The Experts below are selected from a list of 130452 Experts worldwide ranked by ideXlab platform

Angus I. Lamond - One of the best experts on this subject based on the ideXlab platform.

  • Multidimensional proteomics for cell biology
    Nature Reviews Molecular Cell Biology, 2015
    Co-Authors: Mark Larance, Angus I. Lamond
    Abstract:

    Advances in mass spectrometry-based proteomics are enabling the Multidimensional Analysis of protein properties such as abundance, localization, post-translational modifications and interactions for thousands of proteins. Complemented by new tools for data Analysis and integration, these advances are transforming our understanding of various biological processes.

  • Multidimensional proteomics for cell biology
    Nature Reviews Molecular Cell Biology, 2015
    Co-Authors: Mark Larance, Angus I. Lamond
    Abstract:

    The proteome is a dynamic system in which each protein has interconnected properties - dimensions - that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data Analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the Multidimensional Analysis of the proteome are transforming our understanding of various cellular and physiological processes.

Mark Larance - One of the best experts on this subject based on the ideXlab platform.

  • Multidimensional proteomics for cell biology
    Nature Reviews Molecular Cell Biology, 2015
    Co-Authors: Mark Larance, Angus I. Lamond
    Abstract:

    Advances in mass spectrometry-based proteomics are enabling the Multidimensional Analysis of protein properties such as abundance, localization, post-translational modifications and interactions for thousands of proteins. Complemented by new tools for data Analysis and integration, these advances are transforming our understanding of various biological processes.

  • Multidimensional proteomics for cell biology
    Nature Reviews Molecular Cell Biology, 2015
    Co-Authors: Mark Larance, Angus I. Lamond
    Abstract:

    The proteome is a dynamic system in which each protein has interconnected properties - dimensions - that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data Analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the Multidimensional Analysis of the proteome are transforming our understanding of various cellular and physiological processes.

Alain Delobbe - One of the best experts on this subject based on the ideXlab platform.

  • Physiologic Determinants of Exercise Capacity in Pulmonary Langerhans Cell Histiocytosis: A Multidimensional Analysis
    PLoS ONE, 2017
    Co-Authors: Camille Rolland-debord, Stephanie Fry, Nicolas Bricout, Agnes Bellocq, Olivier Le Rouzic, Jonathan Giovannelli, Carole Langlois, Stephane Dominique, Bernard Aguilaniu, Alain Delobbe
    Abstract:

    Background Reduced exercise capacity severely impacts quality of life in pulmonary Langerhans cell histiocytosis. Ascertaining mechanisms that impair exercise capacity is necessary to identify targets for symptomatic treatments. Methods Dyspnea, pulmonary function tests and cardiopulmonary exercise test were analysed in 62 study participants. Data were compared between subjects with impaired and normal aerobic capacity (V’O2 peak less than 84% versus 84% predicted or more). Data were reduced using a principal component Analysis. Multivariate Analysis included V’O2 peak as the dependent variable and principal components as covariates. Results V’O2 peak was reduced in 44 subjects (71%). Subjects with impaired aerobic capacity presented: (i) decreased FEV1, FVC, FEV1/FVC, DLCO and DLCO/VA and increased AaDO2, (ii) increased ventilatory equivalents at ventilatory threshold, VD/VT peak, AaDO2 peak and PaCO2 peak and decreased ventilatory reserve and PaO2 peak. There was no difference between groups in dyspnea scores. Principal component Analysis extracted 4 principal components interpreted as follows: PC1: gas exchange; PC2: “pseudorestriction”; PC3: exercise-induced hyperpnea; PC4: air trapping. Multivariate Analysis explained 65% of V’O2 peak. The 4 principal components were independently associated with V’O2 peak (βcoefficients: PC1: 9.3 [4.6; 14], PC2: 7.5 [3; 11.9], PC3: -5.3 [-9.6;-1.], PC4: -9.8 [-14,9;-4.7]). Conclusion Impaired exercise capacity is frequent in pulmonary Langerhans cell histiocytosis. It is mainly caused by pulmonary changes but is not associated with increased dyspnea intensity. Therefore, treating the lung represents a relevant approach for improving exercise capacity, even in patients experiencing mild dyspnea.

David G Perry - One of the best experts on this subject based on the ideXlab platform.

