The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Rui Sun - One of the best experts on this subject based on the ideXlab platform.
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Benefits of local Tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database
Journal of translational medicine, 2017Co-Authors: Jian Sun, Zhongying Huang, Rui SunAbstract:There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary Nasopharynx Tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local Tumor excision and 79 (20.31%) received pharyngectomy. Local Tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age
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Benefits of local Tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database
BMC, 2017Co-Authors: Jian Sun, Zhongying Huang, Rui SunAbstract:Abstract Background There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. Methods 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary Nasopharynx Tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Results Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local Tumor excision and 79 (20.31%) received pharyngectomy. Local Tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age
Jian Sun - One of the best experts on this subject based on the ideXlab platform.
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Benefits of local Tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database
Journal of translational medicine, 2017Co-Authors: Jian Sun, Zhongying Huang, Rui SunAbstract:There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary Nasopharynx Tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local Tumor excision and 79 (20.31%) received pharyngectomy. Local Tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age
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Benefits of local Tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database
BMC, 2017Co-Authors: Jian Sun, Zhongying Huang, Rui SunAbstract:Abstract Background There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. Methods 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary Nasopharynx Tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Results Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local Tumor excision and 79 (20.31%) received pharyngectomy. Local Tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age
Zhongying Huang - One of the best experts on this subject based on the ideXlab platform.
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Benefits of local Tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database
Journal of translational medicine, 2017Co-Authors: Jian Sun, Zhongying Huang, Rui SunAbstract:There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary Nasopharynx Tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local Tumor excision and 79 (20.31%) received pharyngectomy. Local Tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age
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Benefits of local Tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database
BMC, 2017Co-Authors: Jian Sun, Zhongying Huang, Rui SunAbstract:Abstract Background There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. Methods 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary Nasopharynx Tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Results Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local Tumor excision and 79 (20.31%) received pharyngectomy. Local Tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age
Chuan-hung Sun - One of the best experts on this subject based on the ideXlab platform.
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Multifocal head and neck amyloidosis as a diagnostic clue of systemic lupus erythematosus (SLE): A case report.
Medicine, 2019Co-Authors: Chih-hao Chen, Chuan-hung SunAbstract:RATIONALE Amyloidosis accounts for 2% of head and neck Tumors. Amyloidosis that develops in the head and neck region is localized amyloidosis. Multifocal amyloidosis in the head and neck region is extremely rare. PATIENT CONCERNS The patient presented to the clinic of otolaryngology with nasal obstruction, anosmia and left neck mass for several months. DIAGNOSIS A left Nasopharynx Tumor was revealed under nasopharyngeal scope. Eosinophilic, proteinaceous material was revealed under a pathology scope in the Nasopharynx tissue and neck Tumor. Congo red staining demonstrated pale congophilic amorphous material with apple-green birefringence under cross-polarized light, and multifocal amyloidosis was diagnosed. Amyloidosis secondary to systemic lupus erythematosus (SLE) was confirmed after a series of investigations. INTERVENTIONS The patient underwent local excision for multifocal amyloidosis without following management. To control underlying SLE, the patient accepted steroid pulse therapy and immunosuppressants. The patient eventually achieved disease remission. OUTCOMES During the 6 months of follow-up in the outpatient department of otolaryngology and rheumatology, complications, recurrence of nasopharyngeal amyloidosis, and SLE flare-up were not observed. LESSONS Head and neck amyloidosis involving the Nasopharynx is a rare presentation of this disease. Head and neck multifocal amyloidosis should be taken as a hint of systemic disease. In head and neck amyloidosis, a comprehensive survey should be performed to clarify the underlying disease predisposing to amyloidosis and organ involvement.
Nancy A. Kucik - One of the best experts on this subject based on the ideXlab platform.
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Carcinoma of the Nasopharynx: factors affecting prognosis.
International journal of radiation oncology biology physics, 1992Co-Authors: Carlos A. Perez, V.r. Devineni, Victor A. Marcial-vega, James E. Marks, Joseph R. Simpson, Nancy A. KucikAbstract:This is a retrospective analysis of 143 patients with histologically confirmed epidermoid carcinoma of the Nasopharynx treated with definitive irradiation. Patients were treated with a combination of Cobalt-60, 4 to 6 MV X rays, and 18 to 25 MV X rays to the primary Tumor and the upper necks, excluding the spinal cord at 4000 to 4500 cGy to total doses of 6000 to 7000 cGy. At 10 years the actuarial primary Tumor failure rate was 15% in T1, 25% in T2, 33% in T3, and 60% in T4 lesions. The corresponding failure rate in the neck was 18% for N0, 14% for N1, and 33% for N2 and N3 lymphadenopathy. The incidence of distant metastasis was related to the stage of the cervical lymphadenopathy: 16% in patients with N0-N1 nodes compared with 40% in the N2-3 node group. The actuarial 10-year disease-free survival rate was 55% to 60% for T1-3N0-1 Tumors, 45% for T1-3N2-3 Tumors, 35% for T4N0-1, and 20% for T4N2-3 lesions. The overall 10-year survival rate was about 40% for patients with T1-2N0-1 Tumors, 30% for those with T3 any N stage Tumors, and only 10% for the patients with T4 lesions. Multivariate analysis showed that Tumor stage and histological type, cranial nerve involvement, patient age, and doses of irradiation to the Nasopharynx were significant prognostic factors for local/regional Tumor control. Increasing doses of irradiation resulted in Nasopharynx Tumor control in 80% of the patients receiving 6600 to 7000 cGy and 100% of those receiving over 7000 cGy in the T1, T2, and T3 Tumors. However, the Tumor control rate did not rise above 55% even for doses over 7000 cGy in the T4 lesions. Local Tumor control was higher in patients who had simulation (55/78 = 71%) compared with those on whom simulation was not performed (34/61 = 56%) (p = 0.10). Moreover, patients with more than 75% of the reviewed films judged as adequate had 69% primary Tumor control (66/96) compared with 53% (23/43) for those with fewer than 75% adequate portal films (p = 0.07).
