The Experts below are selected from a list of 102156 Experts worldwide ranked by ideXlab platform

Aaron S. Kelly - One of the best experts on this subject based on the ideXlab platform.

  • Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity.
    Pediatric Research, 2015
    Co-Authors: Justin R. Ryder, Michael O'connell, Tyler A. Bosch, Lisa S. Chow, Kyle Rudser, Donald R. Dengel, Claudia K. Fox, Julia Steinberger, Aaron S. Kelly
    Abstract:

    Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity

  • Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity.
    Pediatric research, 2015
    Co-Authors: Justin R. Ryder, Michael O'connell, Tyler A. Bosch, Kyle Rudser, Donald R. Dengel, Claudia K. Fox, Julia Steinberger, Lisa Chow, Aaron S. Kelly
    Abstract:

    We examined whether sympathetic Nervous System activity influences hypertension status and systolic blood pressure (SBP) independent of adiposity in youth ranging from normal-weight to severe obesity. We examined the association of heart rate variability (HRV) with hypertension status and SBP among youth (6-18 y old; n = 188; 103 female). Seated SBP was measured using an automated cuff. Prehypertension (SBP percentile ≥ 90th to <95th) and hypertension (SBP percentile ≥ 95th) were defined by age-, sex-, and height-norms. Autonomic Nervous System activity was measured using HRV via SphygmoCor MM3 System and analyzed for time- and frequency-domains. Total body fat was measured via dual-energy X-ray absorptiometry. Logistic regression models demonstrated lower values in each time-domain HRV measure and larger low-frequency (LF):high-frequency (HF) ratio to be significantly associated with higher odds of being prehypertensive/hypertensive (11-47% higher odds) independent of total body fat (P < 0.05). In linear regression analysis, lower time-domain, but not frequency-domain, HRV measures were significantly associated with higher SBP independent of total body fat (P < 0.05). These data suggest that impaired cardiac autonomic Nervous System Function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth.

Patrícia Maciel - One of the best experts on this subject based on the ideXlab platform.

  • Role of the ubiquitin–proteasome System in Nervous System Function and disease: using C. elegans as a dissecting tool
    Cellular and Molecular Life Sciences, 2012
    Co-Authors: Márcio S. Baptista, Carlos B. Duarte, Patrícia Maciel
    Abstract:

    In addition to its central roles in protein quality control, regulation of cell cycle, intracellular signaling, DNA damage response and transcription regulation, the ubiquitin–proteasome System (UPS) plays specific roles in the Nervous System, where it contributes to precise connectivity through development, and later assures Functionality by regulating a wide spectrum of neuron-specific cellular processes. Aberrations in this System have been implicated in the etiology of neurodevelopmental and neurodegenerative diseases. In this review, we provide an updated view on the UPS and highlight recent findings concerning its role in normal and diseased Nervous Systems. We discuss the advantages of the model organism Caenorhabditis elegans as a tool to unravel the major unsolved questions concerning this biochemical pathway and its involvement in Nervous System Function and dysFunction, and expose the new possibilities, using state-of-the-art techniques, to assess UPS Function using this model System.

  • Role of the ubiquitin-proteasome System in Nervous System Function and disease: using C. elegans as a dissecting tool.
    Cellular and molecular life sciences : CMLS, 2012
    Co-Authors: Márcio S. Baptista, Carlos B. Duarte, Patrícia Maciel
    Abstract:

    In addition to its central roles in protein quality control, regulation of cell cycle, intracellular signaling, DNA damage response and transcription regulation, the ubiquitin–proteasome System (UPS) plays specific roles in the Nervous System, where it contributes to precise connectivity through development, and later assures Functionality by regulating a wide spectrum of neuron-specific cellular processes. Aberrations in this System have been implicated in the etiology of neurodevelopmental and neurodegenerative diseases. In this review, we provide an updated view on the UPS and highlight recent findings concerning its role in normal and diseased Nervous Systems. We discuss the advantages of the model organism Caenorhabditis elegans as a tool to unravel the major unsolved questions concerning this biochemical pathway and its involvement in Nervous System Function and dysFunction, and expose the new possibilities, using state-of-the-art techniques, to assess UPS Function using this model System.

Justin R. Ryder - One of the best experts on this subject based on the ideXlab platform.

  • Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity.
    Pediatric Research, 2015
    Co-Authors: Justin R. Ryder, Michael O'connell, Tyler A. Bosch, Lisa S. Chow, Kyle Rudser, Donald R. Dengel, Claudia K. Fox, Julia Steinberger, Aaron S. Kelly
    Abstract:

    Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity

  • Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity.
    Pediatric research, 2015
    Co-Authors: Justin R. Ryder, Michael O'connell, Tyler A. Bosch, Kyle Rudser, Donald R. Dengel, Claudia K. Fox, Julia Steinberger, Lisa Chow, Aaron S. Kelly
    Abstract:

    We examined whether sympathetic Nervous System activity influences hypertension status and systolic blood pressure (SBP) independent of adiposity in youth ranging from normal-weight to severe obesity. We examined the association of heart rate variability (HRV) with hypertension status and SBP among youth (6-18 y old; n = 188; 103 female). Seated SBP was measured using an automated cuff. Prehypertension (SBP percentile ≥ 90th to <95th) and hypertension (SBP percentile ≥ 95th) were defined by age-, sex-, and height-norms. Autonomic Nervous System activity was measured using HRV via SphygmoCor MM3 System and analyzed for time- and frequency-domains. Total body fat was measured via dual-energy X-ray absorptiometry. Logistic regression models demonstrated lower values in each time-domain HRV measure and larger low-frequency (LF):high-frequency (HF) ratio to be significantly associated with higher odds of being prehypertensive/hypertensive (11-47% higher odds) independent of total body fat (P < 0.05). In linear regression analysis, lower time-domain, but not frequency-domain, HRV measures were significantly associated with higher SBP independent of total body fat (P < 0.05). These data suggest that impaired cardiac autonomic Nervous System Function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth.

Márcio S. Baptista - One of the best experts on this subject based on the ideXlab platform.

  • Role of the ubiquitin–proteasome System in Nervous System Function and disease: using C. elegans as a dissecting tool
    Cellular and Molecular Life Sciences, 2012
    Co-Authors: Márcio S. Baptista, Carlos B. Duarte, Patrícia Maciel
    Abstract:

    In addition to its central roles in protein quality control, regulation of cell cycle, intracellular signaling, DNA damage response and transcription regulation, the ubiquitin–proteasome System (UPS) plays specific roles in the Nervous System, where it contributes to precise connectivity through development, and later assures Functionality by regulating a wide spectrum of neuron-specific cellular processes. Aberrations in this System have been implicated in the etiology of neurodevelopmental and neurodegenerative diseases. In this review, we provide an updated view on the UPS and highlight recent findings concerning its role in normal and diseased Nervous Systems. We discuss the advantages of the model organism Caenorhabditis elegans as a tool to unravel the major unsolved questions concerning this biochemical pathway and its involvement in Nervous System Function and dysFunction, and expose the new possibilities, using state-of-the-art techniques, to assess UPS Function using this model System.

  • Role of the ubiquitin-proteasome System in Nervous System Function and disease: using C. elegans as a dissecting tool.
    Cellular and molecular life sciences : CMLS, 2012
    Co-Authors: Márcio S. Baptista, Carlos B. Duarte, Patrícia Maciel
    Abstract:

    In addition to its central roles in protein quality control, regulation of cell cycle, intracellular signaling, DNA damage response and transcription regulation, the ubiquitin–proteasome System (UPS) plays specific roles in the Nervous System, where it contributes to precise connectivity through development, and later assures Functionality by regulating a wide spectrum of neuron-specific cellular processes. Aberrations in this System have been implicated in the etiology of neurodevelopmental and neurodegenerative diseases. In this review, we provide an updated view on the UPS and highlight recent findings concerning its role in normal and diseased Nervous Systems. We discuss the advantages of the model organism Caenorhabditis elegans as a tool to unravel the major unsolved questions concerning this biochemical pathway and its involvement in Nervous System Function and dysFunction, and expose the new possibilities, using state-of-the-art techniques, to assess UPS Function using this model System.

Michael O'connell - One of the best experts on this subject based on the ideXlab platform.

  • Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity.
    Pediatric Research, 2015
    Co-Authors: Justin R. Ryder, Michael O'connell, Tyler A. Bosch, Lisa S. Chow, Kyle Rudser, Donald R. Dengel, Claudia K. Fox, Julia Steinberger, Aaron S. Kelly
    Abstract:

    Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity

  • Impaired cardiac autonomic Nervous System Function is associated with pediatric hypertension independent of adiposity.
    Pediatric research, 2015
    Co-Authors: Justin R. Ryder, Michael O'connell, Tyler A. Bosch, Kyle Rudser, Donald R. Dengel, Claudia K. Fox, Julia Steinberger, Lisa Chow, Aaron S. Kelly
    Abstract:

    We examined whether sympathetic Nervous System activity influences hypertension status and systolic blood pressure (SBP) independent of adiposity in youth ranging from normal-weight to severe obesity. We examined the association of heart rate variability (HRV) with hypertension status and SBP among youth (6-18 y old; n = 188; 103 female). Seated SBP was measured using an automated cuff. Prehypertension (SBP percentile ≥ 90th to <95th) and hypertension (SBP percentile ≥ 95th) were defined by age-, sex-, and height-norms. Autonomic Nervous System activity was measured using HRV via SphygmoCor MM3 System and analyzed for time- and frequency-domains. Total body fat was measured via dual-energy X-ray absorptiometry. Logistic regression models demonstrated lower values in each time-domain HRV measure and larger low-frequency (LF):high-frequency (HF) ratio to be significantly associated with higher odds of being prehypertensive/hypertensive (11-47% higher odds) independent of total body fat (P < 0.05). In linear regression analysis, lower time-domain, but not frequency-domain, HRV measures were significantly associated with higher SBP independent of total body fat (P < 0.05). These data suggest that impaired cardiac autonomic Nervous System Function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth.