The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
William Perry - One of the best experts on this subject based on the ideXlab platform.
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The quantitative assessment of Motor Activity in mania and schizophrenia.
Journal of affective disorders, 2010Co-Authors: Arpi Minassian, Brook L Henry, Mark A Geyer, Martin P Paulus, Jared W Young, William PerryAbstract:Increased Motor Activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor Activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify Motor Activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM). 28 patients in the manic phase of BD, 17 SCZ patients, and 21 nonpatient (NC) subjects were tested in the BPM, an unfamiliar room containing novel objects. Motor Activity was measured with a wearable ambulatory monitoring device (LifeShirt). Manic BD patients exhibited higher levels of Motor Activity when exploring the novel environment than SCZ and NC groups. Motor Activity showed some modest relationships with symptom ratings of mania and psychosis and was not related to smoking or body mass index. Although Motor Activity did not appear to be impacted significantly by antipsychotic or mood-stabilizing medications, this was a naturalistic study and medications were not controlled, thus limiting conclusions about potential medication effects on Motor Activity. Manic BD patients exhibit a unique signature of Motoric overActivity in a novel exploratory environment. The use of an objective method to quantify exploration and Motor Activity may help characterize the unique aspects of BD and, because it is amenable to translational research, may further the study of the biological and genetic bases of the disease.
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The quantitative assessment of Motor Activity in mania and schizophrenia.
Journal of Affective Disorders, 2009Co-Authors: Arpi Minassian, Brook L Henry, Mark A Geyer, Martin P Paulus, Jared W Young, William PerryAbstract:Background Increased Motor Activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor Activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify Motor Activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM).
Gerard A. Kerkhof - One of the best experts on this subject based on the ideXlab platform.
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Plasma arginine vasopressin and Motor Activity in major depression.
Biological psychiatry, 1998Co-Authors: Liesbeth Van Londen, Gerard A. Kerkhof, Frans Van Den Berg, Jaap G. Goekoop, Koos H. Zwinderman, Ank C. Frankhuijzen-sierevogel, Victor M. Wiegant, David De WiedAbstract:Background: Previously, we found that mean plasma concentrations of arginine vasopressin (AVP), but not of oxytocin (OT), were higher in depressed patients than in healthy controls. Plasma AVP concentrations were positively correlated to clinically rated psychoMotor retardation. To further explore this previously reported relation we studied psychoMotor retardation by means of an Activity monitor, which is a more fine-focused and more objective instrument to analyze Motor retardation than a clinical rating scale. Methods: Plasma AVP and OT concentrations, and day-and nighttime wrist Activity were measured in 48 in- and outpatients with major depression and 30 healthy controls during a period of 5 consecutive days and nights. Results: Principal components analysis revealed three components of Motor Activity: Motor Activity during wakefulness, Motor Activity during sleep, and the awake/sleep time ratio. In patients and controls an inverse relationship between plasma AVP concentrations and Motor Activity during wakefulness was found. Patients with elevated AVP plasma levels showed increased Motor Activity during sleep. Conclusions: These results suggest that high plasma AVP levels are related to the clinical picture of daytime psychoMotor retardation and nighttime Motor Activity in major depression. Mean plasma OT concentrations were not related to measures of Motor Activity.
