The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Anika M. S. Hartz - One of the best experts on this subject based on the ideXlab platform.
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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice.
PloS one, 2016Co-Authors: Andrea Wolf, Björn Bauer, Erin L. Abner, Tal Ashkenazy-frolinger, Anika M. S. HartzAbstract:Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid beta (Aβ) pathology and cognition. Tg2576 mice on a B6;SJL background strain carry a recessive rd1 mutation that leads to early retinal degeneration and visual impairment in homozygous carriers. This can impair performance in behavioral Tests that rely on visual cues, and thus, affect study results. Therefore, B6;SJL/Tg2576 mice were systematically backcrossed with 129S6/SvEvTac mice resulting in 129S6/Tg2576 mice that lack the rd1 mutation. 129S6/Tg2576 mice do not develop retinal degeneration but still show Aβ accumulation in the brain that is comparable to the original B6;SJL/Tg2576 mouse. However, comprehensive studies on cognitive decline in 129S6/Tg2576 mice are limited. In this study, we used two dementia mouse models on a 129S6 background--scopolamine-treated 129S6/SvEvTac mice (3-5 month-old) and transgenic 129S6/Tg2576 mice (11-13 month-old)-to establish a behavioral Test Battery for assessing learning and memory. The Test Battery consisted of five Tests to evaluate different aspects of cognitive impairment: a Y-Maze forced alternation task, a novel object recognition Test, the Morris water maze, the radial arm water maze, and a Y-maze spontaneous alternation task. We first established this behavioral Test Battery with the scopolamine-induced dementia model using 129S6/SvEvTac mice and then evaluated 129S6/Tg2576 mice using the same Testing protocol. Both models showed distinctive patterns of cognitive impairment. Together, the non-invasive behavioral Test Battery presented here allows detecting cognitive impairment in scopolamine-treated 129S6/SvEvTac mice and in transgenic 129S6/Tg2576 mice. Due to the modular nature of this Test Battery, more behavioral Tests, e.g. invasive assays to gain additional cognitive information, can easily be added.
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a comprehensive behavioral Test Battery to assess learning and memory in 129s6 tg2576 mice
PLOS ONE, 2016Co-Authors: Andrea Wolf, Björn Bauer, Erin L. Abner, Anika M. S. Hartz, Tal AshkenazyfrolingerAbstract:Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid beta (Aβ) pathology and cognition. Tg2576 mice on a B6;SJL background strain carry a recessive rd1 mutation that leads to early retinal degeneration and visual impairment in homozygous carriers. This can impair performance in behavioral Tests that rely on visual cues, and thus, affect study results. Therefore, B6;SJL/Tg2576 mice were systematically backcrossed with 129S6/SvEvTac mice resulting in 129S6/Tg2576 mice that lack the rd1 mutation. 129S6/Tg2576 mice do not develop retinal degeneration but still show Aβ accumulation in the brain that is comparable to the original B6;SJL/Tg2576 mouse. However, comprehensive studies on cognitive decline in 129S6/Tg2576 mice are limited. In this study, we used two dementia mouse models on a 129S6 background--scopolamine-treated 129S6/SvEvTac mice (3-5 month-old) and transgenic 129S6/Tg2576 mice (11-13 month-old)-to establish a behavioral Test Battery for assessing learning and memory. The Test Battery consisted of five Tests to evaluate different aspects of cognitive impairment: a Y-Maze forced alternation task, a novel object recognition Test, the Morris water maze, the radial arm water maze, and a Y-maze spontaneous alternation task. We first established this behavioral Test Battery with the scopolamine-induced dementia model using 129S6/SvEvTac mice and then evaluated 129S6/Tg2576 mice using the same Testing protocol. Both models showed distinctive patterns of cognitive impairment. Together, the non-invasive behavioral Test Battery presented here allows detecting cognitive impairment in scopolamine-treated 129S6/SvEvTac mice and in transgenic 129S6/Tg2576 mice. Due to the modular nature of this Test Battery, more behavioral Tests, e.g. invasive assays to gain additional cognitive information, can easily be added.
