The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
Philipp Jung - One of the best experts on this subject based on the ideXlab platform.
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Neonatal Assessment in the delivery room – Trial to Evaluate a Specified Type of Apgar (TEST-Apgar)
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Jacob Aranda, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Khaled El-atawi, Sascha Ifflaender, Philipp JungAbstract:Background Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Methods Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Results Of 2150 eligible newborns, data on 1855 infants with a mean GA of 28^6/7 ± 2^3/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. Conclusion The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. Trial registration clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
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Neonatal Assessment in the delivery room trial to evaluate a specified type of apgar test apgar
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Sascha Ifflaender, Jacob V Aranda, Khaled Elatawi, Philipp JungAbstract:Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Of 2150 eligible newborns, data on 1855 infants with a mean GA of 286/7 ± 23/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
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Neonatal Assessment in the delivery room – Trial to Evaluate a Specified Type of Apgar (TEST-Apgar)
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Khaled El-atawi, Sascha Ifflaender, Jacob V Aranda, Philipp JungAbstract:Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Of 2150 eligible newborns, data on 1855 infants with a mean GA of 286/7 ± 23/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
Daniela Ricci - One of the best experts on this subject based on the ideXlab platform.
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application of a Neonatal Assessment of visual function in a population of low risk full term newborn
Early Human Development, 2008Co-Authors: Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Daniela Ricci, Laura Cesarini, Costantino RomagnoliAbstract:BACKGROUND: We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. AIM OF THE STUDY: Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. STUDY DESIGN AND SUBJECTS: 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. RESULTS: The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p<0.05) and the ability to discriminate stripes and attention at distance (p<0.001). CONCLUSION: Our results provide information on the visual abilities in a low risk population of term-born infants and the distribution of frequency of their visual responses to our battery of visual tests. These findings may be used as reference data when using our visual test battery in both clinical and research settings.
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application of a Neonatal Assessment of visual function in a population of low risk full term newborn
Early Human Development, 2008Co-Authors: Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Daniela Ricci, Laura Cesarini, Costantino RomagnoliAbstract:Abstract Background We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. Aim of the study Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. Study design and subjects 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. Results The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p Conclusion Our results provide information on the visual abilities in a low risk population of term-born infants and the distribution of frequency of their visual responses to our battery of visual tests. These findings may be used as reference data when using our visual test battery in both clinical and research settings.
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Application of a Neonatal Assessment of visual function in a population of low risk full-term newborn
Early Human Development, 2008Co-Authors: Daniela Ricci, Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Costantino Romagnoli, Laura Cesarini, Frances CowanAbstract:Background: We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. Aim of the study: Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. Study design and subjects: 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. Results: The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p < 0.05) and the ability to discriminate stripes and attention at distance (p < 0.001). Conclusion: Our results provide information on the visual abilities in a low risk population of term-born infants and the distribution of frequency of their visual responses to our battery of visual tests. These findings may be used as reference data when using our visual test battery in both clinical and research settings. © 2007 Elsevier Ireland Ltd. All rights reserved.
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Application of a Neonatal Assessment of visual function in a population of low risk full-term newborn
Early Human Development, 2007Co-Authors: Daniela Ricci, Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Costantino Romagnoli, Laura Cesarini, Frances M. CowanAbstract:BACKGROUND: We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. AIM OF THE STUDY: Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. STUDY DESIGN AND SUBJECTS: 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. RESULTS: The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p
Costantino Romagnoli - One of the best experts on this subject based on the ideXlab platform.
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application of a Neonatal Assessment of visual function in a population of low risk full term newborn
Early Human Development, 2008Co-Authors: Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Daniela Ricci, Laura Cesarini, Costantino RomagnoliAbstract:BACKGROUND: We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. AIM OF THE STUDY: Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. STUDY DESIGN AND SUBJECTS: 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. RESULTS: The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p<0.05) and the ability to discriminate stripes and attention at distance (p<0.001). CONCLUSION: Our results provide information on the visual abilities in a low risk population of term-born infants and the distribution of frequency of their visual responses to our battery of visual tests. These findings may be used as reference data when using our visual test battery in both clinical and research settings.
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application of a Neonatal Assessment of visual function in a population of low risk full term newborn
Early Human Development, 2008Co-Authors: Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Daniela Ricci, Laura Cesarini, Costantino RomagnoliAbstract:Abstract Background We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. Aim of the study Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. Study design and subjects 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. Results The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p Conclusion Our results provide information on the visual abilities in a low risk population of term-born infants and the distribution of frequency of their visual responses to our battery of visual tests. These findings may be used as reference data when using our visual test battery in both clinical and research settings.
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Application of a Neonatal Assessment of visual function in a population of low risk full-term newborn
Early Human Development, 2008Co-Authors: Daniela Ricci, Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Costantino Romagnoli, Laura Cesarini, Frances CowanAbstract:Background: We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. Aim of the study: Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. Study design and subjects: 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. Results: The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p < 0.05) and the ability to discriminate stripes and attention at distance (p < 0.001). Conclusion: Our results provide information on the visual abilities in a low risk population of term-born infants and the distribution of frequency of their visual responses to our battery of visual tests. These findings may be used as reference data when using our visual test battery in both clinical and research settings. © 2007 Elsevier Ireland Ltd. All rights reserved.
