The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform
David R. Strauser - One of the best experts on this subject based on the ideXlab platform.
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Work Personality, Core Self-evaluation and Perceived Career Barriers in Young Adult Central Nervous System Cancer Survivors.
Journal of Occupational Rehabilitation, 2020Co-Authors: David R. Strauser, Chelsea Greco, Elizabeth Fine, Shen, Cori LiptakAbstract:PURPOSE: The purpose of this study is to examine the relationship between work personality, core self-evaluation (CSE), and perceived internal and external barriers to employment in a group of young adult CNS survivors. METHODS: The participants consisted of 110 young adult survivors of pediatric central Nervous System (CNS) tumors aged between 18 and 30 years old (M = 23.05, SD = 3.36). Mediation analysis with structural equational modeling (SEM) technique was used to correlate a number of different measures (Work Personality [WP], Perceived Employment Barriers [PEB], and Core-Self Evaluation [CSE]). RESULTS: Results revealed an exceptionally well-fitting model to our data with work personality predicting CSE positively: β = 0.34, SE = 0.07, 95% CI (0.18, 0.47) while CSE inversely predicts Perceived Barriers to Employment, β = - 0.60, SE = 0.06, 95% CI (- 0.70, - 0.49). There is a direct pathway from WP to PEB once CSE was accounted for β = - 0.20, SE = 0.07, 95% CI (- 0.33, - 0.06). The presence of both significant direct and indirect effects of WP on PEB implied that there was a partial mediating effect of CSE on the association between WP and PEB. CONCLUSIONS: Work personality is a robust construct that can be applied to young adult CNS survivors in effort to gain more insight into the personality and psychological factors that impact career development and employment in this group. The major finding of this study was that work personality and CSE had a significant direct effect on perceived career barriers and that there was a significant indirect effect with CSE acting as a mediator between developmental work personality and perceived career barriers.
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Work Personality, Core Self-evaluation and Perceived Career Barriers in Young Adult Central Nervous System Cancer Survivors
Journal of Occupational Rehabilitation, 2020Co-Authors: David R. Strauser, Sa Shen, Chelsea Greco, Elizabeth Fine, Cori LiptakAbstract:Purpose The purpose of this study is to examine the relationship between work personality, core self-evaluation (CSE), and perceived internal and external barriers to employment in a group of young adult CNS survivors. Methods The participants consisted of 110 young adult survivors of pediatric central Nervous System (CNS) tumors aged between 18 and 30 years old ( M = 23.05, SD = 3.36). Mediation analysis with structural equational modeling (SEM) technique was used to correlate a number of different measures (Work Personality [WP], Perceived Employment Barriers [PEB], and Core-Self Evaluation [CSE]). Results Results revealed an exceptionally well-fitting model to our data with work personality predicting CSE positively: β = 0.34, SE = 0.07, 95% CI (0.18, 0.47) while CSE inversely predicts Perceived Barriers to Employment, β = − 0.60, SE = 0.06, 95% CI (− 0.70, − 0.49). There is a direct pathway from WP to PEB once CSE was accounted for β = − 0.20, SE = 0.07, 95% CI (− 0.33, − 0.06). The presence of both significant direct and indirect effects of WP on PEB implied that there was a partial mediating effect of CSE on the association between WP and PEB. Conclusions Work personality is a robust construct that can be applied to young adult CNS survivors in effort to gain more insight into the personality and psychological factors that impact career development and employment in this group. The major finding of this study was that work personality and CSE had a significant direct effect on perceived career barriers and that there was a significant indirect effect with CSE acting as a mediator between developmental work personality and perceived career barriers.
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Vocational identity, positive affect, and career thoughts in a group of young adult central Nervous System Cancer survivors.
