The Experts below are selected from a list of 20493 Experts worldwide ranked by ideXlab platform
Feng Chen - One of the best experts on this subject based on the ideXlab platform.
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vesicle like Nanospheres of amorphous calcium phosphate sonochemical synthesis using the adenosine 5 triphosphate disodium salt and their application in ph responsive drug delivery
Journal of Materials Chemistry B, 2015Co-Authors: Yingjie Zhu, Yonggang Zhang, Yingying Jiang, Feng ChenAbstract:A rapid and simple strategy is reported for the synthesis of amorphous calcium phosphate (ACP) vesicle-like Nanospheres using the adenosine 5′-triphosphate (ATP) disodium salt as a biocompatible phosphorus source and stabilizer by the sonochemical method in mixed solvents of water and ethylene glycol (EG). The ACP vesicle-like Nanospheres are characterized by X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV/Vis absorption spectroscopy, thermogravimetric (TG) analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), dynamic light scattering (DLS) and Brunauer–Emmett–Teller (BET) nitrogen adsorption. The ACP vesicle-like Nanospheres exhibit essentially inappreciable toxicity to the cells in vitro. Furthermore, the as-prepared ACP vesicle-like Nanospheres can be used as anticancer drug nanocarriers and show a pH-responsive drug release behaviour using doxorubicin (Dox) as a model drug. The ACP vesicle-like nanosphere drug delivery system exhibits a high ability to damage cancer cells, thus, it is promising for application in pH-responsive drug delivery.
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highly stable amorphous calcium phosphate porous Nanospheres microwave assisted rapid synthesis using atp as phosphorus source and stabilizer and their application in anticancer drug delivery
Chemistry: A European Journal, 2013Co-Authors: Chao Qi, Xinyu Zhao, Bingqiang Lu, Qili Tang, Jing Zhao, Feng ChenAbstract:: Highly stable amorphous calcium phosphate (ACP) porous Nanospheres with a relatively uniform size and an average pore diameter of about 10 nm have been synthesized by using a microwave-assisted hydrothermal method with adenosine 5'-triphosphate disodium salt (ATP) as the phosphorus source and stabilizer. The as-prepared ACP porous Nanospheres have a high stability in the phosphate buffer saline (PBS) solution for more than 150 h without phase transformation to hydroxyapatite, and the morphology and size were essentially not changed. The important role of ATP and effects of experimental conditions on the formation of ACP porous Nanospheres were also investigated. The ACP porous Nanospheres were characterized by X-ray powder diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). This method is facile, rapid, surfactant-free and environmentally friendly. The as-prepared ACP porous Nanospheres are efficient for anticancer drug (docetaxel) loading and release. The ACP porous nanosphere drug-delivery system with docetaxel shows a high ability to damage tumor cells, thus, is promising for the application in anticancer treatment.
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highly stable amorphous calcium phosphate porous Nanospheres microwave assisted rapid synthesis using atp as phosphorus source and stabilizer and their application in anticancer drug delivery
Chemistry: A European Journal, 2013Co-Authors: Yingjie Zhu, Xinyu Zhao, Qili Tang, Jing Zhao, Feng ChenAbstract:Highly stable amorphous calcium phosphate (ACP) porous Nanospheres with a relatively uniform size and an average pore diameter of about 10 nm have been synthesized by using a microwave-assisted hydrothermal method with adenosine 5'-triphosphate disodium salt (ATP) as the phosphorus source and stabilizer. The as-prepared ACP porous Nanospheres have a high stability in the phosphate buffer saline (PBS) solution for more than 150 h without phase transformation to hydroxyapatite, and the morphology and size were essentially not changed. The important role of ATP and effects of experimental conditions on the formation of ACP porous Nanospheres were also investigated. The ACP porous Nanospheres were characterized by X-ray powder diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). This method is facile, rapid, surfactant-free and environmentally friendly. The as-prepared ACP porous Nanospheres are efficient for anticancer drug (docetaxel) loading and release. The ACP porous nanosphere drug-delivery system with docetaxel shows a high ability to damage tumor cells, thus, is promising for the application in anticancer treatment.
Yoshiaki Kawashima - One of the best experts on this subject based on the ideXlab platform.
