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Andreas F. Widmer - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic choriomeningitis virus meningitis after Needlestick Injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic choriomeningitis virus (LCMV), the virus can be transmitted to humans through Needlestick Injury and lead to serious acute illness up to meningitis. We report of a case of LCMV meningitis in a laboratory worker who sustained a penetrating Needlestick Injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the sharps waste bin. Four days after Needlestick Injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV meningitis, coupled with seroconversion, following Needlestick Injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.
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correction to lymphocytic choriomeningitis virus meningitis after Needlestick Injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:The original article [1] contains several mentions of a potentially misleading assertion which the authors would like to clarify; each mention relating to LCMV Needlestick Injury and its potential capacity for Injury.
Y E Cossart - One of the best experts on this subject based on the ideXlab platform.
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Needlestick Injury in medical students
The Medical Journal of Australia, 1994Co-Authors: B Devries, Y E CossartAbstract:OBJECTIVE: To determine the incidence of Needlestick injuries and the prevalence of hepatitis B vaccination among medical students, dentistry students, and hospital staff. DESIGN AND SUBJECTS: Anonymous survey of final year medical students and dentistry students enrolled at Sydney University in 1992, and nursing staff and doctors employed in the wards and emergency department of Royal Prince Alfred Hospital, Sydney. RESULTS: During their clinical training, 22% of medical students and 72% of dentistry students had received one or more contaminated, penetrating "sharps" injuries. Of hospital staff, 50% of ward nurses, 71% of ward doctors, and 50% of emergency staff had received this type of Injury during the previous two years. Students were significantly more likely to be vaccinated against hepatitis B than hospital staff (P < 0.001)--98% of medical students and 95% of dentistry students had received a full course of vaccination. The rate of vaccination among hospital staff ranged from 79% in emergency staff to 85% in ward nurses. CONCLUSIONS: Clinical students sustain Needlestick injuries at a rate comparable with hospital personnel and therefore face a significant risk of exposure to transmissible pathogens, including hepatitis B virus, HIV, and hepatitis C virus. The rate of hepatitis B vaccination is high among clinical hospital staff and almost universal among medical and dentistry students.
G. Zullo - One of the best experts on this subject based on the ideXlab platform.
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Needlestick Injury in hospital personnel a multicenter survey from central italy
Infection Control and Hospital Epidemiology, 1992Co-Authors: F Albertoni, L Sommella, V Di Nardo, Elisabetta Franco, Elisabetta Rapiti, Giuseppe Ippolito, Nicola Petrosillo, C Ricci, Carlo A. Perucci, G. ZulloAbstract:OBJECTIVES: To assess the rate of Needlestick Injury in hospital personnel in an Italian region. To identify risk factors potentially amendable to correction. DESIGN: Hospital workers undergoing hepatitis B prevaccination testing in 1985 through 1986 were interviewed regarding Needlestick Injury in the previous year, job category, area of work, years of employment, and other pertinent information. SETTING: Of the 98 public hospitals of the Latium region, 68 participated in the survey: 32 of 55 with less than 200 beds, 20 of 25 with 200 to 300 beds, 11 of 13 with 400 to 900 beds, and all of the 5 with more than 1,000 beds. PARTICIPANTS: All healthcare workers providing direct patient care or environmental services as well as student nurses were invited by the hospital directors to undergo hepatitis B prevaccination testing and vaccination, if eligible. RESULTS: Of 30,226 hospital workers of the 68 participating hospitals, 20,055 were interviewed (66.3%): 47.7% of the 7,172 doctors, 71% of the 14,157 nurses, 55.9% of the 2,513 technicians, and 71.9% of the 6,384 ancillary workers. Needlestick Injury was recalled by 29.3%; the rates were 54.9%, 35.3%, 33.8%, 26.5%, 18.7%, and 14.7% in surgeons, registered and unskilled nurses, physicians, ancillary workers, and technicians, respectively. The recalled Injury rate was 39.7% and 34.0% in surgical and intensive care areas; in infectious diseases, it was 16.7%. Rates were lower in hospitals with 200 to 300 beds (25.6%). The Needlestick Injury rate declined from 32% in those with less than 5 years of employment to 28% in those with more than 20 years (p less than .01). Prevalence of HBV infection was higher in student nurses and young workers recalling a Needlestick exposure (14.3% and 15.8%, respectively), versus 10.1% and 12.8% in those not exposed (p less than .01 and less than .05, respectively). CONCLUSIONS: Parenteral exposure to blood-borne infectious agents is a relevant risk among healthcare workers in our region, particularly in defined job categories and hospital areas (surgeons, nurses, surgical, and intensive care areas). Immunization and educational efforts should be made along with better designs of devices to reduce the risk of infection.