Grant L. Iverson - One of the best experts on this subject based on the ideXlab platform.
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examining Test reTest reliability and reliable change for cognition endpoints for the center tbi neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Toril Skandsen, Noah D Silverberg, Rune Hatlestad Karlsen, Grant L. IversonAbstract:Objective: Seven candidate cognition composite scores have been developed and evaluated as part of a research program designed to validate a cognition endpoint for traumatic brain injury (TBI) research and clinical trials, but these composites have yet to be examined longitudinally. This study examined Test-reTest reliability and methods for determining reliable change for these seven candidate composite scores, using the neuropsychological Test Battery from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants (18-59 years-old) with mild TBI (n = 124), orthopedic trauma without head injury (n = 67), and healthy community controls (n = 63) from the Trondheim MTBI follow-up study completed the CENTER-TBI neuropsychological Test Battery at 2 weeks and 3 months after injury. The Battery included both traditional paper-and-pencil Tests and computerized Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper-and-pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites in total on each assessment): the overall Test Battery mean (OTBM); global deficit score (GDS); neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. The OTBM was calculated by averaging T scores for all Tests. The other composite scores were deficit-based scores, assigning different weights to low scores. Results: All composites revealed better cognitive performance at the 3-month assessment compared to the 2-week assessment and the magnitude of improvement was similar across groups. Differences, in terms of effect sizes, were largest on the OTBMs. In the combined composites, the Test-reTest correlation was highest for the OTBM (Spearman's rho = 0.87, in the community control group) and lowest for the number of scores ≤5th percentile (rho = 0.41). Conclusion: The high Test-reTest reliability of the OTBM appears to favor its use in TBI research; however, future studies are needed to examine these candidate composite scores in participants with more severe TBIs and cognitive deficits and the association of the composites with functional outcomes.
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developing cognition endpoints for the center tbi neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Douglas P Terry, Simen B Saksvik, Toril Skandsen, Noah D Silverberg, Grant L. IversonAbstract:Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several neuropsychological Test scores into composite, or summary, scores exists. This study examined several possible composite scores for the Test Battery used in the large-scale study Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants with mild traumatic brain injury (MTBI; n = 140), orthopedic trauma (n = 72), and healthy community controls (n = 70) from the Trondheim MTBI follow-up study completed the CENTER-TBI Test Battery at 2 weeks after injury, which includes both traditional paper-and-pencil Tests and Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper and pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites): the overall Test Battery mean (OTBM); global deficit score (GDS); neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. Results: The OTBM and the number of scores <50th percentile composites had distributional characteristics approaching a normal distribution. The other composites were in general highly skewed and zero-inflated. When the MTBI group, the trauma control group, and the community control group were compared, effect sizes were negligible to small for all composites. Subgroups with vs. without loss of consciousness at the time of injury did not differ on the composite scores and neither did subgroups with complicated vs. uncomplicated MTBIs. Intercorrelations were high within the paper-and-pencil composites, the CANTAB composites, and the combined composites and lower between the paper-and-pencil composites and the CANTAB composites. Conclusion: None of the composites revealed significant differences between participants with MTBI and the two control groups. Some of the composite scores were highly correlated and may be redundant. Additional research on patients with moderate to severe TBIs is needed to determine which scores are most appropriate for TBI clinical trials.
Paul D. Frymier - One of the best experts on this subject based on the ideXlab platform.
