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Sung Kwon Kang - One of the best experts on this subject based on the ideXlab platform.
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Multicomponent System of NPS-1034, an Orally Administered Lung Cancer Drug Candidate, with Sulfonic Acids and Solid State Characterization
2016Co-Authors: Jangmi Lee, Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon Kang, Soon Hong Yuk, Eun Hee LeeAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic acid, poly(ethylene glycol) 400, and ethanol. Solubility of amorphous of NPS-1034 with camphorsulfonic acid showed a significant increase in all three solvents. This work will give some insight into how various types of sulfonic acids interact with pharmaceutically important compounds containing the pyrrolepyridine moiety
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Multicomponent System of nps 1034 an orally administered lung cancer drug candidate with sulfonic acids and solid state characterization
Crystal Growth & Design, 2013Co-Authors: Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon KangAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic a...
Suzie Park - One of the best experts on this subject based on the ideXlab platform.
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Multicomponent System of NPS-1034, an Orally Administered Lung Cancer Drug Candidate, with Sulfonic Acids and Solid State Characterization
2016Co-Authors: Jangmi Lee, Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon Kang, Soon Hong Yuk, Eun Hee LeeAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic acid, poly(ethylene glycol) 400, and ethanol. Solubility of amorphous of NPS-1034 with camphorsulfonic acid showed a significant increase in all three solvents. This work will give some insight into how various types of sulfonic acids interact with pharmaceutically important compounds containing the pyrrolepyridine moiety
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Multicomponent System of nps 1034 an orally administered lung cancer drug candidate with sulfonic acids and solid state characterization
Crystal Growth & Design, 2013Co-Authors: Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon KangAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic a...
Rasinger Georg - One of the best experts on this subject based on the ideXlab platform.
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Synthetisierung und Charakterisierung von metallischen Mehrkomponentenschichten mit Schichtdicken von bis zu 10 Mikrometern
'Universidad Norbert Wiener', 2020Co-Authors: Rasinger GeorgAbstract:Abweichender Titel nach Übersetzung der Verfasserin/des VerfassersIn der Materialwissenschaft und der Werkstofftechnik steigen stets die Anforderungen an die verwendeten Materialen. Um diesen Anforderungen gerecht zu werden, öffnen sich ständig neue Forschungsgebiete. In diesem Jahrzehnt begann die intensive Forschung an Hoch Entropie Legierungen. Dabei handelt es sich um Legierungen, die sich, im Unterschied zu klassischen, nicht nur aus zwei, sondern aus mindestens vier oder mehr Elementen zusammensetzen. Ziel dieser Arbeit ist die Herstellung eines metallischen MehrkomponentenSystems aus Kupfer, Aluminium, Zink und Magnesium, dieses schlüssig zu charakterisieren und Aussagen über das Prinzip von Hoch Entropie Legierungen zu treffen. Das MehrkomponentenSystem wurde mittels Magnetronsputtern hergestellt und anhand von Energiedispersiver Röntgenspektroskopie, Röntgen-Pulverdiffraktometrie und Vickershärte Messung charakterisiert. Es konnte gezeigt werden, dass es möglich ist, ein metallisches MehrkomponentenSystem zu produzieren, Systematisch zu charakterisieren und Aussagen über die Auswirkung von unterschiedlichen Materialanteilen auf das System zu treffen.In the world of material-science and material-technology the requirements for the used materials are rising constantly. To fulfill these high needs new research areas are opening continuously. This decade an intensive research on High Entropy Alloys began. High Entropy Alloys consist, in comparison to normal alloys, which usually consist of two Elements, of at least four or even more elements. The aim of this thesis is the production of a metallic Multicomponent System made of copper, aluminum, zinc and magnesium, to analyze it Systematically and form conclusions about the principle of High Entropy Alloys. The Multicomponent System was produced using magnetron sputtering and characterized using energy-dispersive X-ray spectroscopy, X-ray powder diffractometry and Vickers indentation hardness measurement. It could be shown that it is possible to produce and conclusively characterize a metallic Multicomponent System. Furthermore conclusions, about how varying proportions of the different components influence the System, could be made.7
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Herstellung und Charakterisierung von metallischen Mehrkomponentenschichten mit Schichtdicken von bis zu 10 Mikrometern
