The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
German Gunther - One of the best experts on this subject based on the ideXlab platform.
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Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (
2013Co-Authors: Susana A. Sanchez, Enrico Gratton, Antonio L. Zanocco, Else Lemp, German GuntherAbstract:Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (MPS), R = C17H35 Stearic Acid Derivative (MSS).
Susana A. Sanchez - One of the best experts on this subject based on the ideXlab platform.
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Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (
2013Co-Authors: Susana A. Sanchez, Enrico Gratton, Antonio L. Zanocco, Else Lemp, German GuntherAbstract:Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (MPS), R = C17H35 Stearic Acid Derivative (MSS).
Felix Kratz - One of the best experts on this subject based on the ideXlab platform.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society, 2008Co-Authors: Felix KratzAbstract:Albumin is playing an increasing role as a drug carrier in the clinical setting. Principally, three drug delivery technologies can be distinguished: coupling of low-molecular weight drugs to exogenous or endogenous albumin, conjugation with bioactive proteins and encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in solid tumors forms the rationale for developing albumin-based drug delivery systems for tumor targeting. Clinically, a methotrexate-albumin conjugate, an albumin-binding prodrug of doxorubicin, i.e. the (6-maleimido)caproylhydrazone Derivative of doxorubicin (DOXO-EMCH), and an albumin paclitaxel nanoparticle (Abraxane) have been evaluated clinically. Abraxane has been approved for treating metastatic breast cancer. An alternative strategy is to bind a therapeutic peptide or protein covalently or physically to albumin to enhance its stability and half-life. This approach has been applied to peptides with antinociceptive, antidiabetes, antitumor or antiviral activity: Levemir, a Myristic Acid Derivative of insulin that binds to the fatty Acid binding sites of circulating albumin, has been approved for the treatment of diabetes. Furthermore, Albuferon, a fusion protein of albumin and interferon, is currently being assessed in phase III clinical trials for the treatment of hepatitis C and could become an alternative to pegylated interferon. This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.
Enrico Gratton - One of the best experts on this subject based on the ideXlab platform.
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Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (
2013Co-Authors: Susana A. Sanchez, Enrico Gratton, Antonio L. Zanocco, Else Lemp, German GuntherAbstract:Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (MPS), R = C17H35 Stearic Acid Derivative (MSS).
Antonio L. Zanocco - One of the best experts on this subject based on the ideXlab platform.
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Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (
2013Co-Authors: Susana A. Sanchez, Enrico Gratton, Antonio L. Zanocco, Else Lemp, German GuntherAbstract:Chemical structure of studied sucrose monoesters, R = C7H15 Octyl Acid Derivative (MOS), R = C9H19 Capric Acid Derivative (MCS), R = C11H23 Lauric Acid Derivative (MLS), R = C13H27 Myristic Acid Derivative (MMS), R = C15H31 Palmitic Acid Derivative (MPS), R = C17H35 Stearic Acid Derivative (MSS).
