The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Hans Mickley - One of the best experts on this subject based on the ideXlab platform.
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Classification of Myocardial Infarction: frequency and features of type 2 Myocardial Infarction
The American Journal of Medicine, 2013Co-Authors: Lotte Saaby, Tina Svenstrup Poulsen, Susanne Hosbond, Torben Bjerregaard Larsen, Axel Cosmus Pyndt Diederichsen, Jesper Hallas, Kristian Thygesen, Hans MickleyAbstract:Abstract Background The classification of Myocardial Infarction into 5 types was introduced in 2007 as an important component of the universal definition. In contrast to the plaque rupture–related type 1 Myocardial Infarction, type 2 Myocardial Infarction is considered to be caused by an imbalance between demand and supply of oxygen in the myocardium. However, no specific criteria for type 2 Myocardial Infarction have been established. Methods We prospectively studied unselected hospital patients who had cardiac troponin I measured on clinical indication. The diagnosis and classification of Myocardial Infarction were established, and the frequency and features of type 2 Myocardial Infarction were investigated by use of novel developed criteria. Results From January 2010 to January 2011, a total of 7230 consecutive patients who had cardiac troponin I measured were evaluated, and 4499 patients qualified for inclusion. The diagnosis of Myocardial Infarction was established in 553 patients, of whom 386 (72%) had a type 1 Myocardial Infarction and 144 (26%) had a type 2 Myocardial Infarction. Patients in the group with type 2 Myocardial Infarction were older and more likely to be female, and had more comorbidities. The proportion of patients without significant coronary artery disease was higher in those with type 2 Myocardial Infarction (45%) than in those with type 1 Myocardial Infarction (12%) ( P .001). Tachyarrhythmias, anemia, and respiratory failure were the most prevalent mechanisms causing type 2 Myocardial Infarction. Conclusions In a cohort of patients with Myocardial Infarction who were admitted consecutively through 1 year, the category of type 2 Myocardial Infarction comprised one fourth when diagnosed by the use of newly developed criteria. Approximately half of patients with type 2 Myocardial Infarction had no significant coronary artery disease.
Kristian Thygesen - One of the best experts on this subject based on the ideXlab platform.
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Classification of Myocardial Infarction: frequency and features of type 2 Myocardial Infarction
The American Journal of Medicine, 2013Co-Authors: Lotte Saaby, Tina Svenstrup Poulsen, Susanne Hosbond, Torben Bjerregaard Larsen, Axel Cosmus Pyndt Diederichsen, Jesper Hallas, Kristian Thygesen, Hans MickleyAbstract:Abstract Background The classification of Myocardial Infarction into 5 types was introduced in 2007 as an important component of the universal definition. In contrast to the plaque rupture–related type 1 Myocardial Infarction, type 2 Myocardial Infarction is considered to be caused by an imbalance between demand and supply of oxygen in the myocardium. However, no specific criteria for type 2 Myocardial Infarction have been established. Methods We prospectively studied unselected hospital patients who had cardiac troponin I measured on clinical indication. The diagnosis and classification of Myocardial Infarction were established, and the frequency and features of type 2 Myocardial Infarction were investigated by use of novel developed criteria. Results From January 2010 to January 2011, a total of 7230 consecutive patients who had cardiac troponin I measured were evaluated, and 4499 patients qualified for inclusion. The diagnosis of Myocardial Infarction was established in 553 patients, of whom 386 (72%) had a type 1 Myocardial Infarction and 144 (26%) had a type 2 Myocardial Infarction. Patients in the group with type 2 Myocardial Infarction were older and more likely to be female, and had more comorbidities. The proportion of patients without significant coronary artery disease was higher in those with type 2 Myocardial Infarction (45%) than in those with type 1 Myocardial Infarction (12%) ( P .001). Tachyarrhythmias, anemia, and respiratory failure were the most prevalent mechanisms causing type 2 Myocardial Infarction. Conclusions In a cohort of patients with Myocardial Infarction who were admitted consecutively through 1 year, the category of type 2 Myocardial Infarction comprised one fourth when diagnosed by the use of newly developed criteria. Approximately half of patients with type 2 Myocardial Infarction had no significant coronary artery disease.
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universal definition of Myocardial Infarction
Racionalʹnaâ Farmakoterapiâ v Kardiologii, 2008Co-Authors: Kristian Thygesen, Joseph S Alpert, Harvey D WhiteAbstract:Myocardial Infarction is a major cause of death and disability worldwide. Coronary atherosclerosis is a chronic disease with stable and unstable periods. During unstable periods with activated inflammation in the vascular wall, patients may develop a Myocardial Infarction. Myocardial Infarction may be a minor event in a lifelong chronic disease, it may even go undetected, but it may also be a major catastrophic event leading to sudden death or severe hemodynamic deterioration. A Myocardial Infarction may be the first manifestation of coronary artery disease, or it may occur, repeatedly, in patients with established disease. Information on Myocardial Infarction attack rates can provide useful data regarding the burden of coronary artery disease within and across populations, especially if standardized data are collected in a manner that demonstrates the distinction between incident and recurrent events. From the epidemiological point of view, the incidence of Myocardial Infarction in a population can be used as a proxy for the prevalence of coronary artery disease in that population. Furthermore, the term Myocardial Infarction has major psychological and legal implications for the individual and society. It is an indicator of one of the leading health problems in the world, and it is an outcome measure in clinical trials and observational studies. With these perspectives, Myocardial Infarction may be defined from a number of different clinical, electrocardiographic, biochemical, imaging, and pathological characteristics. In the past, a general consensus existed for the clinical syndrome designated as Myocardial Infarction. In studies of disease prevalence, the World Health Organization (WHO) defined Myocardial Infarction from symptoms, ECG abnormalities, and enzymes. However, the development of more sensitive and specific serological biomarkers and precise imaging techniques allows detection of ever smaller amounts of Myocardial necrosis. Accordingly, current clinical practice, health care delivery systems, as well as epidemiology and clinical trials all require a …
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universal definition of Myocardial Infarction
European Heart Journal, 2007Co-Authors: Kristian Thygesen, Harvey D White, Joseph S Alpert, Allan S Jaffe, Fred S Apple, Marcello Galvani, Hugo A Katus, Kristin L Newby, Jan Ravkilde, Bernard R ChaitmanAbstract:![Graphic][1] Myocardial Infarction is a major cause of death and disability worldwide. Coronary atherosclerosis is a chronic disease with stable and unstable periods. During unstable periods with activated inflammation in the vascular wall, patients may develop a Myocardial Infarction. Myocardial Infarction may be a minor event in a lifelong chronic disease, it may even go undetected, but it may also be a major catastrophic event leading to sudden death or severe haemodynamic deterioration. A Myocardial Infarction may be the first manifestation of coronary artery disease, or it may occur, repeatedly, in patients with established disease. Information on Myocardial Infarction attack rates can provide useful data regarding the burden of coronary artery disease within and across populations, especially if standardized data are collected in a manner that demonstrates the distinction between incident and recurrent events. From the epidemiological point of view, the incidence of Myocardial Infarction in a population can be used as a proxy for the prevalence of coronary artery disease in that population. Furthermore, the term Myocardial Infarction has major psychological and legal implications for the individual and society. It is an indicator of one of the leading health problems in the world, and it is an outcome measure in clinical trials and observational studies. With these perspectives, Myocardial Infarction may be defined from a number of different clinical, electrocardiographic, biochemical, imaging, and pathological characteristics. In the past, a general consensus existed for the clinical syndrome designated as Myocardial Infarction. In studies of disease prevalence, the World Health Organization (WHO) defined Myocardial Infarction from symptoms, ECG abnormalities, and enzymes. However, the development of more sensitive and specific serological biomarkers and precise imaging techniques allows detection of ever smaller amounts of Myocardial necrosis. Accordingly, current clinical practice, health care delivery systems, as well as epidemiology and clinical trials all require a … [1]: /embed/inline-graphic-1.gif
Lotte Saaby - One of the best experts on this subject based on the ideXlab platform.
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Classification of Myocardial Infarction: frequency and features of type 2 Myocardial Infarction
The American Journal of Medicine, 2013Co-Authors: Lotte Saaby, Tina Svenstrup Poulsen, Susanne Hosbond, Torben Bjerregaard Larsen, Axel Cosmus Pyndt Diederichsen, Jesper Hallas, Kristian Thygesen, Hans MickleyAbstract:Abstract Background The classification of Myocardial Infarction into 5 types was introduced in 2007 as an important component of the universal definition. In contrast to the plaque rupture–related type 1 Myocardial Infarction, type 2 Myocardial Infarction is considered to be caused by an imbalance between demand and supply of oxygen in the myocardium. However, no specific criteria for type 2 Myocardial Infarction have been established. Methods We prospectively studied unselected hospital patients who had cardiac troponin I measured on clinical indication. The diagnosis and classification of Myocardial Infarction were established, and the frequency and features of type 2 Myocardial Infarction were investigated by use of novel developed criteria. Results From January 2010 to January 2011, a total of 7230 consecutive patients who had cardiac troponin I measured were evaluated, and 4499 patients qualified for inclusion. The diagnosis of Myocardial Infarction was established in 553 patients, of whom 386 (72%) had a type 1 Myocardial Infarction and 144 (26%) had a type 2 Myocardial Infarction. Patients in the group with type 2 Myocardial Infarction were older and more likely to be female, and had more comorbidities. The proportion of patients without significant coronary artery disease was higher in those with type 2 Myocardial Infarction (45%) than in those with type 1 Myocardial Infarction (12%) ( P .001). Tachyarrhythmias, anemia, and respiratory failure were the most prevalent mechanisms causing type 2 Myocardial Infarction. Conclusions In a cohort of patients with Myocardial Infarction who were admitted consecutively through 1 year, the category of type 2 Myocardial Infarction comprised one fourth when diagnosed by the use of newly developed criteria. Approximately half of patients with type 2 Myocardial Infarction had no significant coronary artery disease.
