Nausea

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John E. Fortunato - One of the best experts on this subject based on the ideXlab platform.

  • chronic Nausea and orthostatic intolerance diagnostic utility of orthostatic challenge duration Nausea profile questionnaire and neurohumoral measures
    Neurogastroenterology and Motility, 2018
    Co-Authors: Ashley L. Wagoner, Sally E. Tarbell, Hossam A. Shaltout, Debra E Weesemayer, John E. Fortunato
    Abstract:

    BACKGROUND: Chronic Nausea in pediatrics is a debilitating condition with unclear etiology. We aimed to define hemodynamic and neurohumoral characteristics of chronic Nausea associated with orthostatic intolerance in order to improve identification and elucidate mechanism. METHODS: Children (10-18 years) meeting Rome III criteria for functional dyspepsia with Nausea and symptoms of orthostatic intolerance (OI) completed a Nausea Profile Questionnaire followed by prolonged (45 minutes rather than the traditional 10 minutes) head-upright tilt (HUT) (70° tilt up) test. Circulating catecholamines, vasopressin, aldosterone, renin, and angiotensins were measured supine and after 15 minutes into HUT. Beat-to-beat heart rate and blood pressure were continuously recorded to calculate their variability and baroreflex sensitivity. KEY RESULTS: Within 10 and 45 minutes of HUT, 46% and 85% of subjects, respectively, had an abnormal tilt test (orthostatic hypotension, postural orthostatic tachycardia, or syncope). At 15 and 45 minutes of HUT, Nausea was elicited in 42% and 65% of subjects respectively. Higher Nausea Profile Questionnaire scores correlated with positive HUT testing at 10 minutes (P = 0.004) and baroreflex sensitivity at 15 minutes (P ≤ 0.01). Plasma vasopressin rose 33-fold in subjects with HUT-induced Nausea compared to twofold in those who did not experience HUT-induced Nausea (P < 0.01). CONCLUSIONS AND INFERENCES: In children with chronic Nausea and OI, longer duration HUT elicited higher frequency of abnormal tilt testing and orthostatic-induced Nausea. The Nausea Profile Questionnaire predicted the orthostatic response to tilt testing. Exaggerated vasopressin release differentiated patients with HUT-induced Nausea (vs those without Nausea), suggesting a possible mechanism for chronic Nausea in childhood.

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea
    Experimental Brain Research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score ( r  = 0.71, p  

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea.
    Experimental brain research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score (r = 0.71, p < 0.01) and 3 subscales: somatic (r = 0.64, p < 0.01), gastrointestinal (r = 0.48, p = 0.01), and emotional (r = 0.74, p < 0.01). Nausea was positively associated with state anxiety, total Nausea (r = 0.55, p < 0.01), somatic (r = 0.48, p < .01), gastrointestinal (r = .30, p < .05), and emotional (r = .64, p < .01) subscales. Within 10 min of HUT, 27 patients tested normal and 21 demonstrated OI. After 45 min of HUT, only 13 patients (27%) remained normal. Nausea reported on the Nausea Profile before HUT was associated with OI measured at 10 min of tilt (Nausea total r = 0.35, p < 0.05; Nausea emotional subscale r = 0.40, p < 0.01) and lower HRV at 10 min of HUT (F = 6.39, p = 0.01). We conclude that Nausea is associated with both anxiety symptoms and OI. The finding of decreased HRV suggests an underlying problem in autonomic nervous system function in children and adolescents with chronic unexplained Nausea.

Sally E. Tarbell - One of the best experts on this subject based on the ideXlab platform.

  • chronic Nausea and orthostatic intolerance diagnostic utility of orthostatic challenge duration Nausea profile questionnaire and neurohumoral measures
    Neurogastroenterology and Motility, 2018
    Co-Authors: Ashley L. Wagoner, Sally E. Tarbell, Hossam A. Shaltout, Debra E Weesemayer, John E. Fortunato
    Abstract:

    BACKGROUND: Chronic Nausea in pediatrics is a debilitating condition with unclear etiology. We aimed to define hemodynamic and neurohumoral characteristics of chronic Nausea associated with orthostatic intolerance in order to improve identification and elucidate mechanism. METHODS: Children (10-18 years) meeting Rome III criteria for functional dyspepsia with Nausea and symptoms of orthostatic intolerance (OI) completed a Nausea Profile Questionnaire followed by prolonged (45 minutes rather than the traditional 10 minutes) head-upright tilt (HUT) (70° tilt up) test. Circulating catecholamines, vasopressin, aldosterone, renin, and angiotensins were measured supine and after 15 minutes into HUT. Beat-to-beat heart rate and blood pressure were continuously recorded to calculate their variability and baroreflex sensitivity. KEY RESULTS: Within 10 and 45 minutes of HUT, 46% and 85% of subjects, respectively, had an abnormal tilt test (orthostatic hypotension, postural orthostatic tachycardia, or syncope). At 15 and 45 minutes of HUT, Nausea was elicited in 42% and 65% of subjects respectively. Higher Nausea Profile Questionnaire scores correlated with positive HUT testing at 10 minutes (P = 0.004) and baroreflex sensitivity at 15 minutes (P ≤ 0.01). Plasma vasopressin rose 33-fold in subjects with HUT-induced Nausea compared to twofold in those who did not experience HUT-induced Nausea (P < 0.01). CONCLUSIONS AND INFERENCES: In children with chronic Nausea and OI, longer duration HUT elicited higher frequency of abnormal tilt testing and orthostatic-induced Nausea. The Nausea Profile Questionnaire predicted the orthostatic response to tilt testing. Exaggerated vasopressin release differentiated patients with HUT-induced Nausea (vs those without Nausea), suggesting a possible mechanism for chronic Nausea in childhood.

