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Robert J. Collins - One of the best experts on this subject based on the ideXlab platform.
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Fine needle aspiration cytology of epithelial-Myoepithelial Carcinoma of salivary glands. A report of three cases.
Acta Cytologica, 1999Co-Authors: Waikuen Ng, Carolyn Choy, Philip P.c. Ip, Wai-hung Shek, Robert J. CollinsAbstract:BACKGROUND: Epithelial-Myoepithelial Carcinoma is a rare, low grade malignant tumor of the salivary glands. Histologically, it has a biphasic cellular composition and exhibits a high degree of differentiation. The fine needle aspiration cytology of this rare tumor is rarely described in the literature. CASES: We report the fine needle aspiration cytology of three epithelial-Myoepithelial Carcinomas, arising in the right parotid, left parotid and minor salivary gland of the hard palate. Cytology showed a biphasic population consisting of cells of ductal epithelial and Myoepithelial origin arranged in small clusters and sheets. The Myoepithelial cells had small, uniform nuclei; ample, clear cytoplasm and distinct cell borders, while the ductal epithelial cells had larger, mildly pleomorphic nuclei and scanty cytoplasm. These ductal cells tended to form tubules among background sheets of clear Myoepithelial cells. This feature, if present, was an important diagnostic clue. Hyaline material surrounding cell clusters and focal adenoid cystic Carcinoma-like areas with orangeophilic globules were also not uncommon. CONCLUSION: While the cytologic appearance of epithelial-Myoepithelial Carcinoma may closely mimic that of other salivary gland tumors, such as adenoid cystic Carcinoma, pleomorphic adenoma and basal cell adenoma, certain peculiar cytologic features may allow a distinction to be made on fine needle aspiration biopsy.
Waikuen Ng - One of the best experts on this subject based on the ideXlab platform.
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Fine needle aspiration cytology of epithelial-Myoepithelial Carcinoma of salivary glands. A report of three cases.
Acta Cytologica, 1999Co-Authors: Waikuen Ng, Carolyn Choy, Philip P.c. Ip, Wai-hung Shek, Robert J. CollinsAbstract:BACKGROUND: Epithelial-Myoepithelial Carcinoma is a rare, low grade malignant tumor of the salivary glands. Histologically, it has a biphasic cellular composition and exhibits a high degree of differentiation. The fine needle aspiration cytology of this rare tumor is rarely described in the literature. CASES: We report the fine needle aspiration cytology of three epithelial-Myoepithelial Carcinomas, arising in the right parotid, left parotid and minor salivary gland of the hard palate. Cytology showed a biphasic population consisting of cells of ductal epithelial and Myoepithelial origin arranged in small clusters and sheets. The Myoepithelial cells had small, uniform nuclei; ample, clear cytoplasm and distinct cell borders, while the ductal epithelial cells had larger, mildly pleomorphic nuclei and scanty cytoplasm. These ductal cells tended to form tubules among background sheets of clear Myoepithelial cells. This feature, if present, was an important diagnostic clue. Hyaline material surrounding cell clusters and focal adenoid cystic Carcinoma-like areas with orangeophilic globules were also not uncommon. CONCLUSION: While the cytologic appearance of epithelial-Myoepithelial Carcinoma may closely mimic that of other salivary gland tumors, such as adenoid cystic Carcinoma, pleomorphic adenoma and basal cell adenoma, certain peculiar cytologic features may allow a distinction to be made on fine needle aspiration biopsy.
Mitchell R. Gore - One of the best experts on this subject based on the ideXlab platform.
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Epithelial-Myoepithelial Carcinoma: a population-based survival analysis
BMC Ear Nose and Throat Disorders, 2018Co-Authors: Mitchell R. GoreAbstract:Epithelial-Myoepithelial Carcinoma is an uncommon malignant neoplasm seen most frequently in the salivary glands, representing approximately 1 to 2% of salivary gland tumors. Less than 600 cases have been reported in the literature since its initial description in 1972. The aim of this study was to examine demographic, site, stage, and survival factors in patients with epithelial-Myoepithelial Carcinoma. The 1973–2014 SEER (Surveillance, Epidemiology, and End Results) cancer database was queried for patients treated for epithelial-Myoepithelial Carcinoma. The data was analyzed for patient T (tumor), N (nodal), and M (metastasis) stage, tumor site, and demographic characteristics. The Kaplan-Meier model was used to estimate actuarial survival. A total of 468 patients were identified. White patients represented 78.0% of the total. There were 291 female patients and 177 male patients. Overall 5-, 10-, and 20-year survival was 72.7%, 59.5%, and 38.3%, respectively. Mean survival time was 165.5 months. Parotid gland was the most common site with 57.7% of patients, with submandibular gland representing 9.8% of patients. Distant metastasis (M) status was unknown in 33.3%, with 2.6% being M1, 3.0% being MX, and 61.1% M0. Nodal metastasis (N) status was unknown in 33.3%, while 4.4% were N+, 4.7% were NX, and 57.5% were N0. 88.2% of patients had surgery as part or all of the treatment regimen. Univariate Kaplan-Meier analysis showed that AJCC overall stage, primary tumor (T) stage, nodal (N) stage, presence of distant metastasis (M1), age at diagnosis, race, and non-surgical treatment significantly affected survival. On multivariate analysis age, race, AJCC stage, T, N, M stage, and treatment type were significant. Epithelial-Myoepithelial Carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival.
