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Susan M Carden - One of the best experts on this subject based on the ideXlab platform.
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retinopathy of Prematurity postmenstrual age at threshold in a transitional economy is similar to that in developed countries
Clinical and Experimental Ophthalmology, 2008Co-Authors: Susan M Carden, Tess Huynh, Tinh Xuan Nguyen, William V GoodAbstract:BACKGROUND: To analyse the timing of threshold disease in infants requiring treatment for retinopathy of Prematurity in a transitional economy. DESIGN: Retrospective, observational, cohort study. SETTING: National Hospital of Paediatrics, Hanoi, Vietnam. STUDY POPULATION: Premature infants in the Neonatal ward requiring laser treatment for threshold retinopathy of Prematurity. MAIN OUTCOME MEASURES: Chronological age and postmenstrual age at treatment. RESULTS: From January 2002 to November 2004, 42 infants from the National Hospital of Paediatrics required laser surgery for threshold retinopathy of Prematurity. The mean +/- standard deviation (SD) of birth weight was 1369 +/- 184 g (range 1000-1700); the mean +/- SD of gestation at birth was 30 +/- 1.8 weeks (range 27-34); and the mean +/- SD of postmenstrual age at which treatment occurred in these infants was 36.2 +/- 2.5 weeks (range 31.4-42). A further 58 infants were transferred from other hospitals for laser surgery between January 2004 and October 2004. The mean +/- SD of birth weight was 1325.5 +/- 237.2 g (range 800-1900); the mean +/- SD of gestation at birth was 30 +/- 1.7 weeks (range 28-35); and the mean +/- SD of postmenstrual age at which treatment was given in these infants was 36.3 +/- 2.3 weeks (range 32.71-44.3). DISCUSSIONS: Despite the relative maturity of the gestation of these infants compared with infants in developed countries who develop severe retinopathy of Prematurity, the timing of treatment for threshold disease appears to be related to postmenstrual age.
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retinopathy of Prematurity postmenstrual age at threshold in a transitional economy is similar to that in developed countries
Clinical and Experimental Ophthalmology, 2008Co-Authors: Susan M Carden, Tess Huynh, Tinh Xuan Nguyen, Lan Ngoc Luu, William V GoodAbstract:BACKGROUND To analyse the timing of threshold disease in infants requiring treatment for retinopathy of Prematurity in a transitional economy. METHODS DESIGN Retrospective, observational, cohort study. SETTING National Hospital of Paediatrics, Hanoi, Vietnam. STUDY POPULATION Premature infants in the Neonatal ward requiring laser treatment for threshold retinopathy of Prematurity. MAIN OUTCOME MEASURES Chronological age and postmenstrual age at treatment. RESULTS From January 2002 to November 2004, 42 infants from the National Hospital of Paediatrics required laser surgery for threshold retinopathy of Prematurity. The mean +/- standard deviation (SD) of birth weight was 1369 +/- 184 g (range 1000-1700); the mean +/- SD of gestation at birth was 30 +/- 1.8 weeks (range 27-34); and the mean +/- SD of postmenstrual age at which treatment occurred in these infants was 36.2 +/- 2.5 weeks (range 31.4-42). A further 58 infants were transferred from other hospitals for laser surgery between January 2004 and October 2004. The mean +/- SD of birth weight was 1325.5 +/- 237.2 g (range 800-1900); the mean +/- SD of gestation at birth was 30 +/- 1.7 weeks (range 28-35); and the mean +/- SD of postmenstrual age at which treatment was given in these infants was 36.3 +/- 2.3 weeks (range 32.71-44.3). DISCUSSIONS Despite the relative maturity of the gestation of these infants compared with infants in developed countries who develop severe retinopathy of Prematurity, the timing of treatment for threshold disease appears to be related to postmenstrual age.
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zone 1 retinopathy of Prematurity in a transitional economy a cautionary note
American Journal of Ophthalmology, 2006Co-Authors: Susan M Carden, Tess HuynhAbstract:Purpose To describe three low risk infants in whom severe retinopathy of Prematurity developed. Design A prospective, observational case series. Methods setting : National Hospital of Pediatrics, Hanoi, Vietnam. study population : Premature infants in the neonatal ward. observation procedure : Eye examinations. Results Severe retinopathy of Prematurity occurred in three infants. All had zone 1 disease and other unusually severe findings, such as neovascularization of the disk. These infants would not be at risk for the development of such severe retinopathy of Prematurity in countries with a developed economy. Conclusions Unusual characteristics of retinopathy of Prematurity may be occurring in countries with transitional economies. Screening programs should be implemented and should take into consideration the possibility that retinopathy of Prematurity may occur in infants who fall outside the screening guidelines that are used in the developed world.
