The Experts below are selected from a list of 19281 Experts worldwide ranked by ideXlab platform
Jan Skov Jensen - One of the best experts on this subject based on the ideXlab platform.
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very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function hypertension and diabetes
Circulation, 2004Co-Authors: Klaus Klausen, Knut Borchjohnsen, Bo Feldtrasmussen, Gorm B Jensen, Peter Clausen, Henrik Scharling, M Appleyard, Jan Skov JensenAbstract:Background— The aim of this study was to assess the level of urinary albumin excretion (microalbuminuria), which is associated with increased risk of coronary heart disease and death, in the population. Microalbuminuria has been suggested as an atherosclerotic risk factor. However, the lower cutoff level of urinary albumin excretion is unknown. It is also unknown whether impaired renal function confounds the association. Methods and Results— In the Third Copenhagen City Heart Study in 1992 to 1994, 2762 men and women 30 to 70 years of age underwent a detailed cardiovascular investigation program, including a timed overnight urine sample. The participants were then followed up prospectively by registers until 1999 with respect to coronary heart disease and until 2001 with respect to death. During follow-up, 109 incident cases of coronary heart disease and 276 deaths were traced. A urinary albumin excretion above the Upper Quartile, ie, 4.8 μg/min, was associated with increased risk of coronary heart diseas...
K. -t. Khaw - One of the best experts on this subject based on the ideXlab platform.
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Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British cohort study
The journal of nutrition health & aging, 2015Co-Authors: Victoria L. Keevil, R. Luben, N. Dalzell, S. Hayat, A. A. Sayer, N. J. Wareham, K. -t. KhawAbstract:Objectives The relationship between obesity and grip strength, a key indicator of sarcopenia, has been inconsistently reported. We aimed to examine associations between grip strength and both body mass index (BMI), a clinical indicator of total adiposity, and waist circumference (WC), an indicator of central adiposity. Design Cross-sectional study. Setting and Participants Data collected from 8,441 men and women, aged 48–92 years old, who attended the third health examination of the European Prospective Investigation into Cancer-Norfolk study was used. Measurements Maximum grip strength (Smedley dynamometer), BMI (weight/height^2) and WC (measured at the natural waist) were ascertained at a research clinic. The associations between grip strength and adiposity measures were explored using linear regression with adjustment for age, height, social class, physical activity, prevalent disease, smoking status and alcohol intake. Results Men and women were examined separately and those in the Upper Quartile of BMI were 2.70kg (95%CI 2.07, 3.33) and 1.46kg (95%CI 1.05, 1.86) stronger respectively than those in the bottom Quartile (P trends
Bu B Yeap - One of the best experts on this subject based on the ideXlab platform.
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plasma free thyroxine in the Upper Quartile is associated with an increased incidence of major cardiovascular events in older men that do not have thyroid dysfunction according to conventional criteria
International Journal of Cardiology, 2017Co-Authors: Jonathan Golledge, Graeme J Hankey, Osvaldo P Almeida, Leon Flicker, Paul Norman, Bu B YeapAbstract:Abstract Background The aim of this study was to assess the association of plasma free thyroxine (FT4) and serum thyroid stimulating hormone (TSH) concentrations with the past diagnosis of cardiovascular disease and incidence of new cardiovascular events in older men with no known thyroid disease. Methods This study involved a cohort of community-recruited older men without known thyroid disease. Plasma FT4 and serum TSH were measured by immunoassay. Past cardiovascular disease diagnosis was defined through questionnaire data. The incidence of major cardiovascular events were assessed using the Western Australian Data Linkage System. The associations of plasma FT4 and serum TSH with the past diagnosis of cardiovascular disease and the incidence of new major cardiovascular events (cardiovascular death, myocardial infarction or stroke) were examined using logistic regression and Cox proportional hazard analyses. Results 3712 men were followed for a mean of 9.5years. Men with plasma FT4 in the Upper Quartile, compared to other men, were more likely to have been previously diagnosed with cardiovascular disease but this association did not persist after adjustment for other risk factors. Men with plasma FT4 in the Upper Quartile, compared to other men, had an increased incidence of major cardiovascular events (adjusted hazard ratio, HR, 1.15, 95% CI 1.00–1.31) and myocardial infarction alone (adjusted HR 1.29, 95% CI 1.06–1.54). Conclusion This study suggests that older men with higher levels of plasma FT4 not meeting current criteria for the diagnosis of hyperthyroidism are at increased risk of major cardiovascular events.
Klaus Klausen - One of the best experts on this subject based on the ideXlab platform.
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very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function hypertension and diabetes
Circulation, 2004Co-Authors: Klaus Klausen, Knut Borchjohnsen, Bo Feldtrasmussen, Gorm B Jensen, Peter Clausen, Henrik Scharling, M Appleyard, Jan Skov JensenAbstract:Background— The aim of this study was to assess the level of urinary albumin excretion (microalbuminuria), which is associated with increased risk of coronary heart disease and death, in the population. Microalbuminuria has been suggested as an atherosclerotic risk factor. However, the lower cutoff level of urinary albumin excretion is unknown. It is also unknown whether impaired renal function confounds the association. Methods and Results— In the Third Copenhagen City Heart Study in 1992 to 1994, 2762 men and women 30 to 70 years of age underwent a detailed cardiovascular investigation program, including a timed overnight urine sample. The participants were then followed up prospectively by registers until 1999 with respect to coronary heart disease and until 2001 with respect to death. During follow-up, 109 incident cases of coronary heart disease and 276 deaths were traced. A urinary albumin excretion above the Upper Quartile, ie, 4.8 μg/min, was associated with increased risk of coronary heart diseas...
Kjell Grankvist - One of the best experts on this subject based on the ideXlab platform.
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Circulating estrogens and progesterone during primiparous pregnancies and risk of maternal breast cancer
International Journal of Cancer, 2012Co-Authors: Annekatrin Lukanova, Marjo Kaasila, Hans Ake Lakso, Helena Schock, Eva Lundin, Pentti Koskela, Anika Hüsing, Rudolf Kaaks, Heljä-marja Surcel, Kjell GrankvistAbstract:Pregnancy reduces maternal risk of breast cancer in the long term, but the biological determinants of the protection are unknown. Animal experiments suggest that estrogens and progesterone could be involved, but direct human evidence is scant. A case-control study (536 cases and 1,049 controls) was nested within the Finnish Maternity Cohort. Eligible were primiparous women who delivered at term a singleton offspring before age 40. For each case, two individually matched controls by age (±6 months) and date of sampling (±3 months) were selected. Estradiol, estrone and progesterone in first-trimester serum were measured by high-performance liquid chromatography tandem mass spectrometry and sex-hormone binding globulin (SHBG) by immunoassay. Odds ratios (OR) and 95% confidence intervals (CI) were estimated through conditional logistic regression. In the whole study population there was no association of breast cancer with any of the studied hormones. In analyses stratified by age at diagnosis, however, estradiol concentrations were positively associated with risk of breast cancer before age 40 (Upper Quartile OR, 1.81; CI, 1.08-3.06), but inversely associated with risk in women who were diagnosed ≥age 40 (Upper Quartile OR, 0.64; CI, 0.40-1.04), p(interaction) 0.004. Risk estimates for estrone mirrored those for estradiol but were less pronounced. Progesterone was not associated with risk of subsequent breast cancer. Our results provide initial evidence that concentrations of estrogens during the early parts of a primiparous pregnancy are associated with maternal risk of breast cancer and suggest that the effect may differ for tumors diagnosed before and after age 40.
