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Joel S Schuman - One of the best experts on this subject based on the ideXlab platform.
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imaging of the optic Nerve and retinal Nerve Fiber Layer an essential part of glaucoma diagnosis and monitoring
Survey of Ophthalmology, 2014Co-Authors: Jacek Kotowski, Hiroshi Ishikawa, Gadi Wollstein, Joel S SchumanAbstract:Because glaucomatous damage is irreversible early detection of structural changes in the optic Nerve head and retinal Nerve Fiber Layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic Nerve head, retinal Nerve Fiber Layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive glaucomatous damage and provide a review of the current knowledge on the clinical performance of these technologies.
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comparison of retinal Nerve Fiber Layer thickness measurement bias and imprecision across three spectral domain optical coherence tomography devices
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Nancy M Buchser, Gadi Wollstein, Hiroshi Ishikawa, Robert J Noecker, Richard A Bilonick, Yun Ling, Lindsey S Folio, Larry Kagemann, Eiyass Albeiruti, Joel S SchumanAbstract:Purpose. We compared retinal Nerve Fiber Layer (RNFL) bias and imprecision among three spectral-domain optical coherence tomographs (SD-OCT).
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optical coherence tomography longitudinal evaluation of retinal Nerve Fiber Layer thickness in glaucoma
Archives of Ophthalmology, 2005Co-Authors: Gadi Wollstein, Joel S Schuman, Ellen Hertzmark, L L Price, Ali Aydin, Paul Stark, Edward C Lai, Hiroshi Ishikawa, Cynthia MattoxAbstract:Objectives To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal Nerve Fiber Layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry. Methods Retrospective evaluation of 64 eyes (37 patients) of glaucoma suspects or patients with glaucoma participating in a prospective longitudinal study. All participants underwent comprehensive clinical assessment, visual field (VF) testing, and OCT every 6 months. Field progression was defined as a reproducible decline of at least 2 dB in VF mean deviation from baseline. Progression of OCT was defined as reproducible mean retinal Nerve Fiber Layer thinning of at least 20 μm. Results Each patient had a median of 5 usable OCT scans at median follow-up of 4.7 years. The difference in the linear regression slopes of retinal Nerve Fiber Layer thickness between glaucoma suspects and patients with glaucoma was nonsignificant for all variables; however, Kaplan-Meier survival curve analysis demonstrated a higher progression rate by OCT vs VF. Sixty-six percent of eyes were stable throughout follow-up, whereas 22% progressed by OCT alone, 9% by VF mean deviation alone, and 3% by VF and OCT. Conclusions A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods.
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optical coherence tomography assessment of retinal Nerve Fiber Layer thickness changes after glaucoma surgery
Ophthalmology, 2003Co-Authors: Ali Aydin, James G Fujimoto, Gadi Wollstein, L L Price, Joel S SchumanAbstract:Purpose To assess changes in retinal Nerve Fiber Layer (NFL) thickness in glaucoma patients after filtration surgery by using optical coherence tomography (OCT).
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evaluation of focal defects of the Nerve Fiber Layer using optical coherence tomography
Ophthalmology, 1999Co-Authors: Liselotte Pieroth, Joel S Schuman, Tamar Pedutkloizman, Ellen Hertzmark, J R Wilkins, Jeffery G Coker, Carmen A Puliafito, Cynthia Mattox, Michael R Hee, James G FujimotoAbstract:Objective To analyze glaucomatous eyes with known focal defects of the Nerve Fiber Layer (NFL), relating optical coherence tomography (OCT) findings to clinical examination, NFL and stereoscopic optic Nerve head (ONH) photography, and Humphrey 24–2 visual fields.
Jung-yeul Kim - One of the best experts on this subject based on the ideXlab platform.
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Peripapillary retinal Nerve Fiber Layer (pRNFL) thickness of each group.
'Public Library of Science (PLoS)', 2021Co-Authors: Min-woo Lee, Hyung-bin Lim, Hyung-moon Koo, Young-hoon Lee, Jung-yeul KimAbstract:Peripapillary retinal Nerve Fiber Layer (pRNFL) thickness of each group.
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Estimated mean peripapillary retinal Nerve Fiber Layer (pRNFL) thickness after adjusting for covariants.
'Public Library of Science (PLoS)', 2021Co-Authors: Min-woo Lee, Hyung-bin Lim, Hyung-moon Koo, Young-hoon Lee, Jung-yeul KimAbstract:Estimated mean peripapillary retinal Nerve Fiber Layer (pRNFL) thickness after adjusting for covariants.