Tess Huynh - One of the best experts on this subject based on the ideXlab platform.
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retinopathy of Prematurity postmenstrual age at threshold in a transitional economy is similar to that in developed countries
Clinical and Experimental Ophthalmology, 2008Co-Authors: Susan M Carden, Tess Huynh, Tinh Xuan Nguyen, William V GoodAbstract:BACKGROUND: To analyse the timing of threshold disease in infants requiring treatment for retinopathy of Prematurity in a transitional economy. DESIGN: Retrospective, observational, cohort study. SETTING: National Hospital of Paediatrics, Hanoi, Vietnam. STUDY POPULATION: Premature infants in the Neonatal ward requiring laser treatment for threshold retinopathy of Prematurity. MAIN OUTCOME MEASURES: Chronological age and postmenstrual age at treatment. RESULTS: From January 2002 to November 2004, 42 infants from the National Hospital of Paediatrics required laser surgery for threshold retinopathy of Prematurity. The mean +/- standard deviation (SD) of birth weight was 1369 +/- 184 g (range 1000-1700); the mean +/- SD of gestation at birth was 30 +/- 1.8 weeks (range 27-34); and the mean +/- SD of postmenstrual age at which treatment occurred in these infants was 36.2 +/- 2.5 weeks (range 31.4-42). A further 58 infants were transferred from other hospitals for laser surgery between January 2004 and October 2004. The mean +/- SD of birth weight was 1325.5 +/- 237.2 g (range 800-1900); the mean +/- SD of gestation at birth was 30 +/- 1.7 weeks (range 28-35); and the mean +/- SD of postmenstrual age at which treatment was given in these infants was 36.3 +/- 2.3 weeks (range 32.71-44.3). DISCUSSIONS: Despite the relative maturity of the gestation of these infants compared with infants in developed countries who develop severe retinopathy of Prematurity, the timing of treatment for threshold disease appears to be related to postmenstrual age.
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retinopathy of Prematurity postmenstrual age at threshold in a transitional economy is similar to that in developed countries
Clinical and Experimental Ophthalmology, 2008Co-Authors: Susan M Carden, Tess Huynh, Tinh Xuan Nguyen, Lan Ngoc Luu, William V GoodAbstract:BACKGROUND To analyse the timing of threshold disease in infants requiring treatment for retinopathy of Prematurity in a transitional economy. METHODS DESIGN Retrospective, observational, cohort study. SETTING National Hospital of Paediatrics, Hanoi, Vietnam. STUDY POPULATION Premature infants in the Neonatal ward requiring laser treatment for threshold retinopathy of Prematurity. MAIN OUTCOME MEASURES Chronological age and postmenstrual age at treatment. RESULTS From January 2002 to November 2004, 42 infants from the National Hospital of Paediatrics required laser surgery for threshold retinopathy of Prematurity. The mean +/- standard deviation (SD) of birth weight was 1369 +/- 184 g (range 1000-1700); the mean +/- SD of gestation at birth was 30 +/- 1.8 weeks (range 27-34); and the mean +/- SD of postmenstrual age at which treatment occurred in these infants was 36.2 +/- 2.5 weeks (range 31.4-42). A further 58 infants were transferred from other hospitals for laser surgery between January 2004 and October 2004. The mean +/- SD of birth weight was 1325.5 +/- 237.2 g (range 800-1900); the mean +/- SD of gestation at birth was 30 +/- 1.7 weeks (range 28-35); and the mean +/- SD of postmenstrual age at which treatment was given in these infants was 36.3 +/- 2.3 weeks (range 32.71-44.3). DISCUSSIONS Despite the relative maturity of the gestation of these infants compared with infants in developed countries who develop severe retinopathy of Prematurity, the timing of treatment for threshold disease appears to be related to postmenstrual age.
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zone 1 retinopathy of Prematurity in a transitional economy a cautionary note
American Journal of Ophthalmology, 2006Co-Authors: Susan M Carden, Tess HuynhAbstract:Purpose To describe three low risk infants in whom severe retinopathy of Prematurity developed. Design A prospective, observational case series. Methods setting : National Hospital of Pediatrics, Hanoi, Vietnam. study population : Premature infants in the neonatal ward. observation procedure : Eye examinations. Results Severe retinopathy of Prematurity occurred in three infants. All had zone 1 disease and other unusually severe findings, such as neovascularization of the disk. These infants would not be at risk for the development of such severe retinopathy of Prematurity in countries with a developed economy. Conclusions Unusual characteristics of retinopathy of Prematurity may be occurring in countries with transitional economies. Screening programs should be implemented and should take into consideration the possibility that retinopathy of Prematurity may occur in infants who fall outside the screening guidelines that are used in the developed world.
William V Good - One of the best experts on this subject based on the ideXlab platform.
