Nerve Fiber Layer

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Joel S Schuman - One of the best experts on this subject based on the ideXlab platform.

  • imaging of the optic Nerve and retinal Nerve Fiber Layer an essential part of glaucoma diagnosis and monitoring
    Survey of Ophthalmology, 2014
    Co-Authors: Jacek Kotowski, Hiroshi Ishikawa, Gadi Wollstein, Joel S Schuman
    Abstract:

    Because glaucomatous damage is irreversible early detection of structural changes in the optic Nerve head and retinal Nerve Fiber Layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic Nerve head, retinal Nerve Fiber Layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive glaucomatous damage and provide a review of the current knowledge on the clinical performance of these technologies.

  • comparison of retinal Nerve Fiber Layer thickness measurement bias and imprecision across three spectral domain optical coherence tomography devices
    Investigative Ophthalmology & Visual Science, 2012
    Co-Authors: Nancy M Buchser, Gadi Wollstein, Hiroshi Ishikawa, Robert J Noecker, Richard A Bilonick, Yun Ling, Lindsey S Folio, Larry Kagemann, Eiyass Albeiruti, Joel S Schuman
    Abstract:

    Purpose. We compared retinal Nerve Fiber Layer (RNFL) bias and imprecision among three spectral-domain optical coherence tomographs (SD-OCT).

  • optical coherence tomography longitudinal evaluation of retinal Nerve Fiber Layer thickness in glaucoma
    Archives of Ophthalmology, 2005
    Co-Authors: Gadi Wollstein, Joel S Schuman, Ellen Hertzmark, L L Price, Ali Aydin, Paul Stark, Edward C Lai, Hiroshi Ishikawa, Cynthia Mattox
    Abstract:

    Objectives To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal Nerve Fiber Layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry. Methods Retrospective evaluation of 64 eyes (37 patients) of glaucoma suspects or patients with glaucoma participating in a prospective longitudinal study. All participants underwent comprehensive clinical assessment, visual field (VF) testing, and OCT every 6 months. Field progression was defined as a reproducible decline of at least 2 dB in VF mean deviation from baseline. Progression of OCT was defined as reproducible mean retinal Nerve Fiber Layer thinning of at least 20 μm. Results Each patient had a median of 5 usable OCT scans at median follow-up of 4.7 years. The difference in the linear regression slopes of retinal Nerve Fiber Layer thickness between glaucoma suspects and patients with glaucoma was nonsignificant for all variables; however, Kaplan-Meier survival curve analysis demonstrated a higher progression rate by OCT vs VF. Sixty-six percent of eyes were stable throughout follow-up, whereas 22% progressed by OCT alone, 9% by VF mean deviation alone, and 3% by VF and OCT. Conclusions A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods.

  • optical coherence tomography assessment of retinal Nerve Fiber Layer thickness changes after glaucoma surgery
    Ophthalmology, 2003
    Co-Authors: Ali Aydin, James G Fujimoto, Gadi Wollstein, L L Price, Joel S Schuman
    Abstract:

    Purpose To assess changes in retinal Nerve Fiber Layer (NFL) thickness in glaucoma patients after filtration surgery by using optical coherence tomography (OCT).

  • evaluation of focal defects of the Nerve Fiber Layer using optical coherence tomography
    Ophthalmology, 1999
    Co-Authors: Liselotte Pieroth, Joel S Schuman, Tamar Pedutkloizman, Ellen Hertzmark, J R Wilkins, Jeffery G Coker, Carmen A Puliafito, Cynthia Mattox, Michael R Hee, James G Fujimoto
    Abstract:

    Objective To analyze glaucomatous eyes with known focal defects of the Nerve Fiber Layer (NFL), relating optical coherence tomography (OCT) findings to clinical examination, NFL and stereoscopic optic Nerve head (ONH) photography, and Humphrey 24–2 visual fields.

Jung-yeul Kim - One of the best experts on this subject based on the ideXlab platform.

Antonio P Ciardella - One of the best experts on this subject based on the ideXlab platform.

Robert N Weinreb - One of the best experts on this subject based on the ideXlab platform.

