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Mustafa Megahed - One of the best experts on this subject based on the ideXlab platform.
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Pagetoide Retikulose bei einem Patienten mit Mycosis fungoides
Der Hautarzt, 2010Co-Authors: C. Mühlhoff, Barabara Krenkel, Albert Rübben, Mustafa MegahedAbstract:ZusammenfassungDie pagetoide Retikulose ist ein Subtyp der Mycosis fungoides, die sich durch ausgeprägten Epidermotropismus, lokalisiertes Befallsmuster und langsamen Verlauf mit günstiger Prognose auszeichnet. Wir berichten über einen 67-jährigen Patienten mit vorbekannter klassischer Mycosis fungoides, der im Verlauf eine pagetoide Retikulose der rechten Ferse entwickelte. Mit einer lokalisierten Elektronenbestrahlung konnte eine Abheilung der Läsionen erzielt werden. Seitdem ist der Patient 3 Monate rezidivfrei.AbstractPagetoid reticulosis is a Mycosis fungoides subtype. It is characterized by a prominent epidermotropism, localized lesions, slow progression and benign prognosis. We report on a 67-year-old patient with a history of classic Mycosis fungoides, who developed pagetoid reticulosis on the right heel. Local electron beam therapy induced a complete remission, with no recurrence over three months of follow-up.
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Pagetoide Retikulose bei einem Patienten mit Mycosis fungoides
Der Hautarzt, 2010Co-Authors: C. Mühlhoff, Barabara Krenkel, Albert Rübben, Mustafa MegahedAbstract:Die pagetoide Retikulose ist ein Subtyp der Mycosis fungoides, die sich durch ausgeprägten Epidermotropismus, lokalisiertes Befallsmuster und langsamen Verlauf mit günstiger Prognose auszeichnet. Wir berichten über einen 67-jährigen Patienten mit vorbekannter klassischer Mycosis fungoides, der im Verlauf eine pagetoide Retikulose der rechten Ferse entwickelte. Mit einer lokalisierten Elektronenbestrahlung konnte eine Abheilung der Läsionen erzielt werden. Seitdem ist der Patient 3 Monate rezidivfrei. Pagetoid reticulosis is a Mycosis fungoides subtype. It is characterized by a prominent epidermotropism, localized lesions, slow progression and benign prognosis. We report on a 67-year-old patient with a history of classic Mycosis fungoides, who developed pagetoid reticulosis on the right heel. Local electron beam therapy induced a complete remission, with no recurrence over three months of follow-up.
Eric C Vonderheid - One of the best experts on this subject based on the ideXlab platform.
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defining early Mycosis fungoides
Journal of The American Academy of Dermatology, 2005Co-Authors: Nicola Pimpinelli, Eric C Vonderheid, Lorenzo Cerroni, Elise A Olsen, Marco Santucci, Andreas Haeffner, Seth R Stevens, Guenter Burg, Brigitte Dreno, Earl J GlusacAbstract:This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early Mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early Mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early Mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.
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Mycosis fungoides palmaris et plantaris.
Archives of Dermatology, 1995Co-Authors: Kenneth S. Resnik, Lilian Chooback, Harry S. Cooper, Gary R Kantor, Marshall E. Kadin, Stuart R. Lessin, Eric C VonderheidAbstract:Background: Mycosis fungoides primarily localized to the palms and soles is rare and has been previously reported as cutaneous lymphoma in four patients or as Woringer-Kolopp disease in eight patients. Observations: Four patients were initially diagnosed and treated unsuccessfully for various palmoplantar dermatitides until histopathologic findings revealed Mycosis fungoides. Each case exhibited a clonal rearrangement of T-cell receptor gamma genes and immunohistochemical studies consonant with Mycosis fungoides. All patients had limited skin involvement without evidence of extracutaneous involvement. Conclusions: Mycosis fungoides palmaris et plantaris is an uncommon expression of Mycosis fungoides that manifests primarily on the palms and soles and clinically may mimic various inflammatory palmoplantar dermatoses. A biopsy is recommended in the evaluation of recalcitrant palmoplantar dermatoses. (Arch Dermatol. 1995;131:1052-1056)
Omar P. Sangueza - One of the best experts on this subject based on the ideXlab platform.
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Anetodermic Mycosis fungoides: a new clinicopathological variant of Mycosis fungoides.
The British journal of dermatology, 2007Co-Authors: Luis Requena, E. González‐guerra, J. Angulo, A.e. Devore, Omar P. SanguezaAbstract:Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Several rare clinicopathological variants of Mycosis fungoides have been described. Patients with these variants often also have classic Mycosis fungoides at other sites of the body. Anetoderma is a cutaneous disorder in which multiple, oval lesions or atrophic plaques with wrinkled surface develop progressively due to loss of the dermal elastic tissue. Primary anetoderma occurs when there is no underlying associated disease and it arises on clinically normal skin, whereas secondary anetoderma appears in the same site as a previous specific skin lesion. There is a large list of heterogeneous dermatoses associated with secondary anetoderma. Two patients developed areas of secondary anetoderma on plaque stage lesions of Mycosis fungoides. The lesions consisted of exophytic nodular lesions, with very soft consistency on palpation, scattered over the hyperpigmented plaques in one patient and violaceous indurated plaques with overlying epidermal atrophy and mild scale in the other. Histopathological study demonstrated that the cells involving the dermis were mainly T-helper lymphocytes, with few histiocytes and some multinucleate giant cells engulfing distorted elastic fibres. Elastic tissue stain demonstrated that elastic fibres were almost completely absent in the dermis of the anetodermic lesions. Anetodermic Mycosis fungoides should be added to the list of clinicopathological variants of Mycosis fungoides and Mycosis fungoides should also be considered as a possible disease causing secondary anetoderma. Anetodermic Mycosis fungoides shows clinical and histopathological features different from those of granulomatous slack skin.
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Mycosis fungoides induced by phenytoin
European Journal of Dermatology, 1993Co-Authors: Omar P. Sangueza, David E. Cohen, A. Calciano, Matthew J. StillerAbstract:We report a case of Mycosis fungoides which was temporally related to phenytoin administration in a 14-year-old hispanic adolescent. The clinical, histopathological and immunological findings were consonant with a diagnosis of Mycosis fungoides. While we cannot be certain, there is strong circumstantial evidence indicating this may be the first case of phenytoin-induced Mycosis fungoides. Pseudo-Mycosis fungoides, an unusual variant of the pseudolymphoma syndrome is resolved within 3-4 of cessation of phenytoin therapy. This patient's cutaneous eruption is still present nine months after discontinuation of anticonvulsant therapy
Ayse Dursun - One of the best experts on this subject based on the ideXlab platform.
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Carbamazepine-Induced Pseudo Mycosis fungoides
The Annals of pharmacotherapy, 2003Co-Authors: Ülker Gül, Arzu Kiliç, Ayse DursunAbstract:ObjectiveTo report a case of pseudo Mycosis fungoides due to carbamazepine.Case SummaryA 54-year-old man experienced a skin lesion resembling Mycosis fungoides without any systemic symptoms or signs 2 months after he had begun carbamazepine treatment for his seizures. Skin-punch biopsy specimens revealed Mycosis fungoides–like histopathologic appearance. After drug discontinuation, the patient experienced complete remission of the clinical and pathologic findings. This suggests a diagnosis of pseudo Mycosis fungoides due to carbamazepine.DiscussionMycosis fungoides is the cutaneous T-cell lymphoma of the skin that needs aggressive chemotherapy and radiation treatment. Pseudo Mycosis fungoides is a condition caused by certain drugs that has a similar clinical and histopathologic appearance to Mycosis fungoides. When the causative drug is discontinued, the lesions resolve completely.ConclusionsAn objective causality assessment revealed that carbamazepine was highly probable as the cause of the adverse react...
Fátima Pereira - One of the best experts on this subject based on the ideXlab platform.
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Mycosis fungoides bullosa
Journal of the European Academy of Dermatology and Venereology, 2006Co-Authors: João Aranha, Maria Dos Anjos Cabeças, Ana Afonso, Fátima PereiraAbstract:Abstract A case of a 52-year-old man with Mycosis fungoides bullosa, plaque-stage IIA, follicular mucinosis and milia is described. The disease started about 15 years ago and evolved with periods of remission induced by photochemotherapy (PUVA) and, later, by topical nitrogen mustard and etretinate. Vesiculobullous lesions, alopecia and milia sequentially appeared in the course of its evolution. Besides characteristic features of Mycosis fungoides, histopathology revealed subepidermal vesicles and follicular mucinosis associated with lymphoid cells (CD3 + ). The pathophysiology of these particular aspects of the Mycosis fungoides is discussed.