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Plasma Arginine Vasopressin Major Depression and Motor Activity in
1998Co-Authors: Liesbeth Van Londen, Gerard A. Kerkhof, Frans Van Den Berg, Jaap G. Goekoop, Koos H. Zwinderman, Ank C. Frankhuijzen-sierevogel, Victor M. Wiegant, David De WiedAbstract:Background: Previously, we found that mean plasma concentrations of arginine vasopressin (A VP), but not of oxytocin (OT), were higher in depressed patients than in healthy controls. Plasma A VP concentrations were positively correlated to clinically rated psychoMotor retardation. To further explore this previously reported relation we studied psychoMotor retardation by means of an Activity monitor, which is a more fine-Jbcused and more objective instrument to analyze Motor retardation than a clinical rating scale. Methods: Plasma A VP and OT concentrations, and dayand nighttime wrist Activity were measured in 48 in- and outpatients with major depression and 30 healthy controls during a period of 5 consecutive days and nights. Results: Principal components analysis revealed three components of Motor Activity: Motor Activity during wakefulness, Motor Activity during sleep, and the awake/sleep time ratio. In patients and controls an inverse relationship between plasma A VP concentrations and Motor Activity during wakefulness was found. Patients with elevated A VP plasma levels showed increased Motor Activity during sleep. Conclusions: These results suggest that high plasma A VP levels are related to the clinical picture of daytime psychoMotor retardation and nighttime Motor Activity in major depression. Mean plasma OT concentrations were not related to measures of Motor Activity. Biol Psychiatry 1998;43:196-204 © 1998 Society of Biological Psychiatry
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Diurnal effects of Motor Activity and fatigue in Parkinson's disease.
Journal of neurology neurosurgery and psychiatry, 1993Co-Authors: J.j. Van Hilten, Huub A. M. Middelkoop, Gerard A. Kerkhof, G. Hoogland, E. A. Van Der Velde, R. A. C. RoosAbstract:Wrist Motor Activity was monitored continuously in 65 patients with Parkinson's disease (PD) to assess the influence of disease severity and excessive fatigue on the diurnal Motor Activity pattern. Mildly or moderately affected PD patients had a similar diurnal pattern to that of 68 healthy controls, with a late morning peak; however, mean levels of Motor Activity were lower. The most severely affected patients showed an overall flattened diurnal pattern. Results refute the existence of end of day deterioration, but instead suggest a "depressed morning start" in the most severely affected patients with PD. Excessive fatigue was not reported at a particular time of day and did not influence the diurnal Motor Activity pattern.
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A new approach in the assessment of Motor Activity in Parkinson's disease.
Journal of neurology neurosurgery and psychiatry, 1991Co-Authors: J.j. Van Hilten, Huub A. M. Middelkoop, Gerard A. Kerkhof, R. A. C. RoosAbstract:Motor Activity was recorded continuously with a wrist-worn Activity monitor for almost six days in nine patients with different predominant manifestations of Parkinson's disease and 10 normal subjects. The indices of diurnal Motor Activity decreased with the progressive worsening of hypokinesia and rigidity. With this monitor and a simple diary it was possible to determine the contribution of a moderate resting tremor and choreiform dyskinesias to the Motor Activity level, and to monitor their variability.
Mark A Geyer - One of the best experts on this subject based on the ideXlab platform.
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The quantitative assessment of Motor Activity in mania and schizophrenia.
Journal of affective disorders, 2010Co-Authors: Arpi Minassian, Brook L Henry, Mark A Geyer, Martin P Paulus, Jared W Young, William PerryAbstract:Increased Motor Activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor Activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify Motor Activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM). 28 patients in the manic phase of BD, 17 SCZ patients, and 21 nonpatient (NC) subjects were tested in the BPM, an unfamiliar room containing novel objects. Motor Activity was measured with a wearable ambulatory monitoring device (LifeShirt). Manic BD patients exhibited higher levels of Motor Activity when exploring the novel environment than SCZ and NC groups. Motor Activity showed some modest relationships with symptom ratings of mania and psychosis and was not related to smoking or body mass index. Although Motor Activity did not appear to be impacted significantly by antipsychotic or mood-stabilizing medications, this was a naturalistic study and medications were not controlled, thus limiting conclusions about potential medication effects on Motor Activity. Manic BD patients exhibit a unique signature of Motoric overActivity in a novel exploratory environment. The use of an objective method to quantify exploration and Motor Activity may help characterize the unique aspects of BD and, because it is amenable to translational research, may further the study of the biological and genetic bases of the disease.
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The quantitative assessment of Motor Activity in mania and schizophrenia.
Journal of Affective Disorders, 2009Co-Authors: Arpi Minassian, Brook L Henry, Mark A Geyer, Martin P Paulus, Jared W Young, William PerryAbstract:Background Increased Motor Activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor Activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify Motor Activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM).
