The Experts below are selected from a list of 2631 Experts worldwide ranked by ideXlab platform
Lei Wang - One of the best experts on this subject based on the ideXlab platform.
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Antibacterial Triketone‐Phloroglucinol‐Triketone Adducts from Myrtus communis
Chemistry & biodiversity, 2020Co-Authors: Jiao‐wen Liu, Chao Liu, Xiao-jun Huang, Lei WangAbstract:Myrtucyclitones A-C ((+)- and (-)-1-3), three pairs of new triketone-phloroglucinol-triketone hybrids were isolated from the plant Myrtus communis. Their structures with absolute configurations were established by NMR analysis and chemical calculations. Myrtucyclitones B and C exhibited remarkable antibacterial effect.
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Phloroglucinol Derivatives from Myrtus communis 'Variegata' and Their Antibacterial Activities.
Chemistry & biodiversity, 2020Co-Authors: Ming Chen, Wen-jing Wang, Lei WangAbstract:Myrtucomvalones D-F, three new triketone-phloroglucinol-triketone adducts, and three known ones (myrtucommulone E, myrtucommulone D and callistenone D) were obtained from Myrtus communis 'Variegata'. Myrtucomvalone D is a pair of enantiomers which was further resolved into (+)-myrtucomvalone D and (-)-myrtucomvalone D by chiral HPLC. Their structures and complete stereochemistry were established from interpretation of NMR and crystallographic data and chemical calculations. Myrtucomvalone F, myrtucommulone D and callistenone D showed significant antibacterial activities.
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Isolation, Structure Elucidation, and Total Synthesis of Myrtuspirone A from Myrtus communis.
Organic letters, 2019Co-Authors: Min-jing Cheng, Chao Liu, Xin-yi Yang, Jia-qing Cao, Li-ping Zhong, Ying Wang, Xue-fu You, Lei WangAbstract:A pair of enantiomeric triketone–phloroglucinol hybrids, (+)- and (−)-Myrtuspirone A (1), featuring an unprecedented 3-isopropyl-3H-spiro[benzofuran-2,1′-cyclohexane] backbone, were isolated from the leaves of Myrtus communis. The absolute configuration of each enantiomer of 1 was determined by X-ray diffraction and chemical calculations. Furthermore, the gram-scale total syntheses of (±)-1 and (−)-1 were conducted in four steps using a Michael-N-iodosuccinimide (NIS)-mediated (3 + 2)-annulation reaction. Both (+)- and (−)-1 exhibited antibacterial activities against Gram-positive bacteria including multidrug-resistant strains.
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myrtucomvalones a c three unusual triketone sesquiterpene adducts from the leaves of Myrtus communis variegata
RSC Advances, 2017Co-Authors: Jia-qing Cao, Ming Chen, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
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Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’
RSC Advances, 2017Co-Authors: Ming Chen, Jia-qing Cao, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
Ming Chen - One of the best experts on this subject based on the ideXlab platform.
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Phloroglucinol Derivatives from Myrtus communis 'Variegata' and Their Antibacterial Activities.
Chemistry & biodiversity, 2020Co-Authors: Ming Chen, Wen-jing Wang, Lei WangAbstract:Myrtucomvalones D-F, three new triketone-phloroglucinol-triketone adducts, and three known ones (myrtucommulone E, myrtucommulone D and callistenone D) were obtained from Myrtus communis 'Variegata'. Myrtucomvalone D is a pair of enantiomers which was further resolved into (+)-myrtucomvalone D and (-)-myrtucomvalone D by chiral HPLC. Their structures and complete stereochemistry were established from interpretation of NMR and crystallographic data and chemical calculations. Myrtucomvalone F, myrtucommulone D and callistenone D showed significant antibacterial activities.
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myrtucomvalones a c three unusual triketone sesquiterpene adducts from the leaves of Myrtus communis variegata
RSC Advances, 2017Co-Authors: Jia-qing Cao, Ming Chen, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
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Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’
RSC Advances, 2017Co-Authors: Ming Chen, Jia-qing Cao, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
Ying Wang - One of the best experts on this subject based on the ideXlab platform.