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Use of multidimensional scaling in the selection of wastewater toxicity Test Battery components
Water research, 2003Co-Authors: Shijin Ren, Paul D. FrymierAbstract:In aquatic toxicity Testing, no single Test species is sensitive to all toxicants. Therefore, Test batteries consisting of several individual assays are becoming more common. The organisms in a Test Battery should be representative of the entire system of interest. The results of the assays should be complementary to other components in the Test Battery to avoid redundancy. With the aid of multidimensional scaling (MDS), a multivariate statistical method, we examined the toxicity data of five bioassays (the continuous Shk1, Polytox®, activated sludge respiration inhibition, Nitrosomonas, and Tetrahymena assays) that could serve as Test Battery components for the assessment of wastewater toxicity to activated sludge. MDS mapped the five assays into a two-dimensional space and showed that the Nitrosomonas assay should be included in Test batteries plus one of the remaining four assays for assessing wastewater toxicity to activated sludge.
Jonas Stenberg - One of the best experts on this subject based on the ideXlab platform.
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examining Test reTest reliability and reliable change for cognition endpoints for the center tbi neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Toril Skandsen, Noah D Silverberg, Rune Hatlestad Karlsen, Grant L. IversonAbstract:Objective: Seven candidate cognition composite scores have been developed and evaluated as part of a research program designed to validate a cognition endpoint for traumatic brain injury (TBI) research and clinical trials, but these composites have yet to be examined longitudinally. This study examined Test-reTest reliability and methods for determining reliable change for these seven candidate composite scores, using the neuropsychological Test Battery from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants (18-59 years-old) with mild TBI (n = 124), orthopedic trauma without head injury (n = 67), and healthy community controls (n = 63) from the Trondheim MTBI follow-up study completed the CENTER-TBI neuropsychological Test Battery at 2 weeks and 3 months after injury. The Battery included both traditional paper-and-pencil Tests and computerized Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper-and-pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites in total on each assessment): the overall Test Battery mean (OTBM); global deficit score (GDS); neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. The OTBM was calculated by averaging T scores for all Tests. The other composite scores were deficit-based scores, assigning different weights to low scores. Results: All composites revealed better cognitive performance at the 3-month assessment compared to the 2-week assessment and the magnitude of improvement was similar across groups. Differences, in terms of effect sizes, were largest on the OTBMs. In the combined composites, the Test-reTest correlation was highest for the OTBM (Spearman's rho = 0.87, in the community control group) and lowest for the number of scores ≤5th percentile (rho = 0.41). Conclusion: The high Test-reTest reliability of the OTBM appears to favor its use in TBI research; however, future studies are needed to examine these candidate composite scores in participants with more severe TBIs and cognitive deficits and the association of the composites with functional outcomes.
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developing cognition endpoints for the center tbi neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Douglas P Terry, Simen B Saksvik, Toril Skandsen, Noah D Silverberg, Grant L. IversonAbstract:Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several neuropsychological Test scores into composite, or summary, scores exists. This study examined several possible composite scores for the Test Battery used in the large-scale study Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants with mild traumatic brain injury (MTBI; n = 140), orthopedic trauma (n = 72), and healthy community controls (n = 70) from the Trondheim MTBI follow-up study completed the CENTER-TBI Test Battery at 2 weeks after injury, which includes both traditional paper-and-pencil Tests and Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper and pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites): the overall Test Battery mean (OTBM); global deficit score (GDS); neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. Results: The OTBM and the number of scores <50th percentile composites had distributional characteristics approaching a normal distribution. The other composites were in general highly skewed and zero-inflated. When the MTBI group, the trauma control group, and the community control group were compared, effect sizes were negligible to small for all composites. Subgroups with vs. without loss of consciousness at the time of injury did not differ on the composite scores and neither did subgroups with complicated vs. uncomplicated MTBIs. Intercorrelations were high within the paper-and-pencil composites, the CANTAB composites, and the combined composites and lower between the paper-and-pencil composites and the CANTAB composites. Conclusion: None of the composites revealed significant differences between participants with MTBI and the two control groups. Some of the composite scores were highly correlated and may be redundant. Additional research on patients with moderate to severe TBIs is needed to determine which scores are most appropriate for TBI clinical trials.
Björn Bauer - One of the best experts on this subject based on the ideXlab platform.
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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice.