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Three independent factors characterize spontaneous rat Motor Activity
Behavioural Brain Research, 1993Co-Authors: Martin P Paulus, Mark A GeyerAbstract:A scaling approach was introduced recently to assess sequential and geometrical aspects of animal behavior. This study describes the relationship between different measures of unconditioned Motor Activity of rats. Specifically, the amount of Motor Activity was assessed using both a traditional photobeam break measure, counts, and the temporal scaling exponent, α, which describes the ratio of fast to slow behavioral micro-events. The sequential characteristics of the behavior were assessed by the dynamical entropy, h, describing the degree of unpredictability of future movements. The geometrical characteristics of rat Motor Activity were quantified by the spatial scaling exponent, d. Exploratory Activity was measured by counting rearings and holepoking responses. A factor analysis of these measures was conducted based on results from 137 drug-naive animals that were tested for 1 h in the Behavioral Pattern Monitor. Three independent factors account for 77% of the variance. These factors can be described as the ‘amount of Activity’, ‘sequential response organization’, and ‘exploratory Activity’. The factor loadings support the initial hypothesis that the geometrical structure of rat Motor Activity, i.e. the spatial scaling exponent d, varies independently from the amount of Activity, i.e., counts. In addition, the distribution of these measures did not deviate significantly from normality suggesting that the z-scores of these variables, which have been used previously in the d-α plane description, are able to indicate significant changes of behavior. These results suggest that unconditioned Motor Activity is influenced by at least three independent factors. The independent assessment of these factors may contribute significantly to the understanding of the neural substrates involved in the organization of unconditioned behavior.
Martin P Paulus - One of the best experts on this subject based on the ideXlab platform.
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The quantitative assessment of Motor Activity in mania and schizophrenia.
Journal of affective disorders, 2010Co-Authors: Arpi Minassian, Brook L Henry, Mark A Geyer, Martin P Paulus, Jared W Young, William PerryAbstract:Increased Motor Activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor Activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify Motor Activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM). 28 patients in the manic phase of BD, 17 SCZ patients, and 21 nonpatient (NC) subjects were tested in the BPM, an unfamiliar room containing novel objects. Motor Activity was measured with a wearable ambulatory monitoring device (LifeShirt). Manic BD patients exhibited higher levels of Motor Activity when exploring the novel environment than SCZ and NC groups. Motor Activity showed some modest relationships with symptom ratings of mania and psychosis and was not related to smoking or body mass index. Although Motor Activity did not appear to be impacted significantly by antipsychotic or mood-stabilizing medications, this was a naturalistic study and medications were not controlled, thus limiting conclusions about potential medication effects on Motor Activity. Manic BD patients exhibit a unique signature of Motoric overActivity in a novel exploratory environment. The use of an objective method to quantify exploration and Motor Activity may help characterize the unique aspects of BD and, because it is amenable to translational research, may further the study of the biological and genetic bases of the disease.
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The quantitative assessment of Motor Activity in mania and schizophrenia.
Journal of Affective Disorders, 2009Co-Authors: Arpi Minassian, Brook L Henry, Mark A Geyer, Martin P Paulus, Jared W Young, William PerryAbstract:Background Increased Motor Activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor Activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify Motor Activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM).
