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Kanokporn Pangsomboon - One of the best experts on this subject based on the ideXlab platform.
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effects of lawsone methyl ether Mouthwash on oral candida in hiv infected subjects and subjects with denture stomatitis
Journal of Oral Pathology & Medicine, 2013Co-Authors: Wipawee Nittayananta, Kanokporn Pangsomboon, Pharkphoom Panichayupakaranant, Nilnara Chanowanna, Sureerat Chelae, Varaporn Vuddhakul, Pharanai Sukhumungoon, Nannapat PruphetkaewAbstract:Objectives To determine (i) effects of lawsone methyl ether (LME) Mouthwash on antifungal drug resistance of oral Candida, (ii) effects of LME Mouthwash on changes in genotype of oral Candida, and (iii) allergy and subjects' satisfaction on LME Mouthwash in comparison with chlorhexidine (CHX). Materials and methods A randomized clinical trial was conducted in HIV-infected subjects and denture wearers receiving either LME or CHX Mouthwash. Candidal culture by oral rinse technique was performed as baseline and after using the Mouthwash for 2 weeks. Antifungal drug resistance and changes in genotype of oral Candida were assessed by microdilution assay, inverted repeat polymerase chain reaction and restriction fragment length polymorphism assays, respectively. Allergy and subjects' satisfaction on the Mouthwashes were recorded. Statistical analysis was performed using Chi-squared and Fisher's exact tests. Results Twenty-nine HIV-infected subjects (age range, 26–54 years; mean age, 41 years) and 38 denture wearers (age range, 27–76 years; mean age, 55 years) were enrolled. C. albicans was the most common specie found in both groups followed by C. tropicalis, C. parapsilosis, and C. glabrata. Neither antifungal drug resistance nor significant changes in genotyping of Candida were noted among those receiving LME Mouthwash. Subjects' satisfaction on taste and smell of LME Mouthwash was comparable to that of CHX. Conclusions Use of LME Mouthwash for 2 weeks neither led to antifungal drug resistance nor significant changes in genotype of oral Candida. Thus, LME may be an alternative Mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease.
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antifungal activity of lawsone methyl ether in comparison with chlorhexidine
Journal of Oral Pathology & Medicine, 2011Co-Authors: Nattapon Sritrairat, Pharkphoom Panichayupakaranant, Narin Nukul, Piyanut Inthasame, Attapon Sansuk, Jinda Prasirt, Thassin Leewatthanakorn, Uayporn Piamsawad, Aree Dejrudee, Kanokporn PangsomboonAbstract:J Oral Pathol Med (2011) 40: 90–96 Objective: The aim of this study was to determine the antifungal activity of lawsone methyl ether Mouthwash (LME) in comparison with chlorhexidine Mouthwash (CHX) in vitro and in vivo. Materials and methods: For in vitro study, each Mouthwash preparation was added into the inoculum of Candida. The turbidity was recorded after incubation at 37°C for 48 h. Candidal culture was performed and the number of colony of Candida albicans was recorded. For in vivo study, a crossover clinical trial was conducted in 22 HIV-infected subjects and 32 denture wearers. Clinical examination was performed and oral rinse technique was carried out immediately before and 0, 1, 2 h after using each Mouthwash. Allergy and subjective assessment of the Mouthwashes were recorded. Statistical analysis was performed using one-way ANOVA and linear mixed effect modeling. Results: In vitro, antifungal activity of 0.25% LME was significantly greater than that of 0.12% CHX (P < 0.05) and comparable with that of 0.2% CHX. In vivo, antifungal activity up to 2 hours of 0.025% LME Mouthwash was evidenced in both groups of subjects, although significantly lower than that of 0.12% CHX. No allergic reaction was reported. LME Mouthwash was graded to have less bitter taste than that of CHX. Subjects’ satisfaction on taste and smell of LME Mouthwash was significantly greater than that of CHX (P < 0.05). Conclusions: Lawsone methyl ether Mouthwash possesses potent antifungal activity both in vitro and in vivo. However, concentration of the Mouthwash needs to be adjusted in addition to further clinical trials on long-term use.
Philip Wright - One of the best experts on this subject based on the ideXlab platform.