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Univariate and multivariate linear regression analyses between various clinical factors and peripapillary retinal Nerve Fiber Layer thickness.
'Public Library of Science (PLoS)', 2021Co-Authors: Min-woo Lee, Hyung-bin Lim, Hyung-moon Koo, Young-hoon Lee, Jung-yeul KimAbstract:Univariate and multivariate linear regression analyses between various clinical factors and peripapillary retinal Nerve Fiber Layer thickness.
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longitudinal changes in retinal Nerve Fiber Layer thickness after vitrectomy for epiretinal membrane
Investigative Ophthalmology & Visual Science, 2014Co-Authors: Sungbok Lee, Yongil Shin, Jung-yeul KimAbstract:Purpose We investigated longitudinal changes in retinal Nerve Fiber Layer (RNFL) thickness following vitrectomy for epiretinal membrane (ERM). Methods Thirty-one patients who underwent pars plana vitrectomy with internal limiting membrane (ILM) peeling for ERM were included. Average thickness and four quadrants of RNFL thicknesses were determined before and at 1, 3, 6, and 12 months after surgery by spectral-domain optical coherence tomography (SD-OCT). As macular lesions could affect RNFL thickness, we evaluated changes in RNFL thickness by dividing the RNFL into 12 o'clock hourly positions, defining pathologic area adjacent to the lesion and nonpathologic area. Results Retinal Nerve Fiber Layer thickness of the affected eyes increased at 1 month after vitrectomy and later decreased compared to baseline values. Temporal quadrant RNFL thickness was statistically significantly thicker in affected eyes at baseline and at 1 month after surgery and thinner after 12 months than fellow eyes. Retinal Nerve Fiber Layer thickness in pathologic area decreased after surgery, and the RNFL was statistically significantly thinner at 3, 6, and 12 months postoperatively, compared to the baseline thickness. The RNFL thickness of pathologic area of affected eyes compared to fellow eyes was thicker both at baseline and 1 month after surgery but thinner at 12 months compared to baseline values. Conclusions Postoperative RNFL thickness after vitrectomy combined with ERM removal tended to decrease postoperatively. Retinal Nerve Fiber Layer thicknesses in temporal pathologic area were significantly reduced at 3, 6, and 12 months postoperatively compared to baseline values, whereas RNFL thicknesses in nasal nonpathologic area exhibited no significant postoperative changes. We found that ERM itself and the removal procedure resulted in decreased RNFL thickness.
Antonio P Ciardella - One of the best experts on this subject based on the ideXlab platform.
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retinal Nerve Fiber Layer thickness modification after internal limiting membrane peeling
Retina-the Journal of Retinal and Vitreous Diseases, 2014Co-Authors: Nicole Balducci, Francesco Pichi, Chiara Veronese, Mariachiara Morara, Carlo Torrazza, Antonio P CiardellaAbstract:Purpose:To identify early and late retinal Nerve Fiber Layer thickness (RNFLT) modification after internal limiting membrane peeling for idiopathic macular hole or epiretinal membrane and to correlate RNFLT to visual field indices.Methods:Single-center, prospective, interventional consecutive case s
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swelling of the arcuate Nerve Fiber Layer after internal limiting membrane peeling
Retina-the Journal of Retinal and Vitreous Diseases, 2012Co-Authors: Augustino Clark, Nicole Balducci, Francesco Pichi, Chiara Veronese, Mariachiara Morara, Carlo Torrazza, Antonio P CiardellaAbstract:Purpose:The purpose of the study is to report the incidence of changes of the retinal Nerve Fiber Layer in the early postoperative period after internal limiting membrane peeling for idiopathic macular hole and epiretinal membrane surgery.Methods:Interventional, noncomparative retrospective case ser
Robert N Weinreb - One of the best experts on this subject based on the ideXlab platform.
