The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform
Matthew W. Ryan - One of the best experts on this subject based on the ideXlab platform.
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the effect of saline solutions on nasal patency and Mucociliary Clearance in rhinosinusitis patients
Otolaryngology-Head and Neck Surgery, 2007Co-Authors: Garrett Hauptman, Matthew W. RyanAbstract:ObjectiveTo compare the effect of two saline nasal sprays on nasal patency and Mucociliary Clearance in patients with rhinosinusitis.Study DesignRandomized double-blind trial.Subjects and MethodsEighty patients with rhinosinusitis at a tertiary care academic center had nasal patency and Mucociliary Clearance measured. Each patient was then treated with either physiological or hypertonic saline. Nasal patency and Mucociliary Clearance measurements were repeated after treatment. Subjective evaluation was also performed.ResultsBoth solutions improved saccharine Clearance times (P < 0.0001). Buffered physiological saline significantly affected nasal airway patency (P = 0.006). Both solutions improved symptoms of nasal stuffiness (P < 0.0001) and nasal obstruction (P < 0.0001). Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).ConclusionsBuffered physiological and buffered hypertonic saline nasal sprays both improve Mucociliary clearan...
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Relationship between rhinosinusitis symptoms and Mucociliary Clearance time.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006Co-Authors: Justin E. Boatsman, Karen H. Calhoun, Matthew W. RyanAbstract:Objective To determine the correlation between rhinosinusitis symptoms as assessed by the Sino-Nasal Outcomes Test-20 (SNOT-20) and Mucociliary Clearance as assessed by the saccharin method. Study design and setting This was a cross-sectional study of 50 adult volunteers. Subjects completed the SNOT-20, and Mucociliary Clearance was determined with the saccharine method. Correlation coefficients (Spearman’s Rho) were calculated for the global SNOT-20 score. Results The SNOT-20 scores varied from 20 to 54 (mean 30.28) with a possible range of 20 to 100. Clearance times varied from 418 to 2865 seconds (mean 999). There was no significant correlation between global SNOT-20 score and Clearance time (r = 0.196). Conclusions There is no significant correlation between rhinosinusitis symptoms as assessed by SNOT-20 scores and Mucociliary Clearance. Significance Mucociliary Clearance is important for the health of the sinonasal cavities, but Clearance time does not appear to be associated with symptom severity in the population studied. EBM rating: A-1b
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effects of buffered saline solution on nasal Mucociliary Clearance and nasal airway patency
Otolaryngology-Head and Neck Surgery, 2004Co-Authors: Bounmany K Keojampa, Mai Hoang Nguyen, Matthew W. RyanAbstract:Objective To compare the effects of buffered hypertonic and buffered normal saline nasal spray on Mucociliary Clearance and nasal airway patency. Study design and setting Double-blind trial with subjects acting as their own controls. Tertiary care academic medical center. Results Buffered hypertonic saline and buffered normal saline both improved saccharine Clearance times (P Conclusions Both buffered hypertonic and buffered normal saline nasal spray significantly improved saccharine Clearance times without affecting nasal airway patency. Buffered hypertonic saline affected saccharine Clearance times to a greater degree than buffered normal saline. Clinical significance Buffered hypertonic and buffered normal saline sprays both improve Mucociliary Clearance and should therefore be beneficial in conditions such as rhinitis and sinusitis, which are associated with disruption of Mucociliary Clearance. However, these sprays do not appear to affect the nasal airway. Patients may therefore benefit from other treatments for “nasal congestion.” EBM rating: B-2.
Joanne Rimmer - One of the best experts on this subject based on the ideXlab platform.
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Congenital problems of Mucociliary Clearance: primary ciliary dyskinesia.
Rhinology, 2012Co-Authors: Joanne RimmerAbstract:Mucociliary Clearance is a primary defence mechanism of the airway that can be altered in congenital diseases such as primary ciliary dyskinesia and cystic fibrosis, as well as acquired conditions. This article focuses on primary ciliary dyskinesia and the diagnostic approach to it, which is still evolving.
Byron J. Bailey - One of the best experts on this subject based on the ideXlab platform.
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The relationship between the nasal cycle and Mucociliary Clearance
The Laryngoscope, 1992Co-Authors: Mark C. Littlejohn, Charles M. Stiernberg, James A. Hokanson, Francis B. Quinn, Byron J. BaileyAbstract:Nasal airway resistances were measured bilaterally on subjects at 30-minute intervals over 6 hours using anterior rhinomanometry. The first 10 subjects found to exhibit alternating congestion and decongestion of the nasal mucosa (i.e., the nasal cycle) were included in the study. Using the saccharin method, nasal Mucociliary Clearance was determined for each subject in both the congested and decongested phases of the cycle. The results were statistically significant at the P less than .09 level, highly suggestive of a difference in nasal Mucociliary Clearance between the two phases of the cycle, with the congested phase having the more rapid Clearance. However, when compared to the Mucociliary Clearance times in disease states, the difference in transport times between the two phases is probably not clinically significant.
