The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Leda Menescaldeoliveira - One of the best experts on this subject based on the ideXlab platform.
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glutamate gaba balance in acc modulates the nociceptive responses of vocalization an expression of affective Motivational Component of pain in guinea pigs
Physiology & Behavior, 2014Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda MenescaldeoliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.
Martine Cador - One of the best experts on this subject based on the ideXlab platform.
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the Motivational Component of withdrawal in opiate addiction role of associative learning and aversive memory in opiate addiction from a behavioral anatomical and functional perspective
Reviews in The Neurosciences, 2005Co-Authors: Francois Frenois, Le Moine C, Martine CadorAbstract:Abstract A major challenge in current drug addiction research is not only to understand the immediate effects of drugs of abuse on brain operations, but also to define at the behavioral and neural levels how cognitive, emotional and Motivational processes interact with drug use in order to lead to this psychopathological state which defines addiction. It is now clear that factors other than the direct effects of drugs of abuse are able to powerfully affect drug-seeking and drug-taking behaviors. In former opiate addicts, re-exposure to environmental situations previously paired with withdrawal is able to induce strong craving episodes. It has been proposed that these conditioned stimuli could be strongly involved in precipitating relapse in drug-taking behavior by re-activating the neurobiological circuits which are engaged in an unconditioned way by the withdrawal state itself, leading to a powerful aversive state relieved by drug consumption renewal. In the present review, we provide evidence from a neuropsychopharmacological viewpoint that environmental situations previously paired with the opiate withdrawal syndrome might be able to maintain drug-seeking motivation. Using behavioral models which allow assessment of the aversive and Motivational properties of opiate withdrawal both in the unconditioned and conditioned situations, we have recently investigated using extensive mapping the neurobiological correlates which underlie acute withdrawal and the trace of its memory in the brain in terms of localization and neuronal population involved, with an anatomical and functional approach. Thus, on the basis of our results, and together with a number of data in the literature, we provide a functional model for the formation and retrieval of opiate withdrawal memories.
Joao Zugaib - One of the best experts on this subject based on the ideXlab platform.
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glutamate gaba balance in acc modulates the nociceptive responses of vocalization an expression of affective Motivational Component of pain in guinea pigs
Physiology & Behavior, 2014Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda MenescaldeoliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.
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Glutamate/GABA balance in ACC modulates the nociceptive responses of vocalization: An expression of affective-Motivational Component of pain in guinea pigs
Physiology & Behavior, 2013Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda Menescal-de-oliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.
Mateus Dalbem Ferreira - One of the best experts on this subject based on the ideXlab platform.
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glutamate gaba balance in acc modulates the nociceptive responses of vocalization an expression of affective Motivational Component of pain in guinea pigs
Physiology & Behavior, 2014Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda MenescaldeoliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.
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Glutamate/GABA balance in ACC modulates the nociceptive responses of vocalization: An expression of affective-Motivational Component of pain in guinea pigs
Physiology & Behavior, 2013Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda Menescal-de-oliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.
Marcio Ramos Coutinho - One of the best experts on this subject based on the ideXlab platform.
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glutamate gaba balance in acc modulates the nociceptive responses of vocalization an expression of affective Motivational Component of pain in guinea pigs
Physiology & Behavior, 2014Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda MenescaldeoliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.
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Glutamate/GABA balance in ACC modulates the nociceptive responses of vocalization: An expression of affective-Motivational Component of pain in guinea pigs
Physiology & Behavior, 2013Co-Authors: Joao Zugaib, Marcio Ramos Coutinho, Mateus Dalbem Ferreira, Leda Menescal-de-oliveiraAbstract:Evidence corroborates the role of the anterior cingulate cortex (ACC) in the modulation of cognitive and emotional functions. Its involvement in the Motivational-affective Component of pain has been widely investigated using different methods to elucidate the specific role of different neurotransmitter systems. We used the peripheral noxious stimulus-induced vocalization algesimetric test to verify glutamatergic and GABAergic neurotransmission in the guinea pig ACC. Microinjection of homocysteic acid (DLH; 30 nmol) in the left guinea pig ACC increased the amplitude of vocalizations (pronociception) compared to controls injected with saline. Moreover, microinjection of MK-801 (3.6 nmol), an NMDA receptor antagonist, did not alter the amplitude of vocalizations, but its microinjection prior to DLH prevented the increase in vocalizations induced by this drug. Regarding the GABAergic system, blockade of GABAA receptors with bicuculline (1 nmol) increased the amplitude of vocalizations, while three different doses of the GABAA agonist muscimol (0.5, 1 and 2 nmol) did not influence nociceptive vocalization responses. Finally, a combination of MK-801 (3.6 nmol) and muscimol (1 nmol) reduced the amplitude of vocalizations (antinociception), suggesting that a combination of glutamate and GABA in the ACC modulates the expression of affective-Motivational pain response. We suggest that activation of NMDA receptors or blockade of GABAergic neurotransmission promotes pronociception and that the antinociceptive effect of muscimol depends on the blockade of NMDA receptors.