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establishing chitosan coated plga nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery
International Journal of Pharmaceutics, 2008Co-Authors: Kohei Tahara, Takeshi Sakai, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshiaki KawashimaAbstract:Abstract The purpose of this paper was to establish the surface modified poly( d , l -lactide- co -glycolide) (PLGA) nanosphere platform with chitosan (CS) for gene delivery by using the emulsion solvent diffusion (ESD) method. The advantages of this method are a simple process under mild conditions without sonication. This method requires essentially dissolving both polymer and drug in the organic solvent. Therefore a hydrophilic drug such as nucleic acid is hardly applied to the ESD method. Nucleic acid can easily form an ion-complex with cationic compound, which can be dissolved in the organic solvent. Thereafter, nucleic acid solubility for organic solution can increase by complexation with cationic compound. We used DOTAP as a cationic compound to increase the loading efficiency of nucleic acid. By coating the PLGA Nanospheres with CS, the loading efficiency of nucleic acid in the modified Nanospheres increased significantly. The release profile of nucleic acid from PLGA Nanospheres exhibited sustained release after initial burst. The PLGA Nanospheres coated with chitosan reduced the initial burst of nucleic acid release and prolonged the drugs releasing at later stage. Chitosan coated PLGA nanosphere platform was established to encapsulate satisfactorily wide variety of nucleic acid for an acceptable gene delivery system.
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surface modified plga nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
Journal of Controlled Release, 2005Co-Authors: Hiromitsu Yamamoto, Yoshio Kuno, Shohei Sugimoto, Hirofumi Takeuchi, Yoshiaki KawashimaAbstract:Abstract Surface-modified dl -lactide/glycolide copolymer (PLGA) Nanospheres with chitosan (CS) were prepared by the emulsion solvent diffusion method for pulmonary delivery of peptide, i.e., elcatonin. The nanosphere suspension was successfully aerosolized with a nebulizer similar to the drug solution, whereas the microsphere suspensions could not be aerosolized. After pulmonary administration, CS-modified PLGA Nanospheres were more slowly eliminated from the lungs than unmodified PLGA Nanospheres. CS-modified PLGA Nanospheres loaded with elcatonin reduced blood calcium levels to 80% of the initial calcium concentration and prolonged the pharmacological action to 24 h, which was a significantly longer duration of action than that by CS-unmodified Nanospheres. These results were attributed to the retention of Nanospheres adhered to the bronchial mucus and lung tissue and sustained drug release at the adherence site. In addition, CS and CS on the surface of the Nanospheres enhanced the absorption of drug. The rank order of the absorption of the model drugs with CS solution was carboxyfluorescein>FITC–dextran-4 (FD-4; Mw. 4000)>FD-21 (Mw. 21,000)>FD70 (Mw. 70,000), which corresponded to the molecular weights ([Mw.] given in parentheses). The absorption-enhancing effect may have been caused by opening the intercellular tight junctions.
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prolonged anti inflammatory action of dl lactide glycolide copolymer Nanospheres containing betamethasone sodium phosphate for an intra articular delivery system in antigen induced arthritic rabbit
Pharmaceutical Research, 2002Co-Authors: Eijiro Horisawa, Tsuyoshi Hirota, Satoko Kawazoe, Hirofumi Takeuchi, Hiromitsu Yamamoto, Jun Yamada, Yoshiaki KawashimaAbstract:Purpose. The objective of the present study was to develop prolonged anti-inflammatory action of DL-lactide/glycolide copolymer (PLGA) nanosphere incorporating a water-soluble corticosteroid (betamethasone sodium phosphate; BSP). Another aim was to demonstrate the biocompatibility and biologic efficacy of these BSP-loaded Nanospheres directly administered into ovalbumin-induced chronic synovitis in the rabbit.
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mucoadhesive dl lactide glycolide copolymer Nanospheres coated with chitosan to improve oral delivery of elcatonin
Pharmaceutical Development and Technology, 2000Co-Authors: Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshio KunoAbstract:The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA Nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant Nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the Nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated Nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated Nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated Nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated Nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant Nanospheres did not differ markedly from that of uncoated Nanospheres. The chitosan-coated Nanospheres with elcatonin were administered intragastrically to fasted Wistar rats. The chitosan-coated nanosphere reduced significantly the blood calcium level compared with elcatonin solution and uncoated Nanospheres, and the reduced calcium level was sustained for a period of 48 hr. Even under nonfasting conditions, the mucoadhesion of chitosan-coated Nanospheres was unaltered and the reduction in blood Ca levels was maintained satisfactorily.