Robert C. Hendel - One of the best experts on this subject based on the ideXlab platform.
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Myocardial Infarction in women
The Cardiology, 1995Co-Authors: Maria A. Mendelson, Robert C. HendelAbstract:Cardiovascular disease is the leading cause of mortality in the United States regardless of gender. Women infrequently present with Myocardial Infarction as the initial presentation of coronary heart disease and have unrecognized Infarctions more frequently than men. Myocardial Infarction in women has a similar clinical presentation as in men, with the exception of an increased incidence of non-Q wave Myocardial Infarctions. Complications of acute Infarction in women are probably similar although the majority of data has been drawn from studies involving predominantly men. Women do however experience more strokes and have less postInfarction pericarditis than their male counterparts. Left ventricular function remains the key prognostic determinant in both sexes. Recurrent Infarction is increased in women with resultant elevated mortality rates. However, complex ventricular ectopy following Myocardial Infarction is not predictive of cardiovascular mortality in women. Early and late survival is decreased in women, an effect probably related to the increase in mean age of women as compared with men. Overall, gender distinctions are not usually made in the majority of studies involving Myocardial Infarction. As epidemiologic, pathophysiologic and clinical factors may be different regarding heart disease in women, further research in this important area is warranted.
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Myocardial Infarction in women
The Cardiology, 1995Co-Authors: Maria A. Mendelson, Robert C. HendelAbstract:Cardiovascular disease is the leading cause of mortality in the United States regardless of gender. Women infrequently present with Myocardial Infarction as the initial presentation of coronary heart disease and have unrecognized Infarctions more frequently than men. Myocardial Infarction in women has a similar clinical presentation as in men, with the exception of an increased incidence of non-Q wave Myocardial Infarctions. Complications of acute Infarction in women are probably similar although the majority of data has been drawn from studies involving predominantly men. Women do however experience more strokes and have less postInfarction pericarditis than their male counterparts. Left ventricular function remains the key prognostic determinant in both sexes. Recurrent Infarction is increased in women with resultant elevated mortality rates. However, complex ventricular ectopy following Myocardial Infarction is not predictive of cardiovascular mortality in women. Early and late survival is decreased in women, an effect probably related to the increase in mean age of women as compared with men. Overall, gender distinctions are not usually made in the majority of studies involving Myocardial Infarction. As epidemiologic, pathophysiologic and clinical factors may be different regarding heart disease in women, further research in this important area is warranted.
Stefanie Dimmeler - One of the best experts on this subject based on the ideXlab platform.
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MicroRNAs in Myocardial Infarction
Nature Reviews Cardiology, 2015Co-Authors: Reinier A. Boon, Stefanie DimmelerAbstract:Tissue injury and inflammation regulate microRNAs in the heart after Myocardial Infarction MicroRNAs control many processes in the infarcted heart, such as cardiomyocyte cell death and proliferation, neovascularization, and progenitor-cell-mediated repair Acute inhibition or overexpression of microRNAs after Myocardial Infarction might be useful to limit tissue injury and improve neovascularization to prevent long-term negative remodelling and heart failure Using microRNAs to induce cardiac regeneration by direct cardiac reprogramming of fibroblasts or by inducing cardiomyocyte proliferation offers new therapeutic opportunities MicroRNAs (miRNAs) are small noncoding RNAs that block translation or induce degradation of mRNA and thereby control patterns of gene expression. Acute Myocardial Infarction is a common cardiovascular event that results in cardiac remodelling and can consequently lead to the development of chronic heart failure. Several miRNAs have been shown to control important processes that contribute to the pathophysiological consequences of acute Myocardial Infarction. miRNAs can either promote or inhibit cardiomyocyte cell death, and also regulate postischaemic neovascularization. Cardiac regeneration can also be regulated by miRNAs that control cardiomyocyte proliferation or interfere with cardioprotective effects mediated by stem or progenitor cells. miRNAs can also be used for direct reprogramming of cardiac fibroblasts into cardiomyocytes. In this Review, we focus on the current understanding of the role of miRNAs in these processes, and particularly discuss the therapeutic potential of miRNAs in treating acute Myocardial Infarction. MicroRNAs regulate the processes that underlie cardiac remodelling after Myocardial Infarction, including angiogenesis and cardiomyocyte apoptosis and proliferation. In this Review, Boon and Dimmeler summarize the microRNAs that are involved with these postischaemic pathways, and discuss potential therapeutic interventions to enhance cardiac regeneration in patients with acute Myocardial Infarction.
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MicroRNAs in Myocardial Infarction.
Nature reviews. Cardiology, 2014Co-Authors: Reinier A. Boon, Stefanie DimmelerAbstract:MicroRNAs regulate the processes that underlie cardiac remodelling after Myocardial Infarction, including angiogenesis and cardiomyocyte apoptosis and proliferation. In this Review, Boon and Dimmeler summarize the microRNAs that are involved with these postischaemic pathways, and discuss potential therapeutic interventions to enhance cardiac regeneration in patients with acute Myocardial Infarction.