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efficacy of two alcohol free cetylpyridinium chloride Mouthwashes a randomized double blind crossover study
Journal of Clinical Periodontology, 2008Co-Authors: Andrew Rawlinson, Sarah Pollington, T F Walsh, D J Lamb, Ian Marlow, Julia Haywood, Philip WrightAbstract:Aim: (1) To determine the plaque inhibition properties of two formulations of alcohol-free Mouthwash [0.1% w/w cetylpyridinium chloride (CPC) (B) and 0.05% w/w CPC (A)] versus a placebo Mouthwash (C). (2) To compare the plaque-inhibiting activity between these two new CPC Mouthwashes. Material and Methods: A double-blind, crossover study with three 1-week periods was used. Subjects were randomly assigned to one of the following groups. Group 1 (n = 10) received the Mouthwashes A, C and B in the periods 1, 2 and 3, respectively, group 2 (n = 11) received the Mouthwashes in the order B, A, C, while group 3 (n = 11) received the Mouthwashes in the order C, B, A. Mean plaque areas and Quigley & Hein plaque index scores were analysed using ANOVA (analysis of variance). Measurements were made at the start of each period (baseline) and at 16, 24 and 40 h. Results: Mean plaque scores were similar across the groups at baseline. At all time points thereafter, volunteers using Mouthwash A or B had significantly lower plaque areas and plaque index scores than those using Mouthwash C (p<0.05), but there were no significant differences between the test formulations. At 16h, the reduction in plaque area relative to Mouthwash C was 22% for Mouthwash A and 18% for Mouthwash B; at 24 h, 11% for Mouthwash A and 15% for Mouthwash B; and at 40 h, 15% for Mouthwash A and 16% for Mouthwash B. Conclusions: The use of both CPC Mouthwashes resulted in less plaque accumulation compared with the control. There was no statistically significant difference in plaque accumulation between the two CPC Mouthwashes.
Melviani Melviani - One of the best experts on this subject based on the ideXlab platform.
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Formulasi dan Evaluasi Sediaan Obat Kumur (Mouthwash) dari Ekstrak Etanol Daun Kalangkala (Litsea angulata) sebagai Antiseptik Mulut
'Universitas Muhammadiyah Palangkaraya', 2021Co-Authors: Rohama Rohama, Melviani MelvianiAbstract:Research of Mouthwash formulation and evaluation of kalangkala leaves extract (Litsea angulata) as an oral antiseptic also has been tested in Streptococcus mutans bacteria by variation in the concentration of extract 2%, 2,5%, and 3%, which aims to determine the ideal formula in physical quality and has the highest antibacterial activity based on an inhibition zone of Streptococcus mutans bacteria in Mouthwash formula. The methods used include the step of extraction of Kalangkala leaves, preparation of Mouthwash with 3 formula F1 (2%), F2 (2,5%), and F3 (3%) followed by an evaluation that includes organoleptic, pH test, viscosity test, and the test of inhibition zone bacteria. The test of inhibition zone bacteria used NA media with diffusion method. Stability was performed on weeks 1, 2, 3, and 4. The result showed variation in the concentration of extract kalangkala leaves in a Mouthwash formula affects the diameter of the inhibition zone. But did not have a significant effect on the physical stability properties of the Mouthwash formula. Mouthwash formula has the highest antibacterial activity based on the inhibition zone of Streptococcus mutans that is 3% contained in formula F3
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Formulasi Dan Evaluasi Sediaan Obat Kumur (Mouthwash) Dari Ekstrak Etanol Tanaman Bundung (Actinoscirpus Grossus) Sebagai Antiseptik Mulut
'Universitas Muhammadiyah Palangkaraya', 2020Co-Authors: Noval Noval, Melviani Melviani, Novia Novia, Syahrina DahliaAbstract:Research of Mouthwash formulation and evaluation of bundung plants extract (Actinoscirpus grossus) as an oral antiseptic also has been tested in Streptococcus mutants bacteria by variation in the concentration of extract 2%, 2,5%, 3% and 3,5%, which aims to determine the most ideal formula in physical quality and has the highest antibacterial activity based on an inhibition zone of Streptococcus mutants bacteria in Mouthwash formula. The methods used include the step of extraction of Bundung plants, preparation of Mouthwash with 4 formula F1 (2%), F2 (2,5%), F3 (3%) and F4 (3,5%) followed by an evaluation that includes organoleptic, pH test, viscosity test and the test of inhibition zone bacteria. The test of inhibition zone bacteria used MHA media with diffusion method. Stability performed on weeks 1, 2, 3, 4, 5, and 6. The result showed variation in the concentration of extract bundung plants in a Mouthwash formula has and effect on the diameter of the inhibition zone. But did not have a significant effect on the physical stability properties of the Mouthwash formula. Mouthwash formula which has the highest antibacterial activity based on inhibition zone of Streptococcus mutants that is 3,5% contained in formula IV
Andrew Rawlinson - One of the best experts on this subject based on the ideXlab platform.