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Needlestick Injury in hospital personnel a multicenter survey from central italy
Infection Control and Hospital Epidemiology, 1992Co-Authors: F Albertoni, L Sommella, V Di Nardo, Elisabetta Franco, Elisabetta Rapiti, Giuseppe Ippolito, Nicola Petrosillo, C Ricci, Carlo A. Perucci, G. ZulloAbstract:Objectives:To assess the rate of Needlestick Injury in hospital personnel in an Italian region. To identify risk factors potentially amenable to correction.Design:Hospital workers undergoing hepatitis B prevaccination testing in 1985 through 1986 were interviewed regarding Needlestick Injury in the previous year, job category, area of work, years of employment, and other pertinent information.Setting:Of the 98 public hospitals of the Latium region, 68 participated in the survey: 32 of 55 with less than 200 beds, 20 of 25 with 200 to 300 beds, 11 of 13 with 400 to 900 beds, and all of the 5 with more than 1,000 beds.Participants:All healthcare workers providing direct patient care or environmental services as well as student nurses were invited by the hospital directors to undergo hepatitis B prevaccination testing and vaccination, if eligible.Results:Of 30,226 hospital workers of the 68 participating hospitals, 20,055 were interviewed (66.3%): 47.7% of the 7,172 doctors, 71% of the 14,157 nurses, 55.9% of the 2,513 technicians, and 71.9% of the 6,384 ancillary workers. Needlestick Injury was recalled by 29.3%; the rates were 54.9%, 35.3%, 33.8%, 26.5%, 18.7%, and 14.7% in surgeons, registered and unskilled nurses, physicians, ancillary workers, and technicians, respectively. The recalled Injury rate was 39.7% and 34.0% in surgical and intensive care areas; in infectious diseases, it was 16.7%. Bates were lower in hospitals with 200 to 300 beds (25.6%). The Needlestick Injury rate declined from 32% in those with less than 5 years of employment to 28% in those with more than 20 years (p<.01). Prevalence of HBV infection was higher in student nurses and young workers recalling a Needlestick exposure (14.3% and 15.8%, respectively), versus 10.1% and 12.8% in those not exposed (p<.01 and <.05, respectively).Conclusions:Parenteral exposure to bloodborne infectious agents is a relevant risk among healthcare workers in our region, particularly in defined job categories and hospital areas (surgeons, nurses, surgical, and intensive care areas). Immunization and educational efforts should be made along with better designs of devices to reduce the risk of infection.
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Needlestick Injury in hospital personnel a multicenter survey from central italy the latium hepatitis b prevention group
Infection Control and Hospital Epidemiology, 1992Co-Authors: F Albertoni, L Sommella, V Di Nardo, Elisabetta Franco, Elisabetta Rapiti, Giuseppe Ippolito, Nicola Petrosillo, C Ricci, Carlo A. Perucci, G. ZulloAbstract:OBJECTIVES: To assess the rate of Needlestick Injury in hospital personnel in an Italian region. To identify risk factors potentially amendable to correction. DESIGN: Hospital workers undergoing hepatitis B prevaccination testing in 1985 through 1986 were interviewed regarding Needlestick Injury in the previous year, job category, area of work, years of employment, and other pertinent information. SETTING: Of the 98 public hospitals of the Latium region, 68 participated in the survey: 32 of 55 with less than 200 beds, 20 of 25 with 200 to 300 beds, 11 of 13 with 400 to 900 beds, and all of the 5 with more than 1,000 beds. PARTICIPANTS: All healthcare workers providing direct patient care or environmental services as well as student nurses were invited by the hospital directors to undergo hepatitis B prevaccination testing and vaccination, if eligible. RESULTS: Of 30,226 hospital workers of the 68 participating hospitals, 20,055 were interviewed (66.3%): 47.7% of the 7,172 doctors, 71% of the 14,157 nurses, 55.9% of the 2,513 technicians, and 71.9% of the 6,384 ancillary workers. Needlestick Injury was recalled by 29.3%; the rates were 54.9%, 35.3%, 33.8%, 26.5%, 18.7%, and 14.7% in surgeons, registered and unskilled nurses, physicians, ancillary workers, and technicians, respectively. The recalled Injury rate was 39.7% and 34.0% in surgical and intensive care areas; in infectious diseases, it was 16.7%. Rates were lower in hospitals with 200 to 300 beds (25.6%). The Needlestick Injury rate declined from 32% in those with less than 5 years of employment to 28% in those with more than 20 years (p less than .01). Prevalence of HBV infection was higher in student nurses and young workers recalling a Needlestick exposure (14.3% and 15.8%, respectively), versus 10.1% and 12.8% in those not exposed (p less than .01 and less than .05, respectively). CONCLUSIONS: Parenteral exposure to blood-borne infectious agents is a relevant risk among healthcare workers in our region, particularly in defined job categories and hospital areas (surgeons, nurses, surgical, and intensive care areas). Immunization and educational efforts should be made along with better designs of devices to reduce the risk of infection.