International Journal of Rehabilitation Research, 2014Co-Authors: Dustin D. Lange, David R. Strauser, Alex W.k. Wong, Stacia WagnerAbstract:: The aims of this study were as follows: (a) to compare levels of career thoughts and vocational identity between young adult childhood central Nervous System (CNS) Cancer survivors and nonCancer peers and (b) to investigate the contribution of vocational identity and affect on career thoughts among Cancer survivors. Participants included 45 young adult CNS Cancer survivors and a comparison sample of 60 college students. Participants completed Career Thoughts Inventory, My Vocational Situation, and the Positive and Negative Affect Schedule. Multivariate analysis of variance and multiple regression analysis were used to analyze the data in this study. CNS Cancer survivors had a higher level of decision-making confusion than the college students. Multiple regression analysis indicated that vocational identity and positive affect significantly predicted the career thoughts of CNS survivors. The differences in decision-making confusion suggest that young adult CNS survivors would benefit from interventions that focus on providing knowledge of how to make decisions, while increasing vocational identity and positive affect for this specific population could also be beneficial.
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Perceptions of Young Adult Central Nervous System Cancer Survivors and Their Parents Regarding Career Development and Employment
Rehabilitation Research Policy and Education, 2014Co-Authors: David R. Strauser, Stacia Wagner, Fong Chan, Alex W.k. WongAbstract:Purpose: Identify barriers to career development and employment from both the survivor and parent perspective.Method: Young adult survivors (N = 43) and their parents participated in focus groups to elicit information regarding perceptions regarding career development and employment.Results: Perceptions of both the young adults and parents indicate that there is a significant need for comprehensive career and employment services targeted for young adult central Nervous System Cancer survivors.Conclusions: Findings provide initial evidence and support for the need to incorporate career and vocational services into psychosocial treatment programs. More research is needed in this area to gain an understanding of the specific career and vocational needs and to further explore how the interaction between the young adults and their parents impact vocational outcomes.
Cori Liptak - One of the best experts on this subject based on the ideXlab platform.
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Work Personality, Core Self-evaluation and Perceived Career Barriers in Young Adult Central Nervous System Cancer Survivors
Journal of Occupational Rehabilitation, 2020Co-Authors: David R. Strauser, Sa Shen, Chelsea Greco, Elizabeth Fine, Cori LiptakAbstract:Purpose The purpose of this study is to examine the relationship between work personality, core self-evaluation (CSE), and perceived internal and external barriers to employment in a group of young adult CNS survivors. Methods The participants consisted of 110 young adult survivors of pediatric central Nervous System (CNS) tumors aged between 18 and 30 years old ( M = 23.05, SD = 3.36). Mediation analysis with structural equational modeling (SEM) technique was used to correlate a number of different measures (Work Personality [WP], Perceived Employment Barriers [PEB], and Core-Self Evaluation [CSE]). Results Results revealed an exceptionally well-fitting model to our data with work personality predicting CSE positively: β = 0.34, SE = 0.07, 95% CI (0.18, 0.47) while CSE inversely predicts Perceived Barriers to Employment, β = − 0.60, SE = 0.06, 95% CI (− 0.70, − 0.49). There is a direct pathway from WP to PEB once CSE was accounted for β = − 0.20, SE = 0.07, 95% CI (− 0.33, − 0.06). The presence of both significant direct and indirect effects of WP on PEB implied that there was a partial mediating effect of CSE on the association between WP and PEB. Conclusions Work personality is a robust construct that can be applied to young adult CNS survivors in effort to gain more insight into the personality and psychological factors that impact career development and employment in this group. The major finding of this study was that work personality and CSE had a significant direct effect on perceived career barriers and that there was a significant indirect effect with CSE acting as a mediator between developmental work personality and perceived career barriers.
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Work Personality, Core Self-evaluation and Perceived Career Barriers in Young Adult Central Nervous System Cancer Survivors.