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Epithelial-Myoepithelial Carcinoma: a population-based survival analysis
BMC, 2018Co-Authors: Mitchell R. GoreAbstract:Abstract Background Epithelial-Myoepithelial Carcinoma is an uncommon malignant neoplasm seen most frequently in the salivary glands, representing approximately 1 to 2% of salivary gland tumors. Less than 600 cases have been reported in the literature since its initial description in 1972. The aim of this study was to examine demographic, site, stage, and survival factors in patients with epithelial-Myoepithelial Carcinoma. Methods The 1973–2014 SEER (Surveillance, Epidemiology, and End Results) cancer database was queried for patients treated for epithelial-Myoepithelial Carcinoma. The data was analyzed for patient T (tumor), N (nodal), and M (metastasis) stage, tumor site, and demographic characteristics. The Kaplan-Meier model was used to estimate actuarial survival. Results A total of 468 patients were identified. White patients represented 78.0% of the total. There were 291 female patients and 177 male patients. Overall 5-, 10-, and 20-year survival was 72.7%, 59.5%, and 38.3%, respectively. Mean survival time was 165.5 months. Parotid gland was the most common site with 57.7% of patients, with submandibular gland representing 9.8% of patients. Distant metastasis (M) status was unknown in 33.3%, with 2.6% being M1, 3.0% being MX, and 61.1% M0. Nodal metastasis (N) status was unknown in 33.3%, while 4.4% were N+, 4.7% were NX, and 57.5% were N0. 88.2% of patients had surgery as part or all of the treatment regimen. Univariate Kaplan-Meier analysis showed that AJCC overall stage, primary tumor (T) stage, nodal (N) stage, presence of distant metastasis (M1), age at diagnosis, race, and non-surgical treatment significantly affected survival. On multivariate analysis age, race, AJCC stage, T, N, M stage, and treatment type were significant. Conclusions Epithelial-Myoepithelial Carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival
Nalini Bhat - One of the best experts on this subject based on the ideXlab platform.
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epithelial Myoepithelial Carcinoma in the hard palate a case report
Acta Cytologica, 2010Co-Authors: Susan Cherian, Ratnakar Kulkarni, Nalini BhatAbstract:BACKGROUND: Epithelial-Myoepithelial Carcinoma (EMC) is an uncommon salivary gland tumor. CASE: EMC arising from the minor salivary gland of the hard palate is very rare. A 70-year-old man presented with a nodular swelling in the hard palate. Fine needle aspiration cytology revealed biphasic epithelial (small cell) and Myoepithelial (large/clear cell) clusters in a pseudopapillary and trabecular pattern. The cytology was reported as salivary gland neoplasm. The mass was excised and the histomorphology was suggestive of a low grade EMC. Immunohistochemistry demonstrated the biphasic nature of the tumor and confirmed the diagnosis of EMC. Follow-up for 2 years post surgery to date did not show any recurrence or metastases. CONCLUSION: Though exact cytologic typing of EMC was not possible; this case highlights the importance of awareness of this tumor in the differential diagnosis of biphasic tumors of the salivary gland.
Shinji Masuda - One of the best experts on this subject based on the ideXlab platform.
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sebaceous epithelial Myoepithelial Carcinoma of the salivary gland clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant
The American Journal of Surgical Pathology, 2008Co-Authors: Aya Shinozaki, Toshitaka Nagao, Mitsuyoshi Hirokawa, Hisako Endo, Noriko Kato, Koichi Mizobuchi, Masayo Komatsu, Toshihiko Igarashi, Munehiro Yokoyama, Shinji MasudaAbstract:Epithelial-Myoepithelial Carcinoma (EMC) of the salivary glands is an uncommon, low-grade malignant tumor. A recent report demonstrates sebaceous differentiation in this tumor even though its significance has never been documented as a precise histologic variant. Six cases of EMC exhibiting sebaceou
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An unusual case of epithelial-Myoepithelial Carcinoma of the liver
The American Journal of Surgical Pathology, 1999Co-Authors: Koichi Tsuneyama, Masahiro Hoso, Nobuo Matsuki, Naoko Kono, Masanobu Kitagawa, Shinji Masuda, Yasuni NakanumaAbstract:Abstract The authors present an unusual case of an epithelial-Myoepithelial Carcinoma of the liver in a 67-year-old man who was admitted for resection of a gastric adenoCarcinoma. At operation, a 3 x 3 cm mass in the right liver lobe was also removed. This mass consisted of duct-like structures with dual differentiation. The inner layer was composed of an epithelial lining, and the outer layer consisted of clear cells, all unrelated to the moderately well-differentiated gastric adenoCarcinoma. The clear cells were positive for S-100 and alpha-smooth muscle actin, suggesting Myoepithelial origin. The mass was considered to be low-grade epithelial-Myoepithelial Carcinoma. However, the patient had a history of an oral nodule present since childhood, resected 10 years previously. These slides were reviewed and revealed a mixture of clear cells and basal cells with squamous differentiation. In addition, there were duct-like structures with the two-layer pattern found in the liver tumor. This tumor had numerous mitotic figures and showed perineural invasion, suggesting a high grade of malignancy. These findings led to an interpretation of the oral tumor as also being epithelial-Myoepithelial Carcinoma, which had remained as "benign" for more than 50 years and subsequently underwent malignant transformation. During this long period, liver metastases may have occurred and remained low-grade. Alternatively, the liver and oral tumors may have arisen separately in the foregut during embryologic development, remaining low-grade until malignant transformation occurred.
