The Experts below are selected from a list of 270 Experts worldwide ranked by ideXlab platform
Dmitry Shvartsman - One of the best experts on this subject based on the ideXlab platform.
-
sustained delivery of vegf maintains Innervation and promotes reperfusion in ischemic skeletal Muscles via ngf gdnf signaling
Molecular Therapy, 2014Co-Authors: Dmitry Shvartsman, Cathal J. Kearney, Christine A. Cezar, Yevgeny Brudno, Hannah Storriewhite, Kangwon Lee, Corey M. MccannAbstract:Tissue reInnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal Muscle Innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
-
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling
Molecular Therapy, 2014Co-Authors: Dmitry Shvartsman, Hannah Storrie-white, Cathal J. Kearney, Nhi Ho, Christine A. Cezar, Corey M. Mccann, Erin M. Anderson, Yevgeny Brudno, John KoulliasAbstract:Tissue reInnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal Muscle Innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
Ping Zhou - One of the best experts on this subject based on the ideXlab platform.
-
Innervation zone distribution of the biceps brachii Muscle examined using voluntary and electrically evoked high density surface emg
Journal of Neuroengineering and Rehabilitation, 2019Co-Authors: Cliff S Klein, Zhaojian Meng, Yingchun Zhang, Chengjun Huang, Sheng Li, Ping ZhouAbstract:Background High density surface electromyography (EMG) can be used to estimate Muscle Innervation zones (IZ). The objective of this study was to compare the differences in the distribution of the biceps brachii (BB) IZ derived from voluntary contractions (VC) and electrical stimulation (ES) of the musculocutaneous nerve.
Corey M. Mccann - One of the best experts on this subject based on the ideXlab platform.
-
sustained delivery of vegf maintains Innervation and promotes reperfusion in ischemic skeletal Muscles via ngf gdnf signaling
Molecular Therapy, 2014Co-Authors: Dmitry Shvartsman, Cathal J. Kearney, Christine A. Cezar, Yevgeny Brudno, Hannah Storriewhite, Kangwon Lee, Corey M. MccannAbstract:Tissue reInnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal Muscle Innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
-
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling
Molecular Therapy, 2014Co-Authors: Dmitry Shvartsman, Hannah Storrie-white, Cathal J. Kearney, Nhi Ho, Christine A. Cezar, Corey M. Mccann, Erin M. Anderson, Yevgeny Brudno, John KoulliasAbstract:Tissue reInnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal Muscle Innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
Yevgeny Brudno - One of the best experts on this subject based on the ideXlab platform.
-
sustained delivery of vegf maintains Innervation and promotes reperfusion in ischemic skeletal Muscles via ngf gdnf signaling
Molecular Therapy, 2014Co-Authors: Dmitry Shvartsman, Cathal J. Kearney, Christine A. Cezar, Yevgeny Brudno, Hannah Storriewhite, Kangwon Lee, Corey M. MccannAbstract:Tissue reInnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal Muscle Innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
-
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling
Molecular Therapy, 2014Co-Authors: Dmitry Shvartsman, Hannah Storrie-white, Cathal J. Kearney, Nhi Ho, Christine A. Cezar, Corey M. Mccann, Erin M. Anderson, Yevgeny Brudno, John KoulliasAbstract:Tissue reInnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal Muscle Innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
Wolfgang Gstoettner - One of the best experts on this subject based on the ideXlab platform.
-
intraoperative electromyography for identification of the trapezius Muscle Innervation clinical proof of a new anatomical concept
Laryngoscope, 2002Co-Authors: Antonius C Kierner, Martin Burian, S Bentzien, Wolfgang GstoettnerAbstract:OBJECTIVE/HYPOTHESIS: There is still considerable controversy among surgeons on trapezius Muscle Innervation. In addition, the rate of unexpected postoperative trapezius pareses is unacceptably high. Recent anatomical findings might answer most of the questions. The objective of the present study was to clinically prove the recent anatomical findings, especially the concept of the Innervation of the descending part of the trapezius Muscle. STUDY DESIGN: Intraoperative electromyography of the spinal accessory nerve and its branches in the posterior triangle of the neck. SETTING: Intraoperative electromyography was performed during 17 modified radical neck dissections on 14 patients of both sexes ranging in age from 44 to 68 years (mean age, 56 y). Potentials were registered through pairs of needle electrodes placed in each of the three parts of the trapezius Muscle. Intraoperatively, the spinal accessory nerve and its fine cranial branch passing toward the descending part of the Muscle were identified and stimulated in the posterior triangle of the neck.RESULTS Stimulation of the fine cranial branch of the spinal accessory nerve led to a clearly visible and recordable contraction in the descending part of the trapezius Muscle in all patients. Stimulation of the main trunk of the spinal accessory nerve in the posterior triangle of the neck distal to the above-mentioned branching led to a clearly visible and recordable contraction in the transverse and ascending parts of the Muscle. CONCLUSIONS: The results strongly support recent anatomical findings showing that, functionally, the most important descending part of the trapezius Muscle is innervated by a fine single branch arising from the spinal accessory nerve in the posterior triangle of the neck. This may help to prevent more patients undergoing modified radical neck dissections from shoulder-arm syndrome.