PloS one, 2016Co-Authors: Andrea Wolf, Björn Bauer, Erin L. Abner, Tal Ashkenazy-frolinger, Anika M. S. HartzAbstract:Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid beta (Aβ) pathology and cognition. Tg2576 mice on a B6;SJL background strain carry a recessive rd1 mutation that leads to early retinal degeneration and visual impairment in homozygous carriers. This can impair performance in behavioral Tests that rely on visual cues, and thus, affect study results. Therefore, B6;SJL/Tg2576 mice were systematically backcrossed with 129S6/SvEvTac mice resulting in 129S6/Tg2576 mice that lack the rd1 mutation. 129S6/Tg2576 mice do not develop retinal degeneration but still show Aβ accumulation in the brain that is comparable to the original B6;SJL/Tg2576 mouse. However, comprehensive studies on cognitive decline in 129S6/Tg2576 mice are limited. In this study, we used two dementia mouse models on a 129S6 background--scopolamine-treated 129S6/SvEvTac mice (3-5 month-old) and transgenic 129S6/Tg2576 mice (11-13 month-old)-to establish a behavioral Test Battery for assessing learning and memory. The Test Battery consisted of five Tests to evaluate different aspects of cognitive impairment: a Y-Maze forced alternation task, a novel object recognition Test, the Morris water maze, the radial arm water maze, and a Y-maze spontaneous alternation task. We first established this behavioral Test Battery with the scopolamine-induced dementia model using 129S6/SvEvTac mice and then evaluated 129S6/Tg2576 mice using the same Testing protocol. Both models showed distinctive patterns of cognitive impairment. Together, the non-invasive behavioral Test Battery presented here allows detecting cognitive impairment in scopolamine-treated 129S6/SvEvTac mice and in transgenic 129S6/Tg2576 mice. Due to the modular nature of this Test Battery, more behavioral Tests, e.g. invasive assays to gain additional cognitive information, can easily be added.
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a comprehensive behavioral Test Battery to assess learning and memory in 129s6 tg2576 mice
PLOS ONE, 2016Co-Authors: Andrea Wolf, Björn Bauer, Erin L. Abner, Anika M. S. Hartz, Tal AshkenazyfrolingerAbstract:Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid beta (Aβ) pathology and cognition. Tg2576 mice on a B6;SJL background strain carry a recessive rd1 mutation that leads to early retinal degeneration and visual impairment in homozygous carriers. This can impair performance in behavioral Tests that rely on visual cues, and thus, affect study results. Therefore, B6;SJL/Tg2576 mice were systematically backcrossed with 129S6/SvEvTac mice resulting in 129S6/Tg2576 mice that lack the rd1 mutation. 129S6/Tg2576 mice do not develop retinal degeneration but still show Aβ accumulation in the brain that is comparable to the original B6;SJL/Tg2576 mouse. However, comprehensive studies on cognitive decline in 129S6/Tg2576 mice are limited. In this study, we used two dementia mouse models on a 129S6 background--scopolamine-treated 129S6/SvEvTac mice (3-5 month-old) and transgenic 129S6/Tg2576 mice (11-13 month-old)-to establish a behavioral Test Battery for assessing learning and memory. The Test Battery consisted of five Tests to evaluate different aspects of cognitive impairment: a Y-Maze forced alternation task, a novel object recognition Test, the Morris water maze, the radial arm water maze, and a Y-maze spontaneous alternation task. We first established this behavioral Test Battery with the scopolamine-induced dementia model using 129S6/SvEvTac mice and then evaluated 129S6/Tg2576 mice using the same Testing protocol. Both models showed distinctive patterns of cognitive impairment. Together, the non-invasive behavioral Test Battery presented here allows detecting cognitive impairment in scopolamine-treated 129S6/SvEvTac mice and in transgenic 129S6/Tg2576 mice. Due to the modular nature of this Test Battery, more behavioral Tests, e.g. invasive assays to gain additional cognitive information, can easily be added.