  • evaluation of retinal Nerve Fiber Layer progression in glaucoma a comparison between the fast and the regular retinal Nerve Fiber Layer scans
    Ophthalmology, 2011
    Co-Authors: Christopher Kaishun Leung, Robert N Weinreb, Carol Y Cheung, Chi Pui Pang, Shu Liu, Gilda Lai, Nan Liu, Kwok Kay Tse, Dennis S C Lam
    Abstract:

    Objective To compare the performance of the fast (256 A-scans in each scan circle) and the regular (512 A-scans in each scan circle) retinal Nerve Fiber Layer (RNFL) scan protocols for detection of glaucoma progression using the Stratus optical coherence tomography (OCT) device (Carl Zeiss Meditec, Dublin, CA). Design Retrospective, longitudinal study. Participants One hundred twenty-nine eyes from 72 glaucoma patients. Methods All patients had been followed up for 2.9 to 6.1 years with a median follow-up of 4 months. All eyes had at least 4 serial RNFL measurements obtained with both the fast and the regular RNFL scans. Visual field (VF) assessment was performed on the same day as RNFL imaging. Retinal Nerve Fiber Layer thickness and VF progression were evaluated with linear regression analysis against age. The mean rate of average RNFL thickness reduction was estimated with linear mixed modeling. Main Outcome Measures The agreement of progression detection and the rate of change of RNFL thicknesses. Results A total of 1373 fast and 1373 regular RNFL scans and 1236 VF tests were analyzed. With reference to the average RNFL thickness, the fast RNFL scan detected more eyes with progression (21 eyes from 19 patients vs. 15 eyes from 13 patients) than the regular scan at a comparable level of specificity (96.9% vs. 96.1%). More eyes were found to have increasing RNFL thickness with age at individual clock hours (except for 3, 5, 6, and 11 o'clock) when the measurements were obtained with the regular scan. The agreement between the fast and the regular scan for detection of RNFL progression was fair to moderate, with κ values ranging between 0.14 and 0.49. The rate of average RNFL thickness progression was −1.01 μm per year for the fast RNFL scan and −0.77 μm per year for the regular scan. Conclusions The choice of scan protocols in the Stratus OCT has a significant impact in the evaluation of RNFL progression. The fast RNFL scan seems to be preferable to follow RNFL damage in glaucoma. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.

  • detection of glaucoma progression with stratus oct retinal Nerve Fiber Layer optic Nerve head and macular thickness measurements
    Investigative Ophthalmology & Visual Science, 2009
    Co-Authors: Felipe A Medeiros, Linda M Zangwill, Pamela A Sample, Christopher Bowd, Remo Susanna, Luciana M Alencar, Robert N Weinreb
    Abstract:

    Purpose To evaluate and compare the ability of optical coherence tomography (OCT) retinal Nerve Fiber Layer (RNFL), optic Nerve head, and macular thickness parameters to detect progressive structural damage in glaucoma.

  • five rules to evaluate the optic disc and retinal Nerve Fiber Layer for glaucoma
    Optometry - Journal of The American Optometric Association, 2005
    Co-Authors: Murray Fingeret, Remo Susanna, Felipe A Medeiros, Robert N Weinreb
    Abstract:

    A systematic approach for the examination of the optic disc and retinal Nerve Fiber Layer is described that will aid in the detection of glaucoma. This approach encompasses 5 rules: evaluation of optic disc size, neuroretinal rim size and shape, retinal Nerve Fiber Layer, presence of parapapillary atrophy, and presence of retinal or optic disc hemorrhages. A systematic process enhances the ability to detect glaucomatous damage as well as the detection of progression, and facilitates appropriate management.

  • retinal Nerve Fiber Layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes
    Ophthalmology, 2003
    Co-Authors: Tarek El A Beltagi, Linda M Zangwill, Pamela A Sample, Christopher Bowd, Catherine Boden, Payarn Amini, Robert N Weinreb
    Abstract:

    Abstract Purpose To determine the relationship between areas of glaucomatous retinal Nerve Fiber Layer thinning identified by optical coherence tomography and areas of decreased visual field sensitivity identified by standard automated perimetry in glaucomatous eyes. Design Retrospective observational case series. Partcipants Forty-three patients with glaucomatous optic neuropathy identified by optic disc stereo photographs and standard automated perimetry mean deviations >−8 dB were included. Methods Participants were imaged with optical coherence tomography within 6 months of reliable standard automated perimetry testing. Main outcome measures The location and number of optical coherence tomography clock hour retinal Nerve Fiber Layer thickness measures outside normal limits were compared with the location and number of standard automated perimetry visual field zones outside normal limits. Further, the relationship between the deviation from normal optical coherence tomography–measured retinal Nerve Fiber Layer thickness at each clock hour and the average pattern deviation in each visual field zone was examined by using linear regression ( R 2 ). Results The retinal Nerve Fiber Layer areas most frequently outside normal limits were the inferior and inferior temporal regions. The least sensitive visual field zones were in the superior hemifield. Linear regression results ( R 2 ) showed that deviation from the normal retinal Nerve Fiber Layer thickness at optical coherence tomography clock hour positions 6 o'clock, 7 o'clock, and 8 o'clock (inferior and inferior temporal) was best correlated with standard automated perimetry pattern deviation in visual field zones corresponding to the superior arcuate and nasal step regions ( R 2 range, 0.34–0.57). These associations were much stronger than those between clock hour position 6 o'clock and the visual field zone corresponding to the inferior nasal step region ( R 2 = 0.01). Conclusions Localized retinal Nerve Fiber Layer thinning, measured by optical coherence tomography, is topographically related to decreased localized standard automated perimetry sensitivity in glaucoma patients.