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea
    Experimental Brain Research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score ( r  = 0.71, p  

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea.
    Experimental brain research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score (r = 0.71, p < 0.01) and 3 subscales: somatic (r = 0.64, p < 0.01), gastrointestinal (r = 0.48, p = 0.01), and emotional (r = 0.74, p < 0.01). Nausea was positively associated with state anxiety, total Nausea (r = 0.55, p < 0.01), somatic (r = 0.48, p < .01), gastrointestinal (r = .30, p < .05), and emotional (r = .64, p < .01) subscales. Within 10 min of HUT, 27 patients tested normal and 21 demonstrated OI. After 45 min of HUT, only 13 patients (27%) remained normal. Nausea reported on the Nausea Profile before HUT was associated with OI measured at 10 min of tilt (Nausea total r = 0.35, p < 0.05; Nausea emotional subscale r = 0.40, p < 0.01) and lower HRV at 10 min of HUT (F = 6.39, p = 0.01). We conclude that Nausea is associated with both anxiety symptoms and OI. The finding of decreased HRV suggests an underlying problem in autonomic nervous system function in children and adolescents with chronic unexplained Nausea.

Ashley L. Wagoner - One of the best experts on this subject based on the ideXlab platform.

  • chronic Nausea and orthostatic intolerance diagnostic utility of orthostatic challenge duration Nausea profile questionnaire and neurohumoral measures
    Neurogastroenterology and Motility, 2018
    Co-Authors: Ashley L. Wagoner, Sally E. Tarbell, Hossam A. Shaltout, Debra E Weesemayer, John E. Fortunato
    Abstract:

    BACKGROUND: Chronic Nausea in pediatrics is a debilitating condition with unclear etiology. We aimed to define hemodynamic and neurohumoral characteristics of chronic Nausea associated with orthostatic intolerance in order to improve identification and elucidate mechanism. METHODS: Children (10-18 years) meeting Rome III criteria for functional dyspepsia with Nausea and symptoms of orthostatic intolerance (OI) completed a Nausea Profile Questionnaire followed by prolonged (45 minutes rather than the traditional 10 minutes) head-upright tilt (HUT) (70° tilt up) test. Circulating catecholamines, vasopressin, aldosterone, renin, and angiotensins were measured supine and after 15 minutes into HUT. Beat-to-beat heart rate and blood pressure were continuously recorded to calculate their variability and baroreflex sensitivity. KEY RESULTS: Within 10 and 45 minutes of HUT, 46% and 85% of subjects, respectively, had an abnormal tilt test (orthostatic hypotension, postural orthostatic tachycardia, or syncope). At 15 and 45 minutes of HUT, Nausea was elicited in 42% and 65% of subjects respectively. Higher Nausea Profile Questionnaire scores correlated with positive HUT testing at 10 minutes (P = 0.004) and baroreflex sensitivity at 15 minutes (P ≤ 0.01). Plasma vasopressin rose 33-fold in subjects with HUT-induced Nausea compared to twofold in those who did not experience HUT-induced Nausea (P < 0.01). CONCLUSIONS AND INFERENCES: In children with chronic Nausea and OI, longer duration HUT elicited higher frequency of abnormal tilt testing and orthostatic-induced Nausea. The Nausea Profile Questionnaire predicted the orthostatic response to tilt testing. Exaggerated vasopressin release differentiated patients with HUT-induced Nausea (vs those without Nausea), suggesting a possible mechanism for chronic Nausea in childhood.

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea
    Experimental Brain Research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score ( r  = 0.71, p  

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea.
    Experimental brain research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score (r = 0.71, p < 0.01) and 3 subscales: somatic (r = 0.64, p < 0.01), gastrointestinal (r = 0.48, p = 0.01), and emotional (r = 0.74, p < 0.01). Nausea was positively associated with state anxiety, total Nausea (r = 0.55, p < 0.01), somatic (r = 0.48, p < .01), gastrointestinal (r = .30, p < .05), and emotional (r = .64, p < .01) subscales. Within 10 min of HUT, 27 patients tested normal and 21 demonstrated OI. After 45 min of HUT, only 13 patients (27%) remained normal. Nausea reported on the Nausea Profile before HUT was associated with OI measured at 10 min of tilt (Nausea total r = 0.35, p < 0.05; Nausea emotional subscale r = 0.40, p < 0.01) and lower HRV at 10 min of HUT (F = 6.39, p = 0.01). We conclude that Nausea is associated with both anxiety symptoms and OI. The finding of decreased HRV suggests an underlying problem in autonomic nervous system function in children and adolescents with chronic unexplained Nausea.