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mucoadhesive dl lactide glycolide copolymer Nanospheres coated with chitosan to improve oral delivery of elcatonin
Pharmaceutical Development and Technology, 2000Co-Authors: Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshio KunoAbstract:The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA Nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant Nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the Nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated Nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated Nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated Nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated Nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant nan...
Hiromitsu Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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establishing chitosan coated plga nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery
International Journal of Pharmaceutics, 2008Co-Authors: Kohei Tahara, Takeshi Sakai, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshiaki KawashimaAbstract:Abstract The purpose of this paper was to establish the surface modified poly( d , l -lactide- co -glycolide) (PLGA) nanosphere platform with chitosan (CS) for gene delivery by using the emulsion solvent diffusion (ESD) method. The advantages of this method are a simple process under mild conditions without sonication. This method requires essentially dissolving both polymer and drug in the organic solvent. Therefore a hydrophilic drug such as nucleic acid is hardly applied to the ESD method. Nucleic acid can easily form an ion-complex with cationic compound, which can be dissolved in the organic solvent. Thereafter, nucleic acid solubility for organic solution can increase by complexation with cationic compound. We used DOTAP as a cationic compound to increase the loading efficiency of nucleic acid. By coating the PLGA Nanospheres with CS, the loading efficiency of nucleic acid in the modified Nanospheres increased significantly. The release profile of nucleic acid from PLGA Nanospheres exhibited sustained release after initial burst. The PLGA Nanospheres coated with chitosan reduced the initial burst of nucleic acid release and prolonged the drugs releasing at later stage. Chitosan coated PLGA nanosphere platform was established to encapsulate satisfactorily wide variety of nucleic acid for an acceptable gene delivery system.
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surface modified plga nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
Journal of Controlled Release, 2005Co-Authors: Hiromitsu Yamamoto, Yoshio Kuno, Shohei Sugimoto, Hirofumi Takeuchi, Yoshiaki KawashimaAbstract:Abstract Surface-modified dl -lactide/glycolide copolymer (PLGA) Nanospheres with chitosan (CS) were prepared by the emulsion solvent diffusion method for pulmonary delivery of peptide, i.e., elcatonin. The nanosphere suspension was successfully aerosolized with a nebulizer similar to the drug solution, whereas the microsphere suspensions could not be aerosolized. After pulmonary administration, CS-modified PLGA Nanospheres were more slowly eliminated from the lungs than unmodified PLGA Nanospheres. CS-modified PLGA Nanospheres loaded with elcatonin reduced blood calcium levels to 80% of the initial calcium concentration and prolonged the pharmacological action to 24 h, which was a significantly longer duration of action than that by CS-unmodified Nanospheres. These results were attributed to the retention of Nanospheres adhered to the bronchial mucus and lung tissue and sustained drug release at the adherence site. In addition, CS and CS on the surface of the Nanospheres enhanced the absorption of drug. The rank order of the absorption of the model drugs with CS solution was carboxyfluorescein>FITC–dextran-4 (FD-4; Mw. 4000)>FD-21 (Mw. 21,000)>FD70 (Mw. 70,000), which corresponded to the molecular weights ([Mw.] given in parentheses). The absorption-enhancing effect may have been caused by opening the intercellular tight junctions.
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prolonged anti inflammatory action of dl lactide glycolide copolymer Nanospheres containing betamethasone sodium phosphate for an intra articular delivery system in antigen induced arthritic rabbit
Pharmaceutical Research, 2002Co-Authors: Eijiro Horisawa, Tsuyoshi Hirota, Satoko Kawazoe, Hirofumi Takeuchi, Hiromitsu Yamamoto, Jun Yamada, Yoshiaki KawashimaAbstract:Purpose. The objective of the present study was to develop prolonged anti-inflammatory action of DL-lactide/glycolide copolymer (PLGA) nanosphere incorporating a water-soluble corticosteroid (betamethasone sodium phosphate; BSP). Another aim was to demonstrate the biocompatibility and biologic efficacy of these BSP-loaded Nanospheres directly administered into ovalbumin-induced chronic synovitis in the rabbit.