Geun-ryang Bae - One of the best experts on this subject based on the ideXlab platform.
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Laboratory-acquired dengue virus infection by Needlestick Injury: a case report, South Korea, 2014
Annals of Occupational and Environmental Medicine, 2016Co-Authors: Changhwan Lee, Eun Jung Jang, Donghyok Kwon, Jung Wan Park, Heun Choi, Geun-ryang BaeAbstract:Background Dengue fever is one of the most dominant vector-borne diseases, putting approximately 3.9 billion people at risk worldwide. While it is generally vector-borne, other routes of transmission such as Needlestick Injury are possible. Laboratory workers can be exposed to dengue virus transcutaneously by Needlestick Injury. This is the first case, to our knowledge, of dengue virus infection by Needlestick Injury in a laboratory environment. This paper evaluates the risk and related health concerns of laboratory workers exposed to dengue virus. Case presentation We evaluated a 30-year-old female laboratory worker exposed to the dengue virus by Needlestick Injury while conducting virus filtering. During admission, she showed symptoms of fever, nausea, myalgia, and a characteristic maculopapular rash with elevated aspartate aminotransferase (AST) of 235 IU/L and alanine aminotransferase (ALT) of 269 IU/L. She had been diagnosed by a positive nonstructural protein 1 (NS1) antigen (Ag) rapid test one day prior to symptom onset along with positive immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) on the ninth day of symptom onset. Reverse transcription polymerase chain reaction (RT-PCR), also conducted on the ninth day, was negative. After proper symptomatic treatment, she recovered without any sequelae. As a result of thorough epidemiologic investigation, it was determined that she had tried to recap the needle during the virus filtering procedure and a subsequent Needlestick Injury occurred. Conclusions In the context of health promotion of laboratory workers, we suggest that the laboratory biosafety manual be revised and reinforced, and related prevention measures be implemented. Furthermore, health authorities and health care providers in Korea should be fully informed of proper dengue fever management.
Giuseppe Ippolito - One of the best experts on this subject based on the ideXlab platform.