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retinopathy of Prematurity postmenstrual age at threshold in a transitional economy is similar to that in developed countries
Clinical and Experimental Ophthalmology, 2008Co-Authors: Susan M Carden, Tess Huynh, Tinh Xuan Nguyen, William V GoodAbstract:BACKGROUND: To analyse the timing of threshold disease in infants requiring treatment for retinopathy of Prematurity in a transitional economy. DESIGN: Retrospective, observational, cohort study. SETTING: National Hospital of Paediatrics, Hanoi, Vietnam. STUDY POPULATION: Premature infants in the Neonatal ward requiring laser treatment for threshold retinopathy of Prematurity. MAIN OUTCOME MEASURES: Chronological age and postmenstrual age at treatment. RESULTS: From January 2002 to November 2004, 42 infants from the National Hospital of Paediatrics required laser surgery for threshold retinopathy of Prematurity. The mean +/- standard deviation (SD) of birth weight was 1369 +/- 184 g (range 1000-1700); the mean +/- SD of gestation at birth was 30 +/- 1.8 weeks (range 27-34); and the mean +/- SD of postmenstrual age at which treatment occurred in these infants was 36.2 +/- 2.5 weeks (range 31.4-42). A further 58 infants were transferred from other hospitals for laser surgery between January 2004 and October 2004. The mean +/- SD of birth weight was 1325.5 +/- 237.2 g (range 800-1900); the mean +/- SD of gestation at birth was 30 +/- 1.7 weeks (range 28-35); and the mean +/- SD of postmenstrual age at which treatment was given in these infants was 36.3 +/- 2.3 weeks (range 32.71-44.3). DISCUSSIONS: Despite the relative maturity of the gestation of these infants compared with infants in developed countries who develop severe retinopathy of Prematurity, the timing of treatment for threshold disease appears to be related to postmenstrual age.
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retinopathy of Prematurity postmenstrual age at threshold in a transitional economy is similar to that in developed countries
Clinical and Experimental Ophthalmology, 2008Co-Authors: Susan M Carden, Tess Huynh, Tinh Xuan Nguyen, Lan Ngoc Luu, William V GoodAbstract:BACKGROUND To analyse the timing of threshold disease in infants requiring treatment for retinopathy of Prematurity in a transitional economy. METHODS DESIGN Retrospective, observational, cohort study. SETTING National Hospital of Paediatrics, Hanoi, Vietnam. STUDY POPULATION Premature infants in the Neonatal ward requiring laser treatment for threshold retinopathy of Prematurity. MAIN OUTCOME MEASURES Chronological age and postmenstrual age at treatment. RESULTS From January 2002 to November 2004, 42 infants from the National Hospital of Paediatrics required laser surgery for threshold retinopathy of Prematurity. The mean +/- standard deviation (SD) of birth weight was 1369 +/- 184 g (range 1000-1700); the mean +/- SD of gestation at birth was 30 +/- 1.8 weeks (range 27-34); and the mean +/- SD of postmenstrual age at which treatment occurred in these infants was 36.2 +/- 2.5 weeks (range 31.4-42). A further 58 infants were transferred from other hospitals for laser surgery between January 2004 and October 2004. The mean +/- SD of birth weight was 1325.5 +/- 237.2 g (range 800-1900); the mean +/- SD of gestation at birth was 30 +/- 1.7 weeks (range 28-35); and the mean +/- SD of postmenstrual age at which treatment was given in these infants was 36.3 +/- 2.3 weeks (range 32.71-44.3). DISCUSSIONS Despite the relative maturity of the gestation of these infants compared with infants in developed countries who develop severe retinopathy of Prematurity, the timing of treatment for threshold disease appears to be related to postmenstrual age.
Lois E. H. Smith - One of the best experts on this subject based on the ideXlab platform.
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Retinopathy of Prematurity
Angiogenesis, 2007Co-Authors: Jing Chen, Lois E. H. SmithAbstract:Retinopathy of Prematurity (ROP) is a common blinding disease in children in the developed world despite current treatment, and is becoming increasingly prevalent in the developing world. ROP progresses in two phases. The first phase begins with delayed retinal vascular growth after birth and partial regression of existing vessels, followed by a second phase of hypoxia-induced pathological vessel growth. Two major risk factors of ROP are the use of oxygen and a decreased gestation period. Excessive oxygen contributes to ROP through regulation of vascular endothelial growth factor (VEGF). Suppression of VEGF by oxygen in phase I of ROP inhibits normal vessel growth, whereas elevated levels of VEGF induced by hypoxia in phase II of ROP precipitate pathological vessel proliferation. Insulin-like growth factor 1 (IGF-1) is a critical non-oxygen-regulated factor in ROP. We have found that serum levels of IGF-1 in premature babies directly correlate with the severity of clinical ROP. IGF-1 acts indirectly as a permissive factor by allowing maximal VEGF stimulation of vessel growth. Lack of IGF-1 in preterm infants prevents normal retinal vascular growth in phase I of ROP, despite the presence of VEGF. As infants mature, rising levels of IGF-1 in phase II of ROP allows VEGF stimulated pathological neovascularization. These findings suggest that restoration of IGF-1 to normal levels might be useful in preventing ROP in preterm infants.
