The Experts below are selected from a list of 30348 Experts worldwide ranked by ideXlab platform
Elaine T Freund - One of the best experts on this subject based on the ideXlab platform.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. Results: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. Conclusion: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
Dennis G Thomas - One of the best experts on this subject based on the ideXlab platform.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. Results: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. Conclusion: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
Fred Klaessig - One of the best experts on this subject based on the ideXlab platform.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. Results: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. Conclusion: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
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Understanding biophysicochemical interactions at the nano-bio interface
Nature Materials, 2009Co-Authors: Andre E. Nel, Fred Klaessig, Eric M.v. Hoek, Ponisseril Somasundaran, Tian Xia, Lutz Mädler, Vincent Castranova, Darrell Velegol, Mike ThompsonAbstract:Rapid growth in nanotechnology is increasing the likelihood of engineered Nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the Nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by Nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of Nanomaterials.
David S Paik - One of the best experts on this subject based on the ideXlab platform.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. Results: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. Conclusion: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
Grace A Stafford - One of the best experts on this subject based on the ideXlab platform.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. Results: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. Conclusion: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
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isa tab nano a specification for sharing Nanomaterial research data in spreadsheet based format
BMC Biotechnology, 2013Co-Authors: Dennis G Thomas, Fred Klaessig, Sharon Gaheen, Stacey L Harper, Martin Fritts, Elizabeth Hahndantona, David S Paik, Sue Pan, Grace A Stafford, Elaine T FreundAbstract:The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of Nanomaterials. Owing to the lack of standardization in representing and sharing Nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of Nanomaterials. We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of Nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of Nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing Nanomaterial descriptions and assay metadata. The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate Nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