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mucoadhesive dl lactide glycolide copolymer Nanospheres coated with chitosan to improve oral delivery of elcatonin
Pharmaceutical Development and Technology, 2000Co-Authors: Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshio KunoAbstract:The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA Nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant Nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the Nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated Nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated Nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated Nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated Nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant Nanospheres did not differ markedly from that of uncoated Nanospheres. The chitosan-coated Nanospheres with elcatonin were administered intragastrically to fasted Wistar rats. The chitosan-coated nanosphere reduced significantly the blood calcium level compared with elcatonin solution and uncoated Nanospheres, and the reduced calcium level was sustained for a period of 48 hr. Even under nonfasting conditions, the mucoadhesion of chitosan-coated Nanospheres was unaltered and the reduction in blood Ca levels was maintained satisfactorily.
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mucoadhesive dl lactide glycolide copolymer Nanospheres coated with chitosan to improve oral delivery of elcatonin
Pharmaceutical Development and Technology, 2000Co-Authors: Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshio KunoAbstract:The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA Nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant Nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the Nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated Nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated Nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated Nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated Nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant nan...
Hirofumi Takeuchi - One of the best experts on this subject based on the ideXlab platform.
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establishing chitosan coated plga nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery
International Journal of Pharmaceutics, 2008Co-Authors: Kohei Tahara, Takeshi Sakai, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshiaki KawashimaAbstract:Abstract The purpose of this paper was to establish the surface modified poly( d , l -lactide- co -glycolide) (PLGA) nanosphere platform with chitosan (CS) for gene delivery by using the emulsion solvent diffusion (ESD) method. The advantages of this method are a simple process under mild conditions without sonication. This method requires essentially dissolving both polymer and drug in the organic solvent. Therefore a hydrophilic drug such as nucleic acid is hardly applied to the ESD method. Nucleic acid can easily form an ion-complex with cationic compound, which can be dissolved in the organic solvent. Thereafter, nucleic acid solubility for organic solution can increase by complexation with cationic compound. We used DOTAP as a cationic compound to increase the loading efficiency of nucleic acid. By coating the PLGA Nanospheres with CS, the loading efficiency of nucleic acid in the modified Nanospheres increased significantly. The release profile of nucleic acid from PLGA Nanospheres exhibited sustained release after initial burst. The PLGA Nanospheres coated with chitosan reduced the initial burst of nucleic acid release and prolonged the drugs releasing at later stage. Chitosan coated PLGA nanosphere platform was established to encapsulate satisfactorily wide variety of nucleic acid for an acceptable gene delivery system.
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surface modified plga nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
Journal of Controlled Release, 2005Co-Authors: Hiromitsu Yamamoto, Yoshio Kuno, Shohei Sugimoto, Hirofumi Takeuchi, Yoshiaki KawashimaAbstract:Abstract Surface-modified dl -lactide/glycolide copolymer (PLGA) Nanospheres with chitosan (CS) were prepared by the emulsion solvent diffusion method for pulmonary delivery of peptide, i.e., elcatonin. The nanosphere suspension was successfully aerosolized with a nebulizer similar to the drug solution, whereas the microsphere suspensions could not be aerosolized. After pulmonary administration, CS-modified PLGA Nanospheres were more slowly eliminated from the lungs than unmodified PLGA Nanospheres. CS-modified PLGA Nanospheres loaded with elcatonin reduced blood calcium levels to 80% of the initial calcium concentration and prolonged the pharmacological action to 24 h, which was a significantly longer duration of action than that by CS-unmodified Nanospheres. These results were attributed to the retention of Nanospheres adhered to the bronchial mucus and lung tissue and sustained drug release at the adherence site. In addition, CS and CS on the surface of the Nanospheres enhanced the absorption of drug. The rank order of the absorption of the model drugs with CS solution was carboxyfluorescein>FITC–dextran-4 (FD-4; Mw. 4000)>FD-21 (Mw. 21,000)>FD70 (Mw. 70,000), which corresponded to the molecular weights ([Mw.] given in parentheses). The absorption-enhancing effect may have been caused by opening the intercellular tight junctions.