Journal of Occupational Rehabilitation, 2020Co-Authors: David R. Strauser, Chelsea Greco, Elizabeth Fine, Shen, Cori LiptakAbstract:PURPOSE: The purpose of this study is to examine the relationship between work personality, core self-evaluation (CSE), and perceived internal and external barriers to employment in a group of young adult CNS survivors. METHODS: The participants consisted of 110 young adult survivors of pediatric central Nervous System (CNS) tumors aged between 18 and 30 years old (M = 23.05, SD = 3.36). Mediation analysis with structural equational modeling (SEM) technique was used to correlate a number of different measures (Work Personality [WP], Perceived Employment Barriers [PEB], and Core-Self Evaluation [CSE]). RESULTS: Results revealed an exceptionally well-fitting model to our data with work personality predicting CSE positively: β = 0.34, SE = 0.07, 95% CI (0.18, 0.47) while CSE inversely predicts Perceived Barriers to Employment, β = - 0.60, SE = 0.06, 95% CI (- 0.70, - 0.49). There is a direct pathway from WP to PEB once CSE was accounted for β = - 0.20, SE = 0.07, 95% CI (- 0.33, - 0.06). The presence of both significant direct and indirect effects of WP on PEB implied that there was a partial mediating effect of CSE on the association between WP and PEB. CONCLUSIONS: Work personality is a robust construct that can be applied to young adult CNS survivors in effort to gain more insight into the personality and psychological factors that impact career development and employment in this group. The major finding of this study was that work personality and CSE had a significant direct effect on perceived career barriers and that there was a significant indirect effect with CSE acting as a mediator between developmental work personality and perceived career barriers.
Christina A. Meyers - One of the best experts on this subject based on the ideXlab platform.
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Neuropsychological Sequelae of Non-Central Nervous System Cancer and Cancer Therapy
Neuropsychology Review, 2008Co-Authors: Jeffrey S. Wefel, Mariana E. Witgert, Christina A. MeyersAbstract:Cancer patients report numerous adverse symptoms associated with their disease and treatment including cognitive dysfunction, fatigue, and affective distress. Cognitive dysfunction is ubiquitous in patients with primary central Nervous System (CNS) Cancer and recent evidence has documented similar deficits in patients with non-CNS Cancer as well. Both the Cancer itself and treatments including chemotherapy, biological response modifiers, and hormonal therapies have been demonstrated to adversely impact cognitive and neurobehavioral function. Neuroimaging and neurophysiological investigations have likewise revealed alterations in brain function that are helping to account for the nature of these cognitive disorders. Similarly, preclinical animal research is assisting to identify the pathophysiological mechanisms that underlie treatment-related neurotoxicities. The coalescence of multidisciplinary clinical and research efforts hold promise for the development of interventions that may offer neuroprotection in addition to currently available symptomatic therapies and cognitive rehabilitation techniques.
Sanne B Schagen - One of the best experts on this subject based on the ideXlab platform.
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Impact of Cancer and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012
Journal of Pain and Symptom Management, 2015Co-Authors: Florence Joly, Sanne B Schagen, Bénédicte Giffard, Olivier Rigal, Michiel B. De Ruiter, Brent J. Small, Martine Dubois, Johan Lefel, Tim A. Ahles, Jeffrey S. WefelAbstract:Abstract Context Although cognitive impairments have been identified in patients with non–central Nervous System Cancer, especially breast Cancer, the respective roles of Cancer and therapies, and the mechanisms involved in cognitive dysfunction remain unclear. Objectives To report a state-of-the-art update from the International Cognitive and Cancer Task Force conference held in 2012. Methods A report of the meeting and recent new perspectives are presented. Results Recent clinical data support that non–central Nervous System Cancer per se may be involved in cognitive dysfunctions associated with inflammation parameters. The role of chemotherapy on cognitive decline was confirmed in colorectal and testicular Cancers. Whereas the impact of hormone therapy remains debatable, some studies support a negative impact of targeted therapies on cognition. Regarding interventions, preliminary results of cognitive rehabilitation showed encouraging results. The methodology of future longitudinal studies has to be optimized by a priori end points, the use of validated test batteries, and the inclusion of control groups. Comorbidities and aging are important factors to be taken into account in future studies. Preclinical studies in animal models highlighted the role of Cancer itself on cognition and support the possible benefits of prevention/care during chemotherapy. Progress in neuroimaging will help specify neural processes affected by treatments. Conclusion Clinical data and animal models confirmed that chemotherapy induces direct cognitive deficit. The benefits of cognitive rehabilitation are still to be confirmed. Studies evaluating the mechanisms underlying cognitive impairments using advanced neuroimaging techniques integrating the evaluation of genetic factors are ongoing.
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clinical characteristics pathophysiology and management of noncentral Nervous System Cancer related cognitive impairment in adults
CA: A Cancer Journal for Clinicians, 2015Co-Authors: Jeffrey Scott Wefel, Shelli R Kesler, Kyle Richard Noll, Sanne B SchagenAbstract:Over the past few decades, a body of research has emerged confirming what many adult patients with noncentral Nervous System Cancer have long reported—that Cancer and its treatment are frequently associated with Cancer-related cognitive impairment (CRCI). The severity of CRCI varies, and symptoms can emerge early or late in the disease course. Nonetheless, CRCI is typically mild to moderate in nature and primarily involves the domains of memory, attention, executive functioning, and processing speed. Animal models and novel neuroimaging techniques have begun to unravel the pathophysiologic mechanisms underlying CRCI, including the role of inflammatory cascades, direct neurotoxic effects, damage to progenitor cells, white matter abnormalities, and reduced functional connectivity, among others. Given the paucity of research on CRCI with other Cancer populations, this review synthesizes the current literature with a deliberate focus on CRCI within the context of breast Cancer. A hypothetical case-study approach is used to illustrate how CRCI often presents clinically and how current science can inform practice. While the literature regarding intervention for CRCI is nascent, behavioral and pharmacologic approaches are discussed.
Jeffrey S. Wefel - One of the best experts on this subject based on the ideXlab platform.
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Impact of Cancer and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012
Journal of Pain and Symptom Management, 2015Co-Authors: Florence Joly, Sanne B Schagen, Bénédicte Giffard, Olivier Rigal, Michiel B. De Ruiter, Brent J. Small, Martine Dubois, Johan Lefel, Tim A. Ahles, Jeffrey S. WefelAbstract:Abstract Context Although cognitive impairments have been identified in patients with non–central Nervous System Cancer, especially breast Cancer, the respective roles of Cancer and therapies, and the mechanisms involved in cognitive dysfunction remain unclear. Objectives To report a state-of-the-art update from the International Cognitive and Cancer Task Force conference held in 2012. Methods A report of the meeting and recent new perspectives are presented. Results Recent clinical data support that non–central Nervous System Cancer per se may be involved in cognitive dysfunctions associated with inflammation parameters. The role of chemotherapy on cognitive decline was confirmed in colorectal and testicular Cancers. Whereas the impact of hormone therapy remains debatable, some studies support a negative impact of targeted therapies on cognition. Regarding interventions, preliminary results of cognitive rehabilitation showed encouraging results. The methodology of future longitudinal studies has to be optimized by a priori end points, the use of validated test batteries, and the inclusion of control groups. Comorbidities and aging are important factors to be taken into account in future studies. Preclinical studies in animal models highlighted the role of Cancer itself on cognition and support the possible benefits of prevention/care during chemotherapy. Progress in neuroimaging will help specify neural processes affected by treatments. Conclusion Clinical data and animal models confirmed that chemotherapy induces direct cognitive deficit. The benefits of cognitive rehabilitation are still to be confirmed. Studies evaluating the mechanisms underlying cognitive impairments using advanced neuroimaging techniques integrating the evaluation of genetic factors are ongoing.
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Neuropsychological Sequelae of Non-Central Nervous System Cancer and Cancer Therapy
Neuropsychology Review, 2008Co-Authors: Jeffrey S. Wefel, Mariana E. Witgert, Christina A. MeyersAbstract:Cancer patients report numerous adverse symptoms associated with their disease and treatment including cognitive dysfunction, fatigue, and affective distress. Cognitive dysfunction is ubiquitous in patients with primary central Nervous System (CNS) Cancer and recent evidence has documented similar deficits in patients with non-CNS Cancer as well. Both the Cancer itself and treatments including chemotherapy, biological response modifiers, and hormonal therapies have been demonstrated to adversely impact cognitive and neurobehavioral function. Neuroimaging and neurophysiological investigations have likewise revealed alterations in brain function that are helping to account for the nature of these cognitive disorders. Similarly, preclinical animal research is assisting to identify the pathophysiological mechanisms that underlie treatment-related neurotoxicities. The coalescence of multidisciplinary clinical and research efforts hold promise for the development of interventions that may offer neuroprotection in addition to currently available symptomatic therapies and cognitive rehabilitation techniques.