The Experts below are selected from a list of 2682 Experts worldwide ranked by ideXlab platform
Markku Leino - One of the best experts on this subject based on the ideXlab platform.
-
Studies comparing the efficacy of Nedocromil sodium eye drops with sodium cromoglycate and placebo in seasonal allergic conjunctivitis
Ocular Immunology and Inflammation, 2009Co-Authors: Markku LeinoAbstract:Two multicentre, double-blind, placebo controlled group comparative studies were carried out in Finland, during the birch pollen seasons of 1987 and 1989, to compare the efficacy and tolerability of 2% Nedocromil sodium eye drops (twice daily) with either 2% sodium cromoglycate eye drops (four times daily) and/or placebo, in patients with seasonal allergic conjunctivitis. Study 1 compared Nedocromil sodium (64 patients) with placebo (62 patients) and showed that the opinions of treatment efficacy of both patients and clinicians were significantly in favour of Nedocromil sodium (p = 0.003, patients; p = 0.006, clinicians). In addition, the placebo group used significantly more topical (p
-
studies comparing the efficacy of Nedocromil sodium eye drops with sodium cromoglycate and placebo in seasonal allergic conjunctivitis
Ocular Immunology and Inflammation, 1993Co-Authors: Markku LeinoAbstract:Two multicentre, double-blind, placebo controlled group comparative studies were carried out in Finland, during the birch pollen seasons of 1987 and 1989, to compare the efficacy and tolerability of 2% Nedocromil sodium eye drops (twice daily) with either 2% sodium cromoglycate eye drops (four times daily) and/or placebo, in patients with seasonal allergic conjunctivitis. Study 1 compared Nedocromil sodium (64 patients) with placebo (62 patients) and showed that the opinions of treatment efficacy of both patients and clinicians were significantly in favour of Nedocromil sodium (p = 0.003, patients; p = 0.006, clinicians). In addition, the placebo group used significantly more topical (p<0.05) and oral (p<0.01) concomitant antihistamine therapy. Diary card scores and clinical assessments showed trends for active treatment. Study 2 compared Nedocromil sodium (60 patients) with sodium cromoglycate (61) and placebo (64). Symptomatology was low, in general, but patient diary card scores showed significant cont...
P. J. Barnes - One of the best experts on this subject based on the ideXlab platform.
-
Effect of Nedocromil sodium on airway sensory nerves.
The Journal of allergy and clinical immunology, 1993Co-Authors: P. J. BarnesAbstract:There is increasing evidence that the sensory nerves of the airway play a role in the asthmatic response. Nerve endings are exposed by the epithelial shedding that occurs with asthma. They may become sensitized and activated by inflammatory mediators and may release neuropeptides that then spread and amplify the inflammatory process in the airways. Nedocromil sodium may prevent the sensory nerves from becoming sensitized and inhibit their activation. This possibility is suggested because Nedocromil is highly effective against several indirect challenges that involve sensory nerve stimulation. Nedocromil sodium was able to inhibit the bronchoconstriction induced in patients with asthma by exposure to bradykinin, sulfur dioxide, metabisulfite, and ultrasonically nebulized water. Cough, which is a prominent symptom of asthma, is believed to be a result of sensory nerve activation. In several long-term clinical studies, Nedocromil sodium reduces the severity of cough among patients with asthma. Studies are needed to define how Nedocromil sodium acts on the sensory nerves.
Soliman A Alkharashi - One of the best experts on this subject based on the ideXlab platform.