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efficacy of two alcohol free cetylpyridinium chloride Mouthwashes a randomized double blind crossover study
Journal of Clinical Periodontology, 2008Co-Authors: Andrew Rawlinson, Sarah Pollington, T F Walsh, D J Lamb, Ian Marlow, Julia Haywood, Philip WrightAbstract:Aim: (1) To determine the plaque inhibition properties of two formulations of alcohol-free Mouthwash [0.1% w/w cetylpyridinium chloride (CPC) (B) and 0.05% w/w CPC (A)] versus a placebo Mouthwash (C). (2) To compare the plaque-inhibiting activity between these two new CPC Mouthwashes. Material and Methods: A double-blind, crossover study with three 1-week periods was used. Subjects were randomly assigned to one of the following groups. Group 1 (n = 10) received the Mouthwashes A, C and B in the periods 1, 2 and 3, respectively, group 2 (n = 11) received the Mouthwashes in the order B, A, C, while group 3 (n = 11) received the Mouthwashes in the order C, B, A. Mean plaque areas and Quigley & Hein plaque index scores were analysed using ANOVA (analysis of variance). Measurements were made at the start of each period (baseline) and at 16, 24 and 40 h. Results: Mean plaque scores were similar across the groups at baseline. At all time points thereafter, volunteers using Mouthwash A or B had significantly lower plaque areas and plaque index scores than those using Mouthwash C (p<0.05), but there were no significant differences between the test formulations. At 16h, the reduction in plaque area relative to Mouthwash C was 22% for Mouthwash A and 18% for Mouthwash B; at 24 h, 11% for Mouthwash A and 15% for Mouthwash B; and at 40 h, 15% for Mouthwash A and 16% for Mouthwash B. Conclusions: The use of both CPC Mouthwashes resulted in less plaque accumulation compared with the control. There was no statistically significant difference in plaque accumulation between the two CPC Mouthwashes.
Pharkphoom Panichayupakaranant - One of the best experts on this subject based on the ideXlab platform.
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effects of lawsone methyl ether Mouthwash on oral candida in hiv infected subjects and subjects with denture stomatitis
Journal of Oral Pathology & Medicine, 2013Co-Authors: Wipawee Nittayananta, Kanokporn Pangsomboon, Pharkphoom Panichayupakaranant, Nilnara Chanowanna, Sureerat Chelae, Varaporn Vuddhakul, Pharanai Sukhumungoon, Nannapat PruphetkaewAbstract:Objectives To determine (i) effects of lawsone methyl ether (LME) Mouthwash on antifungal drug resistance of oral Candida, (ii) effects of LME Mouthwash on changes in genotype of oral Candida, and (iii) allergy and subjects' satisfaction on LME Mouthwash in comparison with chlorhexidine (CHX). Materials and methods A randomized clinical trial was conducted in HIV-infected subjects and denture wearers receiving either LME or CHX Mouthwash. Candidal culture by oral rinse technique was performed as baseline and after using the Mouthwash for 2 weeks. Antifungal drug resistance and changes in genotype of oral Candida were assessed by microdilution assay, inverted repeat polymerase chain reaction and restriction fragment length polymorphism assays, respectively. Allergy and subjects' satisfaction on the Mouthwashes were recorded. Statistical analysis was performed using Chi-squared and Fisher's exact tests. Results Twenty-nine HIV-infected subjects (age range, 26–54 years; mean age, 41 years) and 38 denture wearers (age range, 27–76 years; mean age, 55 years) were enrolled. C. albicans was the most common specie found in both groups followed by C. tropicalis, C. parapsilosis, and C. glabrata. Neither antifungal drug resistance nor significant changes in genotyping of Candida were noted among those receiving LME Mouthwash. Subjects' satisfaction on taste and smell of LME Mouthwash was comparable to that of CHX. Conclusions Use of LME Mouthwash for 2 weeks neither led to antifungal drug resistance nor significant changes in genotype of oral Candida. Thus, LME may be an alternative Mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease.
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antifungal activity of lawsone methyl ether in comparison with chlorhexidine
Journal of Oral Pathology & Medicine, 2011Co-Authors: Nattapon Sritrairat, Pharkphoom Panichayupakaranant, Narin Nukul, Piyanut Inthasame, Attapon Sansuk, Jinda Prasirt, Thassin Leewatthanakorn, Uayporn Piamsawad, Aree Dejrudee, Kanokporn PangsomboonAbstract:J Oral Pathol Med (2011) 40: 90–96 Objective: The aim of this study was to determine the antifungal activity of lawsone methyl ether Mouthwash (LME) in comparison with chlorhexidine Mouthwash (CHX) in vitro and in vivo. Materials and methods: For in vitro study, each Mouthwash preparation was added into the inoculum of Candida. The turbidity was recorded after incubation at 37°C for 48 h. Candidal culture was performed and the number of colony of Candida albicans was recorded. For in vivo study, a crossover clinical trial was conducted in 22 HIV-infected subjects and 32 denture wearers. Clinical examination was performed and oral rinse technique was carried out immediately before and 0, 1, 2 h after using each Mouthwash. Allergy and subjective assessment of the Mouthwashes were recorded. Statistical analysis was performed using one-way ANOVA and linear mixed effect modeling. Results: In vitro, antifungal activity of 0.25% LME was significantly greater than that of 0.12% CHX (P < 0.05) and comparable with that of 0.2% CHX. In vivo, antifungal activity up to 2 hours of 0.025% LME Mouthwash was evidenced in both groups of subjects, although significantly lower than that of 0.12% CHX. No allergic reaction was reported. LME Mouthwash was graded to have less bitter taste than that of CHX. Subjects’ satisfaction on taste and smell of LME Mouthwash was significantly greater than that of CHX (P < 0.05). Conclusions: Lawsone methyl ether Mouthwash possesses potent antifungal activity both in vitro and in vivo. However, concentration of the Mouthwash needs to be adjusted in addition to further clinical trials on long-term use.