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device specific risk of Needlestick Injury in italian health care workers
JAMA, 1994Co-Authors: Giuseppe Ippolito, Gabriella De Carli, Claudio Arici, Roberto Bertucci, Luca Bianciardi, Lucio Bonazzi, Adriano Cestrone, Vincenzo Puro, Nicola Petrosillo, M DaglioAbstract:Objectives. —To identify the types of medical devices causing Needlestick injuries among Italian health care workers, to document the device-specific Injury rates and time trends for different hollow-bore needles, and to compare Injury rates from these devices with those reported in the United States. Design. —Longitudinal survey. Settings. —Twelve Italian acute care public hospitals. Methods. —Data were obtained from a multihospital surveillance database on the number of total injuries reported in each device category. Hospitals provided the corresponding number of devices used annually for each needle type. Main Outcome Measure. —Number of Needlestick injuries by type of hollow-bore needle per 100000 devices used per year. Results. —A total of 2524 injuries from hollow-bore needles were reported. Disposable syringes/hypodermic needles accounted for 59.3% of injuries, followed by winged steel needles (33.1%), intravenous catheter stylets (5.4%), and vacuum-tube phlebotomy needles (2.2%). Intravenous catheter stylets had the highest Needlestick Injury rate (15.7/100 000 devices used), and disposable syringes had the lowest Needlestick Injury rate (3.8/100 000). In contrast to the other devices, the Injury rate from winged steel needles increased from 6.2 per 100 000 in 1990 to 13.9 per 100000 in 1992. Conclusions. —The device-specific Needlestick Injury rates in Italy are similar to those reported in the United States, suggesting similar exposure experience in two countries. However, in contrast to the United States, needleless intravenous access is standard practice in Italy and thus eliminates one potential risk to Italian health workers. Implementation of safer equipment, such as shielded or retracting needles, and continuing training programs are needed to further reduce the hazards that health care workers face. ( JAMA . 1994;272:607-610)
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Needlestick Injury in hospital personnel a multicenter survey from central italy
Infection Control and Hospital Epidemiology, 1992Co-Authors: F Albertoni, L Sommella, V Di Nardo, Elisabetta Franco, Elisabetta Rapiti, Giuseppe Ippolito, Nicola Petrosillo, C Ricci, Carlo A. Perucci, G. ZulloAbstract:OBJECTIVES: To assess the rate of Needlestick Injury in hospital personnel in an Italian region. To identify risk factors potentially amendable to correction. DESIGN: Hospital workers undergoing hepatitis B prevaccination testing in 1985 through 1986 were interviewed regarding Needlestick Injury in the previous year, job category, area of work, years of employment, and other pertinent information. SETTING: Of the 98 public hospitals of the Latium region, 68 participated in the survey: 32 of 55 with less than 200 beds, 20 of 25 with 200 to 300 beds, 11 of 13 with 400 to 900 beds, and all of the 5 with more than 1,000 beds. PARTICIPANTS: All healthcare workers providing direct patient care or environmental services as well as student nurses were invited by the hospital directors to undergo hepatitis B prevaccination testing and vaccination, if eligible. RESULTS: Of 30,226 hospital workers of the 68 participating hospitals, 20,055 were interviewed (66.3%): 47.7% of the 7,172 doctors, 71% of the 14,157 nurses, 55.9% of the 2,513 technicians, and 71.9% of the 6,384 ancillary workers. Needlestick Injury was recalled by 29.3%; the rates were 54.9%, 35.3%, 33.8%, 26.5%, 18.7%, and 14.7% in surgeons, registered and unskilled nurses, physicians, ancillary workers, and technicians, respectively. The recalled Injury rate was 39.7% and 34.0% in surgical and intensive care areas; in infectious diseases, it was 16.7%. Rates were lower in hospitals with 200 to 300 beds (25.6%). The Needlestick Injury rate declined from 32% in those with less than 5 years of employment to 28% in those with more than 20 years (p less than .01). Prevalence of HBV infection was higher in student nurses and young workers recalling a Needlestick exposure (14.3% and 15.8%, respectively), versus 10.1% and 12.8% in those not exposed (p less than .01 and less than .05, respectively). CONCLUSIONS: Parenteral exposure to blood-borne infectious agents is a relevant risk among healthcare workers in our region, particularly in defined job categories and hospital areas (surgeons, nurses, surgical, and intensive care areas). Immunization and educational efforts should be made along with better designs of devices to reduce the risk of infection.