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evaluation of retinal Nerve Fiber Layer progression in glaucoma a comparison between the fast and the regular retinal Nerve Fiber Layer scans
Ophthalmology, 2011Co-Authors: Christopher Kaishun Leung, Robert N Weinreb, Carol Y Cheung, Chi Pui Pang, Shu Liu, Gilda Lai, Nan Liu, Kwok Kay Tse, Dennis S C LamAbstract:Objective To compare the performance of the fast (256 A-scans in each scan circle) and the regular (512 A-scans in each scan circle) retinal Nerve Fiber Layer (RNFL) scan protocols for detection of glaucoma progression using the Stratus optical coherence tomography (OCT) device (Carl Zeiss Meditec, Dublin, CA). Design Retrospective, longitudinal study. Participants One hundred twenty-nine eyes from 72 glaucoma patients. Methods All patients had been followed up for 2.9 to 6.1 years with a median follow-up of 4 months. All eyes had at least 4 serial RNFL measurements obtained with both the fast and the regular RNFL scans. Visual field (VF) assessment was performed on the same day as RNFL imaging. Retinal Nerve Fiber Layer thickness and VF progression were evaluated with linear regression analysis against age. The mean rate of average RNFL thickness reduction was estimated with linear mixed modeling. Main Outcome Measures The agreement of progression detection and the rate of change of RNFL thicknesses. Results A total of 1373 fast and 1373 regular RNFL scans and 1236 VF tests were analyzed. With reference to the average RNFL thickness, the fast RNFL scan detected more eyes with progression (21 eyes from 19 patients vs. 15 eyes from 13 patients) than the regular scan at a comparable level of specificity (96.9% vs. 96.1%). More eyes were found to have increasing RNFL thickness with age at individual clock hours (except for 3, 5, 6, and 11 o'clock) when the measurements were obtained with the regular scan. The agreement between the fast and the regular scan for detection of RNFL progression was fair to moderate, with κ values ranging between 0.14 and 0.49. The rate of average RNFL thickness progression was −1.01 μm per year for the fast RNFL scan and −0.77 μm per year for the regular scan. Conclusions The choice of scan protocols in the Stratus OCT has a significant impact in the evaluation of RNFL progression. The fast RNFL scan seems to be preferable to follow RNFL damage in glaucoma. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.
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detection of glaucoma progression with stratus oct retinal Nerve Fiber Layer optic Nerve head and macular thickness measurements
Investigative Ophthalmology & Visual Science, 2009Co-Authors: Felipe A Medeiros, Linda M Zangwill, Pamela A Sample, Christopher Bowd, Remo Susanna, Luciana M Alencar, Robert N WeinrebAbstract:Purpose To evaluate and compare the ability of optical coherence tomography (OCT) retinal Nerve Fiber Layer (RNFL), optic Nerve head, and macular thickness parameters to detect progressive structural damage in glaucoma.
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five rules to evaluate the optic disc and retinal Nerve Fiber Layer for glaucoma
Optometry - Journal of The American Optometric Association, 2005Co-Authors: Murray Fingeret, Remo Susanna, Felipe A Medeiros, Robert N WeinrebAbstract:A systematic approach for the examination of the optic disc and retinal Nerve Fiber Layer is described that will aid in the detection of glaucoma. This approach encompasses 5 rules: evaluation of optic disc size, neuroretinal rim size and shape, retinal Nerve Fiber Layer, presence of parapapillary atrophy, and presence of retinal or optic disc hemorrhages. A systematic process enhances the ability to detect glaucomatous damage as well as the detection of progression, and facilitates appropriate management.
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retinal Nerve Fiber Layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes
Ophthalmology, 2003Co-Authors: Tarek El A Beltagi, Linda M Zangwill, Pamela A Sample, Christopher Bowd, Catherine Boden, Payarn Amini, Robert N WeinrebAbstract:Abstract Purpose To determine the relationship between areas of glaucomatous retinal Nerve Fiber Layer thinning identified by optical coherence tomography and areas of decreased visual field sensitivity identified by standard automated perimetry in glaucomatous eyes. Design Retrospective observational case series. Partcipants Forty-three patients with glaucomatous optic neuropathy identified by optic disc stereo photographs and standard automated perimetry mean deviations >−8 dB were included. Methods Participants were imaged with optical coherence tomography within 6 months of reliable standard automated perimetry testing. Main outcome measures The location and number of optical coherence tomography clock hour retinal Nerve Fiber Layer thickness measures outside normal limits were compared with the location and number of standard automated perimetry visual field zones outside normal limits. Further, the relationship between the deviation from normal optical coherence tomography–measured retinal Nerve Fiber Layer thickness at each clock hour and the average pattern deviation in each visual field zone was examined by using linear regression ( R 2 ). Results The retinal Nerve Fiber Layer areas most frequently outside normal limits were the inferior and inferior temporal regions. The least sensitive visual field zones were in the superior hemifield. Linear regression results ( R 2 ) showed that deviation from the normal retinal Nerve Fiber Layer thickness at optical coherence tomography clock hour positions 6 o'clock, 7 o'clock, and 8 o'clock (inferior and inferior temporal) was best correlated with standard automated perimetry pattern deviation in visual field zones corresponding to the superior arcuate and nasal step regions ( R 2 range, 0.34–0.57). These associations were much stronger than those between clock hour position 6 o'clock and the visual field zone corresponding to the inferior nasal step region ( R 2 = 0.01). Conclusions Localized retinal Nerve Fiber Layer thinning, measured by optical coherence tomography, is topographically related to decreased localized standard automated perimetry sensitivity in glaucoma patients.
