The Experts below are selected from a list of 2211 Experts worldwide ranked by ideXlab platform
Joseph W. Freeman - One of the best experts on this subject based on the ideXlab platform.
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Ligament tissue engineering: an evolutionary materials science approach.
Biomaterials, 2005Co-Authors: Cato T. Laurencin, Joseph W. FreemanAbstract:The anterior cruciate Ligament (ACL) is important for knee stabilization. Unfortunately, it is also the most commonly injured intra-articular Ligament. Due to poor vascularization, the ACL has inferior healing capability and is usually replaced after significant damage has occurred. Currently available replacements have a host of limitations, this has prompted the search for tissue-engineered solutions for ACL repair. Presently investigated scaffolds range from twisted fiber architectures composed of silk fibers to complex three-dimensional braided structures composed of poly (L-lactic acid) fibers. The purpose of these tissue-engineered constructs is to apply approaches such as the use of porous scaffolds, use of cells, and the application of growth factors to promote Ligament tissue regeneration while providing mechanical properties similar to Natural Ligament.
Cato T. Laurencin - One of the best experts on this subject based on the ideXlab platform.
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Ligament tissue engineering: an evolutionary materials science approach.
Biomaterials, 2005Co-Authors: Cato T. Laurencin, Joseph W. FreemanAbstract:The anterior cruciate Ligament (ACL) is important for knee stabilization. Unfortunately, it is also the most commonly injured intra-articular Ligament. Due to poor vascularization, the ACL has inferior healing capability and is usually replaced after significant damage has occurred. Currently available replacements have a host of limitations, this has prompted the search for tissue-engineered solutions for ACL repair. Presently investigated scaffolds range from twisted fiber architectures composed of silk fibers to complex three-dimensional braided structures composed of poly (L-lactic acid) fibers. The purpose of these tissue-engineered constructs is to apply approaches such as the use of porous scaffolds, use of cells, and the application of growth factors to promote Ligament tissue regeneration while providing mechanical properties similar to Natural Ligament.
Mariefrancoise Harmand - One of the best experts on this subject based on the ideXlab platform.
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biocompatible fibrous networks of cellulose nanofibres and collagen crosslinked using genipin potential as artificial Ligament tendons
Macromolecular Bioscience, 2013Co-Authors: Aji P Mathew, Kristiina Oksman, Dorothee Pierron, Mariefrancoise HarmandAbstract:Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Microscopy studies of the prepared materials showed nanostructured fibrous collagen and cellulose dispersed in collagen matrix. Mechanical performance of the sterilized nanocomposites was close to that of Natural Ligament and tendon, in simulated body conditions. Cytocompatibility studies indicated that these nanocomposites allowed human Ligament cell and human endothelial cell adhesion, growth, and differentiation; which is eminently favourable to Ligament tissue engineering.
Eric A. Nauman - One of the best experts on this subject based on the ideXlab platform.
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Development of Ligament-Like Structural Organization and Properties in Cell-Seeded Collagen Scaffolds in vitro
Annals of Biomedical Engineering, 2006Co-Authors: Eileen Gentleman, Glen A. Livesay, Kay C Dee, Eric A. NaumanAbstract:Acute anterior cruciate Ligament (ACL) injuries lead to poor joint function, instability, and eventually osteoarthritis if left untreated. Current surgical treatment options are not ideal; however, tissue engineering may provide mechanically sound, biocompatible reconstructions. Collagen fiber scaffolds were combined with fibroblast-seeded collagen gels and maintained in culture for up to 20 days. The tensile and viscoelastic behavior of the constructs closely mimicked that of Natural Ligament. Constructs’ mechanical and viscoelastic properties did not degrade over time in culture, and peak stress was significantly higher for constructs with embedded fibroblasts. Immunocytochemical and histological analyses demonstrated cell proliferation and Ligament-like organization. We have created an engineered tissue that closely approaches key mechanical and viscoelastic properties of the ACL, does not degrade after 20 days in culture, and is histologically similar to the native tissue. This study should aid in developing effective treatments for ACL injury.
Aji P Mathew - One of the best experts on this subject based on the ideXlab platform.
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biocompatible fibrous networks of cellulose nanofibres and collagen crosslinked using genipin potential as artificial Ligament tendons
Macromolecular Bioscience, 2013Co-Authors: Aji P Mathew, Kristiina Oksman, Dorothee Pierron, Mariefrancoise HarmandAbstract:Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Microscopy studies of the prepared materials showed nanostructured fibrous collagen and cellulose dispersed in collagen matrix. Mechanical performance of the sterilized nanocomposites was close to that of Natural Ligament and tendon, in simulated body conditions. Cytocompatibility studies indicated that these nanocomposites allowed human Ligament cell and human endothelial cell adhesion, growth, and differentiation; which is eminently favourable to Ligament tissue engineering.
