The Experts below are selected from a list of 3765 Experts worldwide ranked by ideXlab platform
Michung Yoon - One of the best experts on this subject based on the ideXlab platform.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Abstract Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba , Melissa officinalis and Artemisia iwayomogi , improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor α (PPARα) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARα target enzymes responsible for fatty acid β-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARα target genes.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor alpha (PPARalpha) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARalpha target enzymes responsible for fatty acid beta-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARalpha target genes.
Jinmi Lee - One of the best experts on this subject based on the ideXlab platform.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Abstract Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba , Melissa officinalis and Artemisia iwayomogi , improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor α (PPARα) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARα target enzymes responsible for fatty acid β-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARα target genes.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor alpha (PPARalpha) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARalpha target enzymes responsible for fatty acid beta-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARalpha target genes.
Mi Ran Kim - One of the best experts on this subject based on the ideXlab platform.
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up601 a standardized botanical composition composed of Morus Alba yerba mate and magnolia officinalis for weight loss
BMC Complementary and Alternative Medicine, 2017Co-Authors: Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Youngchul Lee, Eujin Hyun, Hyunjin Kim, Jeongbum Nam, Mi Ran Kim, Qi JiaAbstract:The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too expensive, their long term usages are hindered by their severe adverse effects. Here we describe the effect of UP601, a standardized blend of extracts from Morus Alba, Yerba mate and Magnolia officinalis, in modulating a number of obesity-related phenotypic and biochemical markers in a high-fat high-fructose (HFF)-induced C57BL/6J mouse model of obesity. Adipogenesis activity of the composition was assessed in 3T3-L1 cells in vitro. Effects of UP601 on body weight and metabolic markers were evaluated. It was administered at oral doses of 300 mg/kg, 450 mg/kg and 600 mg/kg for 7 weeks. Orlistat (40 mg/kg/day) was used as a positive control. Body compositions of mice were assessed using dual energy X-ray absorptiometry (DEXA). Serum biomarkers were measured for liver function and lipid profiling. Relative organ weights were determined. Histopathological analysis was performed for non-alcoholic steatohepatitis (NASH) scoring. UP601 at 250 μg/ml resulted in 1.8-fold increase in lipolysis. Statistically significant changes in body weight (decreased by 9.1, 19.6 and 25.6% compared to the HFF group at week-7) were observed for mice treated with UP601 at 300, 450 and 600 mg/kg, respectively. Reductions of 9.1, 16.9, and 18.6% in total cholesterol; 45.0, 55.0, 63.6% in triglyceride; 34.8, 37.1 and 41.6% in LDL; 3.2, 21.6 (P = 0.03) and 33.7% (P = 0.005) in serum glucose were observed for UP601 at 300, 450 and 600 mg/kg, respectively. Body fat distribution was found reduced by 31.6 and 17.2% for the 450 mg/kg UP601 and orlistat, respectively, from the DEXA scan analysis. Up to an 89.1% reduction in mesenteric fat deposit was observed for UP601 in relative organ weight. Statistically significant improvements in NASH scores were observed for mice treated with UP601. UP601, a standardized botanical composition from Morus Alba, Yerba mate and Magnolia officinalis could potentially be used for achieving healthy weight loss and maintenance.
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appetite suppression and antiobesity effect of a botanical composition composed of Morus Alba yerba mate and magnolia officinalis
Journal of Obesity, 2016Co-Authors: Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Youngchul Lee, Eujin Hyun, Hyunjin Kim, Taewoo Kim, Jeongbum Nam, Mi Ran KimAbstract:Background. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus Alba, Yerba mate, and Magnolia officinalis for appetite suppression and metabolic disorders management. Method. Extracts were standardized to yield a composition designated as UP601. Appetite suppression activity was tested in acute feed intake rat model. Efficacy was evaluated in C57BL/6J mouse models treated with oral doses of 1.3 g/kg/day for 7 weeks. Orlistat at 40 mg/kg/day was used as a positive control. Body compositions of mice were assessed using a dual energy X-ray absorptiometry (DEXA). ELISA was done for insulin, leptin, and ghrelin level quantitation. Nonalcoholic steatohepatitis (NASH) scoring was conducted. Results. Marked acute hypophagia with 81.8, 75.3, 43.9, and 30.9% reductions in food intake at 2, 4, 6, and 24 hours were observed for UP601. Decreases in body weight gain (21.5% compared to the HFD at weeks 7 and 8.2% compared to baseline) and calorie intake (40.5% for the first week) were observed. 75.9% and 46.8% reductions in insulin and leptin, respectively, 4.2-fold increase in ghrelin level, and reductions of 18.6% in cholesterol and 59% in low-density lipoprotein were documented. A percentage body fat of 18.9%, 47.8%, 46.1%, and 30.4% was found for mice treated with normal control, HFD, Orlistat, and UP601, respectively. 59.3% less mesenteric fat pad and improved NASH scores were observed for UP601. Conclusion. UP601, a standardized botanical composition from Morus Alba, Yerba mate, and Magnolia officinalis could be used as a natural alternative for appetite suppression, maintaining healthy body weight and metabolism management.
Kyungsil Chae - One of the best experts on this subject based on the ideXlab platform.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Abstract Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba , Melissa officinalis and Artemisia iwayomogi , improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor α (PPARα) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARα target enzymes responsible for fatty acid β-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARα target genes.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor alpha (PPARalpha) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARalpha target enzymes responsible for fatty acid beta-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARalpha target genes.
Byungyoung Park - One of the best experts on this subject based on the ideXlab platform.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Abstract Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba , Melissa officinalis and Artemisia iwayomogi , improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor α (PPARα) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARα target enzymes responsible for fatty acid β-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARα target genes.
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regulation of obesity and lipid disorders by herbal extracts from Morus Alba melissa officinalis and artemisia capillaris in high fat diet induced obese mice
Journal of Ethnopharmacology, 2008Co-Authors: Jinmi Lee, Kyungsil Chae, Byungyoung Park, Hee Suk Lee, Sunhyo Jeong, Min Young Kim, Michung YoonAbstract:Melissa officinalis L. (Labiatae), Morus Alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus Alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor alpha (PPARalpha) is associated with these events. Mice fed a high-fat diet for 12 weeks exhibited increases in body weight gain and adipose tissue mass compared with mice fed a low fat diet. However, feeding a high-fat diet supplemented with Ob-X significantly reduced these effects. Ob-X treatment also decreased the circulating levels of triglycerides and total cholesterol, and inhibited hepatic lipid accumulation. Ob-X supplementation was found to increase the hepatic mRNA levels of PPARalpha target enzymes responsible for fatty acid beta-oxidation. Moreover, Ob-X elevated the endogenous expression of a luciferase reporter gene containing three copies of a PPAR response element (PPRE) in NMu2Li liver cells. These data demonstrate that Ob-X regulates body weight gain, adipose tissue mass, and lipid metabolism in part through changes in the expression of hepatic PPARalpha target genes.