The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Yingjian Zhu - One of the best experts on this subject based on the ideXlab platform.
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time dependent bladder tissue regeneration using bilayer bladder acellular matrix graft silk fibroin scaffolds in a rat bladder augmentation model
Acta Biomaterialia, 2015Co-Authors: Yang Zhao, Jianhua Guo, Zhe Zhou, Ming Zhang, Juan Zhou, Dongdong Xiao, Zhong Wang, Kang Sun, Yingjian ZhuAbstract:With advances in tissue engineering, various synthetic and natural biomaterials have been widely used in tissue regeneration of the urinary bladder in rat models. However, reconstructive procedures remain insufficient due to the lack of appropriate scaffolding, which should provide a waterproof barrier function and support the needs of various cell types. To address these problems, we have developed a bilayer scaffold comprising a porous network (silk fibroin [SF]) and an underlying natural acellular matrix (bladder acellular matrix graft [BAMG]) and evaluated its feasibility and potential for bladder regeneration in a rat bladder augmentation model. Histological (hematoxylin and eosin and Masson's trichrome staining) and immunohistochemical analyses demonstrated that the bilayer BAMG-SF scaffold promoted smooth Muscle, Blood Vessel, and nerve regeneration in a time-dependent manner. At 12weeks after implantation, bladders reconstructed with the BAMG-SF matrix displayed superior structural and functional properties without significant local tissue responses or systemic toxicity. These results demonstrated that the bilayer BAMG-SF scaffold may be a promising scaffold with good biocompatibility for bladder regeneration in the rat bladder augmentation model.
Ruben Vidal - One of the best experts on this subject based on the ideXlab platform.
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inclusion body myositis Muscle Blood Vessel and cardiac amyloidosis and transthyretin val122ile allele
Annals of Neurology, 2000Co-Authors: Valerie Askanas, King W Engel, Renate B Alvarez, Blas Frangione, Jorge Ghiso, Ruben VidalAbstract:Typical of sporadic inclusion body myositis Muscle biopsies are vacuolated Muscle fibers containing intracellular amyloid deposits and accumulations of "Alzheimer-characteristic" proteins. There is no Muscle Blood Vessel or cardiac amyloidosis. We report on a 70-year-old African-American man homozygous for the transthyretin Val122Ile allele who has both sporadic inclusion body myositis and cardiac amyloidosis. His unique pathological features included transthyretin immunoreactivity in prominent Muscle Blood Vessel amyloid and congophilic amyloid deposits within vacuolated Muscle fibers.
Yang Zhao - One of the best experts on this subject based on the ideXlab platform.
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time dependent bladder tissue regeneration using bilayer bladder acellular matrix graft silk fibroin scaffolds in a rat bladder augmentation model
Acta Biomaterialia, 2015Co-Authors: Yang Zhao, Jianhua Guo, Zhe Zhou, Ming Zhang, Juan Zhou, Dongdong Xiao, Zhong Wang, Kang Sun, Yingjian ZhuAbstract:With advances in tissue engineering, various synthetic and natural biomaterials have been widely used in tissue regeneration of the urinary bladder in rat models. However, reconstructive procedures remain insufficient due to the lack of appropriate scaffolding, which should provide a waterproof barrier function and support the needs of various cell types. To address these problems, we have developed a bilayer scaffold comprising a porous network (silk fibroin [SF]) and an underlying natural acellular matrix (bladder acellular matrix graft [BAMG]) and evaluated its feasibility and potential for bladder regeneration in a rat bladder augmentation model. Histological (hematoxylin and eosin and Masson's trichrome staining) and immunohistochemical analyses demonstrated that the bilayer BAMG-SF scaffold promoted smooth Muscle, Blood Vessel, and nerve regeneration in a time-dependent manner. At 12weeks after implantation, bladders reconstructed with the BAMG-SF matrix displayed superior structural and functional properties without significant local tissue responses or systemic toxicity. These results demonstrated that the bilayer BAMG-SF scaffold may be a promising scaffold with good biocompatibility for bladder regeneration in the rat bladder augmentation model.
Valerie Askanas - One of the best experts on this subject based on the ideXlab platform.
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inclusion body myositis Muscle Blood Vessel and cardiac amyloidosis and transthyretin val122ile allele
Annals of Neurology, 2000Co-Authors: Valerie Askanas, King W Engel, Renate B Alvarez, Blas Frangione, Jorge Ghiso, Ruben VidalAbstract:Typical of sporadic inclusion body myositis Muscle biopsies are vacuolated Muscle fibers containing intracellular amyloid deposits and accumulations of "Alzheimer-characteristic" proteins. There is no Muscle Blood Vessel or cardiac amyloidosis. We report on a 70-year-old African-American man homozygous for the transthyretin Val122Ile allele who has both sporadic inclusion body myositis and cardiac amyloidosis. His unique pathological features included transthyretin immunoreactivity in prominent Muscle Blood Vessel amyloid and congophilic amyloid deposits within vacuolated Muscle fibers.
Ming Zhang - One of the best experts on this subject based on the ideXlab platform.
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time dependent bladder tissue regeneration using bilayer bladder acellular matrix graft silk fibroin scaffolds in a rat bladder augmentation model
Acta Biomaterialia, 2015Co-Authors: Yang Zhao, Jianhua Guo, Zhe Zhou, Ming Zhang, Juan Zhou, Dongdong Xiao, Zhong Wang, Kang Sun, Yingjian ZhuAbstract:With advances in tissue engineering, various synthetic and natural biomaterials have been widely used in tissue regeneration of the urinary bladder in rat models. However, reconstructive procedures remain insufficient due to the lack of appropriate scaffolding, which should provide a waterproof barrier function and support the needs of various cell types. To address these problems, we have developed a bilayer scaffold comprising a porous network (silk fibroin [SF]) and an underlying natural acellular matrix (bladder acellular matrix graft [BAMG]) and evaluated its feasibility and potential for bladder regeneration in a rat bladder augmentation model. Histological (hematoxylin and eosin and Masson's trichrome staining) and immunohistochemical analyses demonstrated that the bilayer BAMG-SF scaffold promoted smooth Muscle, Blood Vessel, and nerve regeneration in a time-dependent manner. At 12weeks after implantation, bladders reconstructed with the BAMG-SF matrix displayed superior structural and functional properties without significant local tissue responses or systemic toxicity. These results demonstrated that the bilayer BAMG-SF scaffold may be a promising scaffold with good biocompatibility for bladder regeneration in the rat bladder augmentation model.