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Needlestick Injury in hospital personnel a multicenter survey from central italy
Infection Control and Hospital Epidemiology, 1992Co-Authors: F Albertoni, L Sommella, V Di Nardo, Elisabetta Franco, Elisabetta Rapiti, Giuseppe Ippolito, Nicola Petrosillo, C Ricci, Carlo A. Perucci, G. ZulloAbstract:Objectives:To assess the rate of Needlestick Injury in hospital personnel in an Italian region. To identify risk factors potentially amenable to correction.Design:Hospital workers undergoing hepatitis B prevaccination testing in 1985 through 1986 were interviewed regarding Needlestick Injury in the previous year, job category, area of work, years of employment, and other pertinent information.Setting:Of the 98 public hospitals of the Latium region, 68 participated in the survey: 32 of 55 with less than 200 beds, 20 of 25 with 200 to 300 beds, 11 of 13 with 400 to 900 beds, and all of the 5 with more than 1,000 beds.Participants:All healthcare workers providing direct patient care or environmental services as well as student nurses were invited by the hospital directors to undergo hepatitis B prevaccination testing and vaccination, if eligible.Results:Of 30,226 hospital workers of the 68 participating hospitals, 20,055 were interviewed (66.3%): 47.7% of the 7,172 doctors, 71% of the 14,157 nurses, 55.9% of the 2,513 technicians, and 71.9% of the 6,384 ancillary workers. Needlestick Injury was recalled by 29.3%; the rates were 54.9%, 35.3%, 33.8%, 26.5%, 18.7%, and 14.7% in surgeons, registered and unskilled nurses, physicians, ancillary workers, and technicians, respectively. The recalled Injury rate was 39.7% and 34.0% in surgical and intensive care areas; in infectious diseases, it was 16.7%. Bates were lower in hospitals with 200 to 300 beds (25.6%). The Needlestick Injury rate declined from 32% in those with less than 5 years of employment to 28% in those with more than 20 years (p<.01). Prevalence of HBV infection was higher in student nurses and young workers recalling a Needlestick exposure (14.3% and 15.8%, respectively), versus 10.1% and 12.8% in those not exposed (p<.01 and <.05, respectively).Conclusions:Parenteral exposure to bloodborne infectious agents is a relevant risk among healthcare workers in our region, particularly in defined job categories and hospital areas (surgeons, nurses, surgical, and intensive care areas). Immunization and educational efforts should be made along with better designs of devices to reduce the risk of infection.
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Needlestick Injury in hospital personnel a multicenter survey from central italy the latium hepatitis b prevention group
Infection Control and Hospital Epidemiology, 1992Co-Authors: F Albertoni, L Sommella, V Di Nardo, Elisabetta Franco, Elisabetta Rapiti, Giuseppe Ippolito, Nicola Petrosillo, C Ricci, Carlo A. Perucci, G. ZulloAbstract:OBJECTIVES: To assess the rate of Needlestick Injury in hospital personnel in an Italian region. To identify risk factors potentially amendable to correction. DESIGN: Hospital workers undergoing hepatitis B prevaccination testing in 1985 through 1986 were interviewed regarding Needlestick Injury in the previous year, job category, area of work, years of employment, and other pertinent information. SETTING: Of the 98 public hospitals of the Latium region, 68 participated in the survey: 32 of 55 with less than 200 beds, 20 of 25 with 200 to 300 beds, 11 of 13 with 400 to 900 beds, and all of the 5 with more than 1,000 beds. PARTICIPANTS: All healthcare workers providing direct patient care or environmental services as well as student nurses were invited by the hospital directors to undergo hepatitis B prevaccination testing and vaccination, if eligible. RESULTS: Of 30,226 hospital workers of the 68 participating hospitals, 20,055 were interviewed (66.3%): 47.7% of the 7,172 doctors, 71% of the 14,157 nurses, 55.9% of the 2,513 technicians, and 71.9% of the 6,384 ancillary workers. Needlestick Injury was recalled by 29.3%; the rates were 54.9%, 35.3%, 33.8%, 26.5%, 18.7%, and 14.7% in surgeons, registered and unskilled nurses, physicians, ancillary workers, and technicians, respectively. The recalled Injury rate was 39.7% and 34.0% in surgical and intensive care areas; in infectious diseases, it was 16.7%. Rates were lower in hospitals with 200 to 300 beds (25.6%). The Needlestick Injury rate declined from 32% in those with less than 5 years of employment to 28% in those with more than 20 years (p less than .01). Prevalence of HBV infection was higher in student nurses and young workers recalling a Needlestick exposure (14.3% and 15.8%, respectively), versus 10.1% and 12.8% in those not exposed (p less than .01 and less than .05, respectively). CONCLUSIONS: Parenteral exposure to blood-borne infectious agents is a relevant risk among healthcare workers in our region, particularly in defined job categories and hospital areas (surgeons, nurses, surgical, and intensive care areas). Immunization and educational efforts should be made along with better designs of devices to reduce the risk of infection.