  • evaluating the optic disc and retinal Nerve Fiber Layer in glaucoma i clinical examination and photographic methods
    Seminars in Ophthalmology, 2000
    Co-Authors: Christopher Bowd, Robert N Weinreb, Linda M Zangwill
    Abstract:

    Glaucoma is a leading cause of blindness worldwide and is characterized in part by specific changes in the optic disc and retinal Nerve Fiber Layer. Currently, subjective clinical examination and fundus photography are the most common ways of detecting structural change in glaucoma and monitoring its progression. In the first part of this two-part article, the authors overview structural changes of the optic disc and retinal Nerve Fiber Layer in glaucoma and describe and evaluate photographic methods for observing these changes. In the second part of this article (this issue), recent developments in computer-based optical imaging techniques that allow objective evaluation of the optic disc and retinal Nerve Fiber Layer are described

Gadi Wollstein - One of the best experts on this subject based on the ideXlab platform.

  • imaging of the optic Nerve and retinal Nerve Fiber Layer an essential part of glaucoma diagnosis and monitoring
    Survey of Ophthalmology, 2014
    Co-Authors: Jacek Kotowski, Hiroshi Ishikawa, Gadi Wollstein, Joel S Schuman
    Abstract:

    Because glaucomatous damage is irreversible early detection of structural changes in the optic Nerve head and retinal Nerve Fiber Layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic Nerve head, retinal Nerve Fiber Layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive glaucomatous damage and provide a review of the current knowledge on the clinical performance of these technologies.

  • comparison of retinal Nerve Fiber Layer thickness measurement bias and imprecision across three spectral domain optical coherence tomography devices
    Investigative Ophthalmology & Visual Science, 2012
    Co-Authors: Nancy M Buchser, Gadi Wollstein, Hiroshi Ishikawa, Robert J Noecker, Richard A Bilonick, Yun Ling, Lindsey S Folio, Larry Kagemann, Eiyass Albeiruti, Joel S Schuman
    Abstract:

    Purpose. We compared retinal Nerve Fiber Layer (RNFL) bias and imprecision among three spectral-domain optical coherence tomographs (SD-OCT).

  • optical coherence tomography longitudinal evaluation of retinal Nerve Fiber Layer thickness in glaucoma
    Archives of Ophthalmology, 2005
    Co-Authors: Gadi Wollstein, Joel S Schuman, Ellen Hertzmark, L L Price, Ali Aydin, Paul Stark, Edward C Lai, Hiroshi Ishikawa, Cynthia Mattox
    Abstract:

    Objectives To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal Nerve Fiber Layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry. Methods Retrospective evaluation of 64 eyes (37 patients) of glaucoma suspects or patients with glaucoma participating in a prospective longitudinal study. All participants underwent comprehensive clinical assessment, visual field (VF) testing, and OCT every 6 months. Field progression was defined as a reproducible decline of at least 2 dB in VF mean deviation from baseline. Progression of OCT was defined as reproducible mean retinal Nerve Fiber Layer thinning of at least 20 μm. Results Each patient had a median of 5 usable OCT scans at median follow-up of 4.7 years. The difference in the linear regression slopes of retinal Nerve Fiber Layer thickness between glaucoma suspects and patients with glaucoma was nonsignificant for all variables; however, Kaplan-Meier survival curve analysis demonstrated a higher progression rate by OCT vs VF. Sixty-six percent of eyes were stable throughout follow-up, whereas 22% progressed by OCT alone, 9% by VF mean deviation alone, and 3% by VF and OCT. Conclusions A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods.

  • optical coherence tomography assessment of retinal Nerve Fiber Layer thickness changes after glaucoma surgery
    Ophthalmology, 2003
    Co-Authors: Ali Aydin, James G Fujimoto, Gadi Wollstein, L L Price, Joel S Schuman
    Abstract:

    Purpose To assess changes in retinal Nerve Fiber Layer (NFL) thickness in glaucoma patients after filtration surgery by using optical coherence tomography (OCT).