Hossam A. Shaltout - One of the best experts on this subject based on the ideXlab platform.

  • chronic Nausea and orthostatic intolerance diagnostic utility of orthostatic challenge duration Nausea profile questionnaire and neurohumoral measures
    Neurogastroenterology and Motility, 2018
    Co-Authors: Ashley L. Wagoner, Sally E. Tarbell, Hossam A. Shaltout, Debra E Weesemayer, John E. Fortunato
    Abstract:

    BACKGROUND: Chronic Nausea in pediatrics is a debilitating condition with unclear etiology. We aimed to define hemodynamic and neurohumoral characteristics of chronic Nausea associated with orthostatic intolerance in order to improve identification and elucidate mechanism. METHODS: Children (10-18 years) meeting Rome III criteria for functional dyspepsia with Nausea and symptoms of orthostatic intolerance (OI) completed a Nausea Profile Questionnaire followed by prolonged (45 minutes rather than the traditional 10 minutes) head-upright tilt (HUT) (70° tilt up) test. Circulating catecholamines, vasopressin, aldosterone, renin, and angiotensins were measured supine and after 15 minutes into HUT. Beat-to-beat heart rate and blood pressure were continuously recorded to calculate their variability and baroreflex sensitivity. KEY RESULTS: Within 10 and 45 minutes of HUT, 46% and 85% of subjects, respectively, had an abnormal tilt test (orthostatic hypotension, postural orthostatic tachycardia, or syncope). At 15 and 45 minutes of HUT, Nausea was elicited in 42% and 65% of subjects respectively. Higher Nausea Profile Questionnaire scores correlated with positive HUT testing at 10 minutes (P = 0.004) and baroreflex sensitivity at 15 minutes (P ≤ 0.01). Plasma vasopressin rose 33-fold in subjects with HUT-induced Nausea compared to twofold in those who did not experience HUT-induced Nausea (P < 0.01). CONCLUSIONS AND INFERENCES: In children with chronic Nausea and OI, longer duration HUT elicited higher frequency of abnormal tilt testing and orthostatic-induced Nausea. The Nausea Profile Questionnaire predicted the orthostatic response to tilt testing. Exaggerated vasopressin release differentiated patients with HUT-induced Nausea (vs those without Nausea), suggesting a possible mechanism for chronic Nausea in childhood.

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea
    Experimental Brain Research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score ( r  = 0.71, p  

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea.
    Experimental brain research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score (r = 0.71, p < 0.01) and 3 subscales: somatic (r = 0.64, p < 0.01), gastrointestinal (r = 0.48, p = 0.01), and emotional (r = 0.74, p < 0.01). Nausea was positively associated with state anxiety, total Nausea (r = 0.55, p < 0.01), somatic (r = 0.48, p < .01), gastrointestinal (r = .30, p < .05), and emotional (r = .64, p < .01) subscales. Within 10 min of HUT, 27 patients tested normal and 21 demonstrated OI. After 45 min of HUT, only 13 patients (27%) remained normal. Nausea reported on the Nausea Profile before HUT was associated with OI measured at 10 min of tilt (Nausea total r = 0.35, p < 0.05; Nausea emotional subscale r = 0.40, p < 0.01) and lower HRV at 10 min of HUT (F = 6.39, p = 0.01). We conclude that Nausea is associated with both anxiety symptoms and OI. The finding of decreased HRV suggests an underlying problem in autonomic nervous system function in children and adolescents with chronic unexplained Nausea.

Debra I. Diz - One of the best experts on this subject based on the ideXlab platform.

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea
    Experimental Brain Research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score ( r  = 0.71, p  

  • Relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea.
    Experimental brain research, 2014
    Co-Authors: Sally E. Tarbell, Hossam A. Shaltout, Ashley L. Wagoner, Debra I. Diz, John E. Fortunato
    Abstract:

    This study evaluated the relationship among Nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained Nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found Nausea to be significantly associated with trait anxiety, including total Nausea score (r = 0.71, p < 0.01) and 3 subscales: somatic (r = 0.64, p < 0.01), gastrointestinal (r = 0.48, p = 0.01), and emotional (r = 0.74, p < 0.01). Nausea was positively associated with state anxiety, total Nausea (r = 0.55, p < 0.01), somatic (r = 0.48, p < .01), gastrointestinal (r = .30, p < .05), and emotional (r = .64, p < .01) subscales. Within 10 min of HUT, 27 patients tested normal and 21 demonstrated OI. After 45 min of HUT, only 13 patients (27%) remained normal. Nausea reported on the Nausea Profile before HUT was associated with OI measured at 10 min of tilt (Nausea total r = 0.35, p < 0.05; Nausea emotional subscale r = 0.40, p < 0.01) and lower HRV at 10 min of HUT (F = 6.39, p = 0.01). We conclude that Nausea is associated with both anxiety symptoms and OI. The finding of decreased HRV suggests an underlying problem in autonomic nervous system function in children and adolescents with chronic unexplained Nausea.

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