The Experts below are selected from a list of 22275 Experts worldwide ranked by ideXlab platform

Zhaohui Liu - One of the best experts on this subject based on the ideXlab platform.

Bart N. Lambrecht - One of the best experts on this subject based on the ideXlab platform.

  • Overview: Mucosal Immunity and Disease of the Respiratory Tract
    Mucosal Immunology, 2015
    Co-Authors: Bart N. Lambrecht
    Abstract:

    This chapter serves as an overview of the section on Mucosal immunity and diseases of the respiratory tract. The lung is proficient in Mucosal defense mechanisms, but it is often affected by diseases such as tuberculosis, asthma, and chronic obstructive pulmonary disease. The Mucosal Immune Response underlying the health and disease of the lung will be covered in this section with an aim toward a better understanding of the Immune Response and improved therapies in the future.

  • The Mucosal Immune Response to Respiratory Viruses
    Mucosal Immunology, 2015
    Co-Authors: Bart N. Lambrecht, Katrijn Neyt, Mary J. Van Helden
    Abstract:

    Because of its air-exchange function, the lung is continuously exposed to foreign particles such as microbes. Viral infections such as influenza A virus, respiratory syncytial virus, human metapneumovirus, and rhinovirus are common and the lung is a very vulnerable organ that needs to preserve gas exchange during antiviral defense. To recognize these threats and at the same time maintain tissue homeostasis, the lung is equipped with an elaborate network of innate and adaptive Immune cells. The innate Mucosal Immune Response to respiratory viruses is made up of natural killer cells and B cells producing low-affinity natural antibodies. Dendritic cells are the sentinels of the Immune system linking sensing by ancient innate Immune system receptors to activation of adaptive immunity to respiratory viruses. These cells also induce the polarization of virus-specific CD4 and CD8 T cell Responses, necessary for viral clearance. Memory Responses to viral antigens are found in the CD4 and CD8 compartment of T cells, and these cells often home back to the lung mucosa to become tissue-resident memory cells, which produce copious amounts of cytokines upon renewed viral encounter. Following respiratory viral infection, there frequently is induction of tertiary lymphoid organs such as bronchus-associated lymphoid tissues that similarly play important roles in maintaining antiviral immunity.

Xu Zhang - One of the best experts on this subject based on the ideXlab platform.

Aruna Mittal - One of the best experts on this subject based on the ideXlab platform.

  • the Mucosal Immune Response to chlamydia trachomatis infection of the reproductive tract in women
    Journal of Reproductive Immunology, 2009
    Co-Authors: Tanvi Agrawal, Vikas Vats, Sudha Salhan, Aruna Mittal
    Abstract:

    Sexually transmitted Chlamydia trachomatis infection is an important public health concern with major adverse effects on female reproductive tract health and function. The magnitude of reproductive morbidity associated with sexually transmitted C. trachomatis infection is enormous, however to date no prophylactic vaccine is available. In part this is due to the lack of information on the Mucosal immunobiology of the host–pathogen interaction and correlates of protective immunity during genital C. trachomatis infection. In this review, we focus on current knowledge of Mucosal innate and adaptive Immune Responses in the female genital tract during C. trachomatis infection, which will eventually help in the development of a vaccine for prevention of chlamydial infection.

  • protective or pathogenic Immune Response to genital chlamydial infection in women a possible role of cytokine secretion profile of cervical Mucosal cells
    Clinical Immunology, 2009
    Co-Authors: Tanvi Agrawal, Rishein Gupta, Raini Dutta, Pragya Srivastava, Apurb Rashmi Bhengraj, S Salhan, Aruna Mittal
    Abstract:

    Abstract Little is known about genital Mucosal Immune Response to chlamydial infection in women with or without sequelae (Chlamydia positive women with or without fertility disorders as infertility and multiple spontaneous abortions). Cervical lymphocytes were stimulated with chlamydial EBs and cytokine secretion was determined by ELISA, RT-PCR and ELISPOT assays. Stimulated cervical cells from women with fertility disorders (FD) secrete significantly (P

Kenneth D. Cain - One of the best experts on this subject based on the ideXlab platform.

  • Identification of a localized Mucosal Immune Response in rainbow trout, Oncorhynchus mykiss (Walbaum), following immunization with a protein‐hapten antigen
    Journal of fish diseases, 2008
    Co-Authors: Christine M. Swan, Nicole M. Lindstrom, Kenneth D. Cain
    Abstract:

    The ability of rainbow trout, Oncorhynchus mykiss (RBT), to produce a localized Mucosal Immune Response was investigated following intraperitoneal (i.p.) or peranal (p.a.) immunization with a protein-hapten carrier, fluorescein isothiocyanate conjugated to keyhole limpet haemocyanin (FITC/KLH). Antibody levels in serum, mucus, tissue culture supernatant from blood and spleen leucocytes, and excised skin, intestine and gill tissues were determined by ELISA. Significantly, elevated antigen-specific antibodies were elicited in both serum and mucus of fish immunized i.p. Mucosal antibody Responses, in general, paralleled serum Responses over time. Leucocytes isolated from spleen and blood of i.p. immunized fish at week 10 produced significantly elevated antibody levels against FITC when cultured in vitro. Excised skin, intestine and gill tissues from these fish also exhibited significantly elevated antibody Responses indicating localized production in the mucosa from tissue-specific B cells. A localized Mucosal Immune Response was elicited only after i.p. and not p.a. immunization, suggesting that systemically stimulated B cells migrate to Mucosal tissues where they produce antibodies locally.