  • gender identity a Multidimensional Analysis with implications for psychosocial adjustment
    Developmental Psychology, 2001
    Co-Authors: Susan K Egan, David G Perry
    Abstract:

    This study examined the relations between components of gender identity and psychosocial adjustment. The aspects of gender identity assessed were (a) feelings of psychological compatibility with one's gender (i.e.. feeling one is a typical member of one's sex and feeling content with one's biological sex), (b) feelings of pressure from parents, peers, and self for conformity to gender stereotypes. and (c) the sentiment that one's own sex is superior to the other (intergroup bias). Adjustment was assessed in terms of self-esteem and peer acceptance. Participants were 182 children in Grades 4 through 8. Felt gender compatibility (when operationalized as either self-perceived gender typicality or feelings of contentment with one's biological sex) was positively related to adjustment, whereas felt pressure and intergroup bias were negatively associated with adjustment. The results provide new insights into the role of gender identity in children's well-being, help identify sources of confusion in previous work, and suggest directions for future inquiry.

  • gender identity a Multidimensional Analysis with implications for psychosocial adjustment
    Developmental Psychology, 2001
    Co-Authors: Susan K Egan, David G Perry
    Abstract:

    This study examined the relations between components of gender identity and psychosocial adjustment. The aspects of gender identity assessed were (a) feelings of psychological compatibility with one's gender (i.e., feeling one is a typical member of one's sex and feeling content with one's biological sex), (b) feelings of pressure from parents, peers, and self for conformity to gender stereotypes, and (c) the sentiment that one's own sex is superior to the other (intergroup bias). Adjustment was assessed in terms of self-esteem and peer acceptance. Participants were 182 children in Grades 4 through 8. Felt gender compatibility (when operationalized as either self-perceived gender typicality or feelings of contentment with one's biological sex) was positively related to adjustment, whereas felt pressure and intergroup bias were negatively associated with adjustment. The results provide new insights into the role of gender identity in children's well-being, help identify sources of confusion in previous work, and suggest directions for future inquiry. Gender is a quintessential element of human identity. Given that one's gender assignment ordinarily is immutable and that many fundamental features of life—including the recreational, academic, occupational, and relationship activities that one is expected to pursue—are governed by gender, it seems likely that most people devote at least some time to reflecting on questions like these: How well do I fit with my gender category? Must I adhere to the stereotypes for my sex or am I free to explore cross-sex options? Is my sex superior or inferior to the other? We believe that beginning in childhood, people do ask these questions of themselves and, moreover, that their answers influence their psychosocial adjustment. The present study was designed to test these propositions. In our view, people's answers to the questions noted above represent components of their gender identity. We view gender identity as a Multidimensional construct encompassing an individual's (a) knowledge of membership in a gender category, (b) felt compatibility with his or her gender group (i.e., self-perceptions of gender typicality as well as feelings of contentment with one's

Camille Rolland-debord - One of the best experts on this subject based on the ideXlab platform.

  • Physiologic Determinants of Exercise Capacity in Pulmonary Langerhans Cell Histiocytosis: A Multidimensional Analysis
    PLoS ONE, 2017
    Co-Authors: Camille Rolland-debord, Stephanie Fry, Nicolas Bricout, Agnes Bellocq, Olivier Le Rouzic, Jonathan Giovannelli, Carole Langlois, Stephane Dominique, Bernard Aguilaniu, Alain Delobbe
    Abstract:

    Background Reduced exercise capacity severely impacts quality of life in pulmonary Langerhans cell histiocytosis. Ascertaining mechanisms that impair exercise capacity is necessary to identify targets for symptomatic treatments. Methods Dyspnea, pulmonary function tests and cardiopulmonary exercise test were analysed in 62 study participants. Data were compared between subjects with impaired and normal aerobic capacity (V’O2 peak less than 84% versus 84% predicted or more). Data were reduced using a principal component Analysis. Multivariate Analysis included V’O2 peak as the dependent variable and principal components as covariates. Results V’O2 peak was reduced in 44 subjects (71%). Subjects with impaired aerobic capacity presented: (i) decreased FEV1, FVC, FEV1/FVC, DLCO and DLCO/VA and increased AaDO2, (ii) increased ventilatory equivalents at ventilatory threshold, VD/VT peak, AaDO2 peak and PaCO2 peak and decreased ventilatory reserve and PaO2 peak. There was no difference between groups in dyspnea scores. Principal component Analysis extracted 4 principal components interpreted as follows: PC1: gas exchange; PC2: “pseudorestriction”; PC3: exercise-induced hyperpnea; PC4: air trapping. Multivariate Analysis explained 65% of V’O2 peak. The 4 principal components were independently associated with V’O2 peak (βcoefficients: PC1: 9.3 [4.6; 14], PC2: 7.5 [3; 11.9], PC3: -5.3 [-9.6;-1.], PC4: -9.8 [-14,9;-4.7]). Conclusion Impaired exercise capacity is frequent in pulmonary Langerhans cell histiocytosis. It is mainly caused by pulmonary changes but is not associated with increased dyspnea intensity. Therefore, treating the lung represents a relevant approach for improving exercise capacity, even in patients experiencing mild dyspnea.