-
efficacy of Nedocromil 2 versus fluorometholone 0 1 a randomised double masked trial comparing the effects on severe vernal keratoconjunctivitis
British Journal of Ophthalmology, 1999Co-Authors: Khalid F. Tabbara, Soliman A AlkharashiAbstract:AIMS To compare the efficacy of topical Nedocromil 2% with fluorometholone 0.1% in vernal keratoconjunctivitis (VKC). METHODS In a double masked random design, 24 patients with severe vernal keratoconjunctivitis were placed at random on Nedocromil 2% eye drops in one eye and fluorometholone 0.1% in the fellow eye. At the end of the 2 week treatment period, the patient crossed over the eye drops (if asymptomatic in one eye), or continued with Nedocromil sodium in both eyes (if asymptomatic in both eyes). All patients were examined weekly and ocular surface temperature recorded for a period of 6 weeks. RESULTS Improvement in the watering, discharge, conjunctival hyperaemia, papillary hypertrophy, and Trantas’ dots was noted in both groups, but overall fluorometholone was significantly more effective than Nedocromil. Eyes treated with fluorometholone showed a significant decrease in ocular surface temperature compared with Nedocromil treated eyes (p = 0.03). CONCLUSIONS Both Nedocromil and fluorometholone were effective in ameliorating the signs and symptoms of vernal keratoconjunctivitis. No adverse effects were noted in the Nedocromil group.
Angela Hicks - One of the best experts on this subject based on the ideXlab platform.
-
supplementation of fexofenadine therapy with Nedocromil sodium 2 ophthalmic solution to treat ocular symptoms of seasonal allergic conjunctivitis
Clinical and Experimental Ophthalmology, 2003Co-Authors: Michael Alexander, Stacey Allegro, Piyush Patel, Angela HicksAbstract:Purpose: Ocular symptoms are often under-treated in patients with allergic rhinoconjunctivitis. The efficacy of fexofenadine hydrochloride 60 mg capsules supplemented with Nedocromil sodium 2% ophthalmic solution was evaluated to determine the optimal drug regimen for control of ocular allergic symptoms. Methods: In this 5-week, open-label, randomized, multicentre comparative study, 89 patients with documented ragweed pollen allergy received fexofenadine b.i.d. with Nedocromil rescue, fexofenadine q.d. with Nedocromil b.i.d., or fexofenadine rescue with Nedocromil b.i.d. during the ragweed pollen season. Results: For all regimens, mean symptom severity scores for itching, burning, tearing, redness, grittiness, discharge, light sensitivity and swelling improved significantly (P < 0.003). Similarly, all groups experienced significant (P < 0.02) improvement in all clinical signs: erythema, oedema, discharge, conjunctival injection and conjunctivitis, as well as quality-of-life scores (P < 0.0001). All regimens reduced overall symptom severity scores after 5 min (P < 0.05) with relief persisting over 12 h (P < 0.03). Improvements in mean symptoms, signs and quality-of-life scores were similar among the treatment groups as were onset and duration of action even though patients in two of the three study arms were taking one-half or less of the recommended fexofenadine dosage. Patients and physicians judged the regimens containing lower fexofenadine dosages (with Nedocromil b.i.d.) to be more effective overall than the regimen containing the highest fexofenadine dosage (with Nedocromil as rescue only). Conclusions: Supplementation of oral fexofenadine therapy with Nedocromil sodium 2% ophthalmic solution relieves ocular symptoms of seasonal allergic rhinoconjunctivitis, allowing control of rhinal symptoms with half the recommended dosage of fexofenadine.
-
Efficacy and acceptability of Nedocromil sodium 2% and olopatadine hydrochloride 0.1% in perennial allergic conjunctivitis
Advances in Therapy, 2000Co-Authors: Michael Alexander, Stacey Allegro, Angela HicksAbstract:In this 2-week, randomized, crossover study, ophthalmic solutions of Nedocromil sodium 2% and olopatadine hydrochloride 0.1% were compared for effectiveness and acceptability in 28 patients with perennial allergic conjunctivitis and previous olopatadine experience. Patients received Nedocromil twice daily or olopatadine twice daily for 1 week, then were crossed over to the alternate medication for 1 week. Outcome measures were patient satisfaction (questionnaire), severity of ocular symptoms (daily diary scores), clinical signs (physician assessments), quality of life (questionnaire), and global assessments of effectiveness. Both medications were well accepted. Of the 28 patients, 16 (57.1%) would request a Nedocromil prescription, 10 (35.7%) an olopatadine prescription ( P =.157); 22 patients (78.6%) would recommend Nedocromil to other allergy sufferers, while 18 (64.3%) would recommend olopatadine ( P =.480). Light sensitivity scores were significantly lower with Nedocromil ( P =.0125); other symptom scores were comparable between medications. Both drugs significantly ( P < .01) and comparably decreased erythema, conjunctival injection, and overall conjunctival signs from baseline. Comparable improvement also occurred in quality-of-life scores. Both physicians and patients judged Nedocromil and olopatadine to be similarly effective in preventing signs and symptoms. Nedocromil sodium 2% is an effective treatment for perennial allergic conjunctivitis. Patients receiving olopatadine can be switched to Nedocromil with no loss in efficacy or satisfaction, but with a reduction in cost.
Malcolm N. Blumenthal - One of the best experts on this subject based on the ideXlab platform.
-
Nedocromil sodium 2 ophthalmic solution for the treatment of ragweed pollen seasonal allergic conjunctivitis
Ocular Immunology and Inflammation, 2000Co-Authors: Malcolm N. Blumenthal, Robert H Schwartz, Harold KaiserAbstract:PURPOSE: To determine the efficacy and safety of Nedocromil sodium 2% ophthalmic solution in the treatment of seasonal allergic conjunctivitis. METHODS: A combined analysis of two multicenter, randomized, comparative, double-masked, placebo-controlled clinical trials involving 261 patients diagnosed with seasonal allergic conjunctivitis was used. Patients were randomly assigned to receive either topical 2% Nedocromil sodium or placebo twice daily for eight weeks. Diary card scores and clinician assessments of allergic symptoms were recorded throughout the study; efficacy was determined by comparing symptom severity at the peak pollen period with symptom severity at baseline. Clinician and patient evaluations of treatment effectiveness were used as secondary measurements of efficacy. RESULTS: Patients treated with Nedocromil sodium experienced improvement in allergy symptoms, with reductions in the summary symptom score, itch, redness, conjunctival injection, and conjunctival edema significantly (p<0.05) greater than those observed in the patients treated with placebo. Clinicians' and patients' opinions of Nedocromil sodium treatment effectiveness were significantly (p<0.02) superior to those of placebo treatment effectiveness. CONCLUSION: Nedocromil sodium is effective in the management of seasonal allergic conjunctivitis.
-
efficacy and safety of Nedocromil sodium 2 ophthalmic solution b i d in the treatment of ragweed seasonal allergic conjunctivitis
Allergy and Asthma Proceedings, 2000Co-Authors: J. Melamed, Malcolm N. Blumenthal, Robert H Schwartz, Howard J ZeitzAbstract:: The efficacy and safety of twice-daily Nedocromil sodium 2% ophthalmic solution and vehicle were compared in the treatment of ragweed seasonal allergic conjunctivitis. Two separate multicenter, randomized, double-masked, placebo-controlled studies were subjected to a combined analysis. Following a one-week baseline period during the beginning of the ragweed pollen season, 189 patients with seasonal allergic conjunctivitis received either Nedocromil sodium or vehicle b.i.d. for eight weeks. Efficacy was evaluated by patient diary cards and clinical eye examinations. Safety was assessed by reports of adverse events. Compared with vehicle, Nedocromil sodium produced significantly greater decreases in summary symptom score (p = 0.005), itch (p = 0.005), tearing (p = 0.004), overall eye condition (p = 0.001), and clinician-evaluated conjunctival edema (p = 0.018), and significantly better (p = 0.001), and patient (p = 0.001) opinions of treatment effectiveness at the peak pollen period. Additionally, the superiority of Nedocromil sodium compared to vehicle approached statistical significance in redness reduction (p = 0.087) and clinician-evaluated conjunctival injection (p = 0.087). There were no serious treatment-related adverse events in either treatment group. In summary, Nedocromil sodium 2% ophthalmic solution b.i.d. was found to be effective and to have a favorable safety profile in the treatment of seasonal allergic conjunctivitis.
