The Experts below are selected from a list of 36765 Experts worldwide ranked by ideXlab platform
Carl P. Weiner - One of the best experts on this subject based on the ideXlab platform.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca2+ concentration and a decrease in the sensitivity of the contractile system to Ca2+. We propose that the cGMP-induced decrease in Ca2+ sensitivity is a strategic way to achieve “active Relaxation” of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings. J. Cell. Physiol. 184:409–420, 2000. © 2000 Wiley-Liss, Inc.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca(2+) concentration and a decrease in the sensitivity of the contractile system to Ca(2+). We propose that the cGMP-induced decrease in Ca(2+) sensitivity is a strategic way to achieve "active Relaxation" of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings.
Jorge A Carvajal - One of the best experts on this subject based on the ideXlab platform.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca2+ concentration and a decrease in the sensitivity of the contractile system to Ca2+. We propose that the cGMP-induced decrease in Ca2+ sensitivity is a strategic way to achieve “active Relaxation” of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings. J. Cell. Physiol. 184:409–420, 2000. © 2000 Wiley-Liss, Inc.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca(2+) concentration and a decrease in the sensitivity of the contractile system to Ca(2+). We propose that the cGMP-induced decrease in Ca(2+) sensitivity is a strategic way to achieve "active Relaxation" of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings.
Juan Pablo Huidobrotoro - One of the best experts on this subject based on the ideXlab platform.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca2+ concentration and a decrease in the sensitivity of the contractile system to Ca2+. We propose that the cGMP-induced decrease in Ca2+ sensitivity is a strategic way to achieve “active Relaxation” of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings. J. Cell. Physiol. 184:409–420, 2000. © 2000 Wiley-Liss, Inc.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca(2+) concentration and a decrease in the sensitivity of the contractile system to Ca(2+). We propose that the cGMP-induced decrease in Ca(2+) sensitivity is a strategic way to achieve "active Relaxation" of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings.
Alfredo M Germain - One of the best experts on this subject based on the ideXlab platform.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca2+ concentration and a decrease in the sensitivity of the contractile system to Ca2+. We propose that the cGMP-induced decrease in Ca2+ sensitivity is a strategic way to achieve “active Relaxation” of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings. J. Cell. Physiol. 184:409–420, 2000. © 2000 Wiley-Liss, Inc.
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molecular mechanism of cgmp mediated smooth Muscle Relaxation
Journal of Cellular Physiology, 2000Co-Authors: Jorge A Carvajal, Alfredo M Germain, Juan Pablo Huidobrotoro, Carl P. WeinerAbstract:Contraction and Relaxation of smooth Muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth Muscle Relaxation. We briefly review the current art regarding cGMP generation and degradation, while focusing on the recent identification of the molecular mechanisms underlying cGMP-mediated smooth Muscle Relaxation. cGMP-induced SM Relaxation is mediated mainly by cGMP-dependent protein kinase activation. It involves several molecular events culminating in a reduction in intracellular Ca(2+) concentration and a decrease in the sensitivity of the contractile system to Ca(2+). We propose that the cGMP-induced decrease in Ca(2+) sensitivity is a strategic way to achieve "active Relaxation" of the smooth Muscle. In summary, we present compelling evidence supporting a key role for cGMP as a mediator of smooth Muscle Relaxation in physiological and pharmacological settings.
Jamie Y Jeremy - One of the best experts on this subject based on the ideXlab platform.
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the effect of sildenafil on corpus cavernosal smooth Muscle Relaxation and cyclic gmp formation in the diabetic rabbit
European Journal of Pharmacology, 2001Co-Authors: C S Thompson, Robert Michael Wallis, Masood A. Khan, F H Mumtaz, Richard Morgan, Gianni D Angelini, Dimitri P Mikhailidis, Jamie Y JeremyAbstract:Sildenafil, a type V phosphodiesterase inhibitor, enhances smooth Muscle Relaxation in normal human and rabbit corpus cavernosum. We investigated the in vitro effects of sildenafil on non-adrenergic, non-cholinergic and nitric oxide (NO)-mediated cavernosal smooth Muscle Relaxation in diabetic rabbits, since alterations in this pathway are recognised in diabetic erectile dysfunction. Diabetes mellitus was induced in male New Zealand White rabbits with alloxan, Cavernosal strips from age-matched control, 3- and 6-month diabetic animals were mounted in organ baths. Relaxation responses to electrical field stimulation (1-20 Hz) or sodium nitroprusside (10(-8)-10(-4) M) were assessed in the absence and presence of sildenafil (10(-8) and 10(-7) M). The effect of sildenafil on cGMP formation by the corpus cavernosum was also assessed following stimulation with sodium nitroprusside, A23187 and acetylcholine. Sodium nitroprusside-stimulated Relaxations were significantly (P < 0.03) impaired in the corpus cavernosum from both diabetic groups, (IC50 = 4.6 x 10(-6) M following 3 months of diabetes mellitus and 4.0 x 10(-6) M following 6 months of diabetes mellitus; compared to 7.5 x 10(-7) M for pooled age-matched controls). Sildenafil (10(-7) M) significantly enhanced sodium nitroprusside-stimulated Relaxation in control (P < 0.05) and diabetic groups (P < 0.03). Electrical field stimulation-mediated Relaxations of the corpus cavernosum were significantly impaired after 6-month diabetes mellitus and enhanced by sildenafil (10(-8) M). cGMP formation by the diabetic corpus cavernosum was impaired significantly, but restored towards normal by sildenafil. We suggest that the impairment of NO-mediated Relaxation of the corpus cavernosum reflect, at least in part, a defect in guanylyl cyclase activity. These findings support the use of sildenafil as an effective, orally administered, treatment for diabetic erectile dysfunction. (C) 2001 Elsevier Science B.V. All rights reserved.