Sharon D. Dell - One of the best experts on this subject based on the ideXlab platform.
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Mucociliary Clearance scan to evaluate primary ciliary dyskinesia in children with bronchiectasis
The Journal of Nuclear Medicine, 2011Co-Authors: Amer Shammas, Martin Charron, Sharon D. DellAbstract:1394 Objectives Primary ciliary dyskinesia (PCD) is characterized by functional or structural defects in the cilia causing abnormal ciliary motion and impaired Mucociliary Clearance. This leads to recurrent respiratory infections and bronchiectasis. Ciliary ultrastructure abnormalities can be identified. However, in some patients the ciliary ultrastructure may appear normal, suggesting functional abnormalities. Mucociliary Clearance scan is a noninvasive procedure and can be used to evaluate Mucociliary Clearance function. The aim of this study was to evaluate the feasibility to use the Mucociliary Clearance scan in the PCD workup in children. Methods Six Mucociliary Clearance scans were reviewed retrospectively in children with bronchiectasis and recurrent respiratory infection. Scans were performed using 99mTc Sulfur Colloid inhaled for 10 minutes with oxygen flow by whisper jet nebulizer system. Imaging in anterior view was obtained dynamically for 30 sec/frame over 60 minutes with the patient in supine position. Cinematic review of the data was performed by two experienced Nuclear Medicine physicians. The evaluation is based on the bolus movement of tracer from the main bronchi to the trachea and frequency. The final Clinical diagnosis was based on the combination of spirometry, chest radiograph, history and symptoms, ultrastructure evaluation, and nasal nitric oxide test. Results Scans were normal in 4 children consistent with final diagnosis and clinical workup. Two children had a final diagnosis of PCD. One of them with a history of situs inversus had abnormal scan. No ciliary ultrastructure abnormalities were found. The study was limited in one patient due to noncooperation and suboptimal tracer distribution. However, no evidence of effective ciliary motion was noted. The nasal nitric oxide test was abnormal. Conclusions Mucociliary Clearance Scan is a noninvasive procedure and can be used effectively as an adjunctive test in the work up of pediatric patient with suspected primary ciliary dyskinesia
E. W. F. W. Alton - One of the best experts on this subject based on the ideXlab platform.
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Effect of amiloride and saline on nasal Mucociliary Clearance and potential difference in cystic fibrosis and normal subjects.
Thorax, 1993Co-Authors: Peter G. Middleton, Duncan M. Geddes, E. W. F. W. AltonAbstract:BACKGROUND--Mucociliary Clearance is an important component of pulmonary defence. Maximum Clearance is thought to depend on an optimal depth of the sol layer, allowing the most efficient interaction between the cilia and the overlying mucus layer. Sodium absorption, the major ion transport in human airways, is thought to be important in the regulation of the depth of the sol layer. In the airways of patients with cystic fibrosis sodium absorption is increased and Mucociliary Clearance decreased. Amiloride, a sodium channel blocker, has been shown to improve pulmonary Mucociliary Clearance in patients with cystic fibrosis. However, its effects on nasal Mucociliary Clearance in either normal subjects or those with cystic fibrosis are unknown. A study was therefore performed to investigate whether nebulised amiloride improves nasal Mucociliary Clearance in normal or cystic fibrosis subjects. METHODS--Nasal Mucociliary Clearance was measured by the saccharin Clearance technique in 12 normal subjects and 12 with cystic fibrosis. For the control study measurements were made on two consecutive days and the mean time for each subject averaged. For the drug study measurements were also made on two consecutive days, after administration of nasally nebulised amiloride or placebo (saline) in a double blind manner. Nasal potential difference was measured in eight patients with cystic fibrosis after the administration of amiloride or placebo to assess the efficacy of deposition and duration of action. RESULTS--Baseline values of Mucociliary Clearance were significantly faster in the normal subjects than in those with cystic fibrosis. In both groups Mucociliary Clearance was increased after both saline and amiloride, with no significant difference between either treatment. As previously reported, baseline nasal potential difference was significantly more negative in the subjects with cystic fibrosis. Amiloride significantly reduced the potential difference for at least 60 minutes in these subjects. CONCLUSIONS--Nebulised saline significantly improves nasal Mucociliary Clearance in both normal subjects and those with cystic fibrosis. Amiloride did not appear to exert any additional effects in either group of subjects, despite evidence of its efficacy of deposition.