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pathogenesis of retinopathy of Prematurity
Acta Paediatrica, 2007Co-Authors: Lois E. H. SmithAbstract:Retinopathy of Prematurity (ROP) is a blinding disease, initiated by delayed retinal vascular growth after premature birth. There are both oxygen-regulated and non-oxygen-regulated factors, which contribute to both normal vascular development and retinal neovascularization. One important oxygen-regulated factor, critical to both phases of ROP, is vascular endothelial growth factor (VEGF). A critical non oxygen-regulated growth factor is insulin-like growth factor (IGF-1). In knockout mice, lack of IGF-1 prevents normal retinal vascular growth, despite the presence of VEGF, important to vessel development. In vitro, low IGF-1 prevents vascular endothelial growth factor-induced activation of Akt, a kinase critical for vascular endothelial cell survival. Premature infants who develop ROP have lower levels of serum IGF-1 than age-matched infants without disease. Conclusion: IGF-1 is critical to normal vascular development. Low IGF-1 predicts ROP and restoration of IGF-1 to normal levels may prevent ROP.
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pathogenesis of retinopathy of Prematurity
Growth Hormone & Igf Research, 2004Co-Authors: Lois E. H. SmithAbstract:Retinopathy of Prematurity (ROP) is a major cause of blindness in children in developed countries. ROP is a two-phase disease, beginning with delayed retinal vascular growth after premature birth (Phase I). Phase II follows when Phase I-induced hypoxia releases factors to stimulate new blood vessel growth. Both oxygen-regulated and non-oxygen-regulated factors contribute to normal vascular development and retinal neovascularization. Vascular endothelial growth factor (VEGF) is an important oxygen-regulated factor. A critical non-oxygen-regulated growth factor is insulin-like growth factor-I (IGF-I). In knockout mice, lack of IGF-I prevents normal retinal vascular growth, despite the presence of VEGF, important to vessel development. In vitro, low IGF-I levels prevent VEGF-induced activation of Akt, a kinase critical for vascular endothelial cell survival. We found that premature infants who develop ROP have low levels of serum IGF-I compared to age-matched infants without disease. IGF-I is critical to normal vascular development. Low IGF-I predicts ROP in premature infants, and restoration of IGF-I to normal levels might prevent ROP.
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pathogenesis of retinopathy of Prematurity
Seminars in Neonatology, 2003Co-Authors: Lois E. H. SmithAbstract:Retinopathy of Prematurity (ROP) is a major cause of blindness in children in developed countries. ROP, a two-phase disease, is initiated with delayed retinal vascular growth after premature birth (phase I). Insufficient vascularization of the developing retina creates hypoxia, which precipitates the release of factors stimulating new and abnormal blood vessel growth (phase II). ROP develops because of abnormalities in both oxygen-regulated and non-oxygen-regulated factors, which affect both phases of the disease. Vascular endothelial growth factor (VEGF) is an important oxygen-regulated factor that, if suppressed, inhibits normal vessel growth, but in excess, precipitates retinal neovascularization. A critical non-oxygen-regulated growth factor is insulin-like growth factor (IGF-1). Similar to VEGF, low levels of IGF-1 prevent normal vessel growth (phase I), and higher levels allow neovascularization (phase II). We found that premature infants who develop ROP have low levels of serum IGF-1 compared with age-matched infants without disease. IGF-1 is critical to normal vascular development. Low IGF-1 predicts ROP, and restoration of IGF-1 to normal levels might prevent ROP.
Michael F Chiang - One of the best experts on this subject based on the ideXlab platform.
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retinopathy of Prematurity a review of risk factors and their clinical significance
Survey of Ophthalmology, 2018Co-Authors: Peter J Campbell, Sang Jin Kim, Alexander D Port, Ryan Swan, R Paul V Chan, Michael F ChiangAbstract:Abstract Retinopathy of Prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of Prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of Prematurity, and to determine future directions in management of and research in ROP.
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original articleincidence of retinopathy of Prematurity from 1996 to 2000 analysis of a comprehensive new york state patient database
Ophthalmology, 2004Co-Authors: Michael F Chiang, John T. Flynn, Raymond R Arons, Justin StarrenAbstract:Objective To determine the current incidence of retinopathy of Prematurity (ROP) in New York state.