-
Three independent factors characterize spontaneous rat Motor Activity
Behavioural Brain Research, 1993Co-Authors: Martin P Paulus, Mark A GeyerAbstract:A scaling approach was introduced recently to assess sequential and geometrical aspects of animal behavior. This study describes the relationship between different measures of unconditioned Motor Activity of rats. Specifically, the amount of Motor Activity was assessed using both a traditional photobeam break measure, counts, and the temporal scaling exponent, α, which describes the ratio of fast to slow behavioral micro-events. The sequential characteristics of the behavior were assessed by the dynamical entropy, h, describing the degree of unpredictability of future movements. The geometrical characteristics of rat Motor Activity were quantified by the spatial scaling exponent, d. Exploratory Activity was measured by counting rearings and holepoking responses. A factor analysis of these measures was conducted based on results from 137 drug-naive animals that were tested for 1 h in the Behavioral Pattern Monitor. Three independent factors account for 77% of the variance. These factors can be described as the ‘amount of Activity’, ‘sequential response organization’, and ‘exploratory Activity’. The factor loadings support the initial hypothesis that the geometrical structure of rat Motor Activity, i.e. the spatial scaling exponent d, varies independently from the amount of Activity, i.e., counts. In addition, the distribution of these measures did not deviate significantly from normality suggesting that the z-scores of these variables, which have been used previously in the d-α plane description, are able to indicate significant changes of behavior. These results suggest that unconditioned Motor Activity is influenced by at least three independent factors. The independent assessment of these factors may contribute significantly to the understanding of the neural substrates involved in the organization of unconditioned behavior.
David De Wied - One of the best experts on this subject based on the ideXlab platform.
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Plasma arginine vasopressin and Motor Activity in major depression.
Biological psychiatry, 1998Co-Authors: Liesbeth Van Londen, Gerard A. Kerkhof, Frans Van Den Berg, Jaap G. Goekoop, Koos H. Zwinderman, Ank C. Frankhuijzen-sierevogel, Victor M. Wiegant, David De WiedAbstract:Background: Previously, we found that mean plasma concentrations of arginine vasopressin (AVP), but not of oxytocin (OT), were higher in depressed patients than in healthy controls. Plasma AVP concentrations were positively correlated to clinically rated psychoMotor retardation. To further explore this previously reported relation we studied psychoMotor retardation by means of an Activity monitor, which is a more fine-focused and more objective instrument to analyze Motor retardation than a clinical rating scale. Methods: Plasma AVP and OT concentrations, and day-and nighttime wrist Activity were measured in 48 in- and outpatients with major depression and 30 healthy controls during a period of 5 consecutive days and nights. Results: Principal components analysis revealed three components of Motor Activity: Motor Activity during wakefulness, Motor Activity during sleep, and the awake/sleep time ratio. In patients and controls an inverse relationship between plasma AVP concentrations and Motor Activity during wakefulness was found. Patients with elevated AVP plasma levels showed increased Motor Activity during sleep. Conclusions: These results suggest that high plasma AVP levels are related to the clinical picture of daytime psychoMotor retardation and nighttime Motor Activity in major depression. Mean plasma OT concentrations were not related to measures of Motor Activity.
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Plasma Arginine Vasopressin Major Depression and Motor Activity in
1998Co-Authors: Liesbeth Van Londen, Gerard A. Kerkhof, Frans Van Den Berg, Jaap G. Goekoop, Koos H. Zwinderman, Ank C. Frankhuijzen-sierevogel, Victor M. Wiegant, David De WiedAbstract:Background: Previously, we found that mean plasma concentrations of arginine vasopressin (A VP), but not of oxytocin (OT), were higher in depressed patients than in healthy controls. Plasma A VP concentrations were positively correlated to clinically rated psychoMotor retardation. To further explore this previously reported relation we studied psychoMotor retardation by means of an Activity monitor, which is a more fine-Jbcused and more objective instrument to analyze Motor retardation than a clinical rating scale. Methods: Plasma A VP and OT concentrations, and dayand nighttime wrist Activity were measured in 48 in- and outpatients with major depression and 30 healthy controls during a period of 5 consecutive days and nights. Results: Principal components analysis revealed three components of Motor Activity: Motor Activity during wakefulness, Motor Activity during sleep, and the awake/sleep time ratio. In patients and controls an inverse relationship between plasma A VP concentrations and Motor Activity during wakefulness was found. Patients with elevated A VP plasma levels showed increased Motor Activity during sleep. Conclusions: These results suggest that high plasma A VP levels are related to the clinical picture of daytime psychoMotor retardation and nighttime Motor Activity in major depression. Mean plasma OT concentrations were not related to measures of Motor Activity. Biol Psychiatry 1998;43:196-204 © 1998 Society of Biological Psychiatry