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prolonged anti inflammatory action of dl lactide glycolide copolymer Nanospheres containing betamethasone sodium phosphate for an intra articular delivery system in antigen induced arthritic rabbit
Pharmaceutical Research, 2002Co-Authors: Eijiro Horisawa, Tsuyoshi Hirota, Satoko Kawazoe, Hirofumi Takeuchi, Hiromitsu Yamamoto, Jun Yamada, Yoshiaki KawashimaAbstract:Purpose. The objective of the present study was to develop prolonged anti-inflammatory action of DL-lactide/glycolide copolymer (PLGA) nanosphere incorporating a water-soluble corticosteroid (betamethasone sodium phosphate; BSP). Another aim was to demonstrate the biocompatibility and biologic efficacy of these BSP-loaded Nanospheres directly administered into ovalbumin-induced chronic synovitis in the rabbit.
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mucoadhesive dl lactide glycolide copolymer Nanospheres coated with chitosan to improve oral delivery of elcatonin
Pharmaceutical Development and Technology, 2000Co-Authors: Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshio KunoAbstract:The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA Nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant Nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the Nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated Nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated Nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated Nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated Nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant Nanospheres did not differ markedly from that of uncoated Nanospheres. The chitosan-coated Nanospheres with elcatonin were administered intragastrically to fasted Wistar rats. The chitosan-coated nanosphere reduced significantly the blood calcium level compared with elcatonin solution and uncoated Nanospheres, and the reduced calcium level was sustained for a period of 48 hr. Even under nonfasting conditions, the mucoadhesion of chitosan-coated Nanospheres was unaltered and the reduction in blood Ca levels was maintained satisfactorily.
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mucoadhesive dl lactide glycolide copolymer Nanospheres coated with chitosan to improve oral delivery of elcatonin
Pharmaceutical Development and Technology, 2000Co-Authors: Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto, Yoshio KunoAbstract:The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA Nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant Nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the Nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated Nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated Nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated Nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated Nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant nan...
Yingjie Zhu - One of the best experts on this subject based on the ideXlab platform.
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vesicle like Nanospheres of amorphous calcium phosphate sonochemical synthesis using the adenosine 5 triphosphate disodium salt and their application in ph responsive drug delivery
Journal of Materials Chemistry B, 2015Co-Authors: Yingjie Zhu, Yonggang Zhang, Yingying Jiang, Feng ChenAbstract:A rapid and simple strategy is reported for the synthesis of amorphous calcium phosphate (ACP) vesicle-like Nanospheres using the adenosine 5′-triphosphate (ATP) disodium salt as a biocompatible phosphorus source and stabilizer by the sonochemical method in mixed solvents of water and ethylene glycol (EG). The ACP vesicle-like Nanospheres are characterized by X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV/Vis absorption spectroscopy, thermogravimetric (TG) analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), dynamic light scattering (DLS) and Brunauer–Emmett–Teller (BET) nitrogen adsorption. The ACP vesicle-like Nanospheres exhibit essentially inappreciable toxicity to the cells in vitro. Furthermore, the as-prepared ACP vesicle-like Nanospheres can be used as anticancer drug nanocarriers and show a pH-responsive drug release behaviour using doxorubicin (Dox) as a model drug. The ACP vesicle-like nanosphere drug delivery system exhibits a high ability to damage cancer cells, thus, it is promising for application in pH-responsive drug delivery.
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highly stable amorphous calcium phosphate porous Nanospheres microwave assisted rapid synthesis using atp as phosphorus source and stabilizer and their application in anticancer drug delivery
Chemistry: A European Journal, 2013Co-Authors: Yingjie Zhu, Xinyu Zhao, Qili Tang, Jing Zhao, Feng ChenAbstract:Highly stable amorphous calcium phosphate (ACP) porous Nanospheres with a relatively uniform size and an average pore diameter of about 10 nm have been synthesized by using a microwave-assisted hydrothermal method with adenosine 5'-triphosphate disodium salt (ATP) as the phosphorus source and stabilizer. The as-prepared ACP porous Nanospheres have a high stability in the phosphate buffer saline (PBS) solution for more than 150 h without phase transformation to hydroxyapatite, and the morphology and size were essentially not changed. The important role of ATP and effects of experimental conditions on the formation of ACP porous Nanospheres were also investigated. The ACP porous Nanospheres were characterized by X-ray powder diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). This method is facile, rapid, surfactant-free and environmentally friendly. The as-prepared ACP porous Nanospheres are efficient for anticancer drug (docetaxel) loading and release. The ACP porous nanosphere drug-delivery system with docetaxel shows a high ability to damage tumor cells, thus, is promising for the application in anticancer treatment.