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evaluating the optic disc and retinal Nerve Fiber Layer in glaucoma i clinical examination and photographic methods
Seminars in Ophthalmology, 2000Co-Authors: Christopher Bowd, Robert N Weinreb, Linda M ZangwillAbstract:Glaucoma is a leading cause of blindness worldwide and is characterized in part by specific changes in the optic disc and retinal Nerve Fiber Layer. Currently, subjective clinical examination and fundus photography are the most common ways of detecting structural change in glaucoma and monitoring its progression. In the first part of this two-part article, the authors overview structural changes of the optic disc and retinal Nerve Fiber Layer in glaucoma and describe and evaluate photographic methods for observing these changes. In the second part of this article (this issue), recent developments in computer-based optical imaging techniques that allow objective evaluation of the optic disc and retinal Nerve Fiber Layer are described
Gadi Wollstein - One of the best experts on this subject based on the ideXlab platform.
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imaging of the optic Nerve and retinal Nerve Fiber Layer an essential part of glaucoma diagnosis and monitoring
Survey of Ophthalmology, 2014Co-Authors: Jacek Kotowski, Hiroshi Ishikawa, Gadi Wollstein, Joel S SchumanAbstract:Because glaucomatous damage is irreversible early detection of structural changes in the optic Nerve head and retinal Nerve Fiber Layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic Nerve head, retinal Nerve Fiber Layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive glaucomatous damage and provide a review of the current knowledge on the clinical performance of these technologies.
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comparison of retinal Nerve Fiber Layer thickness measurement bias and imprecision across three spectral domain optical coherence tomography devices
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Nancy M Buchser, Gadi Wollstein, Hiroshi Ishikawa, Robert J Noecker, Richard A Bilonick, Yun Ling, Lindsey S Folio, Larry Kagemann, Eiyass Albeiruti, Joel S SchumanAbstract:Purpose. We compared retinal Nerve Fiber Layer (RNFL) bias and imprecision among three spectral-domain optical coherence tomographs (SD-OCT).
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optical coherence tomography longitudinal evaluation of retinal Nerve Fiber Layer thickness in glaucoma
Archives of Ophthalmology, 2005Co-Authors: Gadi Wollstein, Joel S Schuman, Ellen Hertzmark, L L Price, Ali Aydin, Paul Stark, Edward C Lai, Hiroshi Ishikawa, Cynthia MattoxAbstract:Objectives To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal Nerve Fiber Layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry. Methods Retrospective evaluation of 64 eyes (37 patients) of glaucoma suspects or patients with glaucoma participating in a prospective longitudinal study. All participants underwent comprehensive clinical assessment, visual field (VF) testing, and OCT every 6 months. Field progression was defined as a reproducible decline of at least 2 dB in VF mean deviation from baseline. Progression of OCT was defined as reproducible mean retinal Nerve Fiber Layer thinning of at least 20 μm. Results Each patient had a median of 5 usable OCT scans at median follow-up of 4.7 years. The difference in the linear regression slopes of retinal Nerve Fiber Layer thickness between glaucoma suspects and patients with glaucoma was nonsignificant for all variables; however, Kaplan-Meier survival curve analysis demonstrated a higher progression rate by OCT vs VF. Sixty-six percent of eyes were stable throughout follow-up, whereas 22% progressed by OCT alone, 9% by VF mean deviation alone, and 3% by VF and OCT. Conclusions A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods.
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optical coherence tomography assessment of retinal Nerve Fiber Layer thickness changes after glaucoma surgery
Ophthalmology, 2003Co-Authors: Ali Aydin, James G Fujimoto, Gadi Wollstein, L L Price, Joel S SchumanAbstract:Purpose To assess changes in retinal Nerve Fiber Layer (NFL) thickness in glaucoma patients after filtration surgery by using optical coherence tomography (OCT).