Neuropathic Pain

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Mark S. Wallace - One of the best experts on this subject based on the ideXlab platform.

  • medical cannabis for Neuropathic Pain
    Current Pain and Headache Reports, 2018
    Co-Authors: Brittany Grovey, Timothy Furnish, Mark S. Wallace
    Abstract:

    Many cultures throughout history have used cannabis to treat a variety of Painful ailments. Neuropathic Pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery has elucidated the intricate role of the endocannabinoid system in the pathophysiology of Neuropathic Pain. As societal perceptions change, and legislation on medical cannabis relaxes, there is growing interest in the use of medical cannabis for Neuropathic Pain. We examined current basic scientific research and data from recent randomized controlled trials (RCTs) evaluating medical cannabis for the treatment of Neuropathic Pain. These studies involved patients with diverse etiologies of Neuropathic Pain and included medical cannabis with different THC concentrations and routes of administration. Multiple RCTs demonstrated efficacy of medical cannabis for treating Neuropathic Pain, with number needed to treat (NNT) values similar to current pharmacotherapies. Although limited by small sample sizes and short duration of study, the evidence appears to support the safety and efficacy of short-term, low-dose cannabis vaporization and oral mucosal delivery for the treatment of Neuropathic Pain. The results suggest medical cannabis may be as tolerable and effective as current Neuropathic agents; however, more studies are needed to determine the long-term effects of medical cannabis use. Furthermore, continued research to optimize dosing, cannabinoid ratios, and alternate routes of administration may help to refine the therapeutic role of medical cannabis for Neuropathic Pain.

  • Pharmacologic treatment of Neuropathic Pain.
    Current pain and headache reports, 2001
    Co-Authors: Mark S. Wallace
    Abstract:

    Neuropathic Pain, or Pain after nervous system injury, can be very refractory to pharmacologic interventions. Through a better understanding of the pathophysiology of Neuropathic Pain, it has been suggested that nonopioid agents, such as antidepressants and anticonvulsants, may be more efficacious in the treatment of Neuropathic Pain than common analgesics, such as opioids or nonsteroidal anti-inflammatory drugs. However, this has not been consistently demonstrated in clinical studies. Conversely, many confounding factors of Neuropathic Pain make it difficult to interpret clinical studies. Therefore, we must develop a better understanding of the preclinical models of Neuropathic Pain to better understand the application of new and old drugs to the human Neuropathic Pain state. This article provides an overview of the commonly used preclinical Neuropathic Pain models, followed by a summary of the efficacy of currently available agents in preclinical Pain models and human correlates.

Michael I. Bennett - One of the best experts on this subject based on the ideXlab platform.

  • Cancer-Related Neuropathic Pain
    Cancers, 2019
    Co-Authors: Helen Edwards, Matthew R. Mulvey, Michael I. Bennett
    Abstract:

    Neuropathic Pain in cancer is common and debilitating. It is important to differentiate Neuropathic Pain from other cancer-related Pains as it is associated with worse Pain outcomes and requires different treatment strategies. This review summarises recent updates to Pain classification, aetiology, Pain assessment and current recommendations for treatment in patients with cancer-related Neuropathic Pain.

  • Diagnosis and management of Neuropathic Pain
    BMJ (Clinical research ed.), 2009
    Co-Authors: Rainer Freynhagen, Michael I. Bennett
    Abstract:

    #### Summary points Neuropathic Pain arises from damage, or pathological change, in the peripheral or central nervous system. It is usually a chronic condition that can be difficult to treat because standard treatment with conventional analgesics does not typically provide effective relief of Pain. Patients with Neuropathic Pain commonly present to primary care professionals, but making a diagnosis may be difficult. Neuropathic Pain is usually associated with substantially greater impairment of quality of life compared with other types of chronic Pain, and the disorder is a large cost burden on healthcare services. In this review, we provide an overview of published evidence to help clinicians recognise and manage patients with Neuropathic Pain. A group of specialists of the International Association for the Study of Pain defines Neuropathic Pain as “Pain arising as a direct consequence of a lesion or disease affecting the somatosensory system.”1 In contrast to inflammatory or nociceptive Pain, which is caused by actual tissue damage or potentially tissue damaging stimuli, Neuropathic Pain is produced either by damage to, or pathological change in, the peripheral or central nervous system, the system that normally signals Pain. As such, the term Neuropathic Pain represents a varying set of symptoms rather than a single diagnosis. Damage to the somatosensory system can provoke a range of responses; an absence of sensation and Pain is probably a more common response than new onset of …

  • Assessment of Neuropathic Pain
    Continuing Education in Anaesthesia Critical Care & Pain, 2008
    Co-Authors: Sarah Callin, Michael I. Bennett
    Abstract:

    Neuropathic Pain is initiated or caused by a primary lesion or dysfunction of the nervous system. A consensus regarding the classification and assessment of Neuropathic Pain has yet to be reached. The diseases responsible for Neuropathic Pain are diverse; the clinical presentation of Pain can vary widely between individuals despite the same underlying aetiology. Common features of Neuropathic Pain include spontaneous and evoked Pains. Investigations may help to identify evidence of nerve dysfunction but it cannot be assumed that it is necessarily the cause of their Pain.

Brittany Grovey - One of the best experts on this subject based on the ideXlab platform.

  • medical cannabis for Neuropathic Pain
    Current Pain and Headache Reports, 2018
    Co-Authors: Brittany Grovey, Timothy Furnish, Mark S. Wallace
    Abstract:

    Many cultures throughout history have used cannabis to treat a variety of Painful ailments. Neuropathic Pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery has elucidated the intricate role of the endocannabinoid system in the pathophysiology of Neuropathic Pain. As societal perceptions change, and legislation on medical cannabis relaxes, there is growing interest in the use of medical cannabis for Neuropathic Pain. We examined current basic scientific research and data from recent randomized controlled trials (RCTs) evaluating medical cannabis for the treatment of Neuropathic Pain. These studies involved patients with diverse etiologies of Neuropathic Pain and included medical cannabis with different THC concentrations and routes of administration. Multiple RCTs demonstrated efficacy of medical cannabis for treating Neuropathic Pain, with number needed to treat (NNT) values similar to current pharmacotherapies. Although limited by small sample sizes and short duration of study, the evidence appears to support the safety and efficacy of short-term, low-dose cannabis vaporization and oral mucosal delivery for the treatment of Neuropathic Pain. The results suggest medical cannabis may be as tolerable and effective as current Neuropathic agents; however, more studies are needed to determine the long-term effects of medical cannabis use. Furthermore, continued research to optimize dosing, cannabinoid ratios, and alternate routes of administration may help to refine the therapeutic role of medical cannabis for Neuropathic Pain.

  • Medical Cannabis for Neuropathic Pain
    Current Pain and Headache Reports, 2018
    Co-Authors: Brittany Grovey, Timothy Furnish, Mark Wallace
    Abstract:

    Purpose of Review Many cultures throughout history have used cannabis to treat a variety of Painful ailments. Neuropathic Pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery has elucidated the intricate role of the endocannabinoid system in the pathophysiology of Neuropathic Pain. As societal perceptions change, and legislation on medical cannabis relaxes, there is growing interest in the use of medical cannabis for Neuropathic Pain. Recent Findings We examined current basic scientific research and data from recent randomized controlled trials (RCTs) evaluating medical cannabis for the treatment of Neuropathic Pain. These studies involved patients with diverse etiologies of Neuropathic Pain and included medical cannabis with different THC concentrations and routes of administration. Multiple RCTs demonstrated efficacy of medical cannabis for treating Neuropathic Pain, with number needed to treat (NNT) values similar to current pharmacotherapies. Summary Although limited by small sample sizes and short duration of study, the evidence appears to support the safety and efficacy of short-term, low-dose cannabis vaporization and oral mucosal delivery for the treatment of Neuropathic Pain. The results suggest medical cannabis may be as tolerable and effective as current Neuropathic agents; however, more studies are needed to determine the long-term effects of medical cannabis use. Furthermore, continued research to optimize dosing, cannabinoid ratios, and alternate routes of administration may help to refine the therapeutic role of medical cannabis for Neuropathic Pain.

Helen Edwards - One of the best experts on this subject based on the ideXlab platform.

  • Cancer-Related Neuropathic Pain
    Cancers, 2019
    Co-Authors: Helen Edwards, Matthew R. Mulvey, Michael I. Bennett
    Abstract:

    Neuropathic Pain in cancer is common and debilitating. It is important to differentiate Neuropathic Pain from other cancer-related Pains as it is associated with worse Pain outcomes and requires different treatment strategies. This review summarises recent updates to Pain classification, aetiology, Pain assessment and current recommendations for treatment in patients with cancer-related Neuropathic Pain.

Mark Wallace - One of the best experts on this subject based on the ideXlab platform.

  • Medical Cannabis for Neuropathic Pain
    Current Pain and Headache Reports, 2018
    Co-Authors: Brittany Grovey, Timothy Furnish, Mark Wallace
    Abstract:

    Purpose of Review Many cultures throughout history have used cannabis to treat a variety of Painful ailments. Neuropathic Pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery has elucidated the intricate role of the endocannabinoid system in the pathophysiology of Neuropathic Pain. As societal perceptions change, and legislation on medical cannabis relaxes, there is growing interest in the use of medical cannabis for Neuropathic Pain. Recent Findings We examined current basic scientific research and data from recent randomized controlled trials (RCTs) evaluating medical cannabis for the treatment of Neuropathic Pain. These studies involved patients with diverse etiologies of Neuropathic Pain and included medical cannabis with different THC concentrations and routes of administration. Multiple RCTs demonstrated efficacy of medical cannabis for treating Neuropathic Pain, with number needed to treat (NNT) values similar to current pharmacotherapies. Summary Although limited by small sample sizes and short duration of study, the evidence appears to support the safety and efficacy of short-term, low-dose cannabis vaporization and oral mucosal delivery for the treatment of Neuropathic Pain. The results suggest medical cannabis may be as tolerable and effective as current Neuropathic agents; however, more studies are needed to determine the long-term effects of medical cannabis use. Furthermore, continued research to optimize dosing, cannabinoid ratios, and alternate routes of administration may help to refine the therapeutic role of medical cannabis for Neuropathic Pain.