The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Changphone Fung - One of the best experts on this subject based on the ideXlab platform.
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community onset klebsiella pneumoniae pneumonia in taiwan clinical features of the disease and associated microbiological characteristics of isolates from pneumonia and Nasopharynx
Frontiers in Microbiology, 2015Co-Authors: Yuping Wang, Fuder Wang, Changphone FungAbstract:Klebsiella pneumoniae is an important cause of community-onset pneumonia in Asian countries and South Africa. We investigated the clinical characteristics of K. pneumoniae causing community-onset pneumonia, and the associated microbiological features between K. pneumoniae isolates from pneumonia and those from the Nasopharynx in Taiwan. This study was conducted at the Taipei Veterans General Hospital during July 2012 to February 2014. The clinical characteristics in patients with community-onset K. pneumoniae pneumonia were analysed. K. pneumoniae isolates from the Nasopharynx of adults attending otorhinolaryngology outpatient clinics were collected to compare their microbiological features with those from pneumonia. Capsular genotypes, antimicrobial susceptibility, and multilocus sequence type (MLST) were determined among these strains. Ninety-one patients with community-onset K. pneumoniae pneumonia were enrolled. We found a high mortality (29.7%) among these patients. Capsular types K1, K2, K5, K20, K54 and K57 accounted for ~70% of the K. pneumoniae isolates causing pneumonia, and ~70% of all the K. pneumoniae strains isolated from the Nasopharynx of patients in outpatient clinics. The MLST profiles further demonstrated the genetic relatedness between most pneumonia isolates and those from the Nasopharynx. In conclusion, our results show that community-onset pneumonia caused by K. pneumoniae was associated with high mortality and could have a reservoir in the Nasopharynx. To tackle this high-mortality disease, the distribution of capsular types and the common virulent clones in the Nasopharynx might have implications for future vaccine development.
Keith P Klugman - One of the best experts on this subject based on the ideXlab platform.
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influence of bacterial interactions on pneumococcal colonization of the Nasopharynx
Trends in Microbiology, 2013Co-Authors: Joshua R Shak, Jorge E Vidal, Keith P KlugmanAbstract:Streptococcus pneumoniae (the pneumococcus) is a common commensal inhabitant of the Nasopharynx and a frequent etiologic agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis. Multiple pneumococcal strains can colonize the Nasopharynx, which is also home to many other bacterial species. Intraspecies and interspecies interactions influence pneumococcal carriage in important ways. Co-colonization by two or more pneumococcal strains has implications for vaccine serotype replacement, carriage detection, and pneumonia diagnostics. Interactions between the pneumococcus and other bacterial species alter carriage prevalence, modulate virulence, and affect biofilm formation. By examining these interactions, this review highlights how the bacterial ecosystem of the Nasopharynx changes the nature and course of pneumococcal carriage.
Peter H Hwang - One of the best experts on this subject based on the ideXlab platform.
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endoscopic endonasal anatomy of the Nasopharynx in a cadaver model
International Forum of Allergy & Rhinology, 2013Co-Authors: Adam M Becker, Peter H HwangAbstract:Background Nasopharyngectomy is an accepted treatment for recurrent nasopharyngeal carcinoma following radiation with or without chemotherapy. Traditionally, the Nasopharynx has been approached through relatively invasive “open” techniques including transpalatal, maxillary swing, and trans-mandibular-pterygoid approaches. Contemporary management has included the use of endoscopic techniques to exenterate tumors in this location. The purpose of the present study is to describe the endoscopic anatomy of this region through cadaveric dissection and to characterize the technical limitations of the approach. Methods Five fresh cadaveric heads were dissected to study the endoscopic anatomy of the Nasopharynx and associated structures. Results Endoscopic dissection of the Nasopharynx was completed in all 5 specimens. Nasopharyngeal anatomy including the buccopharyngeal fascia, pharyngobasilar fascia, superior constrictor, longus capitus, longus coli, fossa of Rosenmuller, basisphenoid, auditory torus, and internal carotid artery were characterized. Conclusion Surgical access to the Nasopharynx has posed significant challenges in the treatment of recurrent or persistent nasopharyngeal carcinoma. This study demonstrated that endoscopic dissection of this region is feasible and has the potential to completely exenterate these lesions.
Bayardo Perezordonez - One of the best experts on this subject based on the ideXlab platform.
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epstein barr virus positive large cell neuroendocrine carcinoma of the Nasopharynx report of a case with complete clinical and radiological response after combined chemoradiotherapy
Head and Neck Pathology, 2018Co-Authors: Jason K Wasserman, Sylvia Papp, Andrew Hope, Bayardo PerezordonezAbstract:Neuroendocrine carcinomas of the head and neck are rare and are classified as well differentiated, moderately differentiated, and poorly differentiated carcinomas with the latter category being subdivided into small cell and large cell neuroendocrine carcinoma (LCNEC). While most carcinomas in the Nasopharynx are associated with Epstein-Barr virus (EBV), there has been only one previous report demonstrating a link between EBV and LCNEC of the Nasopharynx. In this report we describe a second case of EBV-positive LCNEC arising in the Nasopharynx with bilateral cervical metastases. The patient was treated with a combination of radiation and chemotherapy which resulted in a complete clinical and radiological response. The patient is still disease free 3 years after presentation. The results of this case suggest that EBV-positive LCNEC is sensitive to chemoradiotherapy and as a result may have better prognosis than EBV-negative LCNEC arising in the Nasopharynx or other sites.
Joshua R Shak - One of the best experts on this subject based on the ideXlab platform.
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influence of bacterial interactions on pneumococcal colonization of the Nasopharynx
Trends in Microbiology, 2013Co-Authors: Joshua R Shak, Jorge E Vidal, Keith P KlugmanAbstract:Streptococcus pneumoniae (the pneumococcus) is a common commensal inhabitant of the Nasopharynx and a frequent etiologic agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis. Multiple pneumococcal strains can colonize the Nasopharynx, which is also home to many other bacterial species. Intraspecies and interspecies interactions influence pneumococcal carriage in important ways. Co-colonization by two or more pneumococcal strains has implications for vaccine serotype replacement, carriage detection, and pneumonia diagnostics. Interactions between the pneumococcus and other bacterial species alter carriage prevalence, modulate virulence, and affect biofilm formation. By examining these interactions, this review highlights how the bacterial ecosystem of the Nasopharynx changes the nature and course of pneumococcal carriage.