2020Co-Authors: Rasinger GeorgAbstract:In der Materialwissenschaft und der Werkstofftechnik steigen stets die Anforderungen an die verwendeten Materialen. Um diesen Anforderungen gerecht zu werden, öffnen sich ständig neue Forschungsgebiete. In diesem Jahrzehnt begann die intensive Forschung an Hoch Entropie Legierungen. Dabei handelt es sich um Legierungen, die sich, im Unterschied zu klassischen, nicht nur aus zwei, sondern aus mindestens vier oder mehr Elementen zusammensetzen. Ziel dieser Arbeit ist die Herstellung eines metallischen MehrkomponentenSystems aus Kupfer, Aluminium, Zink und Magnesium, dieses schlüssig zu charakterisieren und Aussagen über das Prinzip von Hoch Entropie Legierungen zu treffen. Das MehrkomponentenSystem wurde mittels Magnetronsputtern hergestellt und anhand von Energiedispersiver Röntgenspektroskopie, Röntgen-Pulverdiffraktometrie und Vickershärte Messung charakterisiert. Es konnte gezeigt werden, dass es möglich ist, ein metallisches MehrkomponentenSystem zu produzieren, Systematisch zu charakterisieren und Aussagen über die Auswirkung von unterschiedlichen Materialanteilen auf das System zu treffen.In the world of material-science and material-technology the requirements for the used materials are rising constantly. To fulfill these high needs new research areas are opening continuously. This decade an intensive research on High Entropy Alloys began. High Entropy Alloys consist, in comparison to normal alloys, which usually consist of two Elements, of at least four or even more elements. The aim of this thesis is the production of a metallic Multicomponent System made of copper, aluminum, zinc and magnesium, to analyze it Systematically and form conclusions about the principle of High Entropy Alloys. The Multicomponent System was produced using magnetron sputtering and characterized using energy-dispersive X-ray spectroscopy, X-ray powder diffractometry and Vickers indentation hardness measurement. It could be shown that it is possible to produce and conclusively characterize a metallic Multicomponent System. Furthermore conclusions, about how varying proportions of the different components influence the System, could be made.von Georg RasingerArbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprüftAbweichender Titel nach Übersetzung der Verfasserin/des VerfassersTechnische Universität Wien, Diplomarbeit, 2020(VLID)490557
Youngjoo Byun - One of the best experts on this subject based on the ideXlab platform.
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Multicomponent System of NPS-1034, an Orally Administered Lung Cancer Drug Candidate, with Sulfonic Acids and Solid State Characterization
2016Co-Authors: Jangmi Lee, Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon Kang, Soon Hong Yuk, Eun Hee LeeAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic acid, poly(ethylene glycol) 400, and ethanol. Solubility of amorphous of NPS-1034 with camphorsulfonic acid showed a significant increase in all three solvents. This work will give some insight into how various types of sulfonic acids interact with pharmaceutically important compounds containing the pyrrolepyridine moiety
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Multicomponent System of nps 1034 an orally administered lung cancer drug candidate with sulfonic acids and solid state characterization
Crystal Growth & Design, 2013Co-Authors: Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon KangAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic a...
Seon Joo Yoon - One of the best experts on this subject based on the ideXlab platform.
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Multicomponent System of NPS-1034, an Orally Administered Lung Cancer Drug Candidate, with Sulfonic Acids and Solid State Characterization
2016Co-Authors: Jangmi Lee, Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon Kang, Soon Hong Yuk, Eun Hee LeeAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic acid, poly(ethylene glycol) 400, and ethanol. Solubility of amorphous of NPS-1034 with camphorsulfonic acid showed a significant increase in all three solvents. This work will give some insight into how various types of sulfonic acids interact with pharmaceutically important compounds containing the pyrrolepyridine moiety
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Multicomponent System of nps 1034 an orally administered lung cancer drug candidate with sulfonic acids and solid state characterization
Crystal Growth & Design, 2013Co-Authors: Suzie Park, Seon Joo Yoon, Yong Woo Jung, Youngjoo Byun, Min Keyong Jeon, Sung Kwon KangAbstract:NPS-1034 is a drug candidate targeted for the regulation of c-MET/AXL receptor tyrosin kinase activity. NPS-1034 was developed to improve efficacy and reduce toxicity by targeting c-MET/AXL related signaling pathways. However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming Multicomponent Systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, p-toluenesulfonic acid, and camphorsulfonic acid. Solid state characterization of NPS-1034 salts and amorphous with sulfonic acids was conducted, and the crystal structures of four salts and NPS-1034 were compared and investigated. Sulfonic acid salts of NPS-1034 decreased the melting point of NPS-1034 as much as −155.43 °C. Solubilities of NPS-1034 and salts of NPS-1034 were measured to develop lipid-based formulation for the GLP toxicity study. Solvents studied include oleic a...