The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Antonio Noronha - One of the best experts on this subject based on the ideXlab platform.
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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders - Neural-Immune Interactions in Brain Function and Alcohol Related Disorders
2013Co-Authors: Changhai Cui, Lindsey Grandison, Antonio NoronhaAbstract:Rapid advances in understanding Neural-Immune Interactions have far reaching impact on research in many areas of neuroscience. It is becoming increasingly clear that neuroimmune factors modulate a wide range of brain functions and play an important role in development, normal brain function, and CNS dysfunctions, including neurodegenerative diseases, neuropsychiatric disorders and addiction. Neural Immune Interaction in Brain Function and Alcohol Related Disorders integrates emerging knowledge on Neural-Immune Interactions with related key discoveries in alcohol research to provide a comprehensive overview of neuroimmune system in brain function and behavior associated with alcohol use disorders. Readers will benefit from cutting edge insights provided by outstanding, active researchers in the fields of neuroimmune research and alcohol use disorders
Simon H. L. Thomas - One of the best experts on this subject based on the ideXlab platform.
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Forensic Chemistry - Drugs of abuse
Medicine, 2016Co-Authors: Sl Hill, Simon H. L. ThomasAbstract:Opioids and cannabinoids have been shown to modulate many different parameters of immune responses. In general, opioids and cannabinoids have been found to be immunosuppressive, both in vitro and in vivo in a variety of assays, including response of lymphocytes to mitogens, antibody formation, activation of T-cells, Natural Killer Cell activity, and phagocytosis by macrophages and neutrophils. Drugs in these two classes have also been shown to inhibit migration of cells from the circulatory system to areas of inflammation, including passage across the blood-brain barrier. Opioids and cannabinoids have both been shown to sensitize mice to a variety of infectious agents, which is commensurate with an immunosuppressed state. In specialized rodent models and in monkeys, opioids sensitized to HIV and SIV, possibly related to their ability to cause heterologous desensitization of chemokine co-receptors for these viruses. The literature covered in this chapter supports the existence of a robust Neural-Immune Interaction.
Changhai Cui - One of the best experts on this subject based on the ideXlab platform.
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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders - Neural-Immune Interactions in Brain Function and Alcohol Related Disorders
2013Co-Authors: Changhai Cui, Lindsey Grandison, Antonio NoronhaAbstract:Rapid advances in understanding Neural-Immune Interactions have far reaching impact on research in many areas of neuroscience. It is becoming increasingly clear that neuroimmune factors modulate a wide range of brain functions and play an important role in development, normal brain function, and CNS dysfunctions, including neurodegenerative diseases, neuropsychiatric disorders and addiction. Neural Immune Interaction in Brain Function and Alcohol Related Disorders integrates emerging knowledge on Neural-Immune Interactions with related key discoveries in alcohol research to provide a comprehensive overview of neuroimmune system in brain function and behavior associated with alcohol use disorders. Readers will benefit from cutting edge insights provided by outstanding, active researchers in the fields of neuroimmune research and alcohol use disorders
Yun Zhang - One of the best experts on this subject based on the ideXlab platform.
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Neural-Immune communication in Caenorhabditis elegans.
Cell host & microbe, 2009Co-Authors: Xiaodong Zhang, Yun ZhangAbstract:Communication between the nervous and immune systems is fundamental to animal physiology. However, the complicated anatomy and signaling pathways of these systems in mammals challenge the understanding of the Neural-Immune Interaction at molecular, cellular, and organismic levels. Caenorhabditis elegans has been valuable in this regard because of its simple, well-defined nervous system and accessibility to genetic, molecular, and behavioral analyses. Recent studies in C. elegans have identified neuronal pathways that regulate signaling cascades in innate immune responses, including a neuroendocrine network, a TGF-β pathway and dopaminergic neurotransmission, illuminating how specific neuronal signaling molecules and circuits control integrative immune responses.
Giuseppe Matarese - One of the best experts on this subject based on the ideXlab platform.
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Neuro-Endocrine Networks Controlling Immune System in Health and Disease
Frontiers in immunology, 2014Co-Authors: Claudio Procaccini, Valentina Pucino, Veronica De Rosa, Gianni Marone, Giuseppe MatareseAbstract:The peripheral nervous and immune systems are traditionally thought of as serving separate functions. However, recent clinical and experimental data, together with epidemiological studies, have suggested that the pathogenesis of several immune-mediated disorders such as multiple sclerosis (MS) might involve factors, hormones, and neural mediators, that link the immune and nervous system. These molecules or their receptors are member of the same superfamily which enable the mutual and bi-directional Neural-Immune Interaction. More recently, the discovery of leptin, one of the most abundant adipocyte-derived hormones that controls food intake and metabolism, has suggested that nutritional/metabolic status, acting at central level, can control immune self-tolerance, since it promotes experimental autoimmune encephalomyelitis, an animal model of MS. Here, we summarize the most recent advances and the key players linking the central nervous system, immune tolerance, and the metabolic status. Understanding this coordinated Interaction may advance therapeutic approaches to increase host defense and suppress immunopathology.