The Experts below are selected from a list of 2517 Experts worldwide ranked by ideXlab platform
William Kitching - One of the best experts on this subject based on the ideXlab platform.
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sex pheromone biosynthesis in the female olive fruit fly double labelling from 18o2 dioxygen into 1 7 dioxaspiro 5 5 Undecane
Chemical Communications, 2002Co-Authors: Mary T Fletcher, B E Mazomenos, John H Georgakopoulos, M A Konstantopoulou, Barry J Wood, James J De Voss, William KitchingAbstract:The demonstration that both oxygen atoms of 1,7-dioxaspiro[5.5]Undecane (1), the sex-pheromone of the female olive fly, originate from dioxygen, strongly implicates monooxygenase mediated processes in assembly of (1), and reveals unexpected complexity in the formation of its nine-carbon precursor.
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from r pulegone to 2s 4r 6r 8s 2 4 8 trimethyl 1 7 dioxaspiro 5 5 Undecane a unique spiroacetal from the insect kingdom
Tetrahedron-asymmetry, 1995Co-Authors: Yong Q Tu, Christopher J Moore, William KitchingAbstract:Enantioselective syntheses of the unique, insect-derived spiroacetal, (2S,4R,6R,8S)-2,4,8-trimethyl-1,7-dioxaspiro[5.5]Undecane and some diastereomers, utilising (R)-(+)-pulegone as chiral source-material, and asymmetric dihydroxylation as a key step, are described.
M. Date - One of the best experts on this subject based on the ideXlab platform.
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rifm fragrance ingredient safety assessment 7 9 dimethylspiro 5 5 undecan 3 one cas registry number 83863 64 3
Food and Chemical Toxicology, 2021Co-Authors: A.m. Api, D. Belsito, S. Biserta, D. Botelho, Magnus Bruze, G. A. Burton, J. Buschmann, M.a. Cancellieri, Maria Lúcia Zaidan Dagli, M. DateAbstract:The existing information supports the use of this material as described in this safety assessment. 7,9-Dimethylspiro[5.5]undecan-3-one was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 7,9-dimethylspiro[5.5]undecan-3-one is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class II material, and the exposure to 7,9-dimethylspiro[5.5]undecan-3-one is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). Based on the existing data and readacross material spiro[5.5]undec-8-en-1-one, 2,2,7,9-tetramethyl- (CAS # 502847-01-0), 7,9-dimethylspiro[5.5]undecan-3-one presents no concern for skin sensitization under the current, declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on data and ultraviolet (UV) spectra; 7,9-dimethylspiro[5.5]undecan-3-one is not phototoxic/photoallergenic. The environmental endpoints were evaluated; 7,9-dimethylspiro[5.5]undecan-3-one was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
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RIFM fragrance ingredient safety assessment, Undecane, CAS Registry Number 1120-21-4
Food and Chemical Toxicology, 2020Co-Authors: A.m. Api, D. Belsito, S. Biserta, D. Botelho, Magnus Bruze, G. A. Burton, J. Buschmann, M.a. Cancellieri, Maria Lúcia Zaidan Dagli, M. DateAbstract:Summary: The existing information supports the use of this material as described in this safety assessment. Undecane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog nonane (CAS # 111-84-2) show that Undecane is not expected to be genotoxic. Data on Undecane provide a calculated Margin of Exposure (MOE) >100 for the repeated dose and reproductive toxicity endpoints. Based on existing data and the application of the Dermal Sensitization Threshold (DST), Undecane does not present a safety concern for skin sensitization under the current, declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; Undecane is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to Undecane is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; Undecane was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC [Predicted Environmental Concentration/Predicted No Effect Concentration]), are
Jitender M Khurana - One of the best experts on this subject based on the ideXlab platform.
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an efficient catalyst free synthesis of nitrogen containing spiro heterocycles via 5 1 double michael addition reaction
RSC Advances, 2014Co-Authors: Komal Aggarwal, Kanika Vij, Jitender M KhuranaAbstract:2,4-Diazaspiro[5.5]Undecane-1,3,5,9-tetraones and 3-thioxo-2,4-diazaspiro[5.5]Undecane-1,5,9-triones have been synthesized via double Michael addition of 1,5-diaryl-1,4-pentadien-3-one with active methylene compounds such as N,N-dimethyl barbituric acid, barbituric acid, thio-barbituric acid and N,N-diphenyl thiobarbituric acid in ethylene glycol at 100 °C in the absence of any catalyst to give high yields within a short reaction time. The structure has been confirmed by X-ray analysis. The single-crystal structure of the diazaspiro compound revealed that the CAr–H⋯π, π–π stacking and intermolecular hydrogen bonding interactions act as major driving forces for crystal packing.
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7 11 diaryl 2 4 diazaspiro 5 5 Undecane 1 5 9 triones a new series of spiroheterocycles
Heterocycles, 2007Co-Authors: Jitender M Khurana, Reema Arora, Sarishti SatijaAbstract:A novel two step synthesis of 7,11 -diaryl-2,4-diazaspiro[5.5]Undecane-1,5,9-triones has been reported based on double Michael addition of 2-thiobarbiturates or N,N'-diaryl-2-thiobarbiturates with dibenzalacetones followed by reductive desulfurization with nickel boride.
Eiji Osawa - One of the best experts on this subject based on the ideXlab platform.
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attempted transformation of 2 3 5 6 tetrachloro 4 4 dimethoxypentacyclo 5 4 0 02 6 03 10 05 9 Undecane 8 11 dione toward pentaprismane retaining chloro group
Bulletin of the Chemical Society of Japan, 1992Co-Authors: Vishwakarma Singh, Akio Furusaki, Carlos Jaime, Takeshi Matsumoto, Eiji OsawaAbstract:An attempt towards synthesis of homohypostrophene derivative, 1,2,6,8-tetrachloro-7,7-dimethoxytetracyclo[6.3.0.02,6.05,9]undeca-3,10-diene from 2,3,5,6-tetrachloro-4,4-dimethoxypentacyclo[5.4.0.02,6.03,10.05,9]Undecane-8,11-dione is described.
Kenji Mori - One of the best experts on this subject based on the ideXlab platform.
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enzymatic preparation of 4r 6r 4 hydroxy 1 7 dioxaspiro 5 5 Undecane and its antipode the minor component of the olive fruit fly pheromone
Bioorganic & Medicinal Chemistry, 1996Co-Authors: Yūsuke Yokoyama, Hirosato Takikawa, Kenji MoriAbstract:Abstract (4S,6S)-4-Hydroxy-1,7-dioxaspiro[5.5]Undecane (2) and (4R,6R)-4-acetoxy-1,7-dioxaspiro[5.5]Undecane (3) were prepared by asymmetric hydrolysis of (±)-3 with pig liver esterase.
