The Experts below are selected from a list of 34239 Experts worldwide ranked by ideXlab platform
S. C. Schold - One of the best experts on this subject based on the ideXlab platform.
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Treatment of radiation‐induced Nervous System Injury with heparin and warfarin
Neurology, 1994Co-Authors: Michael Glantz, Peter Burger, Allan H. Friedman, Rodney A. Radtke, S. C. ScholdAbstract:When radiation is used to treat Nervous System cancer, exposure of adjacent normal Nervous System tissue is unavoidable, and radiation-induced Injury may occur. Acute Injury is usually mild and transient, but late forms of radiation-induced Nervous System Injury are usually progressive and debilitating. Treatment with corticosteroids, surgery, and antioxidants is often ineffective. We treated 11 patients with late radiation-induced Nervous System injuries (eight with cerebral radionecrosis, one with a myelopathy, and two with plexopathies, all unresponsive to dexamethasone and prednisone) with full anticoagulation. Some recovery of function occurred in five of the eight patients with cerebral radionecrosis, and all the patients with myelopathy or plexopathy. Anticoagulation was continued for 3 to 6 months. In one patient with cerebral radionecrosis, symptoms recurred after discontinuation of anticoagulation and disappeared again after reinstitution of treatment. We hypothesize that anticoagulation may arrest and reverse small-vessel endothelial Injury--the fundamental lesion of radiation necrosis--and produce clinical improvement in some patients.
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treatment of radiation induced Nervous System Injury with heparin and warfarin
Neurology, 1994Co-Authors: Michael Glantz, Allan H. Friedman, Rodney A. Radtke, Peter C Burger, E W Massey, S. C. ScholdAbstract:When radiation is used to treat Nervous System cancer, exposure of adjacent normal Nervous System tissue is unavoidable, and radiation-induced Injury may occur. Acute Injury is usually mild and transient, but late forms of radiation-induced Nervous System Injury are usually progressive and debilitating. Treatment with corticosteroids, surgery, and antioxidants is often ineffective. We treated 11 patients with late radiation-induced Nervous System injuries (eight with cerebral radionecrosis, one with a myelopathy, and two with plexopathies, all unresponsive to dexamethasone and prednisone) with full anticoagulation. Some recovery of function occurred in five of the eight patients with cerebral radionecrosis, and all the patients with myelopathy or plexopathy. Anticoagulation was continued for 3 to 6 months. In one patient with cerebral radionecrosis, symptoms recurred after discontinuation of anticoagulation and disappeared again after reinstitution of treatment. We hypothesize that anticoagulation may arrest and reverse small-vessel endothelial Injury--the fundamental lesion of radiation necrosis--and produce clinical improvement in some patients.
Naren L Banik - One of the best experts on this subject based on the ideXlab platform.
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therapeutic potential of melatonin in traumatic central Nervous System Injury
Journal of Pineal Research, 2009Co-Authors: Supriti Samantaray, Arabinda Das, Nakul P Thakore, Denise Matzelle, Russel J Reiter, Swapan K Ray, Naren L BanikAbstract:Abstract: A vast literature extolling the benefits of melatonin has accumulated during the past four decades. Melatonin was previously considered of importance to seasonal reproduction and circadian rhythmicity. Currently, it appears to be a versatile anti-oxidative and anti-nitrosative agent, a molecule with immunomodulatory actions and profound oncostatic activity, and also to play a role as a potent neuroprotectant. Nowadays, melatonin is sold as a dietary supplement with differential availability as an over-the-counter aid in different countries. There is a widespread agreement that melatonin is nontoxic and safe considering its frequent, long-term usage by humans at both physiological and pharmacological doses with no reported side effects. Endeavors toward a designated drug status for melatonin may be enormously rewarding in clinics for treatment of several forms of neurotrauma where effective pharmacological intervention has not yet been attained. This mini review consolidates the data regarding the efficacy of melatonin as an unique neuroprotective agent in traumatic central Nervous System (CNS) injuries. Well-documented actions of melatonin in combating traumatic CNS damage are compiled from various clinical and experimental studies. Research on traumatic brain Injury and ischemia/reperfusion are briefly outlined here as they have been recently reviewed elsewhere, whereas the studies on different animal models of the experimental spinal cord Injury have been extensively covered in this mini review for the first time.
Mark H Tuszynski - One of the best experts on this subject based on the ideXlab platform.
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the basal forebrain cholinergic System is essential for cortical plasticity and functional recovery following brain Injury
Neuron, 2005Co-Authors: James M Conner, Andrea A Chiba, Mark H TuszynskiAbstract:A reorganization of cortical representations is postulated as the basis for functional recovery following many types of Nervous System Injury. Neuronal mechanisms underlying this form of cortical plasticity are poorly understood. The present study investigated the hypothesis that the basal forebrain cholinergic System plays an essential role in enabling the cortical reorganization required for functional recovery following brain Injury. The results demonstrate that functional recovery following cortical Injury requires basal forebrain cholinergic mechanisms and suggest that the basis for this recovery is the cholinergic-dependent reorganization of motor representations. These findings raise the intriguing possibility that deficits in cholinergic function may limit functional outcomes following Nervous System Injury.
