monoterpene Alkaloids and a Monoterpene) and 3,3'-demethoxy-4,4'-dehydroxyincarvillateine (6, a synthetic new compound), were examined. The antinociceptive effect of 3,3'-demethoxy-4,4'-dehydroxyincarvillateine was equal to that of incarvillateine. Meanwhile, the other compounds exhibited no or weak activity. These results suggested that the cyclobutane moiety of incarvillateine plays an important role in expression of antinociceptive action.
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Antinociceptive substances from Incarvillea delavayi
Phytochemistry, 2000Co-Authors: Motoyuki Nakamura, Junei Kinjo, Katsumi Kido, Toshihiro NoharaAbstract:Antinociceptive activities of an Incarvillea delavayi extract, as well as its constituents, 8-epideoxyloganic acid and delavayine A, were evaluated in the acetic acid induced writhing test in mice. An oral administration of the delavayi extract weakly decreased the number of writhings and stretchings in this test, in a dose-dependent manner. Furthermore, orally administered 8-epideoxyloganic acid showed weak antinociceptive activity, whereas administration by subcutaneous injection did not. However, subcutaneous injection of delavayine A, a novel Monoterpene Alkaloid, showed a more significant level of antinociceptive activity.
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Strong antinociceptive effect of incarvillateine, a novel Monoterpene Alkaloid from Incarvillea sinensis.
Journal of natural products, 1999Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Yumiko Nakasugi, Nobuto Irino, Shinobu SakuradaAbstract:Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel Monoterpene Alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.
Shinobu Sakurada - One of the best experts on this subject based on the ideXlab platform.
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pharmacological study on the novel antinociceptive agent a novel Monoterpene Alkaloid from incarvillea sinensis
Biological & Pharmaceutical Bulletin, 2005Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Shinobu SakuradaAbstract:To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.
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Structure-antinociceptive activity studies of incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis.
Planta medica, 2001Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Akihiko Yonezawa, Yumiko Nakasugi, Shinobu SakuradaAbstract:Incarvillateine (1), a new Monoterpene Alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice. To investigate the correlation between its structure and antinociceptive activity, and especially to study whether a cyclobutane ring is necessary or not for expression of activity, we evaluated the antinociceptive activity of two constructive units of incarvillateine, such as a Monoterpene unit (incarvilline, 3) and a phenylpropanoid unit (ferulic acid, 2) in the formalin test, and compared activity of the units with that of incarvillateine. Furthermore, in order to obtain more information about the structure-activity relationships, Monoterpene Alkaloid derivatives, such as incarvine C (5, a precursor of incarvillateine), incarvine A (4, an ester compound comprised of two Monoterpene Alkaloids and a Monoterpene) and 3,3'-demethoxy-4,4'-dehydroxyincarvillateine (6, a synthetic new compound), were examined. The antinociceptive effect of 3,3'-demethoxy-4,4'-dehydroxyincarvillateine was equal to that of incarvillateine. Meanwhile, the other compounds exhibited no or weak activity. These results suggested that the cyclobutane moiety of incarvillateine plays an important role in expression of antinociceptive action.
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Strong antinociceptive effect of incarvillateine, a novel Monoterpene Alkaloid from Incarvillea sinensis.
Journal of natural products, 1999Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Yumiko Nakasugi, Nobuto Irino, Shinobu SakuradaAbstract:Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel Monoterpene Alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.
Wen Mei Yan - One of the best experts on this subject based on the ideXlab platform.
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A Monoterpene Alkaloid from incarvillea sinensis.
Chemical & pharmaceutical bulletin, 2005Co-Authors: Yu Ming Chi, Motoyuki Nakamura, Toyokichi Yoshizawa, Xi Ying Zhao, Junei Kinjo, Fumio Hashimoto, Wen Mei Yan, Toshihiro NoharaAbstract:A novel Monoterpene Alkaloid, named incarvillateine E, possessing three moles of incarvilline moieties, has been obtained from the aerial parts of Incarvillea sinensis LAM. (Bignoniaceae). On the basis of spectroscopic evidence, the structure of incarvillateine E has been characterized.
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Structure-antinociceptive activity studies of incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis.
Planta medica, 2001Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Akihiko Yonezawa, Yumiko Nakasugi, Shinobu SakuradaAbstract:Incarvillateine (1), a new Monoterpene Alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice. To investigate the correlation between its structure and antinociceptive activity, and especially to study whether a cyclobutane ring is necessary or not for expression of activity, we evaluated the antinociceptive activity of two constructive units of incarvillateine, such as a Monoterpene unit (incarvilline, 3) and a phenylpropanoid unit (ferulic acid, 2) in the formalin test, and compared activity of the units with that of incarvillateine. Furthermore, in order to obtain more information about the structure-activity relationships, Monoterpene Alkaloid derivatives, such as incarvine C (5, a precursor of incarvillateine), incarvine A (4, an ester compound comprised of two Monoterpene Alkaloids and a Monoterpene) and 3,3'-demethoxy-4,4'-dehydroxyincarvillateine (6, a synthetic new compound), were examined. The antinociceptive effect of 3,3'-demethoxy-4,4'-dehydroxyincarvillateine was equal to that of incarvillateine. Meanwhile, the other compounds exhibited no or weak activity. These results suggested that the cyclobutane moiety of incarvillateine plays an important role in expression of antinociceptive action.
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Strong antinociceptive effect of incarvillateine, a novel Monoterpene Alkaloid from Incarvillea sinensis.
Journal of natural products, 1999Co-Authors: Motoyuki Nakamura, Toyokichi Yoshizawa, Junei Kinjo, Fumio Hashimoto, Toshihiro Nohara, Yu Ming Chi, Wen Mei Yan, Yumiko Nakasugi, Nobuto Irino, Shinobu SakuradaAbstract:Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel Monoterpene Alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.
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Four Monoterpene Alkaloid derivatives from Incarvillea sinensis
Phytochemistry, 1997Co-Authors: Motoyuki Nakamura, Junei Kinjo, Yu Ming Chi, Wen Mei Yan, Toshihiro NoharaAbstract:Two new derivatives of Monoterpene Alkaloids, named incarvillateine C and incarvillateine D which are related to an antinociceptive Alkaloid, incarvillateine, were isolated from the aerial parts of Incarvillea sinensis LAM. On the basis of both chemical and spectroscopic evidence, the structures of the first two were characterized as a bis-demethoxy and demethoxy derivatives of incarvillateine, respectively.
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Incarvine A, a Monoterpene Alkaloid from Incarvillea sinensis
Phytochemistry, 1995Co-Authors: Yu Ming Chi, Fumio Hashimoto, Wen Mei Yan, Toshihiro NoharaAbstract:A novel ester compound comprised of a Monoterpene Alkaloid and a Monoterpene, named incarvine A, has been isolated from Incarvillea sinensis. Its chemical structure was characterized by chemical and spectroscopic means.