The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Tsai Chung Li - One of the best experts on this subject based on the ideXlab platform.
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Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis
BMC Complementary and Alternative Medicine, 2017Co-Authors: Hui-man Cheng, Katherine Li, Eric Wadman, Shung Te Kao, Dion Chen, Jackson Wu, Qingmin Wang, Yang Chang Wu, Michael Song, Tsai Chung LiAbstract:Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unknown due to lack of knowledge about the responsible chemical entity. We took a different approach to this challenge by investigating the molecular profile of Indigo naturalis treatment and impacted pathways. A randomized, double-blind, placebo-controlled clinical study was conducted using Indigo naturalis as topical monotherapy to treat moderate plaque psoriasis in a Chinese cohort (n = 24). Patients were treated with Indigo naturalis ointment (n = 16) or matched placebo (n = 8) twice daily for 8 weeks, with 1 week of follow-up. At week 8, significant improvements in Psoriasis Area and Severity Index (PASI) scores from baseline were observed in Indigo naturalis-treated patients (56.3% had 75% improvement [PASI 75] response) compared with placebo (0.0%). A gene expression signature of moderate psoriasis was established from baseline skin biopsies, which included the up-regulation of the interleukin (IL)-17 pathway as a key component; Indigo naturalis treatment resulted in most of these signature genes returning toward normal, including down-regulation of the IL-17 pathway. Using an in vitro keratinocyte assay, an IL-17-inhibitory effect was observed for tryptanthrin, a component of Indigo naturalis. This study demonstrated the clinical efficacy of Indigo naturalis in moderate psoriasis, and exemplified a novel experimental medicine approach to understand TCM targeting mechanisms. NCT01901705 .
Yinku Lin - One of the best experts on this subject based on the ideXlab platform.
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inhibitory effect of indigo naturalis on tumor necrosis factor α induced vascular cell adhesion molecule 1 expression in human umbilical vein endothelial cells
Molecules, 2010Co-Authors: Hsinning Chang, Jonghwei S Pang, Sienhung Yang, Chifeng Hung, Chihsin Chiang, Tungyi Lin, Yinku LinAbstract:The use of indigo naturalis to treat psoriasis has proved effective in our previous clinical studies. The present study was designed to examine the anti-inflammatory effect of indigo naturalis in primary cultured human umbilical vein endothelial cells (HUVECs). Pretreatment of cells with indigo naturalis extract attenuated TNF-α-induced increase in Jurkat T cell adhesion to HUVECs as well as decreased the protein and messenger (m)RNA expression levels of vascular cell adhesion molecule-1 (VCAM-1) on HUVECs. Indigo naturalis extract also inhibited the protein expression of activator protein-1 (AP-1)/c-Jun, a critical transcription factor for the activation of VCAM-1 gene expression. Since the reduction of lymphocyte adhesion to vascular cells by indigo naturalis extract could subsequently reduce the inflammatory reactions caused by lymphocyte infiltration in the epidermal layer and help to improve psoriasis, this study provides a potential mechanism for the anti-inflammatory therapeutic effect of indigo naturalis extract in psoriasis.
Edward N Zalta - One of the best experts on this subject based on the ideXlab platform.
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naturalized platonism versus platonized Naturalism
The Journal of Philosophy, 1995Co-Authors: Bernard Linsky, Edward N ZaltaAbstract:L'A. defend la these selon laquelle la connaissance des objets abstraits definie par le platonisme naturalise est compatible avec ce qu'il appelle le Naturalisme platonise. Il s'agit d'un platonisme traditionnel fonde sur des principes de comprehension qui sont synthetiques et qui peuvent etre connus de facon a priori
Hui-man Cheng - One of the best experts on this subject based on the ideXlab platform.
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Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis
BMC Complementary and Alternative Medicine, 2017Co-Authors: Hui-man Cheng, Katherine Li, Eric Wadman, Shung Te Kao, Dion Chen, Jackson Wu, Qingmin Wang, Yang Chang Wu, Michael Song, Tsai Chung LiAbstract:Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unknown due to lack of knowledge about the responsible chemical entity. We took a different approach to this challenge by investigating the molecular profile of Indigo naturalis treatment and impacted pathways. A randomized, double-blind, placebo-controlled clinical study was conducted using Indigo naturalis as topical monotherapy to treat moderate plaque psoriasis in a Chinese cohort (n = 24). Patients were treated with Indigo naturalis ointment (n = 16) or matched placebo (n = 8) twice daily for 8 weeks, with 1 week of follow-up. At week 8, significant improvements in Psoriasis Area and Severity Index (PASI) scores from baseline were observed in Indigo naturalis-treated patients (56.3% had 75% improvement [PASI 75] response) compared with placebo (0.0%). A gene expression signature of moderate psoriasis was established from baseline skin biopsies, which included the up-regulation of the interleukin (IL)-17 pathway as a key component; Indigo naturalis treatment resulted in most of these signature genes returning toward normal, including down-regulation of the IL-17 pathway. Using an in vitro keratinocyte assay, an IL-17-inhibitory effect was observed for tryptanthrin, a component of Indigo naturalis. This study demonstrated the clinical efficacy of Indigo naturalis in moderate psoriasis, and exemplified a novel experimental medicine approach to understand TCM targeting mechanisms. NCT01901705 .
Hsinning Chang - One of the best experts on this subject based on the ideXlab platform.
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inhibitory effect of indigo naturalis on tumor necrosis factor α induced vascular cell adhesion molecule 1 expression in human umbilical vein endothelial cells
Molecules, 2010Co-Authors: Hsinning Chang, Jonghwei S Pang, Sienhung Yang, Chifeng Hung, Chihsin Chiang, Tungyi Lin, Yinku LinAbstract:The use of indigo naturalis to treat psoriasis has proved effective in our previous clinical studies. The present study was designed to examine the anti-inflammatory effect of indigo naturalis in primary cultured human umbilical vein endothelial cells (HUVECs). Pretreatment of cells with indigo naturalis extract attenuated TNF-α-induced increase in Jurkat T cell adhesion to HUVECs as well as decreased the protein and messenger (m)RNA expression levels of vascular cell adhesion molecule-1 (VCAM-1) on HUVECs. Indigo naturalis extract also inhibited the protein expression of activator protein-1 (AP-1)/c-Jun, a critical transcription factor for the activation of VCAM-1 gene expression. Since the reduction of lymphocyte adhesion to vascular cells by indigo naturalis extract could subsequently reduce the inflammatory reactions caused by lymphocyte infiltration in the epidermal layer and help to improve psoriasis, this study provides a potential mechanism for the anti-inflammatory therapeutic effect of indigo naturalis extract in psoriasis.