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Isolation, Structure Elucidation, and Total Synthesis of Myrtuspirone A from Myrtus communis.
Organic letters, 2019Co-Authors: Min-jing Cheng, Chao Liu, Xin-yi Yang, Jia-qing Cao, Li-ping Zhong, Ying Wang, Xue-fu You, Lei WangAbstract:A pair of enantiomeric triketone–phloroglucinol hybrids, (+)- and (−)-Myrtuspirone A (1), featuring an unprecedented 3-isopropyl-3H-spiro[benzofuran-2,1′-cyclohexane] backbone, were isolated from the leaves of Myrtus communis. The absolute configuration of each enantiomer of 1 was determined by X-ray diffraction and chemical calculations. Furthermore, the gram-scale total syntheses of (±)-1 and (−)-1 were conducted in four steps using a Michael-N-iodosuccinimide (NIS)-mediated (3 + 2)-annulation reaction. Both (+)- and (−)-1 exhibited antibacterial activities against Gram-positive bacteria including multidrug-resistant strains.
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myrtucomvalones a c three unusual triketone sesquiterpene adducts from the leaves of Myrtus communis variegata
RSC Advances, 2017Co-Authors: Jia-qing Cao, Ming Chen, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
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Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’
RSC Advances, 2017Co-Authors: Ming Chen, Jia-qing Cao, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
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Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K
Organic letters, 2016Co-Authors: Chao Liu, Xiao-jun Huang, Ying Wang, Song Ang, Hai Yan Tian, Yuan Yuan Deng, Dong-mei Zhang, Lei WangAbstract:Five sesquiterpene-based meroterpenoids with three kinds of new skeletons [1, 2, 3, (+)-4, and (−)-4] were isolated from the leaves of Myrtus communis. Compound 1 featured a new carbon skeleton with an unprecedented octahydrospiro[bicyclo[7.2.0]undecane-2,2′-chromene] tetracyclic ring system, which possessed two preferred conformations detected by variable-temperature NMR spectroscopy experiments. In addition, the structure of reported myrtucommulone K was revised to be compound 3. The plausible biosynthetic pathways of these meroterpenoids and their cytotoxicities are discussed.
Jia-qing Cao - One of the best experts on this subject based on the ideXlab platform.
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Isolation, Structure Elucidation, and Total Synthesis of Myrtuspirone A from Myrtus communis.
Organic letters, 2019Co-Authors: Min-jing Cheng, Chao Liu, Xin-yi Yang, Jia-qing Cao, Li-ping Zhong, Ying Wang, Xue-fu You, Lei WangAbstract:A pair of enantiomeric triketone–phloroglucinol hybrids, (+)- and (−)-Myrtuspirone A (1), featuring an unprecedented 3-isopropyl-3H-spiro[benzofuran-2,1′-cyclohexane] backbone, were isolated from the leaves of Myrtus communis. The absolute configuration of each enantiomer of 1 was determined by X-ray diffraction and chemical calculations. Furthermore, the gram-scale total syntheses of (±)-1 and (−)-1 were conducted in four steps using a Michael-N-iodosuccinimide (NIS)-mediated (3 + 2)-annulation reaction. Both (+)- and (−)-1 exhibited antibacterial activities against Gram-positive bacteria including multidrug-resistant strains.
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myrtucomvalones a c three unusual triketone sesquiterpene adducts from the leaves of Myrtus communis variegata
RSC Advances, 2017Co-Authors: Jia-qing Cao, Ming Chen, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
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Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’
RSC Advances, 2017Co-Authors: Ming Chen, Jia-qing Cao, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
Li Feng Chen - One of the best experts on this subject based on the ideXlab platform.
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myrtucomvalones a c three unusual triketone sesquiterpene adducts from the leaves of Myrtus communis variegata
RSC Advances, 2017Co-Authors: Jia-qing Cao, Ming Chen, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
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Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’
RSC Advances, 2017Co-Authors: Ming Chen, Jia-qing Cao, Ying Wang, Li Feng Chen, Lei WangAbstract:Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).
