The Experts below are selected from a list of 14871 Experts worldwide ranked by ideXlab platform
P. Barberger-gateau - One of the best experts on this subject based on the ideXlab platform.
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Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study
Investigative Ophthalmology & Visual Science, 2014Co-Authors: C. Delcourt, A. Cougnard-gregoire, M. Boniol, I. Carriere, J. F. Dore, M. N. Delyfer, M. B. Rougier, M. Le Goff, J. F. Dartigues, P. Barberger-gateauAbstract:PURPOSE: While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. METHODS: The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the Natural Lens at slit-lamp. RESULTS: After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. CONCLUSIONS: This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.
C. Delcourt - One of the best experts on this subject based on the ideXlab platform.
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Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study
Investigative Ophthalmology & Visual Science, 2014Co-Authors: C. Delcourt, A. Cougnard-gregoire, M. Boniol, I. Carriere, J. F. Dore, M. N. Delyfer, M. B. Rougier, M. Le Goff, J. F. Dartigues, P. Barberger-gateauAbstract:PURPOSE: While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. METHODS: The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the Natural Lens at slit-lamp. RESULTS: After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. CONCLUSIONS: This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.
Gerhard Kieselbach - One of the best experts on this subject based on the ideXlab platform.
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Safety and feasibility of a novel intravitreal tamponade using a silicone oil/acetyl-salicylic acid suspension for proliferative vitreoretinopathy: first results of the Austrian Clinical Multicenter Study
Graefe's Archive for Clinical and Experimental Ophthalmology, 2010Co-Authors: Martina T. Kralinger, Ulrike Stolba, M. Velikay, Stefan Egger, Susanne Binder, Andreas Wedrich, Anton Haas, J.-m. Parel, Gerhard KieselbachAbstract:Background The safety and efficacy of a new surgical method of intravitreal tamponade using silicone oil suspended with aspirin (acetylsalicylic acid) was investigated for the treatment of proliferative vitreoretinopathy. Methods The study was designed as a prospective, randomized, controlled, double-blind multicenter study. A total of 29 patients were included; 15 patients were treated with the silicone oil suspended with aspirin, and 14 patients represented the control group receiving only silicone oil. A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In cases in which the Natural Lens was present, simultaneous phacoemulsification was required. The control group received as standard therapy a vitreous tamponade with pure 5000 mPas silicone oil and the treatment group received silicone oil containing 0.2 mg/ml aspirin (AS SiO). At 6 months after surgery, the tamponade was removed from all eyes. The main outcome measure was the incidence of retinal redetachment requiring reoperation. Secondary outcome measures were visual acuity and ophthalmic examination results. Results The rate of redetachment, defined as the primary outcome parameter, was the same for both groups. The AS SiO was well tolerated and remained clear during the 6-month study period. Clinical examination revealed no signs of local or systemic adverse effects. The visual acuities were well matched before inclusion in the study and there were no significant differences during the follow-up period and in the final visual outcome between the two groups. Conclusions Aspirin delivery by intravitreal silicone oil in the human eye is safe and also may provide a delivery vehicle for other antiproliferative agents to the posterior pole.
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Acetylsalicylic acid–silicone oil suspension for proliferative vitreoretinopathie: First results of Austrian clinical multicentre study
Spektrum der Augenheilkunde, 2007Co-Authors: Martina T. Kralinger, Ulrike Stolba, M. Velikay, Stefan Egger, Susanne Binder, Andreas Wedrich, Anton Haas, J.-m. Parel, Gerhard KieselbachAbstract:BACKGROUND: A new surgical method of intravitreal tamponade with silicone oil suspended with acetylsalicylic acid (AS) was investigated for safety and efficiency in the treatment of proliferative vitreoretinopathie. The study was designed as a prospective randomized, controlled double-blind Multicentre Study. METHODS: A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In case a Natural Lens was present simultaneous phacoemulsification was obligatory. The control group received standard therapy vitreous tamponade with pure 5000centistoke silicone oil while the silicone oil was suspended with AS to a concentration of 0.2 mg/ml in the study group. After 6 months follow up the tamponade was removed in all eyes. RESULTS: The safety of AS SiO could be demonstrated: the AS SiO was well tolerated and stayed clear during the study period of 6 months. The clinical examination revealed no signs of local or systemic adverse effects in the study eyes. The visual acuities were well matched before inclusion into the study and there was no evidence of significant differences during the follow up period and in final visual outcome between the two groups. The rate of redetachments defined as the primary outcome parameter was the same for both groups. CONCLUSIONS: Acetylsalicylic acid delivery by intravitreal silicone oil in the human eye was shown a safe method that may offer a delivery route for other antiproliferative agents into the posterior pole.
J. F. Dartigues - One of the best experts on this subject based on the ideXlab platform.
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Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study
Investigative Ophthalmology & Visual Science, 2014Co-Authors: C. Delcourt, A. Cougnard-gregoire, M. Boniol, I. Carriere, J. F. Dore, M. N. Delyfer, M. B. Rougier, M. Le Goff, J. F. Dartigues, P. Barberger-gateauAbstract:PURPOSE: While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. METHODS: The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the Natural Lens at slit-lamp. RESULTS: After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. CONCLUSIONS: This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.
M. B. Rougier - One of the best experts on this subject based on the ideXlab platform.
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Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study
Investigative Ophthalmology & Visual Science, 2014Co-Authors: C. Delcourt, A. Cougnard-gregoire, M. Boniol, I. Carriere, J. F. Dore, M. N. Delyfer, M. B. Rougier, M. Le Goff, J. F. Dartigues, P. Barberger-gateauAbstract:PURPOSE: While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. METHODS: The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the Natural Lens at slit-lamp. RESULTS: After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. CONCLUSIONS: This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.