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Application of a Neonatal Assessment of visual function in a population of low risk full-term newborn
Early Human Development, 2007Co-Authors: Daniela Ricci, Francesco Serrao, Daniela Leone, Domenico M.m. Romeo, Antonio A. Zuppa, Francesco Cota, Francesca Gallini, Costantino Romagnoli, Laura Cesarini, Frances M. CowanAbstract:BACKGROUND: We have previously developed and described a battery of 9 items suitable for assessing different clinical aspects of visual function in newborn infants. AIM OF THE STUDY: Application of the test battery to a cohort of low risk term-born infants at 48 and 72 h after birth 1) to define the normative distribution of results for each item and 2) to document any effect of postnatal age. STUDY DESIGN AND SUBJECTS: 124 term-born low risk infants were assessed at 48 h; fifty of them were re-assessed 24 h later at 72 h. RESULTS: The visual test battery was successfully completed in 110 of the 124 infants assessed at 48 h and in all the 50 infants assessed at 72 h after birth. For 3 of the 9 items (fixation on a black/white target of concentric circles, on a coloured (red/yellow) face and horizontal tracking), the findings were very similar at both ages. For the remaining 6 items the range of findings was wider. There was a statistical difference in the responses obtained at 48 and 72 h for vertical and arc tracking (p
Mario Rüdiger - One of the best experts on this subject based on the ideXlab platform.
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Neonatal Assessment in the delivery room – Trial to Evaluate a Specified Type of Apgar (TEST-Apgar)
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Jacob Aranda, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Khaled El-atawi, Sascha Ifflaender, Philipp JungAbstract:Background Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Methods Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Results Of 2150 eligible newborns, data on 1855 infants with a mean GA of 28^6/7 ± 2^3/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. Conclusion The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. Trial registration clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
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Neonatal Assessment in the delivery room trial to evaluate a specified type of apgar test apgar
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Sascha Ifflaender, Jacob V Aranda, Khaled Elatawi, Philipp JungAbstract:Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Of 2150 eligible newborns, data on 1855 infants with a mean GA of 286/7 ± 23/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
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Neonatal Assessment in the delivery room – Trial to Evaluate a Specified Type of Apgar (TEST-Apgar)
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Khaled El-atawi, Sascha Ifflaender, Jacob V Aranda, Philipp JungAbstract:Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Of 2150 eligible newborns, data on 1855 infants with a mean GA of 286/7 ± 23/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
Nicole Braun - One of the best experts on this subject based on the ideXlab platform.
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Neonatal Assessment in the delivery room – Trial to Evaluate a Specified Type of Apgar (TEST-Apgar)
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Jacob Aranda, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Khaled El-atawi, Sascha Ifflaender, Philipp JungAbstract:Background Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Methods Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Results Of 2150 eligible newborns, data on 1855 infants with a mean GA of 28^6/7 ± 2^3/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. Conclusion The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. Trial registration clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
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Neonatal Assessment in the delivery room trial to evaluate a specified type of apgar test apgar
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Sascha Ifflaender, Jacob V Aranda, Khaled Elatawi, Philipp JungAbstract:Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Of 2150 eligible newborns, data on 1855 infants with a mean GA of 286/7 ± 23/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
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Neonatal Assessment in the delivery room – Trial to Evaluate a Specified Type of Apgar (TEST-Apgar)
BMC Pediatrics, 2015Co-Authors: Mario Rüdiger, Nicole Braun, Marta Aguar, Renate Bergert, Alica Bystricka, Gabriel Dimitriou, Khaled El-atawi, Sascha Ifflaender, Jacob V Aranda, Philipp JungAbstract:Since an objective description is essential to determine infant’s postnatal condition and efficacy of interventions, two scores were suggested in the past but weren’t tested yet: The Specified-Apgar uses the 5 items of the conventional Apgar score; however describes the condition regardless of gestational age (GA) or resuscitative interventions. The Expanded-Apgar measures interventions needed to achieve this condition. We hypothesized that the combination of both (Combined-Apgar) describes postnatal condition of preterm infants better than either of the scores alone. Scores were assessed in preterm infants below 32 completed weeks of gestation. Data were prospectively collected in 20 NICU in 12 countries. Prediction of poor outcome (death, severe/moderate BPD, IVH, CPL and ROP) was used as a surrogate parameter to compare the scores. To compare predictive value the AUC for the ROC was calculated. Of 2150 eligible newborns, data on 1855 infants with a mean GA of 286/7 ± 23/7 weeks were analyzed. At 1 minute, the Combined-Apgar was significantly better in predicting poor outcome than the Specified- or Expanded-Apgar alone. Of infants with a very low score at 5 or 10 minutes 81% or 100% had a poor outcome, respectively. In these infants the relative risk (RR) for perinatal mortality was 24.93 (13.16-47.20) and 31.34 (15.91-61.71), respectively. The Combined-Apgar allows a more appropriate description of infant’s condition under conditions of modern Neonatal care. It should be used as a tool for better comparison of group of infants and postnatal interventions. clinicaltrials.gov Protocol Registration System ( NCT00623038 ). Registered 14 February 2008.