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spontaneous corticospinal axonal plasticity and functional recovery after adult central Nervous System Injury
Proceedings of the National Academy of Sciences of the United States of America, 2001Co-Authors: Norbert Weidner, Nima Salimi, Mark H TuszynskiAbstract:Abstract Although it is believed that little recovery occurs after adult mammalian spinal cord Injury, in fact significant spontaneous functional improvement commonly occurs after spinal cord Injury in humans. To investigate potential mechanisms underlying spontaneous recovery, lesions of defined components of the corticospinal motor pathway were made in adult rats in the rostral cervical spinal cord or caudal medulla. Following complete lesions of the dorsal corticospinal motor pathway, which contains more than 95% of all corticospinal axons, spontaneous sprouting from the ventral corticospinal tract occurred onto medial motoneuron pools in the cervical spinal cord; this sprouting was paralleled by functional recovery. Combined lesions of both dorsal and ventral corticospinal tract components eliminated sprouting and functional recovery. In addition, functional recovery was also abolished if dorsal corticospinal tract lesions were followed 5 weeks later by ventral corticospinal tract lesions. We found extensive spontaneous structural plasticity as a mechanism correlating with functional recovery in motor Systems in the adult central Nervous System. Experimental enhancement of spontaneous plasticity may be useful to promote further recovery after adult central Nervous System Injury.
Michael Glantz - One of the best experts on this subject based on the ideXlab platform.
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Treatment of radiation‐induced Nervous System Injury with heparin and warfarin
Neurology, 1994Co-Authors: Michael Glantz, Peter Burger, Allan H. Friedman, Rodney A. Radtke, S. C. ScholdAbstract:When radiation is used to treat Nervous System cancer, exposure of adjacent normal Nervous System tissue is unavoidable, and radiation-induced Injury may occur. Acute Injury is usually mild and transient, but late forms of radiation-induced Nervous System Injury are usually progressive and debilitating. Treatment with corticosteroids, surgery, and antioxidants is often ineffective. We treated 11 patients with late radiation-induced Nervous System injuries (eight with cerebral radionecrosis, one with a myelopathy, and two with plexopathies, all unresponsive to dexamethasone and prednisone) with full anticoagulation. Some recovery of function occurred in five of the eight patients with cerebral radionecrosis, and all the patients with myelopathy or plexopathy. Anticoagulation was continued for 3 to 6 months. In one patient with cerebral radionecrosis, symptoms recurred after discontinuation of anticoagulation and disappeared again after reinstitution of treatment. We hypothesize that anticoagulation may arrest and reverse small-vessel endothelial Injury--the fundamental lesion of radiation necrosis--and produce clinical improvement in some patients.
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treatment of radiation induced Nervous System Injury with heparin and warfarin
Neurology, 1994Co-Authors: Michael Glantz, Allan H. Friedman, Rodney A. Radtke, Peter C Burger, E W Massey, S. C. ScholdAbstract:When radiation is used to treat Nervous System cancer, exposure of adjacent normal Nervous System tissue is unavoidable, and radiation-induced Injury may occur. Acute Injury is usually mild and transient, but late forms of radiation-induced Nervous System Injury are usually progressive and debilitating. Treatment with corticosteroids, surgery, and antioxidants is often ineffective. We treated 11 patients with late radiation-induced Nervous System injuries (eight with cerebral radionecrosis, one with a myelopathy, and two with plexopathies, all unresponsive to dexamethasone and prednisone) with full anticoagulation. Some recovery of function occurred in five of the eight patients with cerebral radionecrosis, and all the patients with myelopathy or plexopathy. Anticoagulation was continued for 3 to 6 months. In one patient with cerebral radionecrosis, symptoms recurred after discontinuation of anticoagulation and disappeared again after reinstitution of treatment. We hypothesize that anticoagulation may arrest and reverse small-vessel endothelial Injury--the fundamental lesion of radiation necrosis--and produce clinical improvement in some patients.
Minu Patel - One of the best experts on this subject based on the ideXlab platform.
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one year outcome of auditory tactile visual vestibular intervention in the neonatal intensive care unit effects of severe prematurity and central Nervous System Injury
Journal of Child Neurology, 2001Co-Authors: Michael N. Nelson, Ushanalini Vasan, Jean M. Silvestri, Elizabeth M. Comiskey, Susan Littau, Rosemary C Whitetraut, Patricia Meleedyrey, Minu PatelAbstract:Thirty-seven infants with severe central Nervous System Injury or extreme prematurity were randomly assigned to a multisensory (auditory-tactile-visual-vestibular) intervention or control group. Intervention began in the hospital at 33 weeks' postconceptional age and continued twice daily in the home until 2 months' corrected age. Mother-infant interactions during feedings were videotaped, and the Bayley Scales of Infant Development were administered. Control mothers stimulated their infants more during feeding, but these significant differences dissipated by 4 months. The presence of periventricular leukomalacia was associated with significantly poorer mental development, regardless of group assignment. Experimental infants tended to exhibit better motor and mental performance and had 23% fewer cerebral palsy diagnoses at 1 year, but these trends were not statistically significant. The type of brain Injury was more important in determining 1-year developmental outcome than type of postnatal experience, suggesting that periventricular leukomalacia presents a major challenge for infant development.
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One-Year Outcome of Auditory-Tactile-Visual-Vestibular Intervention in the Neonatal Intensive Care Unit: Effects of Severe Prematurity and Central Nervous System Injury:
Journal of child neurology, 2001Co-Authors: Michael N. Nelson, Rosemary C. White-traut, Ushanalini Vasan, Jean M. Silvestri, Elizabeth M. Comiskey, Patricia Meleedy-rey, Susan Littau, Minu PatelAbstract:Thirty-seven infants with severe central Nervous System Injury or extreme prematurity were randomly assigned to a multisensory (auditory-tactile-visual-vestibular) intervention or control group. In...