The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform

Ma Yi-tong - One of the best experts on this subject based on the ideXlab platform.

X Sun - One of the best experts on this subject based on the ideXlab platform.

  • Neither cytochrome P450 family genes nor Neuroendocrine Factors could independently predict the SSRIs treatment in the Chinese Han population.
    Pharmacopsychiatry, 2014
    Co-Authors: X Zhang, X Huang, X Sun
    Abstract:

    This study was intended to explore the relationship between the genetic polymorphisms of the 8 single nucleotide polymorphisms (SNPs) at CYP genes, Neuroendocrine Factors and the response to selective serotonin reuptake inhibitors (SSRIs) in Chinese Han depressive patients. This was a 6-week randomized controlled trial consisting of 290 Chinese Han depressive patients treated with SSRIs. 8 SNPs of CYP450 genes and 7 Neuroendocrine Factors were detected. Allele and genotype frequencies were compared between responders and non-responders. The relationships between Neuroendocrine Factors and treatment response were also analyzed. No significant differences were found in clinical features between 2 groups at the baseline. No statistical correlation was found between either the genotype or allele frequencies of SNPs in CYP1A2, CYP2C19, or CYP2D6 gene and the -efficacy of SSRIs. There were strong linkage disequilibria between rs4986894, rs1853205, and rs12767583 of CYP2C19 genes, and rs2472299, rs2472300 of CYP1A2 genes. No associations were found between the above haplotypes and the antidepressant response. No Neuroendocrine Factor was a significant predictor for a response to SSRI antidepressants independently. The combination of Neuroendocrine Factors, however, predicted the response by 76.1%. There were no significant associations between the 6 SNPs of CYP gene polymorphisms and SSRI response. Neither cytochrome P450 family genes nor Neuroendocrine Factors independently predict the patients' response to the antidepressants separately. A combination of Neuroendocrine Factors, however, does have the potential to predict the response. © Georg Thieme Verlag KG Stuttgart · New York.

  • Neither cytochrome P450 family genes nor Neuroendocrine Factors could independently predict the SSRIs treatment in the Chinese Han population.
    Pharmacopsychiatry, 2014
    Co-Authors: X. D. Zhang, X Huang, X Sun
    Abstract:

    OBJECTIVE This study was intended to explore the relationship between the genetic polymorphisms of the 8 single nucleotide polymorphisms (SNPs) at CYP genes, Neuroendocrine Factors and the response to selective serotonin reuptake inhibitors (SSRIs) in Chinese Han depressive patients. METHOD This was a 6-week randomized controlled trial consisting of 290 Chinese Han depressive patients treated with SSRIs. 8 SNPs of CYP450 genes and 7 Neuroendocrine Factors were detected. Allele and genotype frequencies were compared between responders and non-responders. The relationships between Neuroendocrine Factors and treatment response were also analyzed. RESULTS No significant differences were found in clinical features between 2 groups at the baseline. No statistical correlation was found between either the genotype or allele frequencies of SNPs in CYP1A2, CYP2C19, or CYP2D6 gene and the -efficacy of SSRIs. There were strong linkage disequilibria between rs4986894, rs1853205, and rs12767583 of CYP2C19 genes, and rs2472299, rs2472300 of CYP1A2 genes. No associations were found between the above haplotypes and the antidepressant response. No Neuroendocrine Factor was a significant predictor for a response to SSRI antidepressants independently. The combination of Neuroendocrine Factors, however, predicted the response by 76.1%. CONCLUSION There were no significant associations between the 6 SNPs of CYP gene polymorphisms and SSRI response. Neither cytochrome P450 family genes nor Neuroendocrine Factors independently predict the patients' response to the antidepressants separately. A combination of Neuroendocrine Factors, however, does have the potential to predict the response.

Timothy R. Levine - One of the best experts on this subject based on the ideXlab platform.

  • The Effect of Prenatal Sex Hormones on the Development of Verbal Aggression
    Journal of Communication, 2012
    Co-Authors: Allison Z. Shaw, Michael R. Kotowski, Franklin J. Boster, Timothy R. Levine
    Abstract:

    This article considers the Neuroendocrine Factors leading to systematic differences in trait verbal aggression (VA). Verbally aggressive people produce messages that attack the self-concept of another (D. A. Infante & C. J. Wigley, 1986). A Neuroendocrine Factor, prenatal androgen exposure (PNAE), was proposed as a possible predictor of VA. To explore this possibility, the relationship between the ratio between the length of the second digit and fourth digit (2D:4D), an indicator of PNAE, and VA was examined across 2 studies. Specifically, it was predicted that variance in PNAE would be correlated with variance in trait VA. Results from the 2 studies indicated that 2D:4D is correlated with VA as predicted, even with the influence of sex removed.

Maria Sifaki - One of the best experts on this subject based on the ideXlab platform.

  • Neuroendocrine Factors: The missing link in non‑melanoma skin cancer (Review)
    Oncology reports, 2017
    Co-Authors: Mihai Lupu, Ana Caruntu, Constantin Caruntu, Laura Maria Lucia Papagheorghe, Mihaela Ilie, Vlad Mihai Voiculescu, Daniel Boda, Carolina Constantin, Cristiana Tanase, Maria Sifaki
    Abstract:

    Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Arising primarily on sun‑exposed skin, it has been shown that ultraviolet radiation is, in the majority of cases, the main trigger involved in the pathogenesis of NMSC. Aside from the well‑known etiopathogenic Factors, studies have indicated that several neuroactive Factors are involved in the carcinogenesis of two of the most common types of NMSC, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), with the exception of penile SCC, for which a paucity of specific data on their pathogenic role exists. The complex interaction between the peripheral nervous system and target cells in the skin appears to be mediated by locally released Neuroendocrine Factors, such as catecholamines, substance P, calcitonin gene‑related peptide and somatostatin, as well as neurohormones, such as proopiomelanocortin and its derived peptides, α‑melanocyte‑stimulating hormone and adrenocorticotropin. All these Factors have been, at least at some point, a subject of debate regarding their precise role in the pathogenesis of NMSC. There is also a significant body of evidence indicating that psychological stress is a crucial impact Factor influencing the course of skin cancers, including SCC and BCC. Numerous studies have suggested that Neuroendocrine Factor dysregulation, as observed in stress reactions, may be involved in tumorigenesis, accelerating the development and progression, and suppressing the regression of NMSC. Further studies are required in order to elucidate the exact mechanisms through which neuroactive molecules promote or inhibit cutaneous carcinogenesis, as this could lead to the development of more sophisticated and tailored treatment protocols, as well as open new perspectives in skin cancer research.

Azeddine Driouich - One of the best experts on this subject based on the ideXlab platform.

  • Chromogranin A Induces the Biogenesis of Granules with Calcium- and Actin-Dependent Dynamics and Exocytosis in Constitutively Secreting Cells
    Endocrinology, 2012
    Co-Authors: Salah Elias, Charlène Delestre, Stéphane Ory, Sebastien Marais, Maïté Courel, Rafael Vazquez-martinez, Sophie Bernard, Laurent Coquet, Maria Malagon, Azeddine Driouich
    Abstract:

    Chromogranins are a family of acidic glycoproteins that play an active role in hormone and neuro-peptide secretion through their crucial role in secretory granule biogenesis in Neuroendocrine cells. However, the molecular mechanisms underlying their granulogenic activity are still not fully understood. Because we previously demonstrated that the expression of the major component of secretory granules, chromogranin A (CgA), is able to induce the formation of secretory granules in nonendocrine COS-7 cells, we decided to use this model to dissect the mechanisms triggered by CgA leading to the biogenesis and trafficking of such granules. Using quantitative live cell imaging, we first show that CgA-induced organelles exhibit a Ca 2ϩ-dependent trafficking, in contrast to native vesicle stomatitis virus G protein-containing constitutive vesicles. To identify the proteins that confer such properties to the newly formed granules, we developed CgA-stably-expressing COS-7 cells, purified their CgA-containing granules by subcellular fractionation, and analyzed the granule proteome by liquid chromatography tandem mass spectrometry. This analysis revealed the association of several cytosolic proteins to the granule membrane, including GTPases, cytoskeleton-based molecular motors, and other proteins with actin-and/or Ca 2ϩ-binding properties. Furthermore, disruption of cytoskeleton affects not only the distribution and the transport but also the Ca 2ϩ-evoked exocytosis of the CgA-containing granules, indicating that these granules interact with microtubules and cortical actin for the regulated release of their content. These data demonstrate for the first time that the Neuroendocrine Factor CgA induces the recruitment of cytoskeleton-, GTP-, and Ca 2ϩ-binding proteins in constitutively secreting COS-7 cells to generate vesicles endowed with typical dynamics and exocytotic properties of neuroen-docrine secretory granules. (Endocrinology 153: 0000-0000, 2012)