The Experts below are selected from a list of 195 Experts worldwide ranked by ideXlab platform

Akihiko Nakaizumi - One of the best experts on this subject based on the ideXlab platform.

  • Scanning electron microscopic observations on gastric Mucus secretion in rats, and the effects of tetraprenylacetone.
    Digestion, 1995
    Co-Authors: Masaharu Tatsuta, Reiko Yamamoto, Hiroyasu Iishi, Akihiko Nakaizumi
    Abstract:

    Mucus secretion in the gastric mucosa of rats was studied with a scanning electron microscope. After stimulation, two types of Mucus secretion were observed: exocytosis and apical expulsion. Prolonged administration of tetraprenylacetone (TPA) significantly increased the number of Mucus-Secreting Cells in both the gastric corpus and antrum 12 h after the last administration of TPA. In the Secreting Cells, apical expulsion was significantly more frequent among TPA-treated than in untreated rats. TPA also significantly increased the hexosamine concentration in both gastric corpus and antrum. These findings indicate that TPA stimulates both the content and the secretion of gastric Mucus, and that its secretion is chiefly through apical expulsion.

Masaharu Tatsuta - One of the best experts on this subject based on the ideXlab platform.

  • Scanning electron microscopic observations on gastric Mucus secretion in rats, and the effects of tetraprenylacetone.
    Digestion, 1995
    Co-Authors: Masaharu Tatsuta, Reiko Yamamoto, Hiroyasu Iishi, Akihiko Nakaizumi
    Abstract:

    Mucus secretion in the gastric mucosa of rats was studied with a scanning electron microscope. After stimulation, two types of Mucus secretion were observed: exocytosis and apical expulsion. Prolonged administration of tetraprenylacetone (TPA) significantly increased the number of Mucus-Secreting Cells in both the gastric corpus and antrum 12 h after the last administration of TPA. In the Secreting Cells, apical expulsion was significantly more frequent among TPA-treated than in untreated rats. TPA also significantly increased the hexosamine concentration in both gastric corpus and antrum. These findings indicate that TPA stimulates both the content and the secretion of gastric Mucus, and that its secretion is chiefly through apical expulsion.

Nathalie Herlin-boime - One of the best experts on this subject based on the ideXlab platform.

  • Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia.
    Particle and Fibre Toxicology, 2014
    Co-Authors: Emilie Brun, Frédérick Barreau, Giulia Veronesi, Barbara Fayard, Stéphanie Sorieul, Corinne Chanéac, Christine Carapito, Thierry Rabilloud, Aloïse Mabondzo, Nathalie Herlin-boime
    Abstract:

    BACKGROUND: TiO2 particles are commonly used as dietary supplements and may contain up to 36% of nano-sized particles (TiO2-NPs). Still impact and translocation of NPs through the gut epithelium is poorly documented. RESULTS: We show that, in vivo and ex vivo, agglomerates of TiO2-NPs cross both the regular ileum epithelium and the follicle-associated epithelium (FAE) and alter the paracellular permeability of the ileum and colon epithelia. In vitro, they accumulate in M-Cells and Mucus-Secreting Cells, much less in enterocytes. They do not cause overt cytotoxicity or apoptosis. They translocate through a model of FAE only, but induce tight junctions remodeling in the regular ileum epithelium, which is a sign of integrity alteration and suggests paracellular passage of NPs. Finally we prove that TiO2-NPs do not dissolve when sequestered up to 24 h in gut Cells. CONCLUSIONS: Taken together these data prove that TiO2-NPs would possibly translocate through both the regular epithelium lining the ileum and through Peyer's patches, would induce epithelium impairment, and would persist in gut Cells where they would possibly induce chronic damage.

Keiko Abe - One of the best experts on this subject based on the ideXlab platform.

  • Aquaporin-9 is expressed in a Mucus-Secreting goblet cell subset in the small intestine
    FEBS Letters, 2003
    Co-Authors: Shinji Okada, Takumi Misaka, Ichiro Matsumoto, Hirohito Watanabe, Keiko Abe
    Abstract:

    We analyzed the expression of aquaporins (AQPs) in the small intestine to elucidate their functions, and found that AQP9, which had not previously been detected there, is present in duodenum, jejunum, and ileum. AQP9 is expressed in colon as well, but not in stomach. Also, its expression in these intestinal sections is limited to the basolateral membranes of a goblet cell subset. Our finding that AQP9 is present specifically in goblet Cells as Mucus-Secreting Cells suggests its involvement in the synthesis and/or secretion of a certain kind of Mucus which may protect the intestinal surface and smooth the flow of intestinal contents.

Anthony C. Peatfield - One of the best experts on this subject based on the ideXlab platform.