The Experts below are selected from a list of 12690 Experts worldwide ranked by ideXlab platform
Anders Finkjensen - One of the best experts on this subject based on the ideXlab platform.
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enhanced self administration of alcohol in Muscarinic acetylcholine M4 Receptor knockout mice
European Journal of Pharmacology, 2015Co-Authors: Cecilie De La Cour, Pia Weikop, Ditte Dencker, Gitta Wortwein, Anders Finkjensen, Gunnar Sorensen, Anna MolanderAbstract:� / � ) Alcohol Consumption Extinction Behavior Mice abstract Modulation of cholinergic neurotransmission via nicotinic acetylcholine Receptors is known to alter alcohol-drinking behavior. It is not known if Muscarinic acetylcholine Receptor subtypes have similar effects. The Muscarinic M4 Receptor is highly expressed in the brain reinforcement system and involved in regulation of cholinergic and dopaminergic transmission. Here we investigate, for the first time, the role of the M4 Receptor in alcohol consumption using M4 knockout (M4 � / � ) and wild-type (M 4 þ/ þ ) mice.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission. Here we investigated for the first time the involvement of M4 Receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed M4 Receptor knockout (M4 −/−) mice. We evaluated acquisition of cocaine self-administration in experimentally naive mice. Both cocaine self-administration and food-maintained operant behavior were evaluated under fixed ratio 1 (FR 1) and progressive ratio (PR) schedules of reinforcement. In addition, cocaine-induced dopamine release and cocaine-induced hyperactivity were evaluated. M4 −/− mice earned significantly more cocaine reinforcers and reached higher breaking points than their wild-type littermates (M4 +/+) at intermediate doses of cocaine under both FR 1 and PR schedules of reinforcement. Under the PR schedule, M4 −/− mice exhibited significantly higher response rates at the lowest liquid food concentration. In accordance with these results, cocaine-induced dopamine efflux in the nucleus accumbens and hyperlocomotion were increased in M4 −/− mice compared to M4 +/+ mice. Our data suggest that M4 Receptors play an important role in regulation of the reward circuitry and may serve as a new target in the medical treatment of drug addiction.
Pia Weikop - One of the best experts on this subject based on the ideXlab platform.
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enhanced self administration of alcohol in Muscarinic acetylcholine M4 Receptor knockout mice
European Journal of Pharmacology, 2015Co-Authors: Cecilie De La Cour, Pia Weikop, Ditte Dencker, Gitta Wortwein, Anders Finkjensen, Gunnar Sorensen, Anna MolanderAbstract:� / � ) Alcohol Consumption Extinction Behavior Mice abstract Modulation of cholinergic neurotransmission via nicotinic acetylcholine Receptors is known to alter alcohol-drinking behavior. It is not known if Muscarinic acetylcholine Receptor subtypes have similar effects. The Muscarinic M4 Receptor is highly expressed in the brain reinforcement system and involved in regulation of cholinergic and dopaminergic transmission. Here we investigate, for the first time, the role of the M4 Receptor in alcohol consumption using M4 knockout (M4 � / � ) and wild-type (M 4 þ/ þ ) mice.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission. Here we investigated for the first time the involvement of M4 Receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed M4 Receptor knockout (M4 −/−) mice. We evaluated acquisition of cocaine self-administration in experimentally naive mice. Both cocaine self-administration and food-maintained operant behavior were evaluated under fixed ratio 1 (FR 1) and progressive ratio (PR) schedules of reinforcement. In addition, cocaine-induced dopamine release and cocaine-induced hyperactivity were evaluated. M4 −/− mice earned significantly more cocaine reinforcers and reached higher breaking points than their wild-type littermates (M4 +/+) at intermediate doses of cocaine under both FR 1 and PR schedules of reinforcement. Under the PR schedule, M4 −/− mice exhibited significantly higher response rates at the lowest liquid food concentration. In accordance with these results, cocaine-induced dopamine efflux in the nucleus accumbens and hyperlocomotion were increased in M4 −/− mice compared to M4 +/+ mice. Our data suggest that M4 Receptors play an important role in regulation of the reward circuitry and may serve as a new target in the medical treatment of drug addiction.
Ditte Dencker - One of the best experts on this subject based on the ideXlab platform.
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enhanced self administration of alcohol in Muscarinic acetylcholine M4 Receptor knockout mice
European Journal of Pharmacology, 2015Co-Authors: Cecilie De La Cour, Pia Weikop, Ditte Dencker, Gitta Wortwein, Anders Finkjensen, Gunnar Sorensen, Anna MolanderAbstract:� / � ) Alcohol Consumption Extinction Behavior Mice abstract Modulation of cholinergic neurotransmission via nicotinic acetylcholine Receptors is known to alter alcohol-drinking behavior. It is not known if Muscarinic acetylcholine Receptor subtypes have similar effects. The Muscarinic M4 Receptor is highly expressed in the brain reinforcement system and involved in regulation of cholinergic and dopaminergic transmission. Here we investigate, for the first time, the role of the M4 Receptor in alcohol consumption using M4 knockout (M4 � / � ) and wild-type (M 4 þ/ þ ) mice.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission. Here we investigated for the first time the involvement of M4 Receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed M4 Receptor knockout (M4 −/−) mice. We evaluated acquisition of cocaine self-administration in experimentally naive mice. Both cocaine self-administration and food-maintained operant behavior were evaluated under fixed ratio 1 (FR 1) and progressive ratio (PR) schedules of reinforcement. In addition, cocaine-induced dopamine release and cocaine-induced hyperactivity were evaluated. M4 −/− mice earned significantly more cocaine reinforcers and reached higher breaking points than their wild-type littermates (M4 +/+) at intermediate doses of cocaine under both FR 1 and PR schedules of reinforcement. Under the PR schedule, M4 −/− mice exhibited significantly higher response rates at the lowest liquid food concentration. In accordance with these results, cocaine-induced dopamine efflux in the nucleus accumbens and hyperlocomotion were increased in M4 −/− mice compared to M4 +/+ mice. Our data suggest that M4 Receptors play an important role in regulation of the reward circuitry and may serve as a new target in the medical treatment of drug addiction.
Gitta Wortwein - One of the best experts on this subject based on the ideXlab platform.
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enhanced self administration of alcohol in Muscarinic acetylcholine M4 Receptor knockout mice
European Journal of Pharmacology, 2015Co-Authors: Cecilie De La Cour, Pia Weikop, Ditte Dencker, Gitta Wortwein, Anders Finkjensen, Gunnar Sorensen, Anna MolanderAbstract:� / � ) Alcohol Consumption Extinction Behavior Mice abstract Modulation of cholinergic neurotransmission via nicotinic acetylcholine Receptors is known to alter alcohol-drinking behavior. It is not known if Muscarinic acetylcholine Receptor subtypes have similar effects. The Muscarinic M4 Receptor is highly expressed in the brain reinforcement system and involved in regulation of cholinergic and dopaminergic transmission. Here we investigate, for the first time, the role of the M4 Receptor in alcohol consumption using M4 knockout (M4 � / � ) and wild-type (M 4 þ/ þ ) mice.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission. Here we investigated for the first time the involvement of M4 Receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed M4 Receptor knockout (M4 −/−) mice. We evaluated acquisition of cocaine self-administration in experimentally naive mice. Both cocaine self-administration and food-maintained operant behavior were evaluated under fixed ratio 1 (FR 1) and progressive ratio (PR) schedules of reinforcement. In addition, cocaine-induced dopamine release and cocaine-induced hyperactivity were evaluated. M4 −/− mice earned significantly more cocaine reinforcers and reached higher breaking points than their wild-type littermates (M4 +/+) at intermediate doses of cocaine under both FR 1 and PR schedules of reinforcement. Under the PR schedule, M4 −/− mice exhibited significantly higher response rates at the lowest liquid food concentration. In accordance with these results, cocaine-induced dopamine efflux in the nucleus accumbens and hyperlocomotion were increased in M4 −/− mice compared to M4 +/+ mice. Our data suggest that M4 Receptors play an important role in regulation of the reward circuitry and may serve as a new target in the medical treatment of drug addiction.
Jurgen Wess - One of the best experts on this subject based on the ideXlab platform.
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genetic reduction of Muscarinic M4 Receptor modulates analgesic response and acoustic startle response in a mouse model of fragile x syndrome fxs
Behavioural Brain Research, 2012Co-Authors: Surabi Veeraragavan, Jurgen Wess, Deanna Graham, Nghiem Bui, Lisa A Yuvapaylor, Richard PaylorAbstract:Abstract Introduction The G-protein coupled Muscarinic acetylcholine Receptors, widely expressed in the CNS, have been implicated in fragile X syndrome (FXS). Recent studies have reported an overactive signaling through the Muscarinic Receptors in the Fmr1KO mouse model. Hence, it was hypothesized that reducing Muscarinic signaling might modulate behavioral phenotypes in the Fmr1KO mice. Pharmacological studies from our lab have provided evidence for this hypothesis, with subtype-preferring Muscarinic M1 and M4 Receptor antagonists modulating select behaviors in the Fmr1KO mice. Since the pharmacological antagonists were not highly specific, we investigated the specific role of M4 Receptors in the Fmr1KO mouse model, using a genetic approach. Methods We created a double mutant heterozygous for the M4 Receptor gene and hemizygous for the Fmr1 gene and examined the mutants on various behaviors. Each animal was tested on a behavior battery comprising of open-field activity (activity), light–dark (anxiety), marble burying (perseverative behavior), prepulse inhibition (sensorimotor gating), rotarod (motor coordination), passive avoidance (learning and memory) and hotplate (analgesia). Animals were also tested on the audiogenic seizure protocol and testis weights were measured. Results Reduction of M4 Receptor expression in the heterozygotes completely rescued the analgesic response and partly rescued the acoustic startle response phenotype in the Fmr1KO mice. However, no modulation was observed in a number of behaviors including learning and memory, activity, perseverative behavior and audiogenic seizures. Conclusion Reducing M4 Receptor signaling altered only select behavioral phenotypes in the Fmr1KO mouse model, suggesting that other targets are involved in the modulation of fragile X behaviors.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission.
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increased cocaine self administration in M4 Muscarinic acetylcholine Receptor knockout mice
Psychopharmacology, 2011Co-Authors: Lene S Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jurgen Wess, David P D Woldbye, Gitta Wortwein, Anders FinkjensenAbstract:The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic Muscarinic M4 Receptor subtype plays an important role in regulation of dopaminergic neurotransmission. Here we investigated for the first time the involvement of M4 Receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed M4 Receptor knockout (M4 −/−) mice. We evaluated acquisition of cocaine self-administration in experimentally naive mice. Both cocaine self-administration and food-maintained operant behavior were evaluated under fixed ratio 1 (FR 1) and progressive ratio (PR) schedules of reinforcement. In addition, cocaine-induced dopamine release and cocaine-induced hyperactivity were evaluated. M4 −/− mice earned significantly more cocaine reinforcers and reached higher breaking points than their wild-type littermates (M4 +/+) at intermediate doses of cocaine under both FR 1 and PR schedules of reinforcement. Under the PR schedule, M4 −/− mice exhibited significantly higher response rates at the lowest liquid food concentration. In accordance with these results, cocaine-induced dopamine efflux in the nucleus accumbens and hyperlocomotion were increased in M4 −/− mice compared to M4 +/+ mice. Our data suggest that M4 Receptors play an important role in regulation of the reward circuitry and may serve as a new target in the medical treatment of drug